Articles tagged with Dentistry
Researchers use cryo-electron microscopy to reveal the 3D structure of Mfa pili in P. gingivalis, understanding its role in attaching to host tissues and other microbes. This information can aid in developing therapeutic strategies to block attachment and infection.
This study reveals that Porphyromonas gingivalis induces neuroinflammation and cognitive impairment via microglial ferroptosis triggered by the NOX4/PPAR-α/PGC-1α pathway. The findings provide a molecular target for drug repurposing to intervene in periodontitis-associated Alzheimer's disease.
Researchers propose homeostasis-restoring strategies involving exogenous nitrate interventions and targeted stem cell regulation for diseases such as dental caries, periodontitis, cancer, cardiovascular and metabolic diseases. This new paradigm aims to prevent diseases before they arise.
A patient-derived KDF1 mutation impairs enamel-forming cells by disrupting cell adhesion and Hippo-YAP signaling. Mutant mice exhibit thinner enamel, reduced mineral density, and delayed tooth eruption.
A new study reveals that excessive fibrin deposition drives chronic inflammation in diabetic periodontitis. A targeted peptide successfully stops this inflammation and promotes periodontal bone regeneration, offering a potential universal therapeutic strategy for various immune-mediated diabetic comorbidities.
Researchers have developed a miniature dental robot called MIR that can prepare teeth for crowns with precision, reducing the number of appointments needed. The robot uses a digital plan to remove tooth material and produces a custom-fitted dental splint.
A new survey by the Annenberg Public Policy Center finds Americans sharply divided over the use of fluoride in public drinking water. Supporters of the Make America Healthy Again movement are notably more skeptical about fluoridation's health effects, while a majority trust the American Dental Association's stance on its safety.
A study by King's College London found that following a short-term low-calorie diet can reduce markers of inflammation associated with gum disease. This suggests lifestyle modifications may be important alongside plaque control in managing gum disease.
Persons with diabetes are at higher risk of periodontitis, tooth loss, and peri-implantitis. Poor blood sugar control exacerbates these risks, highlighting the importance of close collaboration between healthcare and dental care providers.
A novel biomaterial containing jackfruit latex, pomegranate peel extract, and simvastatin shows promising efficacy in treating periodontitis. The material has adhesive properties, allowing for targeted release of therapeutic compounds, and has been shown to promote regeneration of periodontal tissues.
A new study found that chronic oral inflammation can impair female fertility by triggering a systemic immune response that affects the ovaries. This leads to oxidative damage, reduced egg quality, disrupted follicle development, and reduced live birth rates.
Researchers found that print angles between 150° to 180° and 50-μm layer thickness performed best for crown accuracy and fit. Printing deviations were not evenly distributed across the inner surface of crowns.
Researchers developed a microneedle patch loaded with mesenchymal stem cell-derived exosomes that accelerate oral ulcer healing by remodeling macrophage-epithelial crosstalk. The patch promotes anti-inflammatory phenotypes and suppresses NF-κB signaling, reducing inflammation and promoting tissue regeneration.
Researchers have discovered a link between tooth aging and the decline of dental pulp stem cells' regenerative capacity. A unique subset of DPSCs, expressing NFATC1 protein, is essential for tooth regeneration. Eliminating this subset can lead to senescence and reduced ability to regenerate after injury.
A new study reveals how maternal antibodies program the mouth to resist aggressive bacteria and prevent bone loss associated with adult gum disease. Maternal IgG also regulates the timing of barrier sealing in the oral epithelium.
A new study shows that while dental opioid prescription fills in the US have dropped by 27% since 2021, the rate remains higher than in other developed countries and the US territory of Puerto Rico. The study suggests that some US dentists are still overprescribing opioids.
A study found that children who need dental care the most are less likely to participate in school-based cavity prevention programs, which can lead to significant savings for state Medicaid programs. Improving participation among high-risk children could save up to $2.4 million annually.
A team of researchers found that Gli2 and Gli3 function synergistically to regulate tooth root morphogenesis. Their study revealed a critical interaction between HH signaling and TGF-β signaling, which is essential for normal root development.
A new study found that older people who forego necessary dental procedures due to financial barriers may experience heart failure, a heart attack, a stroke, or dementia. The researchers suggest that alleviating upstream factors such as financial constraints could prevent chronic disease.
