Scientists at the Princess Máxima Center for Pediatric Oncology discovered a new combination treatment strategy for childhood T-cell acute lymphoblastic leukemia (T-ALL) by analyzing protein activity. The study found that blocking specific proteins, such as LCK and SRC, in combination with an overactive chain reaction of INSR/IGF-1R, k...
Scientists applied a social networking algorithm to the fossil record to track changes in ancient communities during mass extinctions. The study found that community losses did not always correlate with biodiversity decline, suggesting complex ecological interactions.
Researchers have solved the structure of seipin, a protein essential for proper fat storage in humans. The study reveals two conformations of seipin, which create and grow lipid droplets used for energy storage.
A study published in The Nurse Practitioner found that maladaptive coping strategies such as using caffeine and taking daytime naps can actually decrease sleep quality. Patients who used these strategies had longer times to REM sleep and more frequent nighttime arousals compared to those who did not use them.
Scientists create triatomic molecules by applying radio-frequency pulse to an ultracold mixture of sodium and potassium atoms. The resulting association signal suggests a strong binding between the molecules.
A study of 104 transgender and nonbinary youths found that gender-affirming care reduces depression and suicidal thoughts over 12 months. The treatment significantly improved mental health outcomes in the participants.
New research outlines how climate change will shift the future of outdoor recreation in the West, with campsites becoming too hot, ski resorts experiencing fluctuating snowpacks, and rivers facing low water levels. The study provides activity-specific adaptation strategies to prepare for these consequences.
Scientists at Hokkaido University developed a prototype sensor to rapidly measure adenosine triphosphate (ATP) and lactate levels in blood samples. The sensor's sensitivity allows for the accurate detection of these molecules, enabling rapid assessment of disease severity.
A recent field study examines the 2006 Abuja Declaration's effects on N fertilizer use, yield potential, and soil fertility. The study found that partial N balances exceeded optimal ranges, highlighting insufficient N input and elevated risk of soil depletion.
A new, high-quality natural streamflow dataset for China has been developed, achieving high skill metric values and reducing biases in hydrological simulations. The dataset covers all 330 catchments from 1961 to 2018 and has important implications for understanding hydrological processes and river management activities.
A study using machine learning identifies climatic thresholds driving vegetation distribution, highlighting the importance of extreme climate conditions for savannas and deciduous forests. The findings provide valuable insights for improving process-based vegetation models and their coupling with Earth System Models.
Researchers have discovered the structure of C.difficile's protective armor, a chain-mail like layer that prevents molecules from entering the cell. This discovery opens the possibility of designing specific drugs to target the armor and kill the cell.
A study at Merapi Volcano, Indonesia, found that a horseshoe-shaped fracture zone is causing summit dome instabilities. Weakened rocks from the hidden fracture zone are likely the main cause of ongoing instabilities.
A new study using K-Lander observatory technology reveals high variability in methane release from Arctic seabed sites, with implications for estimating global methane budgets. The long-term data series provides valuable insights into short-term and seasonal variations of methane emissions.
Researchers developed an antibiotic prescribing algorithm using genomic sequencing and machine learning analysis, reducing the emergence of antibiotic resistance in bacterial infections. The algorithm matches an antibiotic to a patient's past infection history and microbiome to minimize resistance spread.
A novel graphene-based field effect transistors (FETs) device can detect four different synthetic and natural opioids at once in wastewater. The device uses aptamers to trap opioid metabolites, enabling real-time monitoring with high geographical resolution and low cost.
A recent study by CU Anschutz researchers advances the understanding of the immune system during COVID-19, focusing on the interferon response. The findings provide a new model for staging COVID-19 pathology and have important therapeutic implications for treating severe cases.
Researchers from the University of Turku found that a black hole's axis of rotation is tilted more than 40 degrees relative to the orbiting stellar body. This extreme misalignment challenges current theoretical models and opens up new prospects for studying black hole formation and evolution.
A new study finds that Tumor Treating Fields (TTFields) activate the immune system and trigger an anti-tumor cell response, potentially effectively used together with immunotherapy approaches. TTFields' unique mechanism of action induces a downstream signaling pathway that initiates an active immune response against cancer cells.
Researchers from University of California - Davis found that ultrasounds can detect when abalone are ready to spawn without touching them. The technique creates a gonad index score ranging from 1 to 5 indicating readiness for reproduction.
