Articles tagged with Cancer
The study found that EBV nuclear antigen 1 (EBNA1) significantly increases the expression of Derlin1 and PSMD10 genes in HeLa cells, both associated with enhanced cancer cell survival and proliferation. This suggests a potential mechanism by which EBV may contribute to cervical cancer progression.
A UMass Amherst kinesiologist has received a $2 million NIH grant to study how myosin molecules work together to drive different processes within cells. His research aims to develop drugs for heart failure, neurological conditions and genetic forms of deafness.
A recent study published in JAMA Oncology reports that breast cancer patients who participated in a remote weight loss intervention program lost an average of 4.7% of their baseline body weight after one year, while those in the education-only control group gained an average of 1%. The findings suggest that weight loss following breast...
Researchers found that cancer does not typically affect forensic age estimation accuracy, except for very aggressive forms of cancer. In contrast, blood cancers led to large errors, with ages overestimated by up to 50 years.
A retrospective cohort study found that GLP-1 receptor agonists may reduce overall cancer risk, including lower risks of endometrial and ovarian cancers, among patients with obesity or overweight. However, these medications may also increase the risk of kidney cancer, highlighting the need for longer-term follow-up.
A new genome-wide CRISPR screening tool has been developed to enhance the antitumor activity of chimeric antigen receptor (CAR) NK cell therapies. By removing key gene targets, researchers have improved both innate and CAR-mediated NK cell function, increasing cytotoxicity against cancer cells.
Dr. Anna Gottschlich receives a $916,545 NIH award to investigate socio-genomic associations with endometrial cancer survival among women in Metropolitan Detroit.
Researchers at the University of Navarra have developed FLIP-HEDOS, a model that simulates how much radiation blood absorbs during cancer treatment. The study highlights the importance of protecting blood from radiation, which can impair immune function and lead to hematologic toxicity.
Researchers at Beijing Tiantan Hospital developed a one-stage hybrid operation to treat hypervascular CNS tumors, achieving high rates of gross-total removal and improved neurological function. The technique combines embolization and resection in a single procedure, reducing intraoperative bleeding risk and operative time.
Researchers envision AI-powered systems that identify patients at risk of mental health struggles, provide continuous psychological monitoring and tailor interventions. AI can also overcome barriers to mental health care by delivering support exactly where and when it's needed, including rural areas.
Researchers at UCL discovered that blocking brain damage triggered by glioblastomas can slow cancer growth and maintain normal brain function. The study found that early-stage tumours damaged axons, accelerating tumor growth, but deactivating SARM1 slowed tumor progression.
A new study reveals that DNA damage in multiple myeloma initiates 2-4 decades before diagnosis, with key genomic events including IGH translocation and chr 1q gain. These findings may lead to new precision medicine treatment strategies for patients.
A novel AI model developed by the Dresden research team simultaneously detects multiple genetic alterations directly from routinely stained histological colon cancer tissue sections. The model recognized shared visual patterns rather than independently identifying individual genetic alterations.
A recent study published in Nature Communications provides a comprehensive characterization of Large Cell Neuroendocrine Carcinoma (LCNEC), a rare and aggressive type of lung cancer. The research team analyzed data from 590 patients and found that LCNEC shares features with other types of lung cancer, yet has distinct aspects. They ide...
Researchers at NYU Langone Health discovered that restricted blood flow can accelerate breast cancer growth by aging the immune system. This effect is caused by impaired blood flow triggering a shift towards immune cell populations that cannot efficiently fight infections and cancer.
SRPX2 is a multifunctional protein implicated in cancer progression, neurological disorders and fibrosis, with roles in cell proliferation, migration and angiogenesis. It also interacts with genes like FOXP2 and GRIN2A, regulating language-related synaptic plasticity and cortical development.
Researchers successfully treat mouse tumor with radioactive carbon ion beam, achieving complete control without major neurological side effects. The BARB project advances image-guided particle therapy using exotic beams, showing feasibility and effectiveness.
Adults with a history of cancer are significantly more likely to use depression and anxiety medications than noncancer survivors. Non-Hispanic Black patients exhibit decreased medication use, highlighting disparities in mental health treatment.
Researchers found that combining aramchol with regorafenib killed liver and colorectal cancer cells more effectively than either drug alone, triggering stress responses and disrupting survival pathways. The combination was especially effective in cells with a genetic variant called ATG16L1 T300.
Researchers at the University of Warwick have developed a handheld diamond magnetometer for cancer surgery, which uses magnetic tracer fluid to detect tumours. The device is ultra-sensitive and compact, offering a non-toxic alternative to traditional methods, such as radioactive tracers or blue dye.
