Articles tagged with Aging Populations
The Barshop Institute will conduct the VITAL-H trial, evaluating the repurposing of FDA-approved medications to delay age-related health decline in generally healthy middle-aged adults. The trial aims to preserve everyday abilities during a critical window of midlife aging.
The 'SWISS100' study identified 37 proteins in centenarians' blood whose profile appears linked to slower ageing, with remarkably low oxidative stress markers. Centenarians also show profiles surprisingly close to those of younger individuals, particularly with youthful expression levels of regulatory proteins of the extracellular matrix.
The Long Life Family Study, a long-running international investigation, has revealed insights into features of healthy aging. Researchers have found that most long-lived families have better cardiovascular health, including healthier blood pressures and lower rates of diabetes.
Research shows that expert birders have more compact attention- and perception-related brain areas, linked to accurate bird identification. These structural changes persist in older birders and may benefit cognition as people age.
Researchers developed a new model to predict long-term survival after heart failure in elderly Japanese patients. The Top-20 XGBoost model incorporates physical function metrics, rivaling the importance of traditional cardiovascular risk factors, and provides a more accurate estimation of mortality risk.
Scientists have discovered a mechanism that explains how exercise improves cognition by shoring up the brain's protective barrier. The study found that an exercise-induced liver protein strengthens the blood-brain barrier, reducing inflammation and cognitive decline associated with Alzheimer's disease.
Research reveals that podocytes in aged rats adapt by increasing volume and forming atypical junctions to compensate for loss, while exporting unnecessary cellular components into the extracellular space. The study employed array tomography to elucidate age-related structural changes, shedding light on the mechanisms of aging glomeruli.
Researchers report a significant association between muscle strength and lower mortality risk in women aged 63-99 years. Grip strength and chair stands were found to be key indicators of muscular strength, with even small improvements leading to notable reductions in death risk.
Researchers developed an oxygen-delivering gel to heal chronic wounds that fail to heal for more than a month. The gel conforms to the wound's shape and provides continuous oxygen levels, helping transform nonhealing wounds into normal injuries.
Researchers found that Parkinson's patients experience weight loss due to selective fat depletion, not muscle loss, driven by impaired carbohydrate-based energy production. This metabolic shift highlights a disorder of both the brain and body, driving disease progression.
Reducing air pollution levels may help delay and mitigate physical disability in aging adults, according to a new study published in JAMA Network Open. The findings suggest that lower air pollution levels are associated with slower progression of physical function limitations and disability.
Researchers identified ApoE as a systemic inhibitor of bone repair during aging, and showed that blocking its activity can restore bone regeneration and improve fracture healing. The study provides hope for therapies that actively restore regenerative capacity in older patients, reducing nonunion risk and improving recovery.
A study by NYU School of Global Public Health found that anxiety about aging contributes to accelerated epigenetic aging, with greater concern about declining health having the strongest association. This can lead to physical decline and increased risk of age-related diseases.
Researchers developed BrainIAC, a robust AI foundation model that analyzes brain MRI datasets to identify key neurological health indicators. The tool outperformed conventional AI models in diverse tasks, including predicting dementia risk and detecting brain tumor mutations.
Researchers found that hormone treatment reduces abnormal nerve invasion and improves chronic back pain by limiting nerve growth inside damaged spinal tissue. The study suggests that parathyroid hormone can reverse the process by activating natural signals.
Researchers found molecules such as syringic acid that protect neurons from aging, while others like resveratrol promote neurodegeneration. An AI-powered approach identified potential therapeutic substances to preserve brain function and prevent neurodegenerative diseases.
Researchers discovered that while older rats were as social as younger ones, a subpopulation preferred familiar peers. Altering neural communication reversed this preference, enhancing approach towards new peers. This suggests a distinct neural system underlying aging-related social behavior.
Researchers at Vanderbilt University found that aging cells remodel their endoplasmic reticulum through ER-phagy, a process linked to lifespan and healthy aging. This discovery highlights the ER as a potential drug target for age-related chronic conditions.
The conference brought together researchers, policymakers, and community leaders to discuss evidence-based strategies for ageing in place. Duke-NUS studies found that programmes aligned with older persons' routines and interests are more effective at reducing loneliness and fostering meaningful relationships.
A Concordia University study reveals that nearly half of Montreal's elderly care facilities lack public EV charging stations within a 15-minute walk. This limits access not only for residents but also for caregivers and staff. Strategically placing new chargers in underserved areas can improve accessibility without expanding the network.
