Articles tagged with Metaanalysis
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A meta-analysis of North American correspondence studies found that perceived warmth and competence ratings predicted callback differences between identities. Applicants with lower callback rates were often rated as less warm and competent, highlighting the role of social perceptions in hiring bias.
Researchers found that combining sodium glucose co-transporter 2 inhibitors and glucagon-like peptide-1 receptor agonists reduces the risk of major adverse cardiovascular events and chronic kidney disease progression by 11% and 33%, respectively. The study suggests using this combination to further improve outcomes in patients with typ...
A systematic review and meta-analysis found that technology-assisted Cognitive Behavioural Therapy (CBT) is as effective as face-to-face CBT in treating anxiety and depression in children and young people. The study highlights the potential of technology-assisted CBT to expand access to mental health treatment.
A new study analyzed nearly 1,300 opposite-sex couples and found that both men and women were accurate in rating their own physical attractiveness. Couples also tended to match in attractiveness levels, suggesting they date within their own
A recent review of studies on heart failure patients suggests that reducing salt intake has no clinical benefits and may even be counterproductive. Moderate to strict salt restriction was linked with improved quality of life but not mortality or hospitalization rates among patients with heart failure.
A systematic review of 14 studies found that mindfulness reduced anxiety and stress to a statistically significant extent. The study highlights the importance of combining mindfulness with improving work conditions to manage symptoms of anxiety and stress among nursing staff.
A systematic review and meta-analysis found that one in three people reports symptoms after discontinuing antidepressant treatment. The nocebo effect, where negative expectations contribute to symptoms, is estimated to be responsible for half of these effects.
A systematic review and meta-analysis of over 20,000 patients found that one in six to seven patients will experience discontinuation symptoms directly caused by stopping the medication. Severe symptoms occurred in about 3% of patients, with certain antidepressants increasing the risk.
A new meta-analysis of 29 randomized controlled trials found that omega-3 supplementation can modestly reduce aggression across age and gender. The study suggests that omega-3 could be a useful adjunct to other interventions for reducing aggression.
A meta-analysis of seven randomized trials found that transcatheter aortic valve replacement (TAVR) has comparable long-term safety and efficacy to surgical aortic valve replacement (SAVR). However, TAVR was associated with an increased likelihood of needing a pacemaker and moderate-to-severe paravalvular leaks.
A recent meta-analysis found that one in four patients with insulin-dependent diabetes exhibit eating disorder symptoms, including binge eating and food restriction. Intentional insulin omission is a unique form of disordered eating where insulin doses are restricted or skipped due to fears of weight gain.
A systematic review of psilocybin for treating symptoms of depression has been placed under expression of concern by The BMJ due to a methodological concern related to an error in the calculation of standardized mean differences. This may have resulted in overestimated benefits of psilocybin treatment.
A new study published in the Journal of Affective Disorders found that women in the perimenopausal stage are significantly more likely to experience depression. The meta-analysis of seven studies involving over 9,000 women from around the world reveals a 40% increased risk of depressive symptoms during this life-stage.
A systematic review and meta-analysis found no association between new-onset seizures and SARS-CoV-2 vaccination. The study included over 118,000 participants from randomized clinical trials and found the incidence proportion of new-onset seizures to be similar across vaccine recipients and unvaccinated participants.
Research suggests that mentally active employees are less likely to experience cognitive decline and dementia-related issues. The study analyzed various interventions aimed at boosting mental performance, revealing promising results for those looking to reduce the risk of age-related brain decline.
A systematic review of 41 randomized clinical trials suggests that late-stage cancer incidence can be a suitable alternative end point to cancer-specific mortality in some cancer types, but not others. This finding has implications for multicancer screening tests and may change the way these trials are designed.
A meta-analysis of 11 trials involving 78,607 patients found a 9% reduction in major adverse cardiovascular events (MACE) and a 14% reduction in cardiovascular death with SGLT2 inhibitors. The analysis showed consistent effects across patient groups and subgroups.
A systematic review and meta-analysis found that antibiotic prophylaxis is associated with a reduced risk of infective endocarditis in high-risk individuals following invasive dental procedures. However, its effectiveness in moderate-risk individuals is unclear.
Integrating magnetic resonance imaging (MRI) in prostate cancer screening pathways is associated with reduced unnecessary biopsies and overdiagnosis. MRI maintains clinically significant prostate cancer detection, reducing harm from overtreatment.
