Researchers develop ex vivo treatment of blood stem cells with Rhosin, a RhoA inhibitor, to rejuvenate them and improve the production of healthy blood cells. This strategy targets the core of the ageing process, making blood stem cells more capable of regenerating and producing new healthy blood cells.
Researchers found that antiangiogenic therapy can increase the invasiveness of kidney tumors and induce a poor prognosis. A new biomarker, ALDH1A3, has been identified to predict patient response to treatment.
Researchers developed SeSBAT, a computer program that analyzes magnetic resonance images to detect early signs of neurodegenerative diseases. The tool identifies biomarkers before symptoms appear, allowing for individualized monitoring and more accurate management.
A study of over 600 patients with colorectal cancer found that higher levels of T cells and greater diversity of T cell receptors are associated with better outcomes. The new biomarker, called TCR immuno-sequencing, measures the amount of infiltrated T lymphocytes and their clonality.
Researchers have identified the cellular process by which Cisplatin chemotherapy causes neuronal damage, revealing that it induces senescence of peripheral neurons through overexpression of the p21 protein. This discovery provides new targets for neuroprotective treatments to alleviate or avoid the adverse effects of Cisplatin.
A team of researchers used a mouse model to test the best therapeutic option for a type of relapse sarcoma. The study found that two treatment regimens administered to a patient with lung metastasis helped extend their disease-free period to 46 months.
Researchers discovered that lysosomes are active during mitosis and selectively degrade specific proteins, leading to a toroidal nucleus morphology that may indicate chromosomal instability. This finding provides a new perspective on the connection between autophagy and cell division in cancer and other diseases.
Researchers found that a low-dose combination of four inhibitors is more effective in treating NSCLC with EGFR mutation. The therapy, called MLD, inhibits the action of multiple proteins in the same signaling pathway, blocking cell proliferation and tumor growth.
A study has identified genetic variants that predispose to cancer and impair the immune system. The research found up to 57 genetic variants in 13 types of cancer, which affect the body's defenses. The immune system plays a key role in protecting against malignancies, but cancer cells have mechanisms to escape immune responses.
Researchers discover that nutrient deficiencies in tumor cells trigger the release of cytokines and chemokines, attracting immune cells that inhibit effective attacks. The lack of blood supply is interpreted as a wound, triggering an inflammatory response that promotes angiogenesis and tumor growth.
Researchers from IDIBELL and ICO conducted a pilot study to analyze intestinal microbiota genome in colon cancer patients. They used two sequencing methods, 16s and Shotgun, and found both techniques consistent, with complete sequencing more sensitive but not contradictory to single-gene sequencing.
A new model of chromosome X-linked adrenoleukodystrophy in C. elegans has been identified, accelerating research on the disease and its potential pharmacological targets. The model points to glial cells as responsible for neurological damage, with oxidative stress caused by mitochondria being a major cause.
A study published in the Journal of Psychiatric Research has identified a brain circuit that could indicate the risk of developing Alzheimer's. Researchers discovered that poor connectivity between the brainstem and cerebellum may be predictive of Alzheimer's risk, specifically targeting those with a family history.
Researchers have identified C4BP as a promising therapeutic agent for autoimmune kidney disease, showing improved symptomatology in mice with lupus nephritis. The study demonstrates the immunomodulatory capacity of C4BP, transforming proinflammatory activity into anti-inflammatory and tolerogenic effects.
A multicenter study has identified a new biomarker for vascular dementia, lipocalin 2 protein, found in cerebrospinal fluid. The protein's presence can discriminate between vascular dementia and Alzheimer's disease.
A study found that increased LOXL2 protein levels in alveolar rhabdomyosarcoma cells promote metastasis. The protein's role in regulating metastatic function remains unclear, but it interacts with vimentin, a cytoskeletal protein involved in cell migration.
