Articles tagged with Cancer
A new UCLA study suggests that adding hormone therapy to post-operative radiotherapy may provide little survival benefit for most men with prostate cancer, especially those with low PSA levels. However, men with higher PSA levels before radiation may see modest improvements in survival and metastasis-free survival.
Researchers found that tumors with androgen receptor alterations experienced poorer outcomes, shorter overall survival, and earlier need for subsequent therapy. Serial liquid biopsies revealed real-time molecular changes linked to treatment pressure.
New CAR T cells engineered to detect low levels of CD70 show promise in eradicating kidney, ovarian, and pancreatic tumors in preclinical models. This breakthrough provides a potential strategy for treating multiple solid tumor types with targeted immunotherapy.
A new study analyzing 519 patients with cancer reveals that financial toxicity significantly impacts not only finances but also psychological resources like hope and social support. As these resources weaken, overall life satisfaction declines.
Researchers at Osaka Metropolitan University found that targeting the glutamine transporter ASCT2 can suppress cell growth and induce apoptosis in synovial sarcoma cells. This study suggests a new approach for treating this aggressive malignant tumor by cutting off its nutrient supply.
Ancient genetic fragments called L1 elements destabilise the cancer genome years before diagnosis, giving malignant cells more opportunities to grow and adapt. Long-read sequencing technology reveals large-scale structural rearrangements that seed genomic chaos, potentially driving cancer development.
The article summarizes updated recommendations on fertility preservation in people with cancer, considering potential health risks to offspring and treatment side effects. Clinicians should inform patients about available options before treatment initiation.
An online experiment with 1,051 US adults suggests flagging potentially false cancer treatment claims on social media can help reduce the spread of misinformation. The study found that intervening and reducing sharing of false information on social media may have a positive impact on public health.
The article discusses recent advances in chimeric antigen receptor T-cell (CAR-T) therapy, highlighting its promise and remaining challenges. Next-generation CAR designs aim to improve specificity and reduce on-target/off-tumor toxicity, while addressing access disparities and equity issues.
A study in Science reveals that a healthy gut microbiota enhances immunotherapy's efficacy against cancer, while antibiotics reduce diversity and may impair treatment. Analysis found specific bacterial species associated with better clinical outcomes.
Daily aspirin use offers no quick or reliable way to prevent bowel cancer in the general population, increasing risk of serious bleeding. However, it may have potential long-term benefits for people at high genetic risk of colorectal cancer.
A University of Lausanne research team discovered vitamin B7's role in bypassing glutamine addiction in cancer cells. The study found that pyruvate, enabled by pyruvate carboxylase and vitamin B7, fuels cells' energy cycle even without glutamine.
A research team has engineered bacteria capable of consuming tumours from the inside out, using a novel tool for cancer treatment. The bacteria, Clostridium sporogenes, are designed to multiply in oxygen-free environments found in solid tumours, where they can effectively target and destroy cancerous cells.
Researchers at UCLA have found a way to supercharge immune cells with a fuel source that tumors can't steal, dramatically improving their ability to survive and attack solid tumors. The approach enables T cells to import cellobiose and convert it into usable glucose inside the cell.
Scientists developed a new platform using protein-like polymers to target and degrade cancer-driving proteins like MYC and KRAS. The approach triggers cancer cell death, offering hope for treating aggressive and drug-resistant cancers.
A recent study published in CANCER found that adults with cancer who developed mental health conditions within the first year after diagnosis had a significantly higher likelihood of dying over the next few years. The analysis of data from University of California-affiliated hospitals revealed a 51% increased risk of death among those ...
Researchers found that radiation-resistant cancer cells are vulnerable to NK cell-mediated killing due to increased expression of specific cellular membrane proteins, creating an 'evolutionary double-bind'. The combination of radiation therapy and NK cell-based immunotherapy was more effective in suppressing both sensitive and resistan...
The European Association of Nuclear Medicine (EANM) has launched a new award to accelerate alpha radioligand therapy (α-RLT) research in prostate cancer. The EANM Young Scientist Network Award offers €40,000 in funding for promising researchers.
A new study by Harvard T.H. Chan School of Public Health found that US counties near operational nuclear power plants have higher rates of cancer mortality than those farther away. The researchers estimated around 115,000 cancer deaths in the US over the study period attributed to NPP proximity.
Scientists at Cincinnati Children's Hospital Medical Center have discovered a way to reduce the risk of a lethal side effect in cancer patients treated with immune checkpoint inhibitors. By targeting CD8 T cell-derived tumor necrosis factor, they found that blocking TNF signaling can prevent inflammatory cycle in the heart.