A routine blood test that measures inflammation levels could improve diagnosis and management of debilitating autoimmune diseases. The Systemic Inflammation Index (SII) has shown high accuracy in diagnosing immunological diseases.
A recent study published in The Journal of Pain has found that CBD products are ineffective in reducing chronic pain and may pose health risks. The research, led by the University of Bath, examined existing studies on CBD and concluded that there is no quality evidence to support its use as a pain reliever.
A new study found that COVID-19 vaccine uptake was low across all four UK nations, with only 35% of children receiving the first dose. The study also revealed disparities in vaccination rates based on age, sex, household factors, and location.
A systematic review and meta-analysis found a strong association between alcohol use disorder and suicide mortality across genders. The study highlights the importance of addressing alcohol use disorder as part of comprehensive suicide prevention strategies.
A large-scale review published in The Lancet Regional Health Europe provides an update on the recent advances in understanding and managing risk factors for atrial fibrillation (AF). AF affects around 1.4 million people in the UK, causing irregular heart rates and impairing quality of life. Researchers found that a more individualized ...
A new study found that genetic factors contribute around 33% to the variation in levels of trust among individuals, while life circumstances such as age, health, and relationship status also increase trust. The research used twin studies to disentangle genetic and environmental influences on trust.
Intravenous thrombolysis (IVT) plus thrombectomy demonstrates significant benefits over thrombectomy alone when administered within a short timeframe after symptom onset. This study, based on individual participant data from six randomized clinical trials, found IVT before thrombectomy to be time-dependent and statistically significant.
A systematic review and meta-analysis of 104 studies with 341,000 participants found that physical activity was associated with better late-life cognition, although the association was weak. The findings suggest that even a weak link between physical activity and cognitive decline is still important from a population health perspective.
A new study found a statistically significant increase in ambulance callouts for all causes by 10%, with cardiovascular causes rising by 5%. As heatwaves intensify, the risk of ambulance callouts is expected to rise further, highlighting the need for proactive measures to address heat-related health issues.
A new set of international criteria has been established to diagnose pediatric sepsis and septic shock in children, aiming to improve clinical care and research globally. The Phoenix Sepsis Score of at least 2 can identify potentially life-threatening organ dysfunction in infected children under 18 years old.
A meta-analysis of 5,000 participants found that daily multivitamins showed benefits for memory and global cognition. The study suggests that taking a daily multivitamin can help prevent memory loss and slow down cognitive aging by the equivalent of two years compared to placebo.
A new peer-reviewed study suggests that cannabis is having no significant effect on people's use of opioids, taken outside of medical guidance. The findings have substantial implications for U.S. treatment programs, which still require patients to abstain from cannabis before qualifying for potentially life-saving treatment.
A meta-analysis of 90 studies found that adolescents use nonprescription weight-loss products excessively, with girls being more affected. The study highlights the need for interventions to reduce this behavior and mitigate potential long-term health consequences.
Research has shown that most people cradle babies in the crook of their left arm, as this allows for better sound quality and emotional connection. The theory suggests that this is because the heart is on the left side and humans perceive information faster with their left ear.
Despite improved living conditions, sex differences in personality, verbal skills, and negative emotions are larger in countries with higher standards of living. Women tend to benefit more from these improvements, exhibiting greater altruism and cooperative ability, while men show better cognitive skills but at a smaller advantage.
A new study found that cytisine significantly increases the chances of successful smoking cessation by more than two-fold compared to placebo. The study also suggests that cytisine may be more effective than nicotine replacement therapy in some cases, making it a promising solution for smokers worldwide.
A recent study found that decreases in the number of formerly abundant insect species have contributed significantly to local insect declines. The study's findings challenge the idea that changes in insect biodiversity result from rarer species disappearing.
A systematic review and meta-analysis of 15 clinical trials found daily tooth brushing may reduce hospital-acquired pneumonia rates by up to 50% in high-risk patients. This study suggests that widespread toothbrushing policies could save lives and reduce healthcare costs.
A systematic review has identified 29 primary risk factors associated with long-term arm morbidities following breast cancer treatments. The main risk factors include removal of lymph nodes, high body mass index, mastectomy, radiation therapy, chemotherapy, infection, and trauma to the affected arm.
Research found elevated risks between intimate partner violence and childhood sexual abuse and various health conditions. Intimate partner violence was associated with increased risk of major depressive disorders, maternal abortion, and alcohol misuse, while childhood sexual abuse linked to increased risk of self-harm and alcohol use.
