Articles tagged with Metaanalysis
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The study reveals parental quality of life is compromised during the premature infant's hospitalization period. A family-centered approach with tailored support from the neonatal intensive care unit and postdischarge period can protect and promote parental well-being.
A meta-analysis found nirsevimab to be associated with reduced hospitalizations and emergency department visits for lower respiratory tract infections in young children. This suggests the potential of nirsevimab to decrease respiratory-related morbidity in this population.
A systematic review and meta-analysis found that lithium supplementation did not significantly improve cognitive function in individuals with mild cognitive impairment or Alzheimer's disease. Alternative formulations like LIT-O may be a potential alternative to harness lithium's neuroprotective properties more efficiently.
A global study found that crop rotation increases total yields, energy and protein content, and micronutrient levels in crops such as iron, magnesium, and zinc. The practice also leads to higher farm revenues and less year-on-year yield variability compared to continuous monocultures.
A new meta-analysis of 125 studies reveals that adding biochar to composting systems boosts compost quality and slashes harmful greenhouse gas emissions by up to 51%. Biochar improves aeration, holds nutrients, and creates a favorable habitat for beneficial microbes, accelerating the composting process.
A global study found that biochar significantly reduces methane and nitrous oxide emissions in composting, while conserving nitrogen and stabilizing carbon. The optimal amount of biochar added is critical, with 10-20% achieving the strongest reductions.
A meta-analysis found significantly higher treatment failure and major complication rates within a year with nonoperative management among children and adolescents. Pediatricians can now inform shared decision-making with families using up-to-date data.
A systematic review and meta-analysis found a strong association between alcohol consumption per capita and an increase in suicide mortality rates. The study suggests that targeting alcohol consumption may be a useful strategy for comprehensive national suicide prevention efforts.
Researchers found that specific nutrient supplements like amino acids, probiotics, and herbs like ginger can effectively reduce nausea, vomiting, and diarrhea. Dietary counseling also showed promise in reducing common GI side effects. Oral nutritional supplements, however, did not demonstrate benefits in easing symptoms.
A recent meta-analysis found that Helicobacter pylori eradication may be associated with an increased risk of developing or experiencing reflux oesophagitis. The study analyzed data from 30 studies and showed a statistically significant increase in RE risk in RCTs, but not in cohort studies. Age, underlying diseases, region, and durati...
A systematic review and meta-analysis reveals that adults with hearing loss can enhance social engagement and functional outcomes by using hearing aids or cochlear implants. The study suggests that these devices should be encouraged for individuals with hearing loss to potentially improve their quality of life.
A meta-analysis of 21 studies involving over 178,000 women found that those with infertility history have a 14% increased risk of heart or blood vessel conditions, as well as higher risks of heart disease and stroke. Younger women and those undergoing fertility treatments are at greater risk.
A meta-analysis reveals significant racial and ethnic disparities in the reporting of race and ethnicity in clinical trials for pharmacotherapy of mental disorders. The study underscores the importance of equitable recruitment and reporting in clinical trials to ensure inclusive representation of diverse populations.
A recent study published in JAMA Pediatrics found that prenatal cannabis use is associated with an increased risk of preterm birth and low birth weight. The research also suggests a potential link between cannabis use during pregnancy and smaller-than-average newborns.
A systematic review of child maltreatment found that parents and caregivers with alcohol-related diagnoses were twice as likely to maltreat children. The study pooled data from twelve high-income countries and associated caregiver alcohol-related diagnoses with higher child maltreatment incidence.
A meta-analysis of 15 studies with over 1,200 participants found TM to be highly effective in reducing stress and PTSD symptoms in diverse populations. The study showed a large effect size of 1.01 for TM compared to control groups, with rapid reductions in symptoms observed within one month of practicing TM.
A recent meta-analysis found that generative AI's diagnostic accuracy is lower than that of specialist doctors, with an average accuracy of 52.1%. The study suggests that while generative AI has the potential to support non-specialist doctors in diagnostics, further research is needed to improve its capabilities.
A recent study published in the International Journal of Cardiology analyzed data from multiple clinical trials to assess the therapeutic impact of pulmonary artery denervation (PADN) on pulmonary hypertension patients. PADN showed significant reductions in mean right atrial pressure, mean pulmonary artery pressure, and pulmonary vascu...
A meta-analysis of randomized clinical trials found that glucagon-like peptide-1 receptor agonists (GLP-1RAs) were associated with a statistically significant reduction in all-cause dementia. Cardioprotective glucose-lowering therapies, however, did not show an overall reduction in dementia risk.
