Articles tagged with Cancer
A new study found that fat distribution appears to influence cancer risk, but the relationship varies by cancer type. The study used Mendelian randomization to investigate the role of adiposity distribution in 12 obesity-related cancers.
Researchers at St. Jude Children's Research Hospital have implicated lipids in the initiation of LC3-associated phagocytosis (LAP), a specialized process for degrading dead cells and microbes. This finding opens new avenues for exploring therapeutic strategies to modulate LAP in diseases such as cancer and autoimmune disorders.
Dr. Eggener brings extensive expertise in prostate and testicular cancer detection, diagnosis, and treatment to UCLA Health. He aims to improve prostate cancer detection and treatment through research.
A recent analysis reveals a modest decline in new and additional opioid prescriptions for patients with cancer from 2016 to 2020. For patients with metastatic cancer, prescribing remained stable for those reporting any pain but declined steeply for those reporting no pain.
Researchers discovered PRMT5 regulates ACSL4 methylation, which promotes ferroptosis in renal cell carcinoma. Inhibiting PRMT5 increases ferroptosis and enhances immunotherapeutic treatment efficacy.
Researchers developed an engineered strain of gut-homing bacteria that induces mature tertiary lymphoid structures, associated with improved survival and stronger treatment responses. The therapy also restored healthy gut microbiota and showed excellent biocompatibility.
Recent clinical trials demonstrate the potential benefits of neoadjuvant chemotherapy and immunotherapy in improving tumor response and surgical success for patients with locally advanced colon cancer. The approach also reduces the risk of recurrence and metastasis, increasing survival outcomes and decreasing cancer-related complications.
The NRG Oncology PREDICT-RT study has completed patient accrual, evaluating intensified and de-intensified concurrent radiation regimens for high-risk prostate cancer patients. The study aims to improve quality of life and outcomes by tailoring treatments based on genomic risk scores.
Researchers discovered that blocking two key proteins, Ref-1 and PRDX1, significantly shrunk tumors and increased cancer cell death. The approach also affected the tumor's surrounding environment, highlighting its effectiveness in disrupting the tumor's support system.
A large-scale population study found that oxaliplatin benefits only younger stage III patients, with no added survival benefit for those over 70. The study suggests using an age threshold to make evidence-based choices about chemotherapy.
Researchers at Graz University of Technology created a highly detailed digital twin of the A549 lung cancer cell line, paving the way for individualized cancer treatment. The model simulates calcium dynamics and electrical voltages, allowing for testing of drugs and personalized treatment strategies.
Armida Labs will use the funding to advance preclinical studies of Targefrin, a potential clinical candidate for pancreatic and other cancers. The grant aims to develop an anti-metastatic agent that targets the EphA2 protein, which drives cancer cell invasion and metastasis.
This study analyzed adverse events following HPV vaccination in male recipients of Gardasil 9 and Gardasil. The results showed that most AEFI reports occurred within 30 days post-vaccination, with a lower cumulative incidence for Gardasil 9, suggesting a potentially more favourable safety profile.
Researchers at Salk Institute and UC San Diego have identified a unique sugar called HSAT as a potential therapeutic target for slowing tumor progression and metastasis in pancreatic ductal adenocarcinoma. Boosting HSAT levels may slow the formation and spread of pancreatic cancer, leading to improved survival rates among patients.
A cohort study suggests nicotinamide reduces skin cancer risk, with greatest effect seen after initial skin cancer diagnosis, indicating potential chemopreventive properties of the vitamin B3 derivative
A study published in The New England Journal of Medicine found that nearly 4 million children and adolescents were at higher risk of developing blood cancers due to radiation exposure from medical imaging. The researchers estimated that up to 10% of pediatric blood and bone marrow cancers may be attributable to radiation exposure.
Researchers have identified a secreted form of a protein called Clever-1 that systemically suppresses T cells essential for fighting cancer. The investigational anti-Clever-1 antibody, bexmarilimab, directly inhibits the release of sClever-1, potentially predicting treatment resistance and paving the way for new combination treatments.
A Lund University AI model analyzed mammograms to identify breast cancer patients at high risk of armpit metastasis, suggesting that 41.7% of axillary surgeries could be avoided. The study's findings have the potential to revolutionize breast cancer treatment by enabling more personalized care and reducing unnecessary surgeries.
Researchers developed a fusion protein that blocks the 'do not attack' signal and selectively activates tumor-fighting immune cells. The molecule, combining an IL-2 variant with a PD-1 antibody, induces a multifaceted anti-tumoral T cell response in human lung cancer patients.
Researchers have found that a unique surgical technique combining radiation with silicone oil shows unexpectedly low rates of cancer metastasis and death in patients with uveal melanoma. Over four years, more than 80% of patients remained free of metastatic disease.
