About The Study: This systematic review and meta-analysis found that subjective olfactory impairment is consistently associated with depression, while objective impairment shows associations mainly in aging and anosmic subgroups, suggesting partly distinct underlying mechanisms.
Corresponding Author: To contact the corresponding author, Henry Bode, MD, email henry.bode@ki.se .
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(doi:10.1001/jamaoto.2026.1758)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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JAMA Otolaryngology–Head & Neck Surgery