Articles tagged with Cancer
Adult fibrosarcoma is a rare and highly aggressive malignancy requiring precise diagnosis and multimodal treatment. The case report emphasizes the need for early detection, complete surgical removal, and tailored postoperative care to improve outcomes in patients with this type of tumor.
A federally funded study found children with leukemia who were exposed to pesticides during their mother's pregnancy had a higher risk of death. The study, published in Cancers, examined over 800 children and showed pesticide exposure increased child mortality by up to 60%.
A clinical trial found that patients with mesothelioma who received combination immunotherapy drugs before surgery had successful surgeries and improved early outcomes. The study showed that tracking tumor DNA in the blood could help predict treatment benefit.
Researchers have developed a new technique to measure boron in individual cancer cells, enabling the study of how drugs interact with tumour cells. This breakthrough could lead to more effective treatments for head and neck cancers.
A new study from Mizzou's College of Veterinary Medicine analyzed the effects of radioactive iodine therapy on thyroid cancer in dogs. The research found that tailoring the dose of radiation more precisely for each dog could improve outcomes and potentially lead to more targeted care.
Experts weighed in on the current state of artificial intelligence (AI) in cancer care, noting both its potential for improving efficiency and its challenges. Many expressed excitement over AI's possibilities for helping support an overburdened oncology workforce and accelerating the pursuit of new cures.
Researchers create nanoparticles shaped like bottlebrushes with antibodies guiding them to tumor sites, delivering a large range of chemotherapy drugs directly to cancer cells. This approach reduces the need for potent drugs and enhances customizability of treatment options.
A clinical study suggests that immunotherapy can be effective in treating mesothelioma, a rare cancer affecting the lining of the lungs. The trial found improvements in time to tumor growth and overall length of survival for patients with operable diffuse pleural mesothelioma.
Researchers found that frail patients with residual intra-abdominal bacteria or fungi are at a higher risk of developing postoperative ileus and infections. The study suggests that incorporating frailty assessment and prehabilitation programs into surgical planning may help reduce complications.
The Lung Cancer Genetics Study has launched an open-source data platform, offering no-cost access to de-identified data from consenting participants. Researchers can conduct analyses on germline genotyping, self-reported health and exposure data, and cancer-causing driver mutations, with longitudinal datasets to be added over time.
Researchers harness AlphaFold 3 to predict how T cells recognize peptides, opening avenues for precision immunotherapy and vaccine design. The approach enables in silico identification of immunogenic epitopes that could serve as vaccine targets.
A new study published in the American Cancer Society's journal reveals that nearly 1 in 10 patients undergoing surgery for early-stage cancer will initiate opioid prescriptions long-term. The research found that those with a prior history of chronic pain, comorbidities, and lower socioeconomic status were at higher risk.
Researchers at Indiana University School of Medicine have developed a novel candidate drug that shifts the behavior of immunosuppressive regulatory T cells, turning them from cancer protectors into tumor fighters. The study shows promising results in clearing triple-negative breast cancer tumors and treating other aggressive cancers.
A team of scientists has identified rogue DNA rings as early drivers of glioblastoma growth, suggesting a window of opportunity for earlier detection and treatment. The study suggests that targeting these DNA rings could lead to more effective treatments.
Researchers have developed an immunotherapy drug STF-1623 that safely prevents cancer cells from hiding from the immune system's first responders. The drug works by inhibiting ENPP1 proteins that destroy cGAMP, allowing it to trigger a broader immune response and suppress tumor growth.
Researchers have identified a potential new strategy for treating glioblastoma multiforme (GBM), the most common and aggressive type of adult brain cancer. Disabling a protein called ADAR1 can stall GBM cell proliferation while reprogramming the tumor microenvironment to an anti-tumoral state.
Dr. Steven B. Heymsfield joins an elite group of scholars recognized for advancing knowledge and transforming their fields. He has authored over 1,300 scientific publications with nearly 79,000 citations, placing him among the top 500 most-cited researchers globally.
Researchers at Sanford Burnham Prebys Medical Discovery Institute found that using a drug as a blocker to outcompete the SUMO2 protein may be a winning strategy against synovial sarcoma. This approach aims to reverse aberrant epigenetic rewiring driven by the SS18::SSX fusion oncoproteins and impair sarcomagenesis.
The ASTRO's 2025 Annual Meeting will feature pivotal studies in radiation medicine, highlighting advances in radiopharmaceutical therapy and new indications for low-dose radiation therapy. The meeting will also explore cutting-edge techniques for prostate, breast, lung, and other common cancers.
Researchers uncover how cerebrospinal fluid dynamics drive tumour spread, identifying a way to target this process to inhibit metastasis. The study provides new insights into the role of fluid shear stress in shaping cancer behaviour and offers a promising therapeutic approach for medulloblastoma.
