Research on cancer as a disease, from cause to care. Covers tumor biology, small-cell lung cancer, cancer-linked stroke risk, and cancer center research.
Scientists have identified a new cell type and discovered that many normal-looking prostate cells harbor cancer-related changes. The study's findings could lead to new risk factors, earlier detection methods, and more targeted therapies for patients at high risk of aggressive disease.
A global panel of experts recommends a 10-year trial with 5,000 participants at high risk of cancer due to pre-cursor conditions. The trial will evaluate the potential efficacy of GLP-1 and dual receptor agonists in preventing obesity-related cancers.
The phase III Alliance ATOMIC trial shows that adding immunotherapy to standard chemotherapy improves clinical outcomes for patients with stage III dMMR colon cancer. The study found a 50% reduction in cancer recurrence risk and a 86.3% disease-free survival rate at three years.
A web-based platform, GIFT, educates people with cancer about the impact of genetic variants on their family. The tool allows patients to invite relatives and provides information, decision support, and access to genetic testing.
A recent report found that only two out of 23 identified priorities for childhood cancer research received dedicated UK funding. Five key areas, including improving hospital experiences and addressing emotional wellbeing, were overlooked entirely. The study highlights a significant gap between patient needs and research funding.
International researchers have developed a checklist of best practices for cancer microbiome research, emphasizing the importance of preventing contamination and validating findings. The guidelines aim to improve reproducibility and confidence in the field, supporting future discoveries about microbes and cancer.
A recent study found that breast cancer recurrence remains low even after ten years when patients receive tailored radiotherapy. The research involved 848 patients who underwent chemotherapy and surgery, and showed that radiotherapy can be reduced or eliminated in low-risk patients, leading to a significant decrease in side effects.
A study found CREB5 regulates basal and SCL transcriptional programs and tumor-forming phenotypes in prostate cancer, suggesting a central role in aggressive prostate cancer. Disrupting CREB5-regulated pathways may improve therapeutic responses in advanced disease.
A new study shows that polyurethane-coated breast implants are associated with lower rates of capsular contracture and the need for corrective surgery after radiotherapy. Women who received these implants had a significantly lower risk of developing scarring and needing further surgery compared to those who received standard implants.
Researchers developed a laboratory mouse model closely mirroring TCF3::HLF-positive B-ALL and found an inflammatory feedback loop linking leukemia progression and bone destruction. Blocking IL-1β action slowed leukemia growth and reduced bone damage, suggesting new cancer treatments.
Researchers at Adelaide University identified CD47 as a critical mechanism driving glioblastoma growth and spread. The study found that removing or blocking CD47 reduced tumour cell proliferation, migration, and invasion, leading to improved survival times in animal models.
A study by Cincinnati Children's Hospital Medical Center and the eMERGE network found that sharing genetic disease risk information with patients can be done responsibly, with a 70% success rate. The team shared results with over 24,000 people using various methods, including one-to-one conversations for those with higher-risk findings.
Researchers have developed tiny sensors capable of detecting multiple biomarkers simultaneously, including temperature and chemical changes. These sensors have the potential to revolutionize cancer diagnosis and monitoring by providing reliable and clear information about disease presence in a minimally invasive way.
The European project CGI-Clinics brings AI-powered Cancer Genome Interpreter (CGI) closer to clinical applications, enabling reliable and scalable tumour genome interpretation in precision oncology. The platform leverages machine learning to transform complex genomic data into actionable insights.
A large-scale study of over 421,000 individuals found no link between psychosocial factors and cancer incidence. However, some psychosocial factors were associated with a higher risk of lung cancer, which decreased after adjusting for known risk factors.
UCLA researchers identified a key protein, E2F3, essential for survival in cancer cells lacking the protective gene RB. Blocking E2F3 effectively halted tumor growth, offering a new strategy for treating aggressive cancers.
A new study has identified a PRRX2+ epithelial cell/SPP1+ macrophage axis that promotes gemcitabine resistance via TGF-β signaling in pancreatic cancer. The study suggests that targeting this cellular communication network may be key to overcoming drug resistance.
A novel method for monitoring on-treatment disease burden in high-grade serous ovarian cancer uses tumor-informed breakpoints-spanning ddPCR, detecting superior sensitivity and specificity compared to real-time PCR. The approach may enable sensitive and specific detection of minimal residual disease and early relapse detection.
Researchers engineered supercharged T cells that can recognize and kill prostate cancer cells more effectively. By fine-tuning how they physically interact with tumor cells, the T cells form a stronger bond, allowing them to deliver a targeted immune response without damaging healthy tissue.
Public awareness of the link between drinking alcohol and elevated cancer risk has remained unchanged since February 2025, with over half of Americans acknowledging that regular consumption increases cancer risk. The new US dietary guidelines do not mention this link, sparking criticism from health experts.
