About The Study: This systematic review and meta-analysis including data on 1.1 million cases of infective endocarditis found that antibiotic prophylaxis was associated with a reduced risk of infective endocarditis following invasive dental procedures in individuals at high risk but not in those at moderate or low/unknown risk. Currently, there is insufficient data to support any benefit of antibiotic prophylaxis in individuals at moderate risk.
Authors: Federica Turati, Ph.D., of the Università degli Studi di Milano in Milan, Italy, and Katherine France, D.M.D., M.B.E., of the University of Pennsylvania in Philadelphia, are the corresponding authors.
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(doi:10.1001/jamacardio.2024.0873)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Media advisory: This study is being released to coincide with presentation at the American College of Cardiology’s Annual Scientific Session.
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JAMA Cardiology