Researchers have engineered a novel CAR-T cell that can be switched off on demand using a cancer drug, offering improved safety and efficacy. The new system, known as DROP-CAR-T, uses a clinically approved drug to disrupt tumor cell binding, preserving the cells for continued treatment.
A recent study sequenced cancer genes in domestic cats, comparing them to human cancer-causing mutations. The researchers identified similar oncogenes and tumor-predisposing genes in both species, which could inform veterinary cancer treatments and human medicine.
Dr. James R. Downing will transition to a faculty role at St. Jude in 2026, leading the institution's global mission after an unprecedented growth period. He played a pivotal role in advancing childhood cancer research and treatment worldwide.
Researchers analyzed tumour samples from almost 500 domestic cats across five countries, identifying specific driver genes that lead to cancer development. The study found similarities between cat and human cancers, including a common driver gene associated with worse prognosis in humans.
The ESE and ESPE have launched a landmark Joint Clinical Practice Guidance to support structured and effective transition of young people with endocrine conditions. The Guidance provides practical, evidence-based recommendations to ensure continuity, safety and quality of care during this critical phase in a patient's life.
Researchers are developing a new compound that can break down MDM2, a cancer-driving protein often found in triple-negative breast cancer, showing promise in shrinking tumors. The goal is to create an entirely new class of therapies for this aggressive and difficult-to-treat form of the disease.
Researchers at the University of Turku discovered that surface cells of lymphatic vessels in oral cancer contain proteins indicating cell division, strongly predicting disease progression and mortality. Early-stage oral cancers can be identified by changes in these vessels, which may lead to death even with small tumors.
Researchers developed a free-to-use software tool, PSBench, to verify the accuracy of artificial intelligence-based protein structure predictions. The database includes 1.4 million annotated protein models, verified by experts, and provides reliable information for building more accurate AI systems.
A study published in Nature reveals that a protein called lipocalin 2 (LCN2) is produced by stressed cancer cells to shield them from the immune system. Blocking LCN2 with new drugs enables the immune system to target tumor cells, slowing cancer growth in mice.
Researchers at Case Western Reserve University developed a strategy using ultrasound-activated nanobubbles to break down tumor barriers, making tumors softer and more penetrable to treatment-bearing molecules and immune cells. This breakthrough could fast-track therapy to clinical trials for solid tumors like prostate cancer.
Researchers found patients who retreated with docetaxel had longer overall survival and fewer supportive-care needs compared to those switching to cabazitaxel. The study provides evidence-based options for selected patients previously tolerated docetaxel.
Researchers highlight polyploidy-induced senescence as a coordinated biological program that may drive aging, tissue repair, and cancer risk. Polyploidization in healthy tissues could help maintain organ structure and barrier integrity, but its instability can promote chromosomal instability and malignant transformation.
A multi-institutional effort aims to refine relapse prediction by identifying genetic markers in blood samples from patients with rare blood cancer. Analyzing blood samples from 190 patients, researchers found that tiny traces of persistent NPM1 mutation were linked to worse outcomes and lower survival rates.
A study by University of Texas at Dallas bioengineers found that both cancerous and noncancerous colon tissue from young patients with colorectal cancer was mechanically stiffer than in older patients. This stiffness may promote the development of early-onset colorectal cancer, a condition rising over the past 30 years.
Researchers review the molecular mechanisms of mitophagy in breast cancer, highlighting its potential as a biomarker and therapeutic target. The study suggests that strategic modulation of mitophagy can enhance personalized treatment approaches for BC.
The National Comprehensive Cancer Network has published new guidelines for Pediatric Soft Tissue Sarcomas, highlighting the unique characteristics of this childhood cancer. The guidelines focus on rhabdomyosarcoma (RMS), a subtype with varying genetic changes that influence treatment outcomes.
The conference aims to improve genetic studies, clinical best practices and community interventions to combat the increasing cancer incidence rates. It will bring together top cancer-focused minds to promote precision medicine and stimulate multidisciplinary collaborations for cancer solutions.
A study by RIKEN researchers identifies a MYCN-driven biomarker that predicts the risk of liver cancer. The biomarker, known as the MYCN niche score, uses machine learning to analyze gene expression patterns and indicates whether a tumor-free liver is at high risk for developing tumors.
A new UCLA study found that adding immunotherapy to standard chemotherapy before surgery is safe and shows promise for some patients with borderline-resectable pancreatic cancer. The combination treatment helped patients live long enough to reach surgery, shrank tumors, and produced encouraging survival outcomes.