A UC San Diego study found that older women with a history of depression and anxiety had a 78% higher risk of developing long COVID. The researchers analyzed data from the Women's Health Initiative and hope to inform preventative measures for public health officials and policymakers.
Caring for grandchildren may help prevent cognitive decline in older adults, according to a recent study published by the American Psychological Association. Grandparents who provided childcare scored higher on tests of memory and verbal fluency compared to those who didn't.
A new study published in the New England Journal of Medicine found that many hospital screening policies for late-career physicians lack basic fairness protections. The authors recommend creating policies that balance patient safety with fair treatment of physicians, including clear standards and appeal processes.
A new study found that shingles vaccination is associated with lower inflammation, slower epigenetic aging, and overall slower biological aging in older adults. Vaccination showed benefits even four years after the initial dose.
A new study estimates that over 1.6 million people in the UK will be living with glaucoma by 2060, with nearly 50% higher prevalence than previous estimates. The researchers call for expanded eye health services and increased awareness campaigns to detect early cases and prevent vision loss.
Researchers found a progressive shift in RNA contents of sperm with age, potentially contributing to health risks of having kids later in life. The discovery may lead to improved fertility outcomes and diagnostic tools.
Research reveals structural brain changes in older adults affect ability to shift between tasks and update environmental information. These changes may lead to deficits in behavioral adaptability, emphasizing the importance of identifying age-related brain structure changes.
An 18-week study found that maintaining grip strength and chair-rise performance alongside weight loss was possible without a prescribed strength-training program, alongside improvements in biomarkers linked to metabolic and cognitive aging. A plant-forward diet featuring fresh lean pork supported healthy-aging markers in older adults.
A recent study by researchers at the University of California, Riverside, found that a specific brain region known as the caudate nucleus is strongly linked to physical strength in older adults. The discovery could help detect and prevent frailty before it begins.
The study found that women with two to three children tend to live the longest, while those with an above-average number of children have shorter lifespan. Pregnancies between ages 24 and 38 were also linked to more favorable aging patterns.
Researchers develop new framework to evaluate monetary value of QALY, adjusting for age and lifetime quality of life. Analysis yields key findings on cost-effectiveness of healthcare policies, highlighting benefits of promoting good health throughout life.
A recent genomic study by Dr. Mayana Zatz and colleagues reveals that Brazil's admixed population may hold the key to understanding exceptional aging. The study identifies over 8 million novel genetic variants in the Brazilian population, with potential protective mechanisms against age-related diseases.
A new study from Duke University found that even mild stress before surgery can lead to delirium, uncontrolled pain, and longer hospital stays in older adults. Over 40% of patients reported moderate to high distress levels similar to those with advanced cancer.
Researchers compared brains of stroke patients with healthy controls to reveal differences in language processing mechanisms. People with verbal speech processing issues from stroke have weaker processing of speech sounds than healthy participants.
A new study published in Neurology found that age does not impact neurological recovery after spinal cord injury, but older adults have poorer functional outcomes in tasks such as feeding, bathing, and mobility. The study also found a significant reduction in functional recovery with increasing age, particularly in those over 70.
A new study found that slower reaction time and lower response accuracy in cognitive tasks are associated with higher levels of frailty. The association can be detected in late midlife among individuals aged 57 to 70 years.
Researchers found that heat-inactivated Lentilactobacillus kefiri YRC2606 reduced age-related inflammation and improved immune function in mice. The strain exhibited anti-inflammatory effects by lowering levels of inflammatory cytokines and signaling proteins.
Research by Li-Mei Chen finds that digital tools provide measurable benefits for caregivers and persons living with dementia, improving self-efficacy, emotional well-being, and social connectedness. However, equity gaps remain due to limited access to culturally adapted and inclusive technologies.
A study by NYU Rory Meyers College of Nursing found that older, unpaid caregivers who used the internet more often felt less lonely and coped better with stress. The researchers analyzed data from over 3,957 participants ages 65 and older, and discovered a buffering effect: internet use reduced loneliness in caregivers with health issues.
Researchers argue that widely used proxies for aging may conflate genuine modifications with simpler effects on physiology. Targeting specific pathologies can extend lifespan without slowing aging process. Historically, increased human lifespan was primarily driven by reduced infectious disease mortality, not a fundamental slowing of a...
A new poll suggests that more than 80% of people over 65 drive at least weekly, but less than half have made a plan for when they can no longer drive safely due to health changes. Only 6% of older drivers have discussed their driving with a healthcare provider.
