Articles tagged with Dentistry
Researchers at UF are creating a data biorepository to explore pain pathways and create custom treatments. They're collecting and analyzing human tissue samples and using AI to map and understand the complex relationship between neurons and pain.
Rutgers researchers suggest dentists play a crucial role in identifying and addressing sleep disorders, citing signs such as tooth grinding, tongue scalloping, or patients dozing off. With up to 80% accuracy, dental clinicians can identify at-risk patients with comprehensive care and prevent serious health complications.
A study published in Science Signaling explains the mechanism behind persistent pain related to obstructive sleep apnea. The researchers created a chronic intermittent hypoxia environment in mice and observed an increase in cytokines, which cause sensitivity in nociceptors producing prolonged pain sensitivity.
Researchers found the woman was embalmed with costly imported ingredients, contradicting traditional beliefs about mummification. The study also revealed she suffered from arthritis and had a unique facial expression that may be attributed to a cadaveric spasm caused by intense pain.
A study published in BMJ Public Health found that children living in deprived areas have a three times higher risk of needing dental extractions under general anaesthesia. This highlights the need for targeted interventions and improved access to preventive dental services to address socioeconomic and ethnic inequalities in oral health.
A 6-centimeter-wide fossil of a large cat species, Homotherium, was discovered on the Texas coast. The fossil provided key evidence for the cat's expansion across habitats in Africa, Eurasia, and the Americas.
A study published in Clinical Oral Investigations found that people with post-traumatic stress disorder (PTSD) often experience bruxism, or teeth grinding. The researchers emphasized the importance of collaboration between dentists and psychiatrists to diagnose and treat these patients effectively.
The study introduces pDA-nHA/PEKK composites with high strength and bioactivity, surpassing conventional melt blending techniques. The novel approach mimics the hierarchical structure of cortical bone, resulting in enhanced osteo-inductive abilities and mechanical strength.
A systematic review and meta-analysis found that antibiotic prophylaxis is associated with a reduced risk of infective endocarditis in high-risk individuals following invasive dental procedures. However, its effectiveness in moderate-risk individuals is unclear.
Researchers have designed a chemical sensor array, or an artificial tongue, that distinguishes dental bacteria and can inactivate them. The artificial tongue uses nanoscopic particles coated in DNA strands to detect the presence of bacteria, and can distinguish between healthy and diseased individuals with high accuracy.
Researchers from Niigata University discovered a novel macrolide-DEL-1 axis that drives bone regeneration in aging individuals. The study found that macrolide-based molecules increase DEL-1 protein expression and promote new bone formation, suggesting a potential therapeutic avenue for periodontitis-induced bone loss in humans.
A study reveals that mothers with high levels of dental plaque are 8 times more likely to transfer Candida albicans, a fungus involved in tooth decay, to their babies. This highlights the critical role of good oral hygiene for both mother and child.
A new diagnostic kit allows dentists to screen for oral squamous cell carcinoma with a simple brush biopsy, detecting genetic signals of the disease with over 90% accuracy. The non-invasive test is less complicated than surgical biopsies and can be performed in under a minute without numbing required.
A new study found that daily toothbrushing among hospitalized patients is associated with lower rates of hospital-acquired pneumonia and ICU mortality. The study, which analyzed data from over 2,700 patients, also showed that toothbrushing was linked to shorter durations of mechanical ventilation and ICU length of stay.
A study of Viking Age teeth from Varnhem in Sweden found that 49% of the population had one or more caries lesions, with children's milk teeth being entirely caries-free. The Vikings also underwent dental treatment, including filing front teeth and relieving pressure through holes drilled into molars.
A new study by an international team of researchers found that common oral infections and periodontal diseases are associated with inflammatory metabolic profiles. Oral infections were also predicted to cause future adverse changes in metabolic profiles.
A study by University of Texas Health Science Center at San Antonio researchers found that corticotropin-releasing factor (CRF) activates immune cells in the dura membrane under the skull, leading to pain signals. This discovery may lead to the development of a small-molecule drug therapy to inhibit CRF and MrgprB2 interaction.
A $4.7 million NIH grant will be used to train dental students and faculty, enhance mentoring, and conduct a clinical research study on Sjögren's disease. The grant aims to find an early biomarker for the chronic autoimmune disorder affecting four million Americans.
A three-year USDA grant will train healthcare and social workers in five high-risk rural Missouri counties to address childhood trauma and reduce opioid overdoses. The training covers topics such as ACEs, positive childhood experiences, and trauma-informed care.
Researchers found that Porphyromonas gingivalis inhibits autophagosome-lysosome fusion, worsening cardiac remodeling and causing cardiac rupture after myocardial infarction. The study suggests that treating this oral infection could help prevent fatal heart attacks.
