Most cancer drugs granted accelerated approval show no benefit in overall survival or quality of life within five years. Patients should be informed about the limited effectiveness of these drugs.
A study found that only 43% of accelerated approval drugs demonstrated a clinical benefit in confirmatory trials after five years. The study analyzed 129 cancer drugs approved between 2013-2023 and found that 63% were converted to regular approvals, but 22% were withdrawn due to lack of efficacy.
A novel photonic computing architecture has been developed for tens-of-task lifelong learning, surpassing existing electronic neural networks in capacity and energy efficiency. The L2 ONN demonstrates extraordinary learning capability on challenging tasks, such as vision classification and medical diagnosis.
Research found accelerated aging associated with increased incidence of early-onset solid tumors, including lung, gastrointestinal, and uterine cancers. Biological age, a measure of body and physiological processes, may contribute to cancer development in younger adults.
A team of astronomers led by Kohei Kurahara discovered a mysterious cloud of magnetized plasma, dubbed the Flying Fox, in the Hydra galaxy cluster. The plasma's shape and location have left scientists baffled, with no known class or host galaxy identified.
A biologic drug-device combination therapy has shown promising results in treating metastatic prostate cancer, with 60% of patients experiencing an objective response. The treatment, SYNC-T, uses a cold-temperature probe to kill tumor cells and release immune-stimulating neoantigens, leading to a high response rate without severe toxic...
A study by Professor Jongsik Christian Yi introduces a history of science curriculum at POSTECH, exploring its importance in teaching the Korean history of science. The author argues for a self-reflective approach to education, encouraging students to critically think about their roles and futures in Korean science and technology.
A new approach to heart bypass surgery has been successfully tested, using non-invasive cardiac-CT scan images and AI-powered blood flow analysis. The trial showed a 99.1% feasibility rate, indicating that the procedure is safe and effective without invasive diagnostic catheterisation.
A meta-analysis of 11 trials involving 78,607 patients found a 9% reduction in major adverse cardiovascular events (MACE) and a 14% reduction in cardiovascular death with SGLT2 inhibitors. The analysis showed consistent effects across patient groups and subgroups.
Researchers developed e-calculus to capture asynchronous communications between agents with epistemic states, offering new insights into distributed systems. The study presents a process calculus enriched with operators for passing basic facts and applying action model logic to describe agents' epistemic states.
The randomized clinical trial demonstrates plozasiran's potential to reduce triglyceride levels in patients with severe hypertriglyceridemia. Additional studies are needed to determine its impact on complications associated with the condition.
A new study found that a remote team focused on education and medication management can improve guideline-directed-medical-therapy adherence in patients with type 2 diabetes. Patients who received education simultaneously with medication management demonstrated a higher rate of medication uptake.
The boreal forest and treeless shrublands may experience significant changes due to climate change, with potential loss of biodiversity and ecosystem disruption. The study highlights the need for adaptation and cooperation to mitigate these impacts.
Researchers developed a nanosized polymer that selectively delivers chemotherapeutic drugs to blood vessels supporting tumor growth. The treatment eliminates colorectal cancer liver metastases and prolongs mice survival after a single dose-therapy.
China's Agricultural Green Development (AGD) evaluation system reveals two stages of transformation from 1997 to 2020, with increasing scores but moderate levels. The Socioeconomic dimension shows significant improvement, while Food production and Eco-environmental dimensions require further development.
Scientists have developed a method to precisely control the shape and contact angle of microdroplets, achieving arbitrary shapes and a wide range of contact angles. This breakthrough challenges the traditional Gibbs equation, which predicts contact angles for macro-droplets on rough surfaces.
Researchers found that withdrawing aspirin one month after PCI significantly reduced major and minor bleeding incidents by 55% compared to dual antiplatelet therapy. The study, ULTIMATE-DAPT, showed no increase in adverse ischemic events, suggesting continuing aspirin may cause harm without benefit.
A new study found that combining pelvic floor exercises with behavioral therapy can be more effective than current medical treatments in helping men with frequent urges to urinate. The Bladder Emptying Disorder Therapy (BEST) Trial showed significant improvements in symptoms and quality of life measures after just 12 weeks.
A telephone-based strategy improved guideline-directed medical therapy rates for outpatients with heart failure by 30 days, offering a low-cost solution for rural settings with limited access to care. This study suggests the potential for expanded remote healthcare initiatives to address health disparities.
A new study found that high-dose influenza vaccine significantly improved humoral response in patients with heart failure or prior myocardial infarction. Vaccination remains crucial in preventing influenza-related complications in high-risk populations.
An experimental treatment further lowers triglyceride levels in patients with moderate to severe hypertriglyceridemia, reducing risk of heart attack and stroke by up to 53%.
Scientists developed Te-based THz modulators with improved modulation depth and speed, overcoming the tradeoff between the two. The stacking order of materials significantly impacts the modulation property, which can be regulated through substrate engineering.
A systematic review of 41 randomized clinical trials suggests that late-stage cancer incidence can be a suitable alternative end point to cancer-specific mortality in some cancer types, but not others. This finding has implications for multicancer screening tests and may change the way these trials are designed.
Researchers found that an individualized neoantigen-specific mRNA vaccine, autogene cevumeran, can induce a robust immune response in patients with resectable pancreatic cancer. After a median follow-up of three years, the treatment was associated with a significantly longer median recurrence-free survival compared to those who did not...
Cadanilimab plus chemotherapy improved progression-free and overall survival in HER2-negative, locally advanced or metastatic gastric/GEJ cancer patients with PD-L1-low tumors. The treatment showed a significant survival benefit in these patients.
A NIH-supported study found that daily reminders and incentives increased daily steps by over 1,500 for adults with heart disease risks, leading to a 6% reduced risk of premature death. The study also showed that combining financial and game-like rewards was most effective in sustaining long-term behavior change.