A new analysis found that healthcare workforce employment levels declined in mid-2020, with skilled nursing facilities experiencing a 13.6% decline compared to 2019. Healthcare sector wages also increased at a lower rate relative to the national average, with a 5% increase in 2020 and 1.5% in 2021.
Bar-Ilan University researchers develop a two-step recovery process to revive failed networks by restructuring damaged links and reigniting the entire system through controlled node activation. This approach has shown promise in steering a failed microbiome back to functionality, particularly with probiotic interventions.
A recent study found a high prevalence of HIV, tuberculosis, and malaria in the Gambela region of Ethiopia, highlighting the need for targeted health services. The research suggests that addressing these diseases at a local level could be more effective than a nationwide response.
A recent study by SMU Associate Professors Mark Chong and Angela Leung found that the ultimate form and presentation of alternative protein products significantly impact their acceptance by consumers. Focusing on the end product and framing alternative proteins as a positive highlight of an exciting food future may foster greater accep...
The WHO European Region saw a decrease in reported cases of syphilis, gonorrhoea and chlamydia, but data availability varies widely among non-EU/EEA countries. Georgia had the highest syphilis case rate, while EU/EEA countries had lower rates.
Cedars-Sinai investigators discover that inhibiting RIPK2 function with drugs or CRISPR/Cas9 reduces prostate cancer metastasis in mice, offering new hope for advanced prostate cancer treatment. Targeting this protein could extend patients' lives by several years.
A research team at CUNY ASRC made a breakthrough discovery in nanomaterials and light-wave interactions that enables small, low-energy optical computers capable of advanced computing. The discovery demonstrates unprecedented speeds and nearly zero energy demands for solving complex mathematical problems.
A new study from Washington State University finds that people with a strong desire to travel are more likely to get vaccinated against COVID-19. The research also reveals that emotional appeals and loss-based messaging can be effective in changing vaccine intentions.
A new study published in the Journal of Psychiatric Research found that people with ADHD are significantly more likely to exhibit clinically significant hoarding symptoms. Approximately 19% of participants displayed hoarding symptoms, which can lead to distress and difficulties in everyday life.
A new University of Michigan study found that higher levels of biodiversity reduce extinction risk in birds by providing a safe harbor for species at risk. The researchers used a comprehensive dataset covering over 99% of bird species and found diverse communities protect these species, allowing them to persist.
Remote monitoring of patients with continuous pulse oximetry and heart rate devices was associated with reduced death rates. This technology advance improved patient safety, lowered mortality, and increased accuracy in care.
A cost-effectiveness analysis found that adherence promotion programs like MAPS reduce costs and improve outcomes for adolescent kidney transplant recipients. Strategies with similar costs to MAPS can still be cost-effective if they decrease rejection episodes by a small amount.
Scientists identified 16 compounds that affect SARS-CoV-2 enzymes Mpro and PLpro, which are essential for viral replication. The team found that combining Mpro and PLpro inhibitors has an additive antiviral effect, providing greater inhibition of SARS-CoV-2 replication. These findings offer hope for developing new COVID-19 treatments t...
A study published in Science Immunology reveals that a specific neurotransmitter in immune cells plays a crucial role in cholesterol accumulation and sterile inflammation in atherosclerosis. The researchers found that blocking this neurotransmitter may help reduce inflammation and develop effective treatments for the disease.
Researchers have found that SARS-CoV-2 variants can emerge more quickly than expected, driven by a short-lived increase in mutation rate. This phenomenon was observed in variants such as Delta, which emerged within six weeks of its ancestral form.
Research found walkable neighborhoods with access to parks and outdoor activities are associated with a lower risk of obesity and diabetes. Studies showed that living in highly walkable areas reduced the incidence of pre-diabetes by up to 50% compared to low walkability areas.
A recent study from Oregon State University found that fewer than half of K-12 physical educators use high-quality instruction practices for students with disabilities. The majority of teachers were highly qualified, but lacked specific training in adaptive physical education, leading to many disabled students being excluded from PE cl...
Aston University researchers have developed a technique to boost antimicrobial properties of bioactive glass, which could reduce infections and antibiotic prescriptions. The new approach combines metal oxides, significantly improving bacterial kill rates over single oxides alone.
A study found that older adults are open to using smart packaging to track their medication, with ease of use and social support being key factors. However, device size, cost, and inconsistent technology usage were major drawbacks, highlighting the need for healthcare providers to assess patient needs before recommending these products.
Researchers studied 384 African American women aged 30-46 with 48-hour blood pressure monitoring. Being in debt was linked to higher daytime and nighttime blood pressure and increased risk of sustained hypertension.