A new framework proposes a 'three-strata' model to classify gastrointestinal tract cancers, guiding more precise and effective strategies. The review advocates for chemotherapy-free approaches in highly immunogenic tumors and explores optimized combinations with chemotherapy for intermediate-sensitive tumors.
A recent clinical trial led by Oregon State University scientists found that the composition of a dog's microbiome is linked to its cancer survival rate. The study identified 11 specific types of bacteria that were associated with longer or shorter survival, suggesting potential biomarkers for predicting treatment response and improvin...
The review outlines how vascular-immune crosstalk affects various diseases, revealing novel therapeutic opportunities. It highlights the shared embryonic origin of blood vessel cells and immune cells, as well as coordinated immune cell trafficking mechanisms.
This review examines cancer-inflammation interplay, translational advances, and clinical strategies. Emerging technologies promise to refine precision therapy, while integrating inflammation-targeting approaches with immunotherapy offers a path to personalized cancer care.
Researchers developed AI-IR, a machine learning tool that predicts insulin resistance and implies a link to cancers. The model demonstrated strong predictive power in detecting insulin resistance that BMI alone cannot explain.
Charles Swanton has described the evolution of tumors through genetic mutations, explaining why treatments often fail to eliminate them entirely. His discoveries could lead to more accurate diagnostics and improved cancer treatment.
A study from Lund University found that a climate-friendly diet rich in plant-based foods like wholegrains, legumes, fruit, and vegetables leads to better nutritional status compared to traditional diets. Despite lower meat consumption, most participants achieved sufficient amounts of key vitamins and minerals.
Research by Queen Mary University of London led to changes in NHS guidelines, allowing hundreds of people with advanced bladder cancer to receive fewer chemotherapy cycles. This results in reduced toxic side effects and a better quality of life during treatment.
Researchers developed a PD-L1-binding antigen presenter that redirects antiviral antibodies to target cancer cells, transforming virus-specific immune memory into precision anti-cancer weapons. This strategy has significant potential for treating hard-to-treat cancers and represents a lower-cost, safer avenue for tumor immunotherapy.
The FLOWERS trial demonstrates a significant enhancement in clinical outcomes for NSCLC patients with EGFR and MET mutations when treated with osimertinib plus savolitinib. Patients receiving the combination regimen showed extended progression-free survival and improved tumor response rates compared to those on osimertinib alone.
A case report investigates a woman's development of acute lymphoblastic leukemia and lymphoblastic lymphoma after receiving her second dose of the Pfizer-BioNTech COVID-19 mRNA vaccine, highlighting potential genetic and molecular mechanisms involved in disease pathogenesis.
A new review highlights the growing burden of lung cancer in never-smokers, emphasizing the need for dedicated research, screening, and clinical trials. The study argues that LCINS has distinct causes and biology requiring a different approach to diagnosis and treatment.
The Phase I/II multicenter international CADENZA trial found that 75% of patients with BPDCN treated with pivekimab sunirine achieved a complete response. The treatment delivered the therapeutic drug directly to cancer cells, resulting in rapid cancer cell death with limited targeting of healthy tissue.
Researchers identified a previously unrecognized metabolic defence mechanism in aggressive brain tumours: a sugar-rich shield that protects tumour cells from ferroptosis. The study found that the sugar shield and lipid droplet storage mechanisms cooperate to evade cell death.
The American Society of Hematology released guidelines for frontline and relapsed/refractory management of acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYAs), outlining optimal approaches to treating high-risk patient populations. The guidelines highlight the need for additional research on immunotherapies and tr...
A new analysis found that rural cancer patients treated locally have similar surgical outcomes to those who traveled to urban facilities. The study used Surveillance, Epidemiology, and End Results data from Medicare-eligible patients with lung or colon cancer, aged 65 or older, residing in rural areas.
Researchers have discovered a new mechanism by which an existing cancer drug can block the loss of BCMA molecules on cancer cells, allowing CAR T cell therapy to become effective again in some patients. The study shows that carfilzomib can prevent the degradation of BCMA and restore its presence on the surface of malignant plasma cells.
A study by Silent Spring Institute identified dozens of hazardous chemicals in hair extensions, including products made from human hair. The analysis revealed chemicals linked to cancer, hormone disruption, and developmental problems, prompting calls for stronger oversight and policy change.
Researchers at City of Hope have made significant breakthroughs in cancer treatment, immune system regulation and early disease detection. A study found that subtle RNA changes can shape cancer behavior, opening new avenues for precision oncology. In contrast, combining immunotherapy with chemoradiation did not improve survival rates f...