Researchers found a clear connection between oral health and kidney health, with immune dysregulation and systemic inflammation driving the relationship. The study highlights the need for physicians to integrate oral and renal health into clinical care systems.
New research demonstrates that restoring the physical stiffness of the gingival tissue can fundamentally change how cells respond to infection, potentially paving the way for new treatments. The study uses a hydrogel system to investigate how gum tissue stiffness impacts periodontal disease inflammation.
A study found that dentists have a higher prevalence of vision-related problems due to prolonged exposure to artificial lighting. Chronic dental lighting caused retinal damage, disruption of the blood-retinal barrier, and inflammation, ultimately impairing visual health.
The program aims to support future pediatric-focused professionals in dentistry, medicine and nursing through competitive scholarships and training. With the gift, UT Health San Antonio will expand access to high-quality care for children and families in Bexar County.
A systematic review found consistent evidence that snus causes gum recession, particularly with loose snus. White snus has virtually no studies on its long-term oral health effects, creating a significant knowledge gap.
A study on mouse incisors reveals a cellular mechanism behind the unique decussation patterns of tooth enamel, which form the enamel's hardness through directional sliding and coordinated migration of ameloblasts. The findings provide new insights into how dental stem and progenitor cells maintain and repair enamel-forming tissues.
A new neural circuit has been identified that rewards gnawing behavior in rodents, driving a release of dopamine in the brain. This discovery could help explain oral health issues in humans, including bruxism and malocclusion.
Researchers discover SMAD7 acts as a positive regulator of Wnt/β-catenin signaling, promoting dental pulp stem cell regeneration and tissue repair. The study provides new insights into the molecular mechanisms governing tooth regeneration and holds promise for regenerative endodontic procedures.
Copper metabolism plays a crucial role in inflammatory bone diseases, with copper overload suppressing glycogen synthesis and increasing inflammatory activity. Researchers found that cuproptosis, a form of programmed cell death, can lead to bone weakening and osteoclast formation, providing a potential new therapeutic target.
Research reveals that salivary bacteria from gum disease alter gut metabolism, driving osteoclast activity and systemic bone loss. Microbial metabolites like indole-3-lactic acid inhibit osteoclast differentiation and activity.
A new study by King's College London found that over 35% of patients without reported diabetes had high blood sugar levels consistent with pre-diabetes. The research uses a simple finger-prick blood test to screen for the condition, which can be done during dental appointments in as little as six minutes.
A study from the University of Copenhagen found that children with multiple tooth cavities or severe gingivitis have a significantly higher incidence of stroke, heart attack, and coronary artery disease as adults. Lifestyle factors may play an important role in this correlation.
A study by UCL researchers found large variations in nitrous oxide use across UK dental services, with some sites emitting up to 1,849 kg CO₂e per week. The team recommends reducing wastage, standardizing practice, and considering alternatives to minimize environmental impact.
Researchers have quantified zinc concentration in teeth using 3D X-ray tomography systems. They found a sharp increase in zinc concentration from the outside to the inside of the tooth, particularly near the pulp. This study has implications for dental care and material selection.
Researchers have designed a prototype powder that activates to whiten and repair teeth, promoting oral health. The system uses the piezoelectric effect to generate ROS, killing bacteria and reducing inflammation in lab demonstrations.
Research highlights overlooked social mechanisms connecting oral health, eating and speaking difficulties, and cognitive decline. A six-year longitudinal study found poor oral health is a strong predictor of weight loss in older adults.
Researchers identified altered gene expression in smokers with periodontitis, leading to weakened gum epithelial integrity and excessive inflammation. A new target molecule, CXCL12, was found to drive immune-cell recruitment and inflammation, making it a potential therapeutic approach.
A clinical trial shows that arginine can modify plaque formation on teeth, thereby protecting against dental caries. The study found that arginine reduced the acidity of biofilms and altered their carbohydrate structure, making them less harmful.
Aging mice without teeth experience cognitive decline due to inflammation and cell loss in the hippocampus, essential for memory formation. The study suggests that maintaining chewing ability may be a strategy to preserve cognitive function later in life.
A new composite hydrogel containing Li-Ca-Si bioceramics particles and gelatin methacryloyl matrix has shown promise in treating dental pulp infections by facilitating innervation and odontogenic differentiation. The hydrogel promoted Schwann cell regeneration, cytocompatibility for dental pulp stem cells, and proliferation of DPSCs.
