Articles tagged with Aging Populations
A study published in PLOS Medicine found that socioeconomic inequalities are associated with reduced mobility and function in older adults, with poorer individuals experiencing larger declines in physical abilities. The research highlights the need for policies targeting people with less wealth to reduce health disparities in aging.
The Stein Institute at UC San Diego will serve as the Central Laboratory and Biorepository for the XPRIZE Healthspan Competition. The 10 finalist teams will conduct coordinated clinical trials worldwide to test their treatment approaches, aiming for a decade-long extension of human healthspan.
A cohort study finds that childhood history of maltreatment is associated with increased biological age in late midlife, potentially impacting health outcomes. The study's epigenetic clock analysis sheds light on the long-term effects of early life trauma on aging processes.
A new ACC Scientific Statement highlights the importance of considering cognitive impairment and frailty in cardiovascular care for older adults. The statement outlines practical strategies for prevention, screening, assessment, and management, aiming to improve outcomes such as independence, mobility, and caregiver burden.
The USC Leonard Davis School of Gerontology has received a $7.5 million grant to establish GeroSCORE, a national hub for discovery and collaboration on sex differences in aging. The center will conduct innovative research, develop new tools and analytical methods, and serve as a resource for early-career investigators.
Researchers found that exercise-induced molecular changes contribute to neuronal health, improving movement and quality of life in PD patients. Exercise types such as aerobic exercises, resistance training, balance training, and multimodal exercise were found to be helpful in reducing falls, disabilities, and improving brain function.
A cohort study found associations between perinatal factors and changes in brain maturation among adolescents. The study used conditional-longitudinal models to assess individual growth trajectories and mental health symptoms.
As more Americans with HIV age into Medicare eligibility, costs are expected to increase substantially. The study projects nearly 200,000 beneficiaries by 2035 and $27.3 billion in annual spending. Policy changes like the Inflation Reduction Act could save billions, while generic HIV medications may further reduce costs.
Researchers discovered that depression is associated with a specific area of the hippocampus, independent of Alzheimer's disease risk factors. The study found participants with depression had smaller volumes in the CA23DG region, which plays a crucial role in retrieving memories and distinguishing between similar experiences.
The Boston University-Quantitative Population Science and Healthy Cognitive Aging Research Program (BU-SHARP) aims to better understand how and why Alzheimer's disease manifests among certain populations. The center will fund pilot studies, provide technical assistance, and facilitate access to underutilized datasets.
The LifeAfter90 study found that women 90 and older are at two-fold greater risk for dementia, while Black participants have a 75% greater risk than Asian participants. APOE2's protective effects continue past age 90, reducing risk by 60%, but APOE4 increases the risk among men and Black participants.
A Canadian research team led by Dr. Amanda Grenier is investigating how to address the growing issue of older people falling through the cracks. The AIM BIG initiative will bring together experts, community organizations, and older adults to develop evidence-based resources to support advocacy, decision-making, and service delivery.
Researchers develop first quality-of-life measure specifically designed for Australian aged 65 and over, to improve care and outcomes. The tool will enable consistent monitoring of quality-of-life outcomes across health and aged care settings.
Aging cells become more susceptible to ferroptosis due to elevated levels of acid ceramidase, a previously targeted therapeutic candidate. This vulnerability can be passed to neighboring cells, impacting overall tissue health. The discovery offers new hope for supporting healthy aging and treating age-related diseases.
Researchers found no correlation between SuperAgers' exceptional memory and low inherited Alzheimer's disease risk. Instead, they identified unique biological and psychosocial characteristics associated with SuperAging.
The journal aims to improve understanding of aging to support older adults in aging well. Research articles cover topics such as biological aging, movement behaviors, cognitive functions, and technological advances to enhance aging well.
A study published in PLOS Medicine found that people with dementia, mild cognitive impairment, alcohol addiction, or psychiatric disorders like schizophrenia show increased brain aging patterns. The researchers analyzed MRI data from over 45,900 controls and compared them to 2,698 patients with different brain conditions.
Researchers found that females with live offspring had lower late-life frailty, contradicting previous theories on a potential reproductive cost. The study used companion dogs to investigate the relationship between reproduction and aging, revealing a unique link between parity and robustness.
A new neuroimaging study has identified specific MRI biomarkers that track along with changes in an individual's brain health trajectory over time. These findings demonstrate a holistic, multidimensional index of human performance correlating with physical, measurable changes in brain architecture.