Researchers develop ex vivo treatment of blood stem cells with Rhosin, a RhoA inhibitor, to rejuvenate them and improve the production of healthy blood cells. This strategy targets the core of the ageing process, making blood stem cells more capable of regenerating and producing new healthy blood cells.
A novel study shows that US counties with limited digital tools, weaker support systems, and fewer healthcare resources exhibit poorer cognitive, mental, and physical health. The researchers found that counties with high resilience had significantly better outcomes, and that healthcare infrastructure is a key modifiable factor.
Regularly eating meals alone is associated with poorer diet quality and increased risk of weight loss and frailty among community-living adults aged 65 years and over. Social connections at mealtimes can influence appetite, dietary variety, and overall wellbeing.
A recent study found that multilingual individuals experience slower biobehavioral aging compared to monolinguals. The study analyzed data from 86,149 participants across Europe and showed that multilingualism is associated with a lower risk of accelerated aging.
A Baycrest study found that subtle features of speech timing, such as pauses and fillers, are linked to executive function and predict cognitive decline. The research uses artificial intelligence to analyze natural speech patterns for early detection of dementia.
Exercise promotes angiogenesis and lymphangiogenesis through molecular signaling pathways, enhancing vascular function and immune response. This process offers potential interventions to combat age-related decline and disease, including cardiovascular diseases, muscle atrophy, and metabolic disorders.
Researchers uncover tandem allosteric effect enabling efficient deacetylation of proteins by Sir2, a key enzyme for biological processes. This finding reveals new target for modulating Sir2, potentially leading to novel cancer treatments and therapeutic applications.
The $4 million gift from Jeff and Linda Moslow is supporting the Tufts Women's Health and Menopause Initiative, a unique academic collaboration between Tufts Medicine and the Friedman School of Nutrition Science and Policy. The initiative aims to advance clinical care, education, and research in women's health across the lifespan.
Researchers explore the link between senescent cells and metabolic diseases, highlighting potential treatments known as senotherapeutics. Senolytics, senomorphics, and senosensitizers are interventions aimed at eliminating or suppressing senescent cells to mitigate metabolic disease.
Research from Michigan Medicine uncovers connections between a longevity gene, behavior, and environment, suggesting that manipulating stress responses could extend life without downsides. Touch activates a circuit modulating signals to reduce the longevity effect of dietary restriction.
A team of researchers at Osaka Metropolitan University has successfully treated spinal compression fractures in rats using stem cells derived from adipose tissue. The study found that these cells can promote bone healing and regeneration, making them a potential solution for osteoporotic vertebral fractures.
A survey of 4,890 participants found that people are open to using home-care robots as long as they view them beneficially. Collaboration between users and developers is crucial for adoption, with emphasis on ethical considerations. Robots may play a significant role in addressing Japan's aging population and social healthcare challenges.
Huimin Zhang, a UC Riverside assistant professor, has received a $150,000 grant to study the role of HELIOS in epigenetic regulation of T cell aging and TFH cell differentiation. Her research aims to understand how aging affects the immune system and develop new vaccines and therapies to restore immune vitality in older adults.
Researchers at Ben-Gurion University find that CD4 T cells play a critical role in reducing aging by cleaning out senescence cells. They suggest tracking people in their 30s to assess the pace of aging and developing early interventions.
A study by the Gerald P. Murphy Cancer Foundation's Center for Exceptional Longevity Studies found that retaining gonad function can significantly impact frailty mortality risk. Male dogs with shortest testis exposure had high mortality risks, while those with longest gonad exposure showed no consequence of increasing frailty.
A recent study from the University of Georgia suggests that older adults who use smartphones, computers, and tablets are more socially engaged than their less tech-savvy peers. This increased social engagement is associated with better well-being and a longer, more fulfilling life.
A recent study by Willa Granger examines the transformation of nursing homes in postwar America, tracing the development of the modern nursing home industry through the lens of the Americana Corporation. The research reveals how federal programs and corporate models reshaped eldercare, prioritizing scale and replication over community ...
Researchers analyzed blood samples from dogs in the Dog Aging Project and found that post-translationally modified amino acids are strongly linked to age, suggesting a promising indicator of physiological aging. The study also highlighted an important role of the kidney in the relationship between age and blood metabolites.
Dr. Ana Daugherty, a cognitive neuroscientist with expertise in aging and Alzheimer's disease, joins Wayne State University's Institute of Gerontology as its new director. She will lead interdisciplinary collaboration, training for emerging scholars, and research on risk and resiliency in aging and dementia.