A systematic review and meta-analysis found COVID-19 significantly increases severity, morbidity, and mortality in sarcoidosis patients. Vaccination against SARS-CoV-2 is beneficial for these individuals.
A large study suggests that patients at high risk of heart attacks and strokes should be treated immediately with a combination of a statin and ezetimibe, rather than statins alone. This combination therapy significantly reduces the risk of death from any cause and major adverse cardiovascular events.
Researchers found no clear evidence that red wine mitigates cancer risk, and instead observed a distinction in skin cancer risk. White wine consumption was associated with an increased risk of skin cancer compared to red wine, particularly among women. Heavy wine consumption may correlate to high-risk behaviors.
A systematic review and meta-analysis found that approximately 40% of adults with chronic pain experience clinically significant depression and anxiety. Women, younger people, and those with nociplastic pain are most vulnerable to these conditions.
A recent study by the University of the Basque Country reveals that pollinator diversity is essential for maintaining ecosystem health and plant reproduction. The research, conducted across 46 countries, found that a decline in wild pollinators has a negative impact on plants' reproductive success.
A systematic review and dose-response meta-analysis found a daily 1-hour increment in digital screen time was associated with a 21% higher odds of myopia. Researchers suggest that exposure to screens for less than 1 hour per day may be safe, but prolonged use increases the risk of nearsightedness.
A systematic meta-analysis of online misinformation found that education level has no significant impact on people's ability to distinguish true from false information. In fact, older adults were better at distinguishing between true and false headlines than younger adults. The study also showed that individuals with higher analytical ...
Researchers from Japan found that organizational strategies, third-wave techniques, and problem-solving techniques are the most effective components of cognitive–behavioral therapy in treating ADHD. These approaches can help improve planning, prioritization, organization, emotional regulation, and stress management.
A systematic review and network meta-analysis of 601 trials revealed that SGLT2 inhibitors were more cardioprotective in older adults, while GLP-1 receptor agonists offered greater benefits to younger patients. These findings suggest personalized treatment approaches for type 2 diabetes based on age and sex.
A systematic review and meta-analysis found that cold-water immersion can reduce stress levels within 12 hours, improve sleep quality, and boost quality of life. However, these benefits may fade after three months. Cold showers also showed promise in reducing sickness absence and improving mood.
A new meta-analysis of over 249 studies and 251,713 US teens finds that knowledge about safer sex is not enough to promote condom use. The study highlights the importance of confidence, planning, and effective communication with partners in encouraging condom use among teens.
A new meta-analysis published in the European Journal of Applied Physiology found that using neuromuscular electrical stimulation (NMES) while doing resistance training increases muscle mass and strength compared to resistance training alone. The analysis reviewed over a dozen studies and showed that longer training periods yielded bet...
A systematic review and meta-analysis found an inverse association between fluoride exposure and children's IQ scores. The findings suggest a dose-response relationship between fluoride levels and IQ across multiple countries, highlighting the need for comprehensive public health risk-benefit assessments of fluoride exposures.
Engaging in 30 minutes of aerobic exercise per week modestly reduces body weight, waist circumference, and body fat measures. Aerobic training exceeding 150 minutes per week may be needed for clinically important reductions.
A comprehensive systematic review and meta-analysis demonstrate that eating two servings of unprocessed beef daily has no adverse effects on traditional risk factors for cardiovascular disease. Key findings include consistent evidence from RCTs showing lean beef consumption can be part of a heart-healthy diet.
A systematic review and meta-analysis of 96,000 adults found that higher daily step counts were linked to lower depressive symptoms. Further studies are needed to confirm the potential protective role of daily steps in depression.
A meta-analysis of 61 studies with over 3,400 participants found that Transcendental Meditation (TM) significantly outperforms other meditation techniques in treating PTSD. Results show TM produces large and consistent reductions in PTSD symptoms across various trauma populations.
A systematic review and meta-analysis found CAD is common in cirrhotic patients, but cirrhosis itself may not be associated with increased CAD risk. Non-alcoholic steatohepatitis and hepatitis C virus infection are also linked to CAD presence.
Researchers identified iTBS over the left dorsolateral prefrontal cortex as the most effective method for treating adults with schizophrenia, improving negative and cognitive symptoms. The treatment approach was well-accepted and well-tolerated by participants.
Research reveals that people who use both vapes and cigarettes are less likely to quit smoking compared to those who only smoke or vape. Dual users tend to revert to only smoking cigarettes over time. The study suggests that taking up vaping while continuing to smoke will not help people stop smoking.