Researchers have identified two molecular targets, HER2 and CD24, as promising candidates for new nuclear diagnostics and therapeutics for endometrial cancer. These targets may help clinicians identify patients likely to respond to targeted therapies, offering new hope for those with disseminated or recurrent disease.
Scientists discovered that human melanoma cancer cells behave like stem cells when forced through channels narrower than 10 micrometres, gaining traits to survive, spread, and form new tumours. Researchers created a biomedical device to simulate blood flow through narrow blood vessels, showing the mechanical pressure makes cancer cells...
Researchers at SMART Alliance for Research and Technology developed a powerful tool to scan thousands of biological samples and detect transfer ribonucleic acid (tRNA) modifications, which help control cell growth and response to diseases. The tool opens up new possibilities for disease research, diagnostics, and treatment development.
Researchers discovered that breast cancer cells co-opt iron-recycling immune cells in bone marrow to acquire essential minerals, disrupting red blood cell production. This adaptation enables cancer cells to survive in low-oxygen environments and proliferate, ultimately leading to anemia and poor patient outcomes.
Researchers developed a high-volume method to rapidly build and test large numbers of antibodies at once, accelerating antibody research and treatment development. The oPool+ display platform has potential applications in influenza vaccination research, infectious disease treatment, and cancer research.
Researchers found a unique microbial signature in colorectal cancer samples that can accurately distinguish them from other types of cancer. This discovery has the potential to improve diagnosis and treatment outcomes for patients with colorectal cancer.
A new study assesses ChatGPT 3.5's performance on hematology-oncology tasks, revealing its strengths and limitations in providing accurate information for patients. The study highlights the importance of physician oversight when using AI-generated medical information.
Researchers have created a human vascularized liver cancer-on-a-chip model to evaluate vessel remodeling and cell death in response to embolic agents. This innovative platform replicates the microenvironment of liver tumors, providing unprecedented insight into how tumors respond to embolization.
Researchers at the University of Mississippi have developed a new method to deliver cancer therapies directly to triple-negative breast cancer cells. The sugar-coated nanoparticles effectively target this aggressive cancer, which affects young women and disproportionately impacts Black women. The discovery holds promise for treating no...
A team of scientists has developed a protein-based therapeutic tool called Crunch to target and remove specific living cells, such as cancer cells or overactive immune cells. The new system uses the body's natural waste removal system to clear out unwanted cells, offering hope for improved treatments.
Researchers have developed a novel urine-based test to identify prostate cancer using biomarkers TTC3, H4C5, and EPCAM. The three-biomarker panel accurately detected prostate cancer 91% of the time and ruled out non-cancerous conditions 84% of the time in validation studies.
Prostate cancer incidence rates have reversed from a decline to an increase, with advanced-stage diagnoses rising by 4.6-4.8% per year. Meanwhile, mortality declines slowed from 3-4% per year in the 1990s and 2000s to 0.6% over the past decade. The study highlights wide disparities, with Black men facing twice the risk of death compare...
Scientists have found a way to stop brain cancer cells from spreading by 'freezing' hyaluronic acid molecules in place. This approach could lead to a new type of treatment for glioblastoma, the most aggressive form of brain cancer.
A recent study found that menin promotes bladder cancer malignancy by enhancing TFAP2C/β-catenin signaling, suggesting its potential as a therapeutic target and prognostic marker. Menin upregulates TFAP2C expression, which regulates β-catenin gene transcription via binding to its proximal promoter.
Researchers at Northwestern University have developed a new CRISPR delivery system that triples efficiency using DNA-wrapped nanoparticles, improving safety and effectiveness. The new system, called LNP-SNAs, targets specific cells and tissues, reducing toxicity and boosting gene-editing efficiency by threefold.
Researchers at Lund University identify genetic toolkit to program dendritic cell subtypes for targeted cancer treatment. The discovery could lead to more precise and powerful immunotherapies by supplying patients with tailored dendritic cells.
A subanalysis of the LoDoCo2 trial found that low-dose colchicine slows the growth of clonal hematopoiesis, a common acquired gene mutation linked to cardiovascular disease and cancer. Colchicine was associated with significantly attenuated clonal growth in TET2-mutated CH.
A retrospective cohort study found that cancer patients in Massachusetts experience persistent medical debt, even with high insurance coverage. The study highlights the need for broader systemic reforms to address this issue.
A scientific team co-led by Dr. Lishomwa Ndhlovu at Weill Cornell Medicine has received an NIH MERIT Award to study a handful of people who have managed to clear HIV after a stem cell transplant. The goal is to identify the immune mechanisms that led to remission and develop a broadly applicable immunotherapy for eliminating HIV.
Researchers identified a core group of 15 bacterial genera in 6 types of GI tumors that predicts prognosis. Microbiome signals inside tumors carry prognostic and therapeutic information that can be measured on routine tissue. The study suggests a microbiota-based risk score to identify high-risk patients and inform treatment decisions.