Two Lancet papers call for Japan to redesign its health system and global health strategy by 2040. The country must adapt its approach from a hospital- and service-volume-centred system to one focused on people's lives, health outcomes, and communities.
Subjective olfactory impairment consistently associated with depression, while objective impairment linked to aging and anosmia. The study suggests partly distinct underlying mechanisms for subjective and objective impairments.
Research suggests alcohol interacts with Alzheimer's-related brain circuits in distinct ways, depending on the type of pathological change. Alcohol reduced communication in amyloid-beta models but increased it in tau models, highlighting an important principle in biology.
Recent studies suggest that p16INK4a+ cells, previously thought to be non-beneficial due to their association with aging, actually contribute to tendon regeneration. These mesenchymal cells produce collagen and factors promoting new blood vessel and nerve growth, crucial for normal tendon function.
A study by Rutgers researcher Chien-Chung Huang found that compulsive smartphone habits in older adults can deepen depression. Limited social participation and smartphone addiction were strong predictors of depression, while phone use supporting relationships and interactions was protective.
Research finds that millennials' fear of growing up decreases as they age, while younger generations report higher maturity fears. The study, published by the American Psychological Association, suggests that broader societal factors such as economic uncertainty and social pressures shape how young people view adulthood.
A study found that younger generations are aging faster biologically, increasing their risk of early-onset cancers. The study linked accelerated aging in immune systems and fat tissue to higher risks of lung and colorectal cancer.
A Hiroshima University study finds that practical digital skills, positive financial attitudes, and self-protection are more consistently associated with lower old-age anxiety than traditional financial knowledge alone. The study suggests that financial education may need to move beyond knowledge alone in the digital age.
A large USC-led study found that the main genetic risk factor for Alzheimer's disease may be linked to brain amyloid buildup differently in Hispanic and non-Hispanic white older adults. Hispanic participants generally had lower amyloid levels than non-Hispanic whites with similar characteristics.
A new review suggests that ageing results from overlapping changes occurring simultaneously at many levels of biological organization. This approach is reflected in the concept of the 'hallmarks of ageing', which are interconnected biological characteristics and processes consistently associated with aging.
A study of 585 older adults found that different patterns of depressive symptoms are associated with disability-free survival, differing between men and women. Stronger feelings of 'worthlessness' were a significant risk factor for men, while 'anxiety' was a bigger risk factor for women.
Delirium is a common and preventable complication in older surgical patients, with verified geriatric surgery programs screening nearly every patient. Non-accredited hospitals screen only half of their patients for delirium, leading to a stark gap in care.
A nationwide survey in Japan found a gradual but steady decline in health-related quality of life among the working-age population over seven years. The study also revealed regional differences in HRQoL across prefectures.
A study of 4,967 community-dwelling adults aged 60+ found that being female, polypharmacy, and unintentional weight loss are associated with fragility fractures. Physical activity was not significantly linked to either fractures or falls, contradicting previous debate.
A new study found that social connections can help compensate for the loss of mentally stimulating interactions linked to work, with different types of relationships benefiting women and men. The researchers used data from 27 European countries and found that strong social networks appear to buffer the cognitive disadvantage of not wor...
Researchers identified key factors, including diet, exercise, stress, and social engagement, that contribute to the long lives of Cilento residents. The CIAO Study aims to inform clinical solutions by providing actionable answers on aging and longevity.
Postoperative delirium is a strong predictor of long-term cognitive decline in older adults, according to a new study. Researchers found that delirium was associated with faster cognitive decline than mild cognitive impairment, and rehospitalizations did not explain the effect.
A large Japanese study found that maintaining a healthier profile with lower lifestyle and health risks can significantly lower dementia risk in people with one or no APOE ε4 alleles. However, individuals carrying two APOE ε4 alleles may require different preventive or therapeutic approaches.
A new study finds that immigrants who are socially integrated on some dimensions but not others experience worse health, particularly among minority groups. The 'acculturative discordance' phenomenon is associated with higher disability risks after age 65, affecting one in four adults aged 65 and older.
Dr. Mina Sedrak has been selected to co-lead the Cancer in the Older Adult Committee of The Alliance for Clinical Trials in Oncology, focusing on improving care and outcomes for older adults with cancer. As a leading expert on aging and cancer, Sedrak aims to expand research on this population and address their unique needs.
A recent study found that semaglutide, a widely used GLP-1 drug, slows down the accumulation of biological aging markers in adults with HIV. The treatment reduced chronic immune activation, visceral and ectopic fat, and reprogrammed certain cells, which may help explain its effects on multiple aging clocks.
