Articles tagged with Oncology
The new NCCN Guidelines for Pediatric Bone Sarcoma focus on Ewing sarcoma and other undifferentiated round cell sarcomas, aiming to provide clear medical roadmaps for patients and their families. With a 5-year survival rate of 81% for early-stage diagnosis, these guidelines can help ensure teenagers receive optimal treatment and support.
A new study by City of Hope and TGen found large differences in mutation rates between healthy individuals and cancer patients. The study suggests that individuals who accumulate mutations at a higher rate are more likely to develop cancer.
A new study found a higher prevalence of prior breast cancer in patients with gallbladder cancer compared to patients with other biliary tract cancers. The association was observed in two independent cohorts, with 25.7% of patients with gallbladder cancer having a history of breast cancer.
A new AI platform, Precision AI for Survivorship and Supportive Care, aims to personalize evidence-based support for cancer survivors navigating persistent side effects and other challenges after treatment. The platform uses machine-learning models to identify patterns associated with symptom burden and unplanned healthcare utilization...
The human microbiome may influence cancer development, treatment response, and emerging precision-oncology strategies. Dysbiosis, or an imbalance in microbial communities, has been associated with several cancers, while favorable gut microbial profiles may support responses to immune checkpoint inhibitors.
A phase 3 trial found that delivering focused radiation therapy over three to five sessions after surgery for a large brain metastasis reduced cancer recurrence and improved survival. Patients who received multi-session treatment lived nine months longer than those treated in a single session without significantly increasing side effects.
A randomized trial found that five-treatment stereotactic body radiation therapy (SBRT) provided excellent long-term cancer control and better urinary continence and sexual function compared to surgery. SBRT offered clear advantages for urinary continence and sexual function, with 91% of patients remaining free from biochemical or clin...
Mount Sinai researchers collaborate with Johnson & Johnson to evaluate a liquid radioembolic agent for treating brain tumors. The agent combines radiation delivery and embolization to target tumors, offering a new approach for managing difficult-to-remove tumors.
A randomized phase 2 trial found that five treatments of stereotactic body radiation therapy (SBRT) better preserved physical function and reduced fatigue compared to 28 treatments of conventional radiation therapy with chemotherapy. Rates of cancer remaining in lymph nodes did not differ significantly between the groups.
Researchers at IIT have created nanoparticles that can heat up using infrared light, release antioxidant substances, and stimulate cells when activated by ultrasound. These multifunctional nanotubes have the potential to modulate cellular activity and be used in regenerative medicine and neurostimulation.
A large Medicare analysis found that depression is associated with higher cancer mortality, while psychotherapy soon after diagnosis reduces cancer risk. Patients with depression had a 21% lower risk of cancer-specific mortality after receiving psychotherapy within four weeks of their diagnosis.
Patients with small cell lung cancer and brain metastases lived 17.4 months with radiosurgery, compared to 8.6 months with whole brain treatment. Radiosurgery was associated with a 40% lower risk of death. The study challenges the long-standing reliance on whole brain treatment for SCLC brain metastases.
A large U.S. insurance claims analysis found that fewer than 30% of patients with hormone receptor-positive early-stage breast cancer remained adherent to endocrine therapy for five years after lumpectomy. Younger age and radiation therapy omission were associated with lower adherence rates.
A multi-institutional trial found that ultra-low-dose radiation therapy relieved painful bone lesions from multiple myeloma for most patients, with 81% achieving pain control without additional radiation. Treatment side effects were limited to low-grade fatigue.
Studies on hypofractionated postmastectomy radiotherapy, proton therapy for hepatocellular carcinoma, and stereotactic body radiation therapy for Ewing sarcoma showcase improved patient outcomes. The findings also suggest potential benefits for short-course radiation therapy access and patient navigation in cancer centers.
The Momentum conference brings together European cancer research leaders to discuss ways to accelerate the adoption of new cancer research advances and strengthen cross-border collaboration. The event aims to shorten the path from scientific discovery to clinical practice, ultimately benefiting patients sooner.
A Chinese registry report presents real-world perioperative and survival outcomes for surgically treated pancreatic cancer patients, achieving high overall survival rates and encouraging surgical safety metrics. The study emphasizes the need for national-level benchmarks and standardized clinical protocols for pancreatic surgery in China.
Researchers developed an AI model that uses routine chest CT scans to identify patients at risk of pneumonitis, a potentially life-threatening form of lung inflammation. The model, called CIPHER, achieved high predictive power and maintained strong performance despite differences in patient populations and imaging protocols.
Weill Cornell Medicine has received significant funding for various cancer research projects, including precision medicine and drug target discovery. These initiatives aim to improve patient outcomes for challenging cancers, such as breast cancer and ovarian cancer. The funding supports innovative research approaches, including the stu...
The National Comprehensive Cancer Network presents original research abstracts on tailoring cancer care for different regions during the 2026 World Cancer Congress. The research found that 61% of National Cancer Control Plans include references to existing national or international cancer treatment guidelines, highlighting the need for...