A new study found a strong association between accelerated epigenetic aging and increased risk of colorectal cancer in postmenopausal women. Lifestyle factors like diet significantly influenced this risk, with healthy diets potentially reducing cancer risk associated with biological aging.
Dr. Catheryn Yashar, a renowned radiation oncologist, has been appointed president-elect of the American Society for Radiation Oncology (ASTRO). She will champion innovative radiation therapies and advance health policy reform to improve cancer care outcomes.
Researchers found that HPV16 undermines the body's defenses by reprogramming immune cells surrounding tumors. Blocking IL-23 boosts experimental treatments for HPV to eliminate cancer cells.
Researchers developed a new AI method, MIGHT, to improve the accuracy of medical diagnostics. It outperformed traditional methods in detecting cancer from blood samples and showed promise for other applications.
A study at the Garvan Institute of Medical Research found that inactivation of a stress pathway makes ER+ breast cancer cells ignore stress signals, allowing them to evade treatment. The JNK pathway acts as a cellular alarm system, and its disruption leads to treatment resistance.
Researchers at U. Iowa identify a specific metabolic pathway that fuels tumor growth in MPNST, providing a promising new target for treatment. By blocking this pathway, tumors grow more slowly and are more vulnerable to chemotherapy.
An international team of researchers established standardized guidelines for analyzing oxylipins, bioactive lipids related to inflammation and disease. The guidelines aim to improve reproducibility in laboratories and facilitate the transfer of scientific discoveries to clinical practice.
Tumor electrophysiological abnormalities drive malignancy through membrane potential dysregulation, ion channel network remodeling, and microenvironmental signaling interactions. Precision therapies targeting these abnormalities have advanced significantly, including electric field therapies and nanoparticle systems.
A new study suggests platelets play a role in limiting systemic inflammation and may offer an untapped source of cancer DNA for early detection, potentially improving the sensitivity of liquid biopsies.
The study demonstrates that modulating the vagus nerve can effectively halt the progression of cachexia, enhance chemotherapy outcomes, and improve survival in preclinical models. This intervention restores normal liver metabolism, reduces systemic inflammation, and alleviates cachectic symptoms.
CISD1 expression linked to poor clinical outcomes, increased stemness levels, and tumor aggressiveness in multiple cancers. The gene's role in cellular bioenergetics also highlights its potential as a prognostic marker.
A recent study reveals woefully low awareness of human papillomavirus (HPV), the HPV vaccine, and their association with cancer in the Midwestern and Southern US states. These states have seen a rise in HPV-associated cancers, making suboptimal HPV vaccination rates even more alarming.
Researchers found that pembrolizumab shrank or eliminated tumors in nearly 90% of participants with desmoplastic melanoma, a rare and aggressive skin cancer. The therapy offers a less invasive approach compared to surgery or radiation.
Weill Cornell Medicine researchers Dr. Anna Nam and Dr. Maria Cecilia Lira have been awarded prestigious Pew fellowships to support their innovative cancer and biomedical science research. Dr. Nam is investigating the genetic determinants of Hodgkin lymphoma, while Dr. Lira aims to develop novel therapies for brain tumors.
New research reveals that most people are unaware of the link between human papillomavirus (HPV) and various types of cancer, including cervical, oropharyngeal, anal, vaginal, vulvar, and penile cancers. The study highlights the importance of HPV vaccination in preventing these cancers.
Researchers at University of California San Diego have identified a microbial DNA signature in blood plasma that reliably differentiates primary liver cancer from metastatic colorectal cancer. The finding has potential clinical applications, including early cancer detection and monitoring of high-risk patients.
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
A 36-year-old woman was diagnosed with non-gestational ovarian choriocarcinoma, a rare and aggressive tumor that shares symptoms with pregnancy. She received chemotherapy and showed complete response to treatment.
Researchers discovered that PCAI-27 activates two major signaling pathways, MAPK and PI3K/AKT, leading to increased oxidative stress and apoptosis in AI-resistant breast cancer cells. The compound also disrupts cytoskeletal structure, making cancer cells more vulnerable.
The researchers developed a novel approach to virtual contrast enhancement in MRI imaging, using pixelwise gradient methods with Generative Adversarial Networks. The model excelled in capturing intricate details and textures, outperforming its predecessor in texture representation.
The Pew Charitable Trusts has funded 10 postdoctoral Latin American researchers for two years of biomedical science research in the US. They are exploring topics like brain tumor evolution, immune cell function, and nervous system repair.
