Articles tagged with Cancer
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Chemotherapy-induced pyroptosis in bladder cancer can actually make the disease more resistant to treatment by fueling cancer stem cells. Blocking this inflammatory process with belnacasan may overcome chemoresistance in preclinical models.
A study found that children who lived near Coldwater Creek, a Missouri River tributary polluted by nuclear waste, had a higher risk of developing cancer. The researchers estimated that those living less than one kilometer away from the creek had a 44% higher risk of cancer compared to those living more than 20 kilometers away.
Researchers developed a new method to generate CAR-T cells in laboratory mice with mRNA-based vaccines, which proved effective and safe. The approach eradicated tumors in 75% of mice with B cell lymphoma after several doses.
A new study found that exercise can improve the quality of life and symptom management for CLL patients, but personalized guidance is needed. Patients prefer virtual classes, expert advice from cancer care specialists, and tailored programs addressing their unique challenges.
The review critically examines anti-TGFβ therapies for cancer treatment, highlighting the importance of targeting specific epitopes to mitigate off-target toxicity. It suggests implementing intermittent dosing schedules or optimally timed interventions to alleviate toxicity without compromising efficacy.
A new treatment approach using cyclophosphamide has been found to prevent most graft-versus-host disease in mismatched transplants. The study shows that 80% of patients are alive after a year, similar to outcomes seen in fully matched transplants.
Researchers from Korea University have discovered that the protein WEE1 can paradoxically drive immune resistance in cancer cells when located in the cytoplasm. This study suggests that targeting WEE1 with an inhibitor, such as adavosertib, may sensitize tumors to immunotherapy and reinvigorate antitumor immunity.
The study reveals how nutrients and lipids shape bone marrow blood stem cells from health to aging and leukemia, identifying choline as a key player. Healthy stem cells had high choline levels, which decreased with specialization and aging, suggesting nutritional interventions could maintain stem cell function.
This special issue focuses on cutting-edge advancements in polypharmacology for cancer therapy, addressing mechanisms of drug resistance and rational design of drug combinations. It also covers computational and AI-driven methodologies for discovering novel polypharmacological agents.
Researchers used AI model ChatGPT-4 to extract clinical variables from MRI and CT scans of nearly 1,000 adults with pancreatic cysts. The accuracy rate ranged from 97% for solid components to 99% for calcific lesions, comparable to human performance.
Researchers developed a novel immunotherapy that disrupts the IL-33/IL1RL1 signaling loop to boost immune function and improve survival in leukemia patients. The treatment targeted leukemia stem cells, reducing relapse rates and improving survival without major side effects.
A new study from Uppsala University found that most men with prostate cancer who receive recommended treatment have a good prognosis, with a lower risk of dying from prostate cancer than other causes. The study's findings highlight the importance of assessing a patient's life expectancy in choosing an appropriate treatment strategy.
Researchers found that prostate cancer cells store fats in lipid droplets under low oxygen conditions, making them less vulnerable to ferroptosis. This adaptation allows cancer cells to evade therapies designed to trigger cell death.
A new study by The Endocrine Society finds a strong link between acromegaly and an increased risk of various cancers, often at younger ages than expected. Patients with the rare growth hormone disorder had higher rates of certain types of cancer, including colon, gastric, breast, lung, ovarian, prostate, and blood cancers.
Cancer deaths linked to obesity have increased sharply in the US, especially among women and older adults, with sharp regional disparities. The study highlights the need for targeted public health strategies to address this growing public health crisis.
Researchers found that tirzepatide reduced body weight and body fat by approximately 20% in mice, resulting in a significant reduction of tumor volume. The study suggests that this new anti-obesity drug may have a beneficial impact on breast cancer outcomes.
A study using AI language models analyzed sentiments and emotions expressed by almost 400 pediatric patients on social media, finding that 94% of comments were negative, with sadness and fear prevalent. The study highlights the need for integrated care approaches to support vulnerable young patients managing complex medical conditions.
A Danish study finds that HPV vaccination has reduced prevalence of high-risk HPV types among vaccinated women, suggesting population immunity. However, non-vaccine types remain common and new infections occur more frequently in vaccinated women than unvaccinated women.
A study of 62,839 people diagnosed with non-metastatic prostate cancer in Sweden found that those treated according to NCCN Guidelines were likely to survive their cancer for their remaining life-expectancy. Those with low- and intermediate-risk cancer were six times more likely to die of other causes than prostate cancer.
Researchers found Galectin-1, a sugar-binding protein, plays a critical role in helping hepatocellular carcinoma cells resist thermal ablation and thrive after being treated with high heat. Blocking Gal-1 can make thermal ablation more effective and reduce the risk of recurrence.
