A new AI-based video biomarker is associated with aortic stenosis development and progression, allowing for opportunistic risk stratification across various imaging modalities. The study's findings suggest potential applications on handheld devices for early detection and intervention.
A systematic review and meta-analysis found that antibiotic prophylaxis is associated with a reduced risk of infective endocarditis in high-risk individuals following invasive dental procedures. However, its effectiveness in moderate-risk individuals is unclear.
A randomized clinical trial found that PSA screening compared to no routine screening resulted in a small reduction in prostate cancer deaths after 15 years. The absolute reduction in deaths was modest, but the finding suggests potential benefits of PSA screening.
The CAP trial found that PSA test screening led to a small reduction in prostate cancer deaths, but also resulted in overdiagnosis of 1 in 6 cancers. The study suggests that the benefits of screening do not outweigh the potential harms.
In a preliminary report from an ongoing clinical trial, prostate cancer screenings using PSA, Kallikrein Panel, and MRI detected higher rates of cancer compared to no screening. The study found one additional high-grade cancer per 196 men and one low-grade cancer per 909 men were detected in the screened group.
A new oral vaccine for recurrent Urinary Tract Infections (UTIs) has been shown to prevent infections in over half of participants for up to nine years. The MV140 vaccine was found to be safe and effective, with no notable side effects reported.
A new study found that inter-atrial shunts improve symptoms and outcomes in heart failure patients with reduced left ventricular ejection fraction (LVEF), but worsen outcomes in those with preserved LVEF. The device reduces high pressures in the left atrium, causing shortness of breath and hospitalizations.