A meta-analysis of 15 randomized controlled trials found significant improvements in sleep efficiency and psycho-behavioral symptoms in patients with Alzheimer's disease. Light therapy also alleviated depression and reduced patient agitation and caregiver burden.
A new meta-analysis found that intravenous fluid therapy using balanced solutions can reduce the risk of in-hospital death in critically ill patients by four percent. Balanced solutions are more closely matched to human blood chemistry than commonly used saline, and may be associated with lower mortality rates.
A literature review found that prioritizing circulation before the airway in trauma patients with major blood loss leads to improved outcomes, including lower mortality rates. This approach, known as CAB, has gained acceptance over the ABC model and is now being recommended by the American College of Surgeons.
A comprehensive meta-analysis led by Dr. Micheal Sandbank reveals that many low-quality studies are driving intervention recommendations and patient outcomes in early childhood autism care. The study highlights the need for more rigorous research to understand the positive and negative effects of various interventions.
A systematic review of 13 randomized clinical trials found that app-based interventions are effective in treating moderate to severe depression. The study's findings support the use of mobile apps as a practical tool for clinical practice.
A meta-analysis of 57 studies found that prenatal cannabis exposure is associated with an increased risk of preterm delivery, low birth weight, and neonatal intensive care unit (NICU) admission. However, it does not appear to increase the risk of birth defects or death within one year.
Two systematic reviews and meta-analyses found that delaying umbilical cord clamping by at least two minutes can reduce the risk of death in premature babies. The studies included over 10,000 babies from 60 studies and showed a significant reduction in mortality rates for deferred clamping compared to immediate clamping.
A meta-analysis of studies found guilt has only a small persuasive effect, making it less effective than previously thought. Existential guilt appeals better for broader issues like environmental and educational topics, while personal responsibility-based guilt is less effective in health communications.
A meta-analysis found that prioritizing native species can increase invasion resistance by over 50% and reduce invasive alien species' performance. High-density seeding of functionally similar or multifunctional seed mixtures is effective in controlling invasive species, with priority effects strengthened by increasing time advantage.
A meta-analysis of 40 studies involving 310,000 youths found low treatment rates for depression and anxiety in children and adolescents. Targeted interventions to improve psychiatric disorder treatment rates are urgently required.
A systematic review of global guidelines for AI use found that most valued principles such as transparency, security, and justice. However, fewer guidelines prioritized truthfulness, intellectual property, and children's rights. Most guidelines were normative but lacked practical methods for implementation.
A new study found that body image dissatisfaction during pregnancy varies widely among women, influenced by complex factors such as positive and negative experiences. Negative body image can have serious effects on the mother and baby, including depression, anxiety, and poor quality interactions. The research highlights the importance ...
A meta-analysis found that CPAP treatment adherence is associated with a lower risk of recurrent cardiovascular events in patients with obstructive sleep apnea. Adherence to CPAP therapy may be a key factor in secondary cardiovascular prevention.
A meta-analysis published in Neurology found that short-term exposure to air pollution is linked to an increased risk of stroke and death from stroke. The study involved 110 studies with over 18 million cases of stroke.
Adult Black patients experience higher risk of physical restraint in emergency departments compared to other racial groups, according to a systematic review and meta-analysis. The study emphasizes the importance of considering how racism may affect disparate use of restraints among adult patients.
A new study published in Nature Climate Change assesses the last 24 years of ocean acidification research and finds that negative effects remain consistently observed. The researchers' efforts to reproduce early results have shown improvement over time, with sufficient data contributing to a rebuilt confidence in the community.
A new meta-analysis of 22 clinical trials found that tirzepatide is more effective than semaglutide in controlling blood sugar levels and promoting weight loss. The study showed that higher doses of tirzepatide resulted in greater reductions in HbA1c levels and body weight compared to semaglutide.
A systematic review and meta-analysis found that rehabilitation interventions significantly improve functional exercise capacity, dyspnea, and quality of life in adults with post-COVID-19 condition. The certainty of evidence for these outcomes was moderate to high.
A meta-analysis of 34,000 older adults found that antihypertensive treatment decreased dementia risk compared to untreated hypertension. Individuals with treated hypertension had no increased risk of dementia.
A dose-response meta-analysis of nine randomized trials found gefapixant to improve cough frequency, severity, and quality of life. However, it also led to increased taste-related adverse events compared to placebo.
The study found that fruits pollinated by animals are 23% higher in quality, with benefits independent of geographical regions and pollinator species. This suggests that crop quality depends significantly on the presence of pollinating animals.