Articles tagged with Vascular Biology
A multi-component supplement improved endothelial function, arterial stiffness, and systolic blood pressure in a six-month trial. The findings suggest potential benefits for cardiovascular health, but larger studies are needed to understand the mechanisms and longer-term effects.
A research team identified a signaling pathway involving AQP4, TRPA1, BEST1, and D-serine that helps maintain neuronal activity and cerebral blood-volume responses during prolonged sensory stimulation. Astrocytes release D-serine, which supports neuronal activity and contributes to dilation of brain blood vessels.
The Simons Collaboration on Brain Energetics (SCOBE) investigates how energy constraints shape neural computation, from molecules to circuits to behavior. SCOBE will explore brain energetics at the single-cell level, across brain circuits, neurovascular coupling, and adaptation to energy scarcity.
Scientists studied endothelial cells to understand how blood vessels age from within, finding age-related changes in genes involved in blood flow and inflammation. The Human Aging Endothelial Cell Atlas provides a resource for exploring these changes, highlighting the need for targeted efforts to maintain vascular health.
Researchers identified a substance that reduces blood vessel lesions in the brain, a disease causing fragile blood vessel structures that can lead to hemorrhages and stroke. The substance, dabrafenib, is already used to treat brain tumors in children and could replace surgery as a treatment option for CCM.
A recent study identified a protein in the placenta involved in vascular development, challenging previous beliefs about its function. The protein, soluble platelet-derived growth factor receptor beta, plays a role in infant vascular development and may affect maternal health.
Scientists create novel hybrid bioprinting technique to replicate human vascular networks, achieving scale and complexity previously unattainable. The breakthrough enables the fabrication of hierarchical vascular networks in one, two, and three dimensions.
Scientists at the University of Osaka have created a new technique to build blood supply systems for artificial tissues. They successfully fabricated tubular hydrogel structures with controlled lumen sizes and complex geometries, paving the way for creating vascular models that can investigate the development of fully synthetic tissues.
Researchers identify a specialized lymphatic network in the brain that enables cerebrospinal fluid drainage, which declines with age but can be restored through intranasal VEGF-C delivery. This discovery provides new insights into brain waste clearance and its link to neurodegenerative disorders.
The University of Cincinnati launches the Center for Alzheimer's and Neurodegenerative Diseases Research (CANDR) to improve dementia prevention and treatment outcomes. CANDR aligns with UC's mission to innovate and engage locally while addressing one of the region's most pressing public health challenges.
A multicenter randomized clinical trial found no significant differences in cognitive improvement between exercise, intensive pharmacological reduction of cardiovascular risk factors, or both in older adults. The study results challenge current recommendations on lifestyle modifications for dementia prevention.
A Pennington Biomedical researcher published an editorial on the benefits of fruit intake for vascular health, citing a study on increasing fruit intake with avocados and mangos. The findings suggest that diets rich in fruits can improve nutrient status and health outcomes, aligning with the goals of the Food Is Medicine initiative.
A new study reveals that astrocytes actively participate in motor-learning circuit rewiring by eliminating synapses in the striatum. The research identifies MEGF10 as a key molecular mediator of this process, which is regulated by dopamine signaling and neural activity.
Bird retinas operate under chronic oxygen deprivation, relying on anaerobic energy production. The pecten oculi serves as a metabolic gateway, delivering sugar and removing waste products.
A team of researchers has developed an artificial retina model using 3D printing technology, which closely replicates the pathological microenvironment of retinal vein occlusion. The model exhibited responses similar to those observed in clinical cases, validating its potential as a preclinical drug evaluation system.
A new study from the University of Birmingham found that consuming flavanols can preserve blood vessel function in young healthy men during periods of uninterrupted sitting. The researchers tested whether high-flavanol cocoa could prevent FMD declines, and found significant protection against vascular dysfunction.
The VasCog-2-WSO criteria update provide operationalization and guidance on neuroimaging and fluid biomarkers for VCID diagnosis. This new standard aims to facilitate diagnostic consistency among clinicians and researchers worldwide.
A retrospective cohort study found system-based disparities in pre-dialysis nephrology care contribute to 1/3 of incident vascular access disparities among Hispanics. Targeted policies are needed to improve timely identification and referrals for equitable improvements in kidney failure outcomes.
Scientists have discovered that tiny brain vessels pulse to regulate blood flow through bursts of contraction and relaxation. The research reveals that these bursts originate from the walls of small arteries and spread through the vascular network in short intervals, providing insights into how the brain regulates its blood supply.
Researchers discovered a two-step mechanism where inhibitory neurons release nitric oxide to rapidly dilate blood vessels, followed by slower, localized vasodilation via astrocyte activation. This breakthrough sheds light on how neural signals are translated into blood volume changes in brain imaging.
A novel 3D culture method enables self-organization of precursor cell types into functional liver organoids capable of producing essential clotting factors. The breakthrough advances organoid-based therapies, drug testing, and disease modeling for liver diseases, including hemophilia A.
A new study reveals that the combination of an Alzheimer's peptide and a blood protein forms abnormal clots that trigger early Alzheimer's pathologies, including synapse loss and neuroinflammation. The findings provide hope for patients by identifying a promising new drug target: Aβ/fibrinogen complexes.