A new, incisionless liver cancer treatment called histotripsy was associated with low rates of laboratory toxicity and procedural complications in a real-world review of 972 patients. However, the study found that 11% of patients died within 30 days, suggesting that advanced cancer and overall disease burden may be contributing factors.
Dr. Laura Esserman is recognized for her groundbreaking work in personalized medicine, including the I-SPY TRIALs and RECAST trials. Her research has led to the development of new treatments and improved patient outcomes, and she is a vocal advocate for patients and the oncology community.
The new NCCN Guidelines for Patients with Cancer explain the importance of assessments to tailor cancer care to every person, regardless of age. The guidelines stress the need for support and validation for older adults, who face unique issues such as memory function and treatment interactions with other medications and conditions.
The Alliance for Clinical Trials in Oncology is hosting a public webinar highlighting key findings from Alliance and Alliance Foundation Trials studies presented at the 2026 ASCO Annual Meeting. The webinar will feature treatment advances for breast, lung, and prostate cancers, and will include patient representatives to provide insigh...
Researchers developed targeted fecal qPCR models that showed moderate discrimination for colorectal and pancreatic cancer, offering a potential non-invasive approach for early detection and risk assessment. The study's findings suggest that fecal qPCR could provide complementary information without invasive sampling.
Researchers used a rapid autopsy program to analyze 104 tumors from 20 patients, revealing the genomic architecture and natural history of metastatic bladder cancer subtypes. The study identified distinct differences between subtypes, including how they develop metastasis and respond to treatments.
A meta-analysis of 21 randomized controlled trials involving 8449 participants found that structured exercise was associated with significant improvements in overall survival and reduced risk of cancer recurrence. The benefits were strongest among participants who completed at least 70% of their exercise program.
The study validated the Cancer Stigma Scale (CASS) in the Greek context, examining its relationship with attitudes toward mental illness. The Greek CASS demonstrated high internal consistency and construct validity, with moderate correlations between cancer stigma and attitudes toward mental illness.
The Society of Pelvic Surgeons (SPS) has selected The GOG Foundation, Inc. as its management partner to advance multidisciplinary surgical collaboration worldwide. This partnership aims to strengthen member engagement, expand the society's visibility, and build upon its legacy.
Complimentary press passes are now available for the Association for Molecular Pathology 2026 Annual Meeting & Expo in Seattle, featuring over 200 exhibiting companies, 60 educational sessions, and 500 poster presentations. Reporters can register to attend in person or access press materials online.
A new AI tool has been developed to predict treatment and survival outcomes in patients with advanced non-small cell lung cancer treated with immunotherapy. The tool consistently outperformed standard clinical biomarkers, achieving high accuracy scores in predicting survival outcomes.
A multicenter qualitative study identified key differences in palliative care and oncology teams, affecting end-of-life patient outcomes. The findings highlight the importance of high-quality care for patients with cancer during hospice transitions.
A new study reanalysed data from eight randomised trials on mammography screening, finding overdiagnosis to be less than 5%. The researchers suggest that previous high estimates of overdiagnosis were based on incomplete evidence and taken out of context.
A new case report describes a 68-year-old woman with stage IV lung adenocarcinoma who developed severe hemolysis after receiving pembrolizumab, despite a negative Coombs test. The patient's hemoglobin declined from 11-12 g/dL to 6.4 g/dL, and laboratory markers of hemolysis improved with corticosteroid treatment. The case highlights th...
The study confirms the durability of benefit for pembrolizumab plus chemotherapy as a first-line standard-of-care option for recurrent and metastatic cervical cancer. This treatment regimen has been shown to provide a significant advantage over traditional chemotherapy in patients with this type of cancer.
Researchers used AI to discover a new layer of biology in human cells, revealing how proteins like TM184C facilitate material exchange between cells. This exchange can help cells survive stress, but unequal exchanges can lead to competition for resources.
A new survey by the National Comprehensive Cancer Network (NCCN) reveals that 100% of cancer centers in the US are experiencing a shortage for at least one anti-cancer agent, with 94% noting a shortage of ifosfamide. The survey also found that 71% of centers are experiencing a shortage of carboplatin, a key chemotherapy used to treat v...
Researchers explored strategies to restore MHC-I expression in CNS cancers to make them more visible to the immune system. Approaches include epigenetic therapies, AAV vectors, PCSK9 inhibition, and modifying the tumor microenvironment. However, efficient delivery, antigen processing, and a limited neoantigen repertoire remain signific...
A study from the University of Cologne identified a critical dependency in small cell lung cancer that can be exploited therapeutically. Targeted inhibition of the NMD pathway offers a promising approach to treat SCLC by accumulating mutated proteins and presenting abnormal peptides on the cell surface, making it detectable to the immu...