A study found that 14 million workdays are lost annually due to menopause, while women rely on online misinformation for medical advice. The authors advocate for open conversation and inclusive approaches to combat stigma and support women's health during this transition.
Researchers found that impaired virtual reality path integration was closely tied to brain structure and biomarkers associated with neurodegeneration. This suggests that VR-based navigation errors may reveal hidden changes in the brain long before symptoms arise, making it a promising behavioral marker for preclinical Alzheimer's disease.
A new study projects that climate change will significantly increase the risk of heat-related cardiovascular disease in the US by 2050. The Pacific Northwest and Southern/Midwestern states are expected to experience the highest and steepest increases, respectively. Targeted interventions for vulnerable communities are crucial to mitiga...
Researchers developed a senolytic therapy using dasatinib and quercetin, which preserved disc structure and reduced inflammation, highlighting JUN signaling as a key pathway. This preclinical study provides evidence for a potential therapeutic strategy to slow disease progression in individuals with genetic susceptibility.
Older patients with accessible advance directives in electronic health records had 25% less potentially burdensome end-of-life care and 31% fewer hospital deaths compared to those without these directives. The associations were attenuated among patients with dementia and Black patients, highlighting the need for targeted research.
Researchers at UC Riverside have identified a key neural circuit, the locus coeruleus, which plays a central role in cognitive flexibility and adapting to new rules. Disrupting this circuit impairs the brain's ability to reorganize neural networks during complex decision-making.
A new study suggests that an earlier first sexual intercourse may be associated with a less favorable multidimensional aging profile, including shorter longevity and higher frailty. The researchers found that genetic differences in early sexual debut were linked to poorer health outcomes later in life.
Researchers at Kyoto University found that hospital restructuring improved local capacity for elderly hospital admissions and enabled more efficient bed management. The study suggests that reorganization can alleviate regional healthcare disparities in the elderly population.
A new analysis of police data reveals that one in 10 missing incidents among people with dementia results in serious harm. The study highlights the need for preventative action to keep people with dementia safe and finds that older age, night disappearances, and longer durations of absence are risk factors for harm.
A study published in JMIR Aging predicts early mobility decline in healthy adults aged 45 using a set of home-based measurements and AI. The researchers identified six essential factors, including age, muscle power, and diet, that accurately predict future mobility struggles.
A new study by University College London researchers found that regularly taking part in arts activities slows the pace of biological ageing. Participants who engaged in arts and cultural activities more frequently appeared to have a slower pace of ageing, comparable to those who exercised at least once a week.
A study published in Aging Cell found that reducing dietary fat or animal-based protein can reduce 'biological age' in older adults. After just four weeks, participants showed significant reductions in biomarker profiles indicative of improved health and aging outcomes.
A three-year longitudinal study of 4,000 adults reveals that proactive engagement and self-agency can measurably improve brain performance across the lifespan. The study's findings challenge the notion that cognitive decline is an inevitable part of aging.
A study reveals that S-1-propenyl-L-cysteine, a bioactive compound found in aged garlic extract, promotes inter-organ communication between fat tissue and the brain, enhancing muscle strength. Long-term administration of S1PC reduced frailty scores and increased skeletal muscle force in aged mice.
A study published in JAMA Network Open found that stronger, more stable, and less fragmented daily patterns of rest and activity are associated with slower physiological aging. The research suggests that these patterns may serve as potential targets for interventions to slow the aging process.
A recent study reveals that an individual's readiness to adopt smart technology is deeply tied to their specific experience within their home and community. Researchers identified specific clusters within the older population, ranging from tech-ready urbanites to those in more traditional or isolated residential settings.
Genomic Press launches Brain Health, a new peer-reviewed journal dedicated to the science of lifelong brain resilience, featuring research on glial plasticity and recovery from depression. The inaugural issue explores the intersection of fields including cognitive reserve, sleep, aging biology, nutritional psychiatry, and social sciences.
A new study highlights the importance of involving older people in technology design to ensure devices are useful, respectful, and culturally appropriate. Co-design helps build trust and ensures technologies support older people's autonomy and dignity.
Dr. Hannah Cabré has been appointed as an Assistant Professor and Director of the Aging, Gynecology, and Endocrinology Laboratory at Pennington Biomedical Research Center. Her research focuses on the role of female sex hormones in shaping nutrition, health, and performance across the lifespan.
A new study reveals that menopause causes profound and uneven transformations across the female reproductive system, rather than a uniform decline. The research identified molecular signals associated with aging detectable in blood, allowing for non-invasive monitoring and earlier detection of risks.