A recent survey by Ohio State University Comprehensive Cancer Center found that 80% of Americans are unaware of the lack of noticeable symptoms in early-stage prostate cancer. The disease is treatable if caught early, and regular screening is crucial.
A phase 2 clinical trial found that autologous tumor-infiltrating lymphocyte (TIL) cell therapy helped stabilize metastatic head and neck squamous cell carcinoma (HNSCC) in some patients. The median response duration was 7.6 months, with cancer stabilization occurring in 64% of patients.
The foundation provides $300,000 total funding over four years to investigate cancer causes, mechanisms, therapies, and prevention. This support fosters interdisciplinary research and encourages innovative projects that push boundaries and make breakthroughs.
Researchers mapped the surface envelope glycoprotein of human endogenous retroviruses, opening doors to new diagnostic and therapeutic opportunities. The study revealed specific antibodies that target the viral proteins, potentially leading to new cancer immunotherapies and treatments for autoimmune diseases.
Researchers developed a multi-analyte test that accurately identifies brain cancers using small samples of cerebrospinal fluid, offering a promising new tool for guiding clinical decision-making. The test combines multiple biological markers and demonstrates high sensitivity and specificity in detecting central nervous system cancers.
A new study finds that PAD2-mediated histone citrullination promotes tumor cell proliferation in pancreatic ductal adenocarcinoma. Knocking down the PAD2 gene reduces cell growth and increases survival rates. The researchers identify PAD inhibitors as potential therapeutic targets for treating PDAC.
Network meta-analysis reveals Qigong and Taichi as most effective exercises for pain alleviation in cancer patients. These mind-body therapies are proven to be more beneficial than conventional exercise and have fewer adverse reactions.
Forskolin, a natural compound, significantly improves treatment outcomes for KMT2A-r AML by directly stopping leukaemia cell growth and enhancing chemotherapy effectiveness. Forskolin blocks P-glycoprotein 1, allowing more chemotherapy drugs to enter leukaemia cells, making treatments more potent.
A key contributor is the lab of Prof. Ayal Hendel at Bar-Ilan University's Goodman Faculty of Life Sciences, focusing on evaluating CRISPR-based gene editing precision and safety. The project aims to decentralize CAR-T cell therapy production, making it available to more patients by reducing costs and increasing accessibility.
The American Thyroid Association has released new guidelines for managing adult patients with differentiated thyroid cancer, emphasizing evidence-based recommendations for diagnosis, treatment, and monitoring. The guidelines highlight the importance of patient-reported outcomes and areas for further research.
Researchers identified three distinct molecular subtypes of follicular lymphoma, offering insights into personalized treatment plans. The subtypes C1, C2, and C3 differ in their genetic profiles and tumor microenvironments, guiding the use of specific therapies.
Researchers developed Vesalius to interpret complex data on cancer cell interactions, leading to potential discoveries in treating hard-to-treat cancers. The tool analyzes whole tissue architecture to identify predictive biomarkers and inform treatment options based on individual disease types.
A new guideline from the Canadian Task Force on Preventive Health Care provides a menu of effective options to help people quit smoking, including behavioural and medication options. The guideline aims to address the challenges of nicotine addiction and offers personalized choices for quitting tobacco.
Recent advancements in screening methods and point-of-care diagnostics offer hope for early detection and improved outcomes in colorectal cancer. Emerging technologies such as single-cell sequencing, spatial transcriptomics, and artificial intelligence are being leveraged to enhance diagnostic accuracy and personalized risk prediction.
Researchers from the University of Maryland School of Medicine have developed a reliable measurement for opening the blood-brain barrier using focused ultrasound. By analyzing acoustic emissions signals generated by circulating microbubbles, they found that this method can predict blood-brain barrier opening in patients with glioblasto...
Researchers at Purdue University have developed a new method to study biochemical processes that impair the immune system's ability to recognize and kill cancer cells. The method involves tracking RNA-binding proteins and extracellular vesicles, which can compromise immunotherapy.
A recent study published in CANCER reveals that many patients with advanced cancer report receiving treatment that focuses on longevity rather than comfort. Despite this mismatch, the treatment did not appear to extend life for those who did not want it. The research highlights the importance of open conversations between doctors and p...
Researchers created comprehensive catalogue of human gut microbiota subspecies and developed model predicting colorectal cancer presence from stool samples. The method detected 90% of cancer cases, outperforming current non-invasive detection methods.
Researchers achieved global-first using Brain Perioperative platform to learn how new drug suppresses tumour activity in low-grade gliomas, a slow-growing type of brain cancer. The trial involved patients who took the drug prior to any other cancer treatment and showed promising results.
The study found that EBV nuclear antigen 1 (EBNA1) significantly increases the expression of Derlin1 and PSMD10 genes in HeLa cells, both associated with enhanced cancer cell survival and proliferation. This suggests a potential mechanism by which EBV may contribute to cervical cancer progression.