Researchers have discovered a key mechanism involved in dental pulp inflammation and root apex damage, which could lead to the development of medications against bone loss due to endodontic infections. The study found that tumor necrosis factor-α receptor-1 (TNFR1) plays a crucial role in protecting teeth from inflammatory processes.
A study found that a water additive containing pomegranate extract can limit the formation of plaque and tartar in dogs after professional dental cleaning. The additive was shown to reduce plaque buildup by 47% and tartar by 24%, promoting healthy gums.
A new study finds that targeting the ORAI1 calcium channel may provide a promising approach to treating oral cancer. The study reveals that activating this channel causes an influx of calcium into cancer cells, leading to increased pain sensitivity.
A $450,000 NIH grant will support a training program for Arkansas dentists on evidence-based child behavioral-management skills. This initiative aims to enhance young patient compliance and reduce dental anxiety in children aged 2-10 years.
Researchers successfully created stem-cell derived organoids from human stem cells that secrete three essential enamel proteins. These proteins form a matrix that undergoes mineralization to create a hardened enamel structure. The breakthrough offers hope for developing novel treatments to repair and regenerate teeth.
The study found that network-level variables significantly improved model fit and displayed strong independent associations with oral health outcomes. Network proportion needing dental treatment was positively associated with current dental treatment needs, while exposure to reported dental visits decreased odds of no recent dental vis...
A study published in the Journal of Hospital Infection reveals that pharmacist-led multi-faceted interventions can optimize antimicrobial prescriptions in dental clinics, reducing the incidence of serious infectious diseases. The intervention increased penicillin usage and decreased the use of broad-spectrum antimicrobials.
Research in the BMJ Open journal suggests that mid-life structural changes to the jawbone may signal subsequent height loss in women. The study, conducted on a cohort of women in Gothenburg, Sweden, found that severe cortical erosion and sparse trabeculation in the jawbone predicted significant bone shrinkage over time.
Bitemark analysis, commonly used in court trials, lacks scientific backing due to the uniqueness of human teeth on skin. A study of 26 people wrongfully convicted based on this evidence reveals a high rate of distortion, rendering it unreliable for identification purposes.
Domenick Zero, an Indiana University professor, received the William H. Bowen Research in Dental Caries Award for his groundbreaking research on caries prevention and early detection. His work has improved oral health through innovative methods and tools, shifting focus from invasive treatment to tooth preservation.
Richard Niederman has dedicated his career to generating evidence for oral disease prevention and promotion. He pioneered large-scale school- and community-based oral health programs focusing on fluoride applications.
Monasterio Ocares recognized for his research on oral tissue regeneration and intestinal disorders' impact on oral homeostasis. He receives funding to continue studying mechanisms of initiation and resolution of intestinal disorders in the mouth.
The International Association for Dental Research (IADR) recognized six recipients of the 2023 IADR Colgate Research Travel Awards, which encourage research in preventing oral diseases. The award recipients received travel stipends and commemorative plaques to present their work at the annual conference.
The IADR LION Dental Research Award recognizes innovative research in basic dental science and applied research achievements that improve public dental health. The 2023 recipients were announced during the 101st General Session of IADR in Bogot , Colombia
Chenmin Yao, a young researcher from Wuhan University, China, received the 2023 IADR Toshio Nakao Fellowship to support her training and experience in dental materials science. She has published nine papers in peer-reviewed international journals with high impact factors.
A study led by Dr Mike YY Leung found that internal fixation surgery using titanium plates and screws (SSRO) improves patients' oral health-related quality of life faster than traditional IVRO. Patients who underwent SSRO had better physical and mental health-related QoL, with improvements starting as early as 2 weeks after surgery.
A team of researchers at NYU College of Dentistry has successfully modified an existing anti-nausea drug to target the endosomes within cells, thereby providing a more prolonged analgesic effect. The modified netupitant showed improved pain-relieving properties compared to its original form and other drugs targeting similar receptors.
A study published in Cell Reports found that saturated fatty acids promote the immune escape of oral cancers in mouse models. Obesity helps establish a type of tumor microenvironment that promotes tumor progression by suppressing STING-type-I interferon pathway and NLRC3.
Researchers developed a new metric to analyze the relationship between nerve density and oral cancer progression. Normalized nerve density was found to be associated with poor survival rates for patients with tongue cancer, highlighting its potential as a tool for identifying aggressive tumors.
A pilot study at the University of Eastern Finland found that background music reduced dental students' stress levels and improved their performance during preclinical tooth preparation exercises. The music also increased motivation to learn and practice, while enhancing communication and quality of cavity preparation.