The WIN 2026 Symposium will bring together experts to explore advances in precision oncology and strategies for improving personalized cancer care. The symposium, themed Precision Oncology: Innovation and Equity Across the Globe, will feature an international lineup of distinguished oncology and biomedical research leaders.
Recent health tech advancements include drone delivery for organ transportation, AI tools in education with potential risks to childhood development, and early cancer neurotechnology research. Consumer wearables are shifting towards data interpretation, with wearable platforms needed to provide meaningful insights from collected data.
A Swedish registry study found that IBD patients with multiple close relatives having colorectal cancer are significantly more likely to develop the disease. The study suggests that future cancer screening guidelines should consider the number of cancer cases in a patient's family.
A real-world observational study found no significant survival benefit from post-surgery immunotherapy in NSCLC patients with pathological complete response after neoadjuvant chemoimmunotherapy. The study suggests that these patients may already derive the maximum benefit from neoadjuvant therapy alone.
MRI revealed rare cervical cancer spread into the uterine corpus, which was confirmed by histopathology. The unusual pattern created diagnostic challenges and required careful individual assessment. The study highlights the importance of recognizing less typical imaging features in evaluating suspected cervical malignancy.
A research team has developed a reliable and economical method for studying proteins with sugar molecules attached to them in blood and tissue samples. The method uses commercially available magnetic particles and has the potential to aid in disease diagnosis and treatment.
Four outstanding oncology professionals receive 2026 ESMO awards for their contributions to cancer research, clinical care, and community leadership. The awards recognize pioneering work in cancer prevention, early detection, and immunotherapy.
Researchers found that melanoma cells suppress LL-37 production in neighboring keratinocytes, weakening a local epithelial defense pathway. This mechanism, mediated by melanoma-derived exosomal signals, can be targeted for therapeutic strategies.
Tumor-derived extracellular vesicles exhibit intrinsic organotropism and participate in establishing premetastatic niches, making them promising vehicles for targeted imaging probe delivery. However, current imaging approaches have limitations, including difficulty distinguishing between tumor-derived EVs and normal host cell-derived EVs.
Immunotherapy for gynecological tumors offers durable responses and survival benefits, but complex immune evasion mechanisms and tumor microenvironment pose challenges. Current treatment options, such as ICIs and adoptive cell therapy, show promise, but precision immunotherapy is needed to improve patient outcomes.
A new study from Karolinska Institutet suggests that breast cancer classification may overlook important biological differences between patients that could affect treatment decisions. Women with tumours having low to moderate levels of estrogen receptors have poorer survival rates, highlighting the importance of precise classification.
A review suggests targeting LRG1 could provide a new approach to cancer therapy, with extracellular blockade and intracellular degradation potentially addressing different components of LRG1 biology. This could complement established anti-angiogenic treatments and enhance apoptosis in cancer cells.
UT MD Anderson Cancer Center is honoring the exceptional leadership of Dr. Peter Pisters, who announced his retirement to focus on his next career chapter. Dr. Jeffrey E. Lee has been named interim president, effective immediately, and will work closely with Pisters until the end of September.
A new study found that standard memory tests, such as word-pair or list-learning tests, may fail to detect the real-life memory problems reported by many female breast cancer survivors after chemotherapy. Story-based tests, on the other hand, revealed significant memory difficulties in these women.
PCORI awards funding for new patient-centered comparative clinical effectiveness research, addressing key healthcare questions and generating evidence for better-informed decisions. The projects will focus on emergency, hospital, and surgical care, as well as mental and behavioral health, to improve health outcomes.
A review published in the journal CANCER reveals that cost-effective interventions such as single-dose HPV vaccination, screen-and-treat strategies, and workforce development can substantially improve outcomes in low- and middle-income countries. These interventions can bridge the survival gap between LMICs and wealthier nations.
CDK inhibitors show great potential for cancer treatment, particularly for aggressive tumor types like leukemias, breast, lung, and ovarian cancer. Innovative technologies like PROTACs and molecular glues may further enhance efficacy when combined with existing therapies.
A telemedicine-supported home-injection model for patients with breast cancer has shown to reduce treatment burden by improving convenience and saving time. Most patients who completed home injections chose to continue this approach beyond the pilot, but barriers such as insurance denials and higher copayments may limit its broader imp...
Researchers developed a first-in-class therapy targeting MYC, a protein involved in 70% of cancers, by disrupting its relationship with GSPT1. This approach showed strong anti-cancer activity in multiple types of blood cancers, including treatment-resistant models.
The study aimed to determine the proportion of eligible patients consenting to either thyroid lobectomy or total thyroidectomy. It found that 93.5% of patients who would consent to randomization completed the assigned surgery. The results provide valuable insights for targeting enrollment in future multicenter trials.
Researchers found that active participation in colorectal cancer screening was associated with a 43% lower risk of dying from the disease, compared to just a 26% lower risk for those invited to screening. This study highlights the importance of taking part in colorectal cancer screening to save lives.