The Hebrew University-Hadassah School of Dental Medicine has established a new center dedicated to providing quality dental care for people with physical, cognitive, and complex medical conditions. The center will offer holistic, multidisciplinary care under one roof, serving approximately 30-40 patients daily.
The study found that upper and lower tooth germs exhibit distinct transcriptomic profiles at the cap stage, with maxillary-enriched genes associated with morphogenesis and lower-enriched genes linked to mineralization. The researchers also validated key findings using RT-qPCR and immunofluorescence staining.
Researchers from The University of Osaka found that blood sugar migration to saliva in individuals with type 2 diabetes causes an imbalance in the oral microbiome, leading to cavity development. Improved glycemic control reduces this imbalance and the risk of tooth decay.
A new study reveals that a hand-held, wireless intraoral scanner paired with AI-assisted software can identify early childhood tooth decay as accurately as visual exams. The technology creates a detailed 3D model of a child's mouth within minutes, providing a comprehensive picture of their dental health.
A recent study by Tim Thomassen concludes that good daily habits, including proper brushing techniques and adequate brushing time, are more crucial for preventing oral diseases than expensive dental gadgets.
Researchers found that oral bacteria from tooth infections can worsen diabetes risk through IL-17-driven inflammation. The study revealed a mechanistic link between Porphyromonas gingivalis-induced periapical disease and systemic metabolic dysfunction.
Researchers have designed a quieter dental drill to address the anxiety-causing sound of traditional drills, which can reach nearly 20 kilohertz. The new design optimizes blade geometry and exhaust port to minimize noise while maintaining performance, with the goal of reducing discomfort in patients.
Researchers have identified antimicrobial peptides as a safe alternative to traditional antibiotics for treating oral diseases. These peptides can inhibit bacterial growth, regulate inflammation, and promote tissue repair, making them a game-changer in oral medicine.
Research shows that infants of stressed mothers have an earlier and faster tooth eruption, with more teeth by six months of age. Cortisol levels during late pregnancy are associated with this accelerated process.
Dental teams can identify hypertension and cardiovascular disease risk through blood pressure screenings in routine care visits. The American Heart Association's Healthy Smiles, Healthy Hearts initiative provides standard blood pressure screening and referral guides, empowering dentists to connect patients with primary care.
A study published in Journal of Translational Medicine found that successful root canal treatment can reduce inflammation linked to heart disease and improve levels of blood sugar and cholesterol. The researchers discovered a link between monitoring blood metabolic markers after dental treatment, which could help assess recovery and risk.
Despite government initiatives, UK children's dental health remains poor, with 26.9% of five-year-olds experiencing tooth decay and disadvantaged areas facing higher rates of tooth extractions. The Child of the North initiative highlights the need for scaled-up and strengthened schemes to address this issue.
Researchers have developed a bioinspired material that can regenerate demineralized or eroded enamel, strengthen healthy enamel, and prevent future decay. The new gel, applied like standard fluoride treatments, promotes controlled growth of new mineral to recover enamel structure and properties.
Researchers discovered that young dental cells are directed by their position along the lingual-buccal axis to grow into distinct structures. Cells on one side formed tooth enamel, while those on the other side focused on stem cell activity and supporting tissue growth.
A new study led by Suchitra Nelson aims to advance previous research on two less-invasive options for treating and preventing cavities. The study focuses on older adults living in subsidized housing with limited access to dental care, using Silver Diamine Fluoride (SDF) and Atraumatic Restorative Treatment (ART).
A study published in Neurology Open Access found that people with both gum disease and cavities have a higher risk of ischemic stroke. Researchers analyzed data from 5,986 adults and found that those with both conditions had an 86% higher risk of stroke compared to those with healthy mouths.
A recent study has found an association between gum disease and changes in the brain's white matter, which can affect memory, thinking, balance, and coordination. Adults with gum disease had more white matter hyperintensities, a type of damage that can increase stroke risk.
The UT Dallas researchers have developed a technology that enables same-day, 3D-printed dental restorations made of zirconia, the gold-standard material for permanent dental work. This breakthrough could make same-day permanent dental restorations possible with a reduced debinding time from hours to less than 30 minutes.
Researchers from Korea University Anam Hospital and KAIST introduce an AI system that accurately predicts a child's pubertal growth peak from a single radiograph, streamlining orthodontic treatment. The Attend-and-Refine Network (ARNet-v2) improves efficiency and accuracy, reducing radiation exposure and costs for young patients.