A study on globular glial tauopathy reveals that phosphate groups are not unique to tau protein and can lead to dysfunction in other proteins. Glial cells also play a crucial role in the disease's progression by facilitating the spread of protein inclusions. This research sheds light on potential new drug targets to stop disease progre...
Researchers used CRISPR gene-editing to introduce human mutations into C. elegans worms, identifying genes that modify disease progression and pinpointing harmful drugs. The study found three candidate disease-modifier genes and demonstrated the importance of screening for potential harm in patients with genetic mutations.
Researchers discovered a new protein, clathrin, involved in liver cancer development and progression. High levels of clathrin expression correlate with the activation of TGF-β pathway, promoting tumor growth and invasion.
Researchers used CRISPR gene editing to mimic human SF3B1 mutations in C. elegans worms, identifying three splicing factors as potential targets for cancer therapy. The study also humanized a region of the SF3B1 protein binding site, enabling testing of Pladienolide B-derived molecules.
The ONCOMMUN Program aims to improve patient experience and reduce the impact of cancer in Europe. The program combines monitoring of health and emotional status with video-consultations, online education, and social networking to increase quality of life and therapeutic adherence.
Researchers have discovered that certain molecules in semen, known as miRNAs, may serve as non-invasive biomarkers for prostate cancer. The study found that these molecules can provide reliable information to help diagnose and predict the progression of the disease.
A 16-year study of 452,000 Europeans found a positive association between artificially sweetened and sugar-sweetened soft drinks and an increased risk of death from circulatory and digestive diseases. The findings support public health campaigns aimed at limiting soft drink consumption.
Researchers have described a new treatment that could cope with Heterotopic Ossification and Fibrodysplasia Ossificans Progressiva using a PI3-kinase inhibitor. The study shows promising results in preclinical models, potentially leading to improved treatment options for patients.
Researchers at IDIBELL confirm use of PDX models for studying methylation patterns associated with breast cancer subtypes and response to docetaxel. The study validates the models' representation of human tumor samples, enabling more accurate drug preclinical studies.
A recent study published in Nutrients found that an inflammatory diet increases the risk of colorectal cancer by almost twice. The researchers suggest adopting a Mediterranean diet rich in fruits, vegetables, nuts, whole grains, and healthy oils to reduce the risk of colon cancer.
Scientists at IDIBELL-ICO describe a novel mechanism of resistance to therapies that prevent blood vessel formation, which involves immune cells acting as tumor malignant elements. The study highlights the importance of targeting Sema4D and its secretion by macrophages to inhibit this mechanism.
IDIBELL researchers have discovered a biomarker that predicts resistance to the chemotherapy drug docetaxel in triple-negative breast cancer. The study found that tumors with an amplified chromosome 12 region are more likely to develop resistance to docetaxel, but may be vulnerable to alternative treatment with carboplatin.
A dietary supplement called L-serine has been shown to improve the neuronal function of a patient with a mutation associated with atypical Rett syndrome. The study, led by Dr Xavier Altafaj, found that supplementation with L-serine reversed alterations caused by the mutation and improved the patient's motor and communicative abilities.
Researchers propose evaluating genomic analyzes in cervical cytologies to detect endometrial cancer at an early stage. Molecular tests can refine diagnostic algorithms and benefit asymptomatic women with a high risk of cancer.
Researchers from IDIBELL discovered a negative correlation between orexin A and executive functions in anorexic patients, highlighting potential roles for this neuropeptide in eating disorders and cognitive processes. The study's findings may contribute to the development of biomarkers with clinical applications.
Researchers have identified two proteins that, when inactivated, make tumoral cells more sensitive to chemotherapy and reduce metastatic capacity. This finding provides a rationale for creating new therapies against colorectal cancer, particularly in fibroblast-rich tumor subgroups.
Researchers have described a new muscular disease called Myoglobinopathy, caused by a mutation in the myoglobin gene. The study, led by IDIBELL, identifies characteristics lesions in muscle biopsies and altered biochemical properties of mutated myoglobin.
