Articles tagged with Neurology
Researchers investigated 2.5 million births in Taiwan and found no association between valproate use by fathers and neurodevelopmental disorders or malformations in children. The study's results challenge previous warnings and suggest more research is needed.
A team of researchers at Harvard University sustained brain organoids for nearly six years, demonstrating a lifelike developmental clock. The organoids showed emergence and maturation of neurons, as well as functional maturity, mirroring human brain development.
A nationwide study found that people living within 500 feet of dry cleaners had a 14% greater risk of developing Parkinson's disease compared to those living further away. The study, led by Barrow Neurological Institute, highlights the potential role of environmental exposures in disease development.
A new roadmap for stroke recovery prioritizes genetic and blood biomarkers to drive precision neuro-rehabilitation and biotherapy. The framework seeks to understand the underlying biology of brain repair after a stroke, with the goal of developing effective biotherapeutics.
Researchers discovered how anesthesia, surgery, and intensive care stress alter gene activity in the brain, leading to cognitive impairment and delirium. A new drug, vorinostat, reversed these changes, restoring memory formation and regulating the internal biological clock.
A study identified novel autoantibodies associated with idiopathic myelopathy, specifically those related to vitamin B12 transport. Central nervous system vitamin B12 deficiency was also found in affected individuals. The findings suggest a potential diagnostic approach for myelopathy
The inclusion of benzodiazepines in airline emergency medical kits is crucial for treating seizures that may occur during flights. Benzodiazepines can effectively manage seizure symptoms and prevent complications.
Researchers analyzed EBRAINS-hosted brain data to determine that whole-brain activity patterns predict stimulation outcomes better than local recordings. Targeting specific sensorimotor and visual networks reduces response variability by up to 24%. This study highlights the value of open datasets for enabling large-scale analyses.
A comparative study examines autologous pericranium and G-Patch grafts in cranial duraplasty, finding fewer complications with natural grafts but no significant difference. The study highlights the need for larger multicenter studies to determine comparative effectiveness.
Researchers identified recurring metabolic changes associated with blood-brain barrier disruption, including disrupted glutamate and glutamine metabolism. These findings suggest that characteristic patterns of metabolic changes may be used to detect brain damage in the future.
Patients with severe traumatic brain injury in resource-limited settings are at higher risk of mortality. The study highlights the need for improved acute and postdischarge care to reduce mortality rates.
Researchers developed a multiprotein approach to predict advanced tau pathology among amyloid-positive individuals, outperforming p-tau217 alone. This study suggests a scalable alternative to tau PET staging for clinical or research settings.
Researchers found that exercise-induced molecular changes contribute to neuronal health, improving movement and quality of life in PD patients. Exercise types such as aerobic exercises, resistance training, balance training, and multimodal exercise were found to be helpful in reducing falls, disabilities, and improving brain function.
The Barrow Neurological Institute is conducting a Phase 1/2 clinical trial investigating ibogaine as a therapeutic agent for treating traumatic brain injury (TBI). Researchers aim to enroll 40 participants and determine how effectively ibogaine addresses TBI symptoms and quality of life.
Researchers discovered that depression is associated with a specific area of the hippocampus, independent of Alzheimer's disease risk factors. The study found participants with depression had smaller volumes in the CA23DG region, which plays a crucial role in retrieving memories and distinguishing between similar experiences.
Researchers used real human brain tissue samples to test the underlying mechanisms of deep brain stimulation. They found that brain cells became more synchronized in communicating, similar to memory formation, while altering gene expression across different types of brain cells.
UC San Diego Health has been ranked as the top care facility in California and among the top 20 in the nation for eight medical specialties. The institution achieved this distinction through its patient-dedicated, collaborative spirit and commitment to delivering outstanding care.
Researchers used connected speech analysis to distinguish between nonfluent, logopenic and semantic PPA variants with high accuracy. The study also showed expected atrophy associations and discriminated common neuropathologic classes in an autopsy-confirmed subset.
Research suggests that an overactive immune response in the brain may play a role in Dravet Syndrome, leading to frequent seizures and developmental challenges. Blocking an inflammatory pathway called cGAS-STING-interferon signaling could lead to new therapeutic strategies for epilepsy disorders.
Researchers found two widely used blood tests accurate in detecting Alzheimer’s pathology in participants with Down syndrome. The tests, Lumipulse G p-tau217 and PrecivityAD2, offer an easier path to diagnosis for this high-risk population.