Two new studies found that regular mango consumption is associated with better overall diet quality, higher intakes of essential nutrients like fiber and potassium, and improved glucose control. Mango snacking was also shown to reduce inflammation and improve antioxidant capacity compared to other sweet snacks.
Researchers found that forest trees with a mix of both ectomycorrhiza and arbuscular mycorrhiza had the greatest tree diversity, contradicting previous beliefs. This discovery highlights the importance of considering the coexistence of different mycorrhizal strategies in promoting plant biodiversity.
Research reveals that sugar-sweetened fruit-flavored drinks and toddler milks are misleadingly marketed as healthy options for young children. Experts confirm that these products contain high amounts of added sugars, non-nutritive sweeteners, and little to no juice.
A new study found that an anti-tumor drug, camptothecin, can activate a natural hunger-suppressing pathway in mice, leading to significant weight loss. The mechanism involves the elevation of growth differentiation factor 15 (GDF15), which suppresses food intake and reduces body weight.
Researchers found that 6.7% of jail detainees threatened SSH in the past three months, and 4.5% attempted SSH in the past year. The study suggests that jails should develop an empirically driven suicidal risk assessment to improve institutional safety and prevent suicide.
Researchers used soil microbial communities to track progress and predict post-mining recovery timeframes, offering a new approach for measuring rehabilitation success. The study found that effective rehabilitation can set up a predictable trajectory of recovery, taking 40-60 years to reach the target ecosystem.
Researchers have found that HPV and Chlamydia pathogens work together to reprogram cells, leading to cancer. The study used 3D organoids to investigate the interactions between the pathogens and tissues affected by disease.
Researchers have successfully combined perovskite with silicon in a tandem cell, achieving an efficiency of 21.3%. The team estimates the PCE to be 29.5%, with potential for further improvement through surface optimization.
Bighorn sheep use a combination of past experience and visual information about habitat quality to make informed migratory decisions. The research found that these perception-informed decisions allow the species to better adapt to changing environmental conditions, increasing their chances of survival.
Researchers from the University of Würzburg have discovered new states in 2D materials by exploring their interactions with phonons. This breakthrough enables the creation of hybridized exciton-photon-phonon states, which could lead to room-temperature Bose-Einstein condensation and polariton lasing.
A blood test detecting circulating tumor DNA can accurately predict recurrence of HPV-driven oropharyngeal cancer following treatment. The biomarker test may detect recurrent disease earlier than imaging or other standard methods, allowing physicians to personalize treatment more quickly for patients whose cancer returns.
Researchers developed a new method for generating network layouts that allow for visualizing different information in two- and three-dimensional virtual space. This facilitates the exploration of complex protein interactions and provides more versatile, comprehensible representations of networks.
Researchers from Eötvös Loránd University have created a more efficient method for producing catalysts, which can speed up chemical transformations and reduce environmental impact. This breakthrough could lead to faster drug development and improved pesticide production.
Researchers found that iron supplementation can sustain muscle function, mass, and survival in mouse models of colon cancer. In humans, a small group experienced moderate strength improvement after iron injection, suggesting potential benefits for cachexia sufferers.
A new study published in The Lancet Planetary Health found that improved eye health services are associated with moving closer to achieving seven SDGs. Multiple direct connections were discovered between eye health services and increased productivity, household expenditure, income, education, and equality.
A team of scientists studied the surface rupture caused by two major earthquakes in July 2019 near Ridgecrest, California. They found that the rock surrounding the fault suffered from 'inelastic deformation', resulting in a softer crust that dissipates energy from future earthquakes.
A study analyzing 185 million COVID-19 vaccine doses found no connection between vaccination and sudden sensorineural hearing loss. The results indicate that vaccination is not associated with the development of this condition.
Ferroelectric random access memory (FeRAM) faces reliability challenges due to 'imprint' and 'fatigue'. A novel hafnium-based material has addressed these issues by reducing the impact of charge injection, leading to a 90% improvement in performance. High-temperature baking of capacitors also enhances performance.
A study of Finnish agility dogs reveals differences in training and competing between dog sizes and skill categories. Most dogs trained for under 20 minutes per week, but those at the highest level trained less to maintain their skills.
A collaboration between Berkeley Lab researchers developed a novel approach to mitigate noise in quantum computers, enabling reliable results from IBM quantum computers. The new method combines three other techniques to correct errors, allowing for bigger simulations and tackling complex problems.