A systematic review and network meta-analysis found spinal cord stimulation therapies to be more effective in reducing chronic back and leg pain. These findings suggest spinal cord stimulation as a valuable option for chronic pain management.
A systematic review and meta-analysis found nurse burnout to be associated with lower health care quality and safety, as well as lower patient satisfaction. The association was consistent across various nurse and study characteristics.
A systematic review and meta-analysis found a significant association between Helicobacter pylori infection and the risk of cardia gastric cancer in Asian countries, with stronger associations observed in East Asia. The study suggests that H. pylori infection is a major risk factor for CGC in this region.
A meta-analysis found that individuals carrying the AA genotype at TLR10 rs10004195 locus have a significantly elevated risk of H. pylori infection. This association may be used to assess future risk and provide personalized health guidance.
Using Clinical Design Support Systems (CDSS) can help make maternity services safer for pregnant women, with a meta-analysis of 35 studies showing a 1.69 times higher odds of improved outcomes. The findings support the use of AI and related software tools to improve pregnancy care.
A recent meta-analysis of 21 longitudinal studies revealed that loneliness increases the risk of developing dementia by 31%, with specific causes including Alzheimer's disease and cognitive impairments.
The study found an estimated 2.56% of US adults 40 years and older have glaucoma, highlighting the need for public health planning. Disproportionate impact on black individuals underscores the importance of targeted prevention efforts.
A systematic review and meta-analysis found that weight-loss surgery reduces pancreatic cancer risk among individuals with obesity by 44%, and among those with both obesity and type 2 diabetes by 79%. The study suggests that metabolic-bariatric surgery may play a crucial role in reducing the risk of pancreatic cancer.
Aerobic physical activity was associated with modest short-term and long-term reductions of depression among adults with cancer. The study suggests that aerobic exercise may be an effective strategy for managing depression in cancer patients.
A comprehensive review of population-level tobacco control strategies found tax increases, smoke-free legislation, and anti-smoking campaigns to be effective in reducing smoking. These interventions also increased quit rates and led to higher smoking cessation rates.
The invasive tiger mosquito expands its host range as it spreads across regions, with a greater diversity of hosts in the invasive range. The mosquito's ability to adapt to new environments and act as a bridge vector for pathogens increases the risk of disease transmission.
A new publication provides essential guidance for conducting rigorous systematic reviews on studies with animals and cells. Regular narrative reviews are prone to biases, but systematic reviews follow a rigorous and transparent methodology, helping researchers make sense of conflicting reports and identify gaps in the field.
A systematic review and meta-analysis of over 3.6 million mother-child pairs found that maternal obesity during pregnancy significantly linked with psychiatric and behavioral problems in children later in life, including autism spectrum disorder and attention deficit hyperactivity disorder.
Researchers identified known genetic variants for Alzheimer’s disease as risk factors for all-cause dementia and vascular dementia. The study also found a substantial genetic overlap with vascular dementia and cerebral small-vessel disease.
A recent systematic review and meta-analysis of 28 studies with 1.2 million participants found that wearable technology can accurately detect conditions such as heart rate variability, blood pressure, oxygen levels, sleep quality, skin temperature, hydration, and stress levels. The study suggests that wearable activity trackers could r...
Research reveals that maternal prenatal smoking can limit a child's academic performance and put them behind their peers at school. The systematic review of 19 studies and 1.25 million participants found that 79% of studies reported reduced academic achievement in children exposed to maternal prenatal smoking.
A systematic review and meta-analysis found that cognitive behavioral therapy (CBT) moderately improves mental health and quality of life in people with past or current cancer. CBT was more effective for younger individuals and in-person delivery compared to technology-based platforms.
A review of 148 studies found nearly one in ten patients experience opioid dependence or disorder, while nearly one in three show symptoms. The study emphasizes the need for accurate estimates to develop effective interventions and manage the problem.
Research from Florida Atlantic University reveals that training closer to failure can boost muscle growth, while having no clear impact on strength gains. The study analyzed data from 55 studies and suggests that individuals who aim to build muscle should work within a desired range of 0-5 reps short of failure.
A meta-analysis published in Ecopsychology found that even brief nature exposure can have a positive effect on symptomology, including affect, anxiety, and depression. The study suggests using nature exposure as an intervention to improve health and wellbeing for adults with mental illness.
A systematic review published in Nutrients highlights the positive health outcomes associated with pulse consumption. The study found that eating more pulses reduces the risk of type 2 diabetes and heart disease.