Researchers at Kennedy Krieger Institute discovered that memory consolidation during sleep depends on coordinated activity among three brain regions, disrupting this activity impairs memory performance. Epileptic spikes can also interfere with brain activity, leading to cognitive effects in patients with epilepsy.
A new grant will support research into how strokes disrupt brain networks controlling the bladder, aiming to identify imaging biomarkers predicting treatment response. Researchers will use advanced brain imaging and non-invasive spinal stimulation to develop a personalized approach for treating bladder problems after stroke.
A study published in Neurology Open Access found that Black people with multiple sclerosis (MS) die from the disease at a younger age than white people. The study also found an increasing trend of deaths related to high blood pressure among both groups, emphasizing the need for targeted interventions to control this risk factor.
A Peking University research team has developed the world's first chip that can match the functioning speed of the human brain. The chip, which operates at 50 MHz and uses in-memory computing, reduces data movement and brings high-quality brain modeling closer to real-time use.
Researchers found that brain fluid circulation depends on blood flow in the venous sinuses, and impaired lymphatic vessels lead to accumulated fluids causing pressure buildup. The study opens new avenues for refining diagnosis and improving patient care for patients with IIH.
Researchers used sEEG to examine white matter electrophysiological dynamics during working memory. Load modulates tract-specific power and cross-frequency connectivity, with distinct patterns across different brain regions.
Long-term exposure to road traffic noise was associated with a higher risk of Parkinson's disease, according to the study. Having a quiet facade mitigated this association, suggesting that reducing noise levels may be a viable strategy for preventing or managing the condition.
A new review proposes a roadmap for developing cognitive brain-computer interfaces to treat cognitive disorders, integrating BCI research and clinical neuromodulation. The emerging field aims to detect dysfunctional brain states and respond with adaptive neurostimulation.
New evidence explains why certain parts of the brain are more vulnerable to neurodegenerative diseases. The study suggests that directing therapies to specific protein forms can lead to improved treatment outcomes. Researchers found that subtle differences in protein abundance and complexes assemble determine regional vulnerability.
Researchers found subtle patterns in brain activity while children listened to speech linked to verbal communication abilities in autistic youths. Altered brain signals suggested the brain may process speech less efficiently, with noisier signals associated with lower scores on everyday verbal communication.
A novel salvage surgical approach combining internal neurolysis and targeted glycerol injection has provided durable pain relief for a patient with severe, treatment-resistant MS-TN. The procedure was successful in preserving sensation and reducing medication use.
A recent study published in Neurology found that Black individuals born outside the US have a significantly lower risk of stroke compared to those born in the US. The study, which analyzed data from over 64,000 adults, also found that immigrants who arrived within 15 years of the survey had a 73% lower odds of stroke.
Researchers developed a hybrid technology combining human learning and machine learning in noninvasive BCIs, producing rapid and sustained gains in motor imagery control. The study demonstrates significant scientific and technological advancement in BCIs, establishing a scalable pathway toward robust neural interfaces.
The University of Cincinnati launches the Center for Alzheimer's and Neurodegenerative Diseases Research (CANDR) to improve dementia prevention and treatment outcomes. CANDR aligns with UC's mission to innovate and engage locally while addressing one of the region's most pressing public health challenges.
A team of surgeons used robot-assisted stereotactic surgery to treat a patient with multiple deep brain abscesses, achieving complete resolution and rapid neurological recovery. The minimally invasive strategy reduced surgical trauma and accelerated healing.
A review of hundreds of studies suggests that polyphenol-rich foods like berries, tea, and olive oil may support healthy brain aging by reducing inflammation and promoting nerve cell function. While no single food can prevent Alzheimer's disease, a balanced diet rich in plant-based foods may help preserve cognitive function over time.
Researchers investigated hantavirus infection's neurological effects, finding that they can be severe and uncommon. The study aims to improve understanding of the pathophysiology, identify therapeutic targets, and develop management guidelines for these manifestations.
Researchers identified ZFP384 as a key factor in diminishing microglial reparative functions after stroke. By blocking ZFP384, the study found that microglia retained their reparative properties, leading to enhanced remyelination and synaptic plasticity, and improved long-term neurological function.
A new study published in the Journal of Alzheimer's Disease estimates that dementia-related costs across 30 high-income European countries total €221 billion annually. Family caregivers carry a significant portion of this burden, providing an estimated €128 billion in unpaid care.
A multidecade study found dementia prevalence significantly increased in Mexico, Peru and Puerto Rico from 9.6% to 14.5%, 7.6% to 11.7% and 10.7% to 15.7%, respectively over two decades. Dementia rates remained stable in Cuba and Dominican Republic.
