About The Study: Regional participation in a population-based multicancer early detection (MCED) screening trial was associated with a modest increase in diagnostic delay rates for patients referred for suspected head and neck, lung, and upper gastrointestinal cancers. This increase is unlikely to have materially affected interpretation of the MCED screening trial primary findings. Future trials of population-based screening interventions likely to affect demand for limited health care resources should consider monitoring for system-level spillover effects.
Corresponding Author: To contact the corresponding author, Sean Mann, MSc, email smann@rand.org .
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(doi:10.1001/jama.2026.6803)
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Media advisory: This study is being presented at the 2026 AcademyHealth Annual Research Meeting.
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