A new breast scan system combines photoacoustic and ultrasound imaging to produce clear 3D images of common breast cancer subtypes. The system, called OneTouch-PAT, takes less than a minute to complete and excels at detecting suspicious lesions in women with dense breast tissue.
An international study has shown that BrECADD preserves fertility significantly better than eBEACOPP without worsening recovery chances. After treatment, 95% of women and 86% of men had normal hormone levels, enabling more pregnancies and births.
Researchers discovered a cancer signaling pathway's role in regulating the blood-retina barrier, potentially damaging protective mechanisms. The study also identified a new gene linked to inherited eye condition FEVR, highlighting the need for further investigation into vascular disorders.
A new study published in BioScience found that cancer is incredibly rare in turtles, affecting only about 1% of individuals. The research, led by the University of Nottingham, analyzed medical records and necropsies from hundreds of zoo turtles, revealing tumours rarely spread.
Researchers at Vanderbilt University Medical Center have developed a safe and effective fluorescent imaging agent that can assist surgeons in visualizing nerves during head and neck surgery. The agent, bevonescein, allows for intraoperative nerve-specific fluorescence visualization, reducing the risk of nerve injury.
Researchers identified RTK dependent and independent mechanisms of resistance to EGFR targeted therapies in breast and head and neck cancers, highlighting opportunities for combination therapies and biomarker identification.
A new multi-institutional clinical trial will test zipalertinib, an investigational drug targeting specific EGFR mutations in early-stage non-small cell lung cancer. The goal is to prevent recurrence and improve long-term outcomes for patients with limited treatment options.
Researchers at Boston University have found that exosomes released by obese tissues can turn slow-moving TNBC cells into highly mobile and invasive ones. This discovery could lead to the development of non-invasive biomarkers for metastatic risk and new drug targets like Rho-protein inhibitors.
The American Society for Nutrition (ASN) has announced that NUTRITION 2026 will be held in National Harbor, Maryland, near Washington, DC. The meeting will showcase the latest developments in nutrition science and feature top experts in the field. Abstract submissions open this fall, and award nominations will also be accepted.
A recent analysis of 16 years of data on Japanese adults reveals a strong association between socioeconomic status and the incidence of five common cancers. Communities with low employment rates or low incomes show higher cancer rates compared to those with higher socioeconomic status.
A recent survey found that 39% of respondents incorrectly identified all processed foods as unhealthy. However, the Physicians Committee for Responsible Medicine reports that it is not processed plant foods but rather meat consumption associated with an increased risk of type 2 diabetes and cardiovascular disease.
Researchers identify new group of immune cells driving autoimmune attack on insulin-producing cells in pancreas during cancer immunotherapy. JAK inhibitors, already FDA-approved for psoriasis and arthritis, show potential to prevent and even reverse type 1 diabetes in preclinical models.
Cancer cells utilize more energy from a less efficient pathway, but researchers found that power-generating waves on the cell membrane could be used to stage cancers and target drugs. Measuring these waves may help stage cancers in a standardized way.
A new prototype imaging system combines light-emitting diodes (LEDs) with hyperspectral imaging technology to create detailed maps of tissue properties invisible to conventional cameras. The system shows promise for cancer detection during endoscopy, achieving real-time speeds and high-quality data comparable to reference systems.
A new study from the University of Michigan Rogel Cancer Center identifies a cellular signature that explains why about one-third of prostate cancers respond especially poorly to treatment. The researchers found that docetaxel could be a good option earlier on in patients whose tumor harbors a specific gene program linked to extreme no...
A compound called NSC51349 has shown promise as an antiviral treatment against cutaneous human papillomaviruses (HPVs), reducing viral load without harming host cells. The discovery offers new potential for treating skin infections and cancers in immunocompromised individuals.
Gene coexpression analysis reveals optimal markers of cell types and states, providing opportunities for developing novel biomarkers and targeted treatment strategies for glioma patients. Dr. Oldham's work tackles the reproducibility crisis in science, emphasizing data metadata standardization.
The study highlights a significant increase in early-onset colorectal cancer rates globally, particularly in high-income countries. Younger patients are more likely to receive aggressive treatment without survival advantage, and survivors often report problems with anxiety, body image, and sexual dysfunction.
A novel nanocarrier system utilizing metal-polyphenols enables precise intracellular delivery of therapeutic antibodies into cancer cells. This technology overcomes endosomal entrapment, resulting in suppressed tumor growth and enhanced anti-cancer activity.
A recent study discovered that the mutational landscape of blastic plasmacytoid dendritic cell neoplasm (BPDCN) is similar to other myeloid neoplasms. The researchers identified CCDC50 as a potential biomarker for this disease, which showed promising results in tracking disease activity and monitoring treatment success.
