About The Study: In this systematic review and meta-analysis, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) produced greater weight loss among women than men; however, their efficacy was consistent across other important subpopulations. These findings may inform clinical decision-making.
Corresponding Author: To contact the corresponding author, G. Caleb Alexander, MD, MS, email galexan9@jhmi.edu .
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(doi:10.1001/jamainternmed.2025.8222)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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JAMA Internal Medicine