Researchers at HKU developed a novel smart manufacturing method for dental crowns using generative AI, producing personalised crowns with high accuracy that mimic natural teeth. The 3D-DCGAN algorithm improves the quality of design through internal competition between a generator and a discriminator.
Researchers developed a method to convert eggshells into amorphous calcium phosphate particles, which were found to be safe, cell-friendly, and effective in promoting bone regeneration. The findings promise to create an eco-friendly alternative to commercialized xenograft materials.
A new liposome-based method aims to kill periodontitis-causing leukotoxin while protecting immune cells, providing an alternative treatment for aggressive gum infections. The approach has potential applications against a range of bacteria and could help combat antibiotic resistance.
A growing connection between diabetes, oral health, and dementia highlights the importance of dental care and diabetes management as we age. Older adults with both poor oral health and diabetes experience accelerated cognitive decline, emphasizing the need for regular dental visits and adherence to diabetes treatment.
A Tohoku University study found that soft gingiva is more likely to cause inflammation, hindering the development of collagen fibers. This discovery has implications for the development of advanced biomaterials and microdevices to control local inflammation.
A research team developed a new dentine analogue material that can substitute extracted human teeth in laboratory-based mechanical and fatigue tests. The materials were tested for their mechanical strength, elastic modulus, indentation hardness, and fatigue behaviour, showing comparable results to those based on extracted human teeth.
Researchers used MRI scans and texture analysis to differentiate between two types of benign oral bone lesions, ameloblastomas and odontogenic keratocysts. The study found that certain pixel and voxel organizational parameters in the MRI images were statistically significant, enabling more accurate diagnosis and treatment planning.
Researchers at NYU College of Dentistry have developed a single score to describe the level of cytokines in saliva, which correlates with the severity of clinical gum inflammation. The study found that higher levels of cytokines in saliva match greater gum inflammation.
A NYU school dental program using silver diamine fluoride and sealants prevented 80% of cavities in a randomized trial. The study suggests an efficient and cost-effective approach to improving children's oral health through school-based care.
A Brazilian study found that early sugar consumption and interruption of breastfeeding are key factors contributing to dental caries in infants. Extended breastfeeding was shown to protect babies' teeth as long as they didn't receive sugary food, with the risk declining with falling sugar consumption.
A recent study published in the Journal of Dental Research compared ten pharmacological interventions for managing tooth extraction pain in adults. The study found that NSAIDs with or without acetaminophen result in better pain-related outcomes than opioids with or without acetaminophen.
A new study published in the Journal of Dental Research has found that heavy smokers with severe periodontitis do not receive any benefits from treatment. The study suggests that smoking cessation is crucial for effective treatment and may even worsen the disease during active treatment. The findings highlight the need to rethink pract...
A study by researchers from Okayama University found that Japanese university students' willingness to undergo regular dental check-ups is associated with their thoughts regarding the health-belief model and oral health behaviors. The study suggests that the perceived benefit of undergoing regular check-ups drives young students toward...
Researchers analyzed ancient teeth from Homo erectus and great apes to reveal annual cycles in tooth enamel, providing insights into their diets and seasonal food supplies. The study shows that humans and great apes had distinct dietary patterns, with humans exhibiting less pronounced peaks and lower Sr/Ca values.
Researchers have developed shortwave-infrared and thermal imaging techniques to accurately diagnose active dental caries. SWIR-based approach shows superior results in detecting lesions, while thermal imaging proves less effective.
A new jaw surgery technique, segmental mandibular advancement (SMA), has been shown to effectively treat moderate-to-severe Obstructive Sleep Apnea (OSA) in a pilot study. The procedure resulted in a 50% or more reduction in breathing disturbances at night for 58% of patients, with no signs of sleep apnea.
A study on extinct lemurs has found surprising similarities between ancient primate species and fossil humans. The 'monkey lemur' had novel anatomical features, including tooth chipping patterns similar to those of Neanderthals, suggesting a more complex diet than previously thought.
Researchers developed a customizable, strontium-loaded scaffold that promotes wound healing by stimulating gingival fibroblast activity. The scaffold increased cellular activity of isolated cells while showing minimal toxicity over four days.
Researchers found that activating the non-mutated form of P53 can change the fundamental makeup of cancer stem cells in mouse models of mucoepidermoid carcinoma. This new therapy approach shows promise for treating this lethal form of salivary gland cancer.
A study published in the Journal of Dentistry found that patients with unexplained brain abscesses were three times more likely to have oral bacteria present. The researchers also discovered significantly higher counts of Streptococcus anginosus, a bacterium linked to dental abscesses and infections in internal organs.