Researchers found that elevated L-aspartic acid levels predict gastric cancer risk, while influencing treatment outcomes of Helicobacter pylori eradication and garlic supplementation. This study suggests using plasma L-aspartic acid profiling to tailor prevention efforts and identify high-risk individuals.
A new bioinformatic tool called Cell Marker Accordion has been developed to help researchers understand single-cell analysis results. The tool reveals the presence of altered cells that may be linked to diseases such as blood cancers or solid tumours, and can identify unique genes involved in these alterations.
Rice University professor Lei Li has received a NSF CAREER Award to develop wearable medical imaging technology capable of visualizing deep tissue function in real time. The project aims to miniaturize hospital-grade imaging systems into compact, energy-efficient wearables.
Researchers develop self-assembling nanoparticles that induce ferroptosis in bladder cancer cells while reprogramming the tumor immune microenvironment, boosting anti-tumor activity. The nanomedicine has dual functions as a multifaceted approach to overcome treatment resistance and is Clinically translatable.
A new study from Karolinska Institutet found that adults who have survived childhood cancer are 58% more likely to develop severe COVID-19 if they contract the virus. Despite having a lower risk of infection, childhood cancer survivors experienced more serious consequences when they did become ill.
Recent advances in precision medicine for breast cancer have shown significant progress for each subtype, including HR+/HER2- and HER2-positive breast cancers. Immunotherapy has improved pathological complete response rates and survival for triple-negative breast cancer.
A study by Arc Institute and Stanford University scientists reveals that the target site of a popular STING inhibitor lacks a pocket found in mouse STING, making it challenging to develop effective human treatments. The research proposes targeting STING by preventing oligomerization, a key checkpoint prior to activation.
A new molecular tool, BLOCK-ID, has been developed to study the alternative lengthening of telomeres (ALT) pathway in cancer cells. The tool allows researchers to monitor protein interactions and identify essential proteins like TRIM24, which play a crucial role in ALT telomere maintenance.
The new microscope allows researchers to map and quantify the mechanical properties of biological tissues without interfering with them, enabling real-time monitoring. This breakthrough technology has far-reaching implications for fields such as inflammation, cancer, developmental biology, and biomedical materials.
MIT researchers have designed cheap, disposable electrochemical sensors that can detect multiple diseases using DNA-coated electrodes. The sensors were stabilized with a polymer coating, allowing them to be stored for up to two months, enabling potential use in low-resource regions and at home.
Researchers at Fujita Health University discovered benzaldehyde's mechanism to halt therapy-resistant pancreatic cancer growth and spread. Benzaldehyde prevents key interactions that enable cancer cells' survival and treatment resistance.
A new study from UF Health reveals an antibody-drug conjugate that kills aggressive B cell malignancies while sparing healthy cells. The combination of cancer-hunting antibodies and tiancimycin, a natural compound found in soil microbes, shows promise as a powerful treatment option for diffuse large B cell lymphoma.
Researchers have discovered a protein called BACE1 that helps lung cancer spread to the brain, where treatment options are currently limited. The study suggests that existing Alzheimer's drugs could be repurposed to prevent or slow the spread of lung cancer to the brain.
A new hydrogel-based platform has been developed to preserve live patient-derived tumor tissues in the lab, enabling more accurate testing of cancer treatments. The approach, which uses customizable bioengineered hydrogels, has been shown to retain key features of the original tumor environment.
Researchers identify tumor-associated macrophages that shield tumors from attack and promote metastasis in advanced prostate cancer. Blocking these cells with anti-SPP1 treatment boosts the immune response, slowing cancer progression.
Researchers have identified a single genetic difference in Fas Ligand, an immune protein, that makes it vulnerable to being disabled by plasmin, a tumor-associated enzyme. This vulnerability seems unique to humans and may contribute to the effectiveness of certain cancer treatments.
Researchers have identified WSTF as a protein that could be targeted to block chronic inflammation, allowing the immune system to continue responding appropriately to short-term threats. The study's findings suggest new potential treatments targeting WSTF may combat chronic inflammatory diseases
Researchers developed an innovative FENCY ligation technique combined with preoperative embolization to remove giant plexiform neurofibromas, reducing risk of complications and improving recovery time. The study results in significant functional improvement and high patient satisfaction rates.
Researchers at the University of Illinois Urbana-Champaign have developed a new non-invasive MRI approach that visualizes brain metabolism and detects metabolic alterations associated with brain diseases. The technique uses magnetic resonance spectroscopic imaging to provide insights into brain function and disease processes.
Dysregulation of phosphatases modulates various signaling pathways, including RAS/MAPK, PI3K, HIPPO, and JAK/STAT. This review highlights the tumour suppressive, tumour promoting, and context-dependent activities of phosphatases, as well as their roles in reshaping the tumour microenvironment through exosomal miRNA secretion.