Middle-aged adults diagnosed with acute cystitis are at higher risk of urogenital cancer, particularly prostate and bladder cancers. The risks persist for several years after infection, especially within 3 months of symptoms, with men being more likely to develop the condition.
Scientists at the University of Cambridge created a smarter way to activate the immune system against cancer by harnessing the STING pathway. The new two-part prodrug system triggers the immune response only in tumour tissues, reducing harm to healthy cells.
A growing body of research links environmental pollutants to worsened health and shorter life spans in childhood cancer survivors. The study found that only 25% of pediatric oncology providers felt comfortable discussing environmental pollutant impacts with patients.
A novel method combining biological experiments and information science techniques reveals cancer cells' preference for aerobic glycolysis despite sufficient oxygen availability. This research provides a powerful tool for identifying metabolic vulnerabilities in cancer cells, which could lead to more effective treatments.
Researchers from the Stowers Institute for Medical Research have identified a common process that powers the creation of protein formations that assemble like a 3D puzzle, triggering inflammation and cell death. This 'Catch-22' mechanism may be one of the fundamental reasons why we age.
A $1.7M Department of Defense grant funds the Convergent Science Virtual Cancer Center, strengthening expertise in cancer risks faced by military personnel and their families. The center provides personalized mentorship, immersive workshops, and non-traditional educational opportunities to improve patient outcomes across various cancers.
The Alliance for Clinical Trials in Oncology will host a public webinar showcasing key findings from the 2025 ASCO Annual Meeting. Researchers will discuss latest information on colorectal, squamous cell, and renal cell cancers.
Research has shown that lymph nodes provide the right environment for stem-like T cells to survive, multiply, and produce killer cells. Preserving lymph nodes could strengthen immune responses and increase the effectiveness of immunotherapy. The study's findings have important implications for cancer therapy.
A community-led study found elevated contaminants in animal food sources and rare cancers in local populations, highlighting the need for comprehensive studies on oil sands' health impacts. The authors call for rigorous research to address TRC commitments and protect Indigenous Peoples' environment and health.
A new study found that providing personalized colorectal cancer risk information to patients and their health care providers did not improve screening rates for the deadly ailment. Colorectal cancer is the second-most common cause of death from cancer in the United States, claiming nearly 55,000 lives annually.
Research from Edith Cowan University found that both resistance training and high-intensity interval training (HIIT) reduced breast cancer cell growth by 22-25%. Both types of exercise also increased lean muscle and decreased body fat after 12 weeks of training.
A new tool called Flexynesis uses deep neural networks to evaluate multi-modal data, enabling doctors to make better diagnoses and develop more precise treatment strategies for patients. The tool is designed to be flexible and accessible to non-experts, bridging the gap in precision cancer therapy.
A new study found that Black men often view their primary-care providers as gatekeepers for prostate cancer screening, but are frequently dismissed from getting PSA tests. The study's lead author notes that PSA testing can catch the disease earlier and reduce mortality rates by up to 30% if done in the 40s rather than the 50s.
Researchers have developed a new platform for investigating tumor metastasis using CTC-derived organoids. These organoids provide an in-depth model for analyzing CTC behavior, including interactions with the tumor microenvironment and drug resistance mechanisms.
A chemically modified STn glycoconjugate vaccine has been developed with enhanced antitumor immunity, demonstrating substantial resistance to enzymatic degradation and inducing potent T-cell responses. The vaccine induces functional antibodies capable of initiating both CDC and ADCC against STn-positive tumor cells.
American Indian and Alaska Native residents in Oklahoma face significant cancer disparities due to barriers in accessing lifesaving cancer care. A new care coordination and communication program aims to address these challenges by facilitating virtual huddles between healthcare teams.
A new study finds that women who have overcome cervical cancer are nearly twice as likely to develop anal cancer compared to the general population. The study highlights the need for updated screening guidelines for these patients.
A recent discovery reveals that microbes associated with tumours produce a molecule, which can control cancer progression and boost the effectiveness of chemotherapy. The molecule, 2-methylisocitrate (2-MiCit), was found to inhibit a key enzyme in cancer cells, leading to DNA damage and reducing cancer progression.
A consortium led by the University of Southampton aims to advance cutting-edge treatments for lung cancer, blood cancers, and chronic inflammation. The ON-TRACT project will train researchers in academic, industrial, and clinical settings to develop safer and more effective treatments.
Researchers at King's College London have discovered that cells use electricity to selectively target and eliminate the weakest neighbours, helping to maintain a balanced and healthy protective layer. This process, known as extrusion, is crucial for balancing cell division and death, and disrupting it can lead to disease.