A new study published in Ophthalmology Science has confirmed that The CVI Range Assessment is a valid and reliable instrument for evaluating functional vision in children with Cortical Visual Impairment (CVI). This finding provides evidence that the widely used assessment meets rigorous clinical and psychometric standards, offering a s...
The STEM-PD trial demonstrated the safety and feasibility of stem cell-derived dopaminergic cell transplantation in patients with moderate to advanced Parkinson's disease. The findings mark an important step in evaluating this approach as a potential treatment strategy for neurodegenerative diseases.
Researchers present new insights into an iPSC-derived neural progenitor cell therapy for chronic ischemic stroke, demonstrating safety and biological activity over extended follow-up. The findings have the potential to expand treatment options for patients living with chronic stroke disability.
A recent study reveals that astrocyte subtype dynamics play a crucial role in regulating mental health, particularly in mood disorders such as depression and anxiety. The review highlights how inflammatory signaling, metabolic imbalance, and ion channel dysfunction contribute to disease progression.
A landmark study has shown that transplanting stem-cell derived dopamine progenitor cells into the brain is feasible and safe. Eight patients received the transplanted cell product, with no serious side effects observed during the first year of follow-up.
Two ECNP-affiliated journals, European Neuropsychopharmacology and Neuroscience Applied, have seen significant increases in citation rates. The rise reflects growing interest in the biological underpinnings of mental health, as reflected in the journal's focus on precision psychiatry.
Researchers found that KCL-286 enhances DNA repair and reduces neuronal inflammation in a mouse model of Alzheimer's disease. The drug activates the retinoic acid receptor-beta pathway, promoting the expression of certain repair genes.
A study found people with early-onset dementia experienced reduced work productivity up to 15 years before diagnosis, with average losses of $86,000 per person. The study also revealed varying productivity losses depending on the type of dementia, highlighting a need for interventions to prevent or delay decline.
Research suggests alcohol interacts with Alzheimer's-related brain circuits in distinct ways, depending on the type of pathological change. Alcohol reduced communication in amyloid-beta models but increased it in tau models, highlighting an important principle in biology.
Research found that Parkinson's disease triggers shared 'stress responses' but also differs between men and women at the cellular level, particularly in how glial cells manage energy and protect nerve connections. This discovery may lead to more personalized treatments for patients.
A new aptamer selection strategy termed extracellular vesicle (EV)-SELEX has been developed to rapidly identify highly specific DNA aptamers targeting G protein-coupled receptors. The EV-SELEX platform exploits a natural cellular process to minimize interference and efficiently select biologically relevant receptor conformations.
Researchers found that patients with Parkinson's disease showing little to no Lewy bodies despite long-standing, clinically advanced disease. The study provides new insight into the relationship between clinical symptoms and neuropathological progression.
A standardized on-pitch concussion assessment protocol has been developed and recommended internationally for safe player return to play in football. The protocol is informed by research evidence and expert opinion, aiming to improve diagnosis and treatment of concussions.
A Phase I trial evaluated a novel multi-targeted T-cell therapy for children with deadly brain tumors, offering early evidence that the patient's own immune cells can reach and fight tumors while producing fewer severe side effects. The study suggests a safer and more effective approach for pediatric brain cancers.
Research suggests exposure to extreme heat and cold increases risk of emergency department visits among people with dementia. Extreme temperatures accelerate health events that would otherwise occur later, potentially leading to increased healthcare demand.
Research presented at the European Academy of Neurology Congress 2026 found that women with Parkinson's disease had significantly greater amyloid plaque burden and neuritic plaque density compared to men. The study suggests that women may be more susceptible to Alzheimer's-related changes in the brain.
A simple bedside eye test may predict recovery of consciousness in patients with severe brain injuries, according to new research. The late light-off response (LOR) phase of the pupil response predicted improvements in consciousness seven days later.
A new study finds that multiple sclerosis has a substantial impact on social life and work, with 51% of people reporting an effect. The study highlights the need for comprehensive care addressing not only physical health but also daily functioning, employment, and overall wellbeing.
A young woman's quality of life and ability to walk were restored after a specialized procedure at Semmelweis University. The laparoscopic removal of a rare, benign tumor of neurological origin in the lesser pelvis, known as a schwannoma, was performed using intraoperative electrophysiological monitoring.
A cohort study found that a dietary pattern with lower inflammatory potential was associated with lower dementia risk among individuals with Alzheimer disease pathology. Targeted dietary strategies may help prevent dementia in those already at elevated risk.