A Mayo Clinic study shows that delivering chemotherapy at home is safe and feasible, reducing physical, emotional, and financial burdens associated with cancer treatment. Patients experienced fewer disruptions to daily life while maintaining a continuous connection with their care team through virtual visits and remote monitoring.
The Society for Maternal-Fetal Medicine has released the first evidence-based clinical guidance for cancer diagnosis and treatment during pregnancy. The guidance aims to support both maternal health and pregnancy goals, while also prioritizing effective cancer therapy and fetal well-being.
A study led by Dr. Marco Milán identified mitochondria as a key player in a rare disease causing microcephaly, a condition where the brain develops to a smaller size. The researchers found that mitochondria dysfunction leads to proteotoxic stress, causing cells to accumulate errors in chromosome distribution, resulting in microcephaly.
Researchers at the University of Pennsylvania developed lipid nanoparticles that modify immune metabolism to strengthen mRNA vaccines and reduce common side effects. The new lipid boosts the metabolism of immune cells, providing energy for the body's defenses while dialing down inflammatory signals.
Dr. Aliesha O’Raw, Principal Investigator at TIBI and Co-Founder of OnVagus, has been selected for the 2026 ACS BrightEdge Entrepreneurs Program. The program provides mentorship, entrepreneur training, and early-stage investment support to advance cancer diagnostic and therapeutic solutions.
A phase 3 clinical trial found romiplostim significantly reduced chemotherapy dose delays and improved platelet counts in patients with gastrointestinal cancers who developed persistent low platelet counts during treatment. The therapy enables patients to maintain chemotherapy intensity, potentially preserving the integrity of cancer c...
Researchers developed a targeted genetic therapy using milk-derived nanoparticles to attack cancer cells while sparing healthy tissue. The approach shows promise in treating aggressive bile duct cancer with limited treatment options.
A novel drug delivery system developed by Osaka Metropolitan University improves Paclitaxel absorption by binding to the lipocalin-type prostaglandin D synthase enzyme, enabling selective delivery to cancer tissues. The system demonstrates significant tumor suppression effects even after administration cessation.
Researchers from Institute of Science Tokyo reveal the SPP1–CD44–Hedgehog signaling pathway as a key driver of fibrosis in liver tumors, hinting at its potential as a therapeutic target. The study provides valuable insights into how liver tumors actively shape their surroundings, driving the onset and progression of fibrosis.
Researchers at UCLA have developed a novel immunotherapy that uses CAR-NKT cell therapy to fight endometrial cancer. The therapy achieved complete tumor elimination and prolonged survival in mouse models, outperforming conventional CAR-T cell therapies.
A new clinical trial will investigate whether adding the oral medication vorasidenib to standard chemotherapy improves progression-free survival for people with newly-diagnosed, grade 3 IDH-mutant astrocytoma. The study aims to recruit 400 individuals with this type of brain cancer and evaluate the safety and side-effect profile of the...
A new study found that A&E patients with visible blood in their urine who receive a scan within 48 hours are 2.5% less likely to die within three months. The study also showed that patients with cancer are diagnosed significantly faster when they receive prompt investigation.
Researchers compare prostate cancer screening to breast cancer screening, finding similarities in identifying significant cancers and reducing mortality. The study suggests that prostate cancer screening should be reconsidered, offering benefits over harms, and highlights the need for further analysis on costs.
A new study found that bilingual consent forms significantly improve cancer treatment understanding among people with limited English, with understanding rising from 35% to 60%. The study, published in Supportive Care in Cancer, examined the impact of different translation approaches on cancer treatment understanding among Bengali- and...
Researchers at Duke University have developed a technique using microbubbles and ultrasound to deliver large cancer drugs into cells, causing them to self-destruct. The technology, called SonoPIN, shows promise in precisely delivering therapeutics to cancer cells with minimal off-target effects.
Recent discoveries have shed light on gene expression control in tumor growth, revealing the critical role of epigenetic marks and genomic imprinting. The findings have significant implications for cancer treatment, as they suggest that disrupting the tumor's access to neural signaling may halt its growth.
Researchers at Albert Einstein College of Medicine have developed a new strategy to engineer immune cells that prolong their effectiveness, addressing a major limitation of current treatments. The new method generates longer-lasting immune cells that provide more sustained control of human blood cancers and suppression of HIV-infection.
A new study suggests that exercise can improve mental sharpness and reduce cognitive decline in cancer patients undergoing chemotherapy. Researchers found that patients who exercised while on chemotherapy maintained their daily step goals and reported improved mental clarity, while those who did not exercise experienced significant dec...
A preclinical study reveals a new topical cream that activates the skin's immune defenses and suppresses tumor growth in two models of cutaneous squamous cell carcinoma. The cream works by blocking LSD1, an enzyme that suppresses immune-activating pathways in the skin, prompting immune cells to attack tumors.
Researchers at UCSF have discovered a new therapeutic target, SRC, present on up to half of all tumors, which can be targeted with antibody drugs. The enzyme, normally hidden inside cells, is exposed on the surface of tumor cells due to an overactive disposal system, making it an easy target for cancer-killing antibodies.