Researchers have developed an AI system that can recognize the early warning stages of laryngeal cancer from voice recordings. By analyzing variations in tone, pitch, and volume, the AI can distinguish between voices with benign vocal fold lesions and those with cancer. The study's findings offer a promising breakthrough for non-invasi...
Researchers developed a neoAg mRNA-based vaccine that induces higher frequency of neoAg-specific cytotoxic T cells in mice, leading to tumor regression and eradication. The combination with anti-PD-1 therapy enhances antitumor efficacy, especially against peritoneal metastasis.
A study published in The Lancet Gastroenterology & Hepatology found that routine AI assistance during colonoscopies can lead to a decrease in the ability of endoscopists to detect precancerous growths without AI aid. This reduction in skills may impact patient-related outcomes and highlight the need for further research on the long-ter...
A novel cancer vaccine has shown encouraging early results in patients with pancreatic and colorectal cancer, two of the most difficult-to-treat malignancies. The vaccine targets KRAS mutations found in about 25% of solid tumors and drives about 90% of pancreatic cancers and 50% of colorectal cancers.
A groundbreaking cancer drug, KCL-HO-1i, has shown promise in making chemotherapy-resistant cancers more responsive to therapy by targeting a key defence mechanism used by tumours. In preclinical models, the drug has already demonstrated effectiveness in laboratory tests using mouse models of breast cancer.
Researchers at City of Hope are investigating how wearable devices can detect and prevent long-term health risks in childhood cancer survivors. Yue Liao, a UT Arlington expert, is contributing to the review article, highlighting the potential of digital health tools to monitor daily fluctuations and behavior.
Researchers found that RSPO2 amplification is associated with poor outcomes in PC patients and promotes genes and signaling pathways associated with aggressive PC. The study highlights RSPO2 as a key driver of disease progression and opens new possibilities for treatment strategies.
Researchers at the University of Graz and the University of California, San Diego have developed a novel method to determine omega positions of lipids in complex biological samples. This breakthrough enables the study of biological mechanisms in unprecedented detail, particularly for inflammation-related diseases.
Researchers synthesized AI-driven analysis of protein structures to predict drug interactions and optimize synergy. This fusion approach aims to solve drug resistance, reduce side effects, and guide personalized treatment in precision medicine.
The Lancet commission emphasizes the need for concrete goals to reduce hepatocellular carcinoma's growing disease burden. The authors propose a 2% annual reduction in age-standardized incidence rates and recommend evidence-based strategies to tackle viral hepatitis, alcohol consumption, environmental risk factors, and disparities in he...
Researchers are developing an AI imaging approach to distinguish between tumor progression and treatment effects in glioblastoma patients, promising to improve care and outcomes. The AI approach has already shown accuracy rates of up to 74% in initial testing.
The expansion of Huntsman Cancer Institute's proton therapy center will double treatment capacity and increase access to life-saving cancer care for patients in Utah, Idaho, Montana, Nevada, and Wyoming. The new center will enable the treatment of more patients and expand proton therapy options for certain types of cancers.
Researchers developed pH-responsive graphene-based nanocarriers that can target cancer cells, achieving efficient and safe drug delivery. The material's surface charge adapted to the acidic tumor environment, allowing it to bind and enter cancer cells while avoiding healthy tissues.
Researchers have identified a key architect of resistance to immunotherapy in bone metastases: reprogrammed neutrophils that suppress anti-tumor immune responses. DKK1 blockade restores the sensitivity of bone metastases to cancer immunotherapy, offering new potential targets for treatment.
Exosomes from tumors can promote cancer cell proliferation and angiogenesis, while also suppressing immune responses by delivering immunoinhibitory ligands. The review highlights the potential of exosome-based therapeutics to restore antitumor immunity.
Immune-related adverse events (irAEs) are a significant concern in cancer immunotherapy, arising from the overactivation of the immune system. Clinical characteristics include multi-organ involvement, heterogeneous onset times, and distinct toxicity profiles among different ICIs.
The symposium will feature talks by leading researchers on various aspects of cancer, including molecular discovery, clinical application, and population impact. Key findings include the exploration of genomic inequities and their impact on cancer disparities.
Researchers have discovered a novel microbial consortium called AUN that produces exceptional tumor eradication in both murine and human cancer models. The therapy exhibits high biocompatibility and minimal side effects, offering a long-awaited solution for immunocompromised patients.
A comprehensive analysis reveals how cancer cells hijack immune checkpoints on NK cells to disable the body's frontline defense system. Anti-TIGIT antibodies and CAR-NK innovation offer promising breakthroughs in liver cancer trials and acute myeloid leukemia treatment.