Researchers identify dysfunctional neuronal connections in OCD patients' brains, particularly affecting the orbitofrontal cortex and primary sensory cortices. This study's findings suggest a deficient inhibitory interneuron system, contributing to the disorder's symptoms.
Researchers at IDIBELL have developed Nested CRISPR, a cloning-free method for genome editing using long DNA fragments. The technique involves two steps: inserting a small portion of the fragment into the genome and then using it as a
Researchers found that dopamine precursor levodopa increased hedonic experience and motivational responses, while dopamine antagonist risperidone reduced both. These results suggest that dopamine modulates the reward experiences elicited by music, challenging previous evidence in animal models.
A study suggests defective astrocytes contribute to α-synuclein accumulation, leading to neuronal degeneration. Researchers discovered that healthy astrocytes can prevent α-synuclein buildup and restore neuronal function when cultured with Parkinson's disease neurons.
IDIBELL researchers discovered a novel disease affecting brain white matter in children, caused by DEGS1 gene defect. Fingolimod treatment shows promise in correcting ceramide imbalances and promoting oligodendrocyte survival.
Researchers found that greater cognitive activity throughout life delays the appearance of symptoms and reduces grey matter loss in the brain. Participants with higher educational levels, language proficiency, and cognitive stimulation showed better neuropsychological test scores and slower disease progression.
Researchers have identified NSD2 as a new vulnerability in aggressive, metastatic prostate cancers that have become resistant to hormonal therapies. The study suggests a combined therapeutic approach using an NSD2 inhibitor drug with conventional antiandrogenic drugs to re-sensitize resistant tumors.
A new potential combined treatment for Hepatocellular Carcinoma (HCC) has shown positive results, increasing overall survival in tumor-bearing mice. Researchers found that the combination of mTOR inhibitors and Phenformin causes a metabolic shift to glycolysis, sensitizing liver tumors to dual inhibition of mTOR.
Researchers have developed a new epigenetic drug that slows down cell growth in Mantle Cell Lymphoma by inhibiting the HDAC6 gene. The substance shows high efficacy in cultured cells, murine studies and patient-derived cells with minimal toxicity to healthy cells.
A new drug has been found to reduce symptoms and activate dormant neurons in preclinical models of Rett syndrome, a genetic disorder causing intellectual disability. The treatment, SB216763, also shows promise in improving quality of life by lengthening lifespan and reducing tremors and breathing difficulties.
Researchers found that inheriting a variation in the PM20D1 gene increases the risk of developing Alzheimer's disease, making it an excellent candidate for clinical prevention trials. The study highlights the importance of international scientific collaboration and multidisciplinary research to tackle complex diseases like dementia.
IDIBELL researchers discover EphA2 membrane receptor's role in tumor aggressiveness and metastasis in Ewing sarcoma. The study finds that blocking this receptor activity can significantly decrease metastases incidence and survival rates.
A new study proposes a double mechanism of inhibition of the NF-κB pathway linked to SirT6's action on chromatin. This regulation is associated with cellular stress levels and promotes genome stability and metabolic balance.
The study tested a new combination of gemcitabine and sirolimus in patients with sarcomas, showing a 44% rate of patients free of progression at 3 months. Researchers believe the treatment's positive results warrant further evaluation in subsequent studies.
Researchers have discovered a key cellular receptor involved in ovarian cancer metastasis, CXCR4, which can be targeted with inhibitors to reduce tumor cell dissemination. High expression of CXCR4 is associated with aggressive variants of the disease.
A new study by IDIBELL and ISGlobal found that mild obsessive-compulsive symptoms in healthy children are associated with specific cerebral anatomical changes. The study suggests that these symptoms may be an early manifestation of a more severe mental disorder, highlighting the importance of prevention strategies.
Researchers have identified a neural mechanism that allows us to segment our experience into discrete memory units, which are then stored in long-term memory. This process involves the identification of boundary events, which trigger the reactivation of memories and enable the formation of prediction models.