Recent advances in photonic nanomaterials and healthcare devices have led to the development of wearable and implantable medical devices. These devices utilize light for precise manipulation of cells and tissues, offering new possibilities for early disease detection, light-based therapies, and personalized precision medicine.
The NRG-LU005 trial found that immunotherapy atezolizumab did not improve survival for patients with limited-stage small cell lung cancer when added to chemoradiation. Twice-daily radiation therapy, however, was associated with improved survival in this population.
Scientists have developed a new method to measure the editing process that fuels cancer growth and survival. By analyzing RNA sequencing data, researchers found two distinct cellular editing programs in cancer, one accelerating and the other decelerating tumour growth. This breakthrough may lead to new therapeutic targets and treatment...
Researchers found that a small region of the PRC2 complex, called the SBD, is crucial for its function and can be targeted by cancer inhibitors. The SBD's absence halts the growth of aggressive lymphomas and normalizes gene expression, mimicking the effects of powerful clinical cancer inhibitors.
Researchers developed an experimental therapy to target microscopic precancerous lesions in the pancreas, which nearly doubled survival in mouse models of pancreatic ductal adenocarcinoma. Long-term treatment with the therapy tripled median overall survival time compared to untreated mice.
A new study by UCLA researchers shows that a personalized counseling program, called Motivation and Problem-Solving (MAPS), can help cervical cancer survivors quit smoking, with twice as many women quitting compared to standard support. The program's cost-effectiveness is also demonstrated, with the probability of being cost-effective ...
Researchers identified structural variants as a key driver of childhood cancer, with RAG-mediated recombination found in nearly all subtypes of acute lymphoblastic leukemias. The analysis highlights the importance of structural variants in pediatric blood cancers and provides new insights into the mechanisms driving these diseases.
Researchers developed GluBs to target ASCT2 in aggressive cancers, bypassing the LAT1 route. The agents showed efficacy in limiting tumor growth and demonstrating potential to treat cancers with limited LAT1 expression.
Researchers found that patients who followed an exercise prescription while receiving chemotherapy reported fewer problems with thinking and memory and felt less mentally tired. The study suggests that exercise may help people with cancer stay mentally sharp and better able to handle daily tasks.
The Alliance trial explores the combination of zanubrutinib and sonrotoclax for CLL treatment, aiming to send cancer into remission and allow patients to stop treatment earlier. The study has the potential to be life-changing for patients and their families, reducing the burden of ongoing therapy and improving quality of life.
A large Australian study of over 417,000 women found that fertility treatments were not linked to higher overall cancer rates, but some cancers were slightly more common, while others were less common. Women who received fertility treatment were more likely to develop uterine and ovarian cancer, as well as melanoma, but the overall ris...
A recent survey highlights the importance of Clinical Practice Guidelines in managing rare cancers, with strong overall uptake but inconsistent use for diagnosis and research purposes. High guideline adherence is linked to tangible survival benefits, such as reduced mortality and improved outcomes in various rare tumour types.
Researchers at the University of Gothenburg have identified a protein, ATF4, linked to increased metastasis and recurrence in lung cancer. The study reveals that older individuals' tumors are smaller and grow more slowly, yet more likely to have spread when detected.
Severe COVID-19 and influenza infections can prime the lungs for cancer development, according to new research. Vaccination, however, largely prevents these changes, suggesting a reduced risk of lung cancer.
Researchers discovered yaku'amide B induces CD9 degradation, a cancer stem cell-related protein, in addition to inhibiting ATP synthase, leading to cellular energy depletion and cancer cell suppression. This natural compound has potential as a new therapeutic approach for cancer treatment.
A positive feedback loop between UBE2V1 and HIF-1α drives HCC progression by facilitating tumor growth and metastasis. UBE2V1 promotes HCC progression by competing with HIF-1α for VHL protein binding, leading to sustained HIF-1α stabilization.
A new study found that MYC amplification in metastatic prostate cancer is associated with reduced tumor immunogenicity, making it harder for the immune system to detect and attack the tumor. This reduction in immunogenicity was linked to poorer progression-free survival outcomes in patients with MYC-amplified tumors.
Patients with type 2 diabetes and brain metastases who used GLP-1 receptor agonists showed a significant reduction in all-cause mortality. The use of these medications was associated with reduced neuroinflammation, preservation of the blood-brain barrier, and lowered oxidative stress and mitochondrial dysfunction.
Researchers will investigate how a common dietary nutrient controls a hidden layer of gene regulation in cancer cells. The study aims to understand how changes in RNA modifications and methionine availability impact cancer cell behavior, with potential therapeutic implications.
A population-level cohort study of 20 low-mortality countries found that females aged 35-60 have higher cancer mortality rates than males, despite similar treatment and diagnostic pathways. The study highlights the need for targeted action to improve the prevention, early detection, and treatment of female reproductive cancers.