Researchers have discovered a new method to enhance brain waste clearance by precisely stimulating the lymphatics under skin on the neck and face. This non-invasive approach may offer a safer alternative to current treatments for age-related neurological disorders, such as Alzheimer's disease.
Research highlights Nup93's critical role in endothelial cell function and vascular health, with promising findings for new treatments to slow down aging. Low Nup93 levels are associated with inflammation and cellular aging, while restoring its levels can reverse harmful effects.
Researchers at Åbo Akademi University have discovered a crucial protein, TLNRD1, that helps maintain blood vessel stability in the brain. The study highlights the potential for targeted molecular therapies to improve patient outcomes in CCM disease.
A team of scientists created a new method to 3D print vascular networks that mimic naturally occurring blood vessels. After perfusion, the printed biomimetic vessels displayed healthy and functional heart tissue responses, including synchronization with cardiac drugs.
Researchers used advanced imaging techniques to create detailed maps of mouse brains, identifying areas vulnerable to blood vessel degeneration. These changes can lead to cognitive decline and neurodegenerative disorders like Alzheimer's disease.
Researchers found that immune-modulating cells may slow the expansion of bulges in the aorta by creating a less-inflammatory environment. A second study discovered evidence that a COVID-19 infection promotes the enlargement of abdominal aortic aneurysms, which are extremely dangerous and potentially fatal if they rupture.
Vascular diseases such as atherosclerosis are associated with the reorganization of blood vessel structure through transdifferentiation. The researchers discovered that endothelial cells can transdifferentiate into smooth muscle cells, driven by HIF1α, and that this process contributes to neointima formation.
Idiopathic plasmacytic lymphadenopathy (IPL) has been confirmed as a distinct clinicopathologically uniform disease, which can be reclassified into an independent subtype of idiopathic multicentric Castleman disease (iMCD). IPL showed greater plasmacytosis and hyperplastic germinal centers compared to non-IPL groups.
Researchers at Osaka University have developed a mouse model that shows Favine protein can protect against atherosclerosis and thrombosis. The study also found that reduced levels of Favine are associated with calcification and thrombus formation, revealing a new potential therapeutic target for treating atherosclerosis.
Research from RCSI University of Medicine and Health Sciences found a link between high von Willebrand Factor levels and poorer breast cancer outcomes. High levels in the bloodstream can increase the risk of life-threatening blood clots and cancer spread in patients.
A study by RCSI University of Medicine and Health Sciences has identified barriers and motivators to blood donation for people from ethnic minority groups in Ireland. Factors that motivate people from minority ethnic backgrounds to give blood include religious reasons and a desire to help others in their own communities.
A new mouse model study found that stress and depression can increase heart disease risk by preventing the beneficial effects of cholesterol-lowering medications. The research suggests that chronic stress can mediate epigenetic changes that make bone marrow precursors more inflammatory, leading to increased plaque formation.
Researchers found that a blueberry phenolic extract improved vascularization and cell migration in live wounds, leading to a 12% increase in wound closure. The study suggests wild blueberries have the potential to enhance wound healing, particularly for patients with chronic wounds.
The University of South Florida has received a five-year, $1.35 million NIH institutional grant to train scientists in vascular inflammation and injury research. The grant will support the comprehensive training of pre- and postdoctoral scientists focused on this emerging area of research.
Researchers in mice found that chemotherapy enhances cancer's spread by making blood vessel walls more receptive, allowing cancer cells to latch on. The study shows how a chemo drug like cyclophosphamide alters non-cancer cells' properties, facilitating the cancer cells' attachment and progression.
Researchers from the University of Queensland found that COVID-19 causes cardiovascular complications due to inflammation in infected airway cells. The study clarifies a key debate about the relationship between the virus and blood vessel linings, suggesting inflammation as the primary cause of damage.
Researchers identify key neurons and signaling pathway regulating female activity before ovulation. Discoveries could lead to new treatments for menopause that sidestep estrogen and reactivates the circuit with CRISPRa technology.
A study found that a naturally occurring protein called nNIF improved stroke recovery in mice by blocking the formation of NETs, which can cause blood clots and brain damage. The researchers believe that this protein could potentially improve stroke outcomes in humans.
A new study by the University of California, San Francisco found that consuming even one alcoholic drink can significantly increase the risk of atrial fibrillation. The research involved tracking 100 patients with documented AF and found that those who consumed more alcohol had higher odds of experiencing an AF episode.
Researchers found that resveratrol supplementation reduced aortic stiffness by up to 9.1 percent in patients with high arterial stiffness, but the effect was not significant in those with normal aortic stiffness. Resveratrol may activate the longevity gene SIRT1 as a potential mechanism for its effects.
Dr. Michael A Gimbrone, Jr has made significant contributions to the field of vascular biology through his research on endothelial cells and the development of methods for culturing these cells. His work has led to a paradigm shift in our understanding of vascular diseases and has paved the way for countless studies and discoveries.
University of North Carolina cardiologist Cam Patterson received the 2012 Judah Folkman Award in Vascular Biology. His groundbreaking work on angiogenesis and VEGF cell receptor signaling has led to basic research findings being translated into clinical trials for new cardiovascular therapies.
Ruhul Abid's groundbreaking research reveals that reactive oxygen species (ROS) play a beneficial role in activating eNOS and maintaining coronary vasodilation, challenging the long-held notion of ROS being harmful. The discovery has potential implications for the development of therapeutic modalities for vascular diseases.