Research by University of Pittsburgh scientists discovered that damaging telomeres can lead to dysfunctional T cell function. To combat this, they developed a targeted antioxidant approach that rescued T cell function, opening the door for novel therapies in cancer immunotherapies.
Researchers evaluated a tool based on NCCN Guidelines to identify high-risk medications and their association with frailty and outcomes in over 380,000 older adults diagnosed with cancer. The study found that each additional high-risk medication increased the odds of being mildly or moderately-to-severely frail by 66%.
High-grade endometrial cancer (HGEC) consists of aggressive variants with poor prognosis and resistance to conventional therapies. The article proposes a molecular-histologic integration framework using the Cancer Genome Atlas to refine diagnosis, guide clinical management, and inform targeted therapy.
A quicker and cheaper two-part MRI scan is just as effective as the current 30-40 minute scan in detecting prostate cancer. The PRIME trial confirms that this streamlined approach can diagnose cancer at the same rate as a full three-part scan, cutting scan time to 15-20 minutes and reducing costs.
A new study from Mizzou's College of Veterinary Medicine analyzed the effects of radioactive iodine therapy on thyroid cancer in dogs. The research found that tailoring the dose of radiation more precisely for each dog could improve outcomes and potentially lead to more targeted care.
Experts weighed in on the current state of artificial intelligence (AI) in cancer care, noting both its potential for improving efficiency and its challenges. Many expressed excitement over AI's possibilities for helping support an overburdened oncology workforce and accelerating the pursuit of new cures.
Researchers create nanoparticles shaped like bottlebrushes with antibodies guiding them to tumor sites, delivering a large range of chemotherapy drugs directly to cancer cells. This approach reduces the need for potent drugs and enhances customizability of treatment options.
Children undergoing cancer treatment often lose skeletal muscle at a time when they should be rapidly gaining it, which can increase treatment complications and raise the risk of long-term health problems. Muscle loss makes children more vulnerable to heart and metabolic issues like high blood sugar and insulin resistance.
Oral mucositis increases infection risks in stem cell transplant patients by nearly four times, according to new research. A superior AI tool has been introduced to accurately predict these risks, enabling targeted oral care before transplants and reducing complications.
Adult fibrosarcoma is a rare and highly aggressive malignancy requiring precise diagnosis and multimodal treatment. The case report emphasizes the need for early detection, complete surgical removal, and tailored postoperative care to improve outcomes in patients with this type of tumor.
A federally funded study found children with leukemia who were exposed to pesticides during their mother's pregnancy had a higher risk of death. The study, published in Cancers, examined over 800 children and showed pesticide exposure increased child mortality by up to 60%.
A clinical trial found that patients with mesothelioma who received combination immunotherapy drugs before surgery had successful surgeries and improved early outcomes. The study showed that tracking tumor DNA in the blood could help predict treatment benefit.
Researchers have developed a new technique to measure boron in individual cancer cells, enabling the study of how drugs interact with tumour cells. This breakthrough could lead to more effective treatments for head and neck cancers.
A clinical study suggests that immunotherapy can be effective in treating mesothelioma, a rare cancer affecting the lining of the lungs. The trial found improvements in time to tumor growth and overall length of survival for patients with operable diffuse pleural mesothelioma.
Researchers found that frail patients with residual intra-abdominal bacteria or fungi are at a higher risk of developing postoperative ileus and infections. The study suggests that incorporating frailty assessment and prehabilitation programs into surgical planning may help reduce complications.
The Lung Cancer Genetics Study has launched an open-source data platform, offering no-cost access to de-identified data from consenting participants. Researchers can conduct analyses on germline genotyping, self-reported health and exposure data, and cancer-causing driver mutations, with longitudinal datasets to be added over time.
Researchers harness AlphaFold 3 to predict how T cells recognize peptides, opening avenues for precision immunotherapy and vaccine design. The approach enables in silico identification of immunogenic epitopes that could serve as vaccine targets.
A new study published in the American Cancer Society's journal reveals that nearly 1 in 10 patients undergoing surgery for early-stage cancer will initiate opioid prescriptions long-term. The research found that those with a prior history of chronic pain, comorbidities, and lower socioeconomic status were at higher risk.
Researchers at Indiana University School of Medicine have developed a novel candidate drug that shifts the behavior of immunosuppressive regulatory T cells, turning them from cancer protectors into tumor fighters. The study shows promising results in clearing triple-negative breast cancer tumors and treating other aggressive cancers.
A team of scientists has identified rogue DNA rings as early drivers of glioblastoma growth, suggesting a window of opportunity for earlier detection and treatment. The study suggests that targeting these DNA rings could lead to more effective treatments.