A study published in Global Public Health reveals that tobacco companies are using cash payments, holidays, and exclusive events to incentivize retailers, bypassing current laws. Former employees describe the tactics as aimed at increasing market share and driving sales through retailer loyalty.
Researchers estimate that adding floating solar panels to existing hydropower stations could generate up to 10,600 terawatt-hours of power annually. This would account for about 35% of global electricity consumption in 2018.
A study examined individual-level changes in alcohol use among U.S. adults before and during the COVID-19 pandemic. The research found that adult alcohol use increased during this time period, leading to various negative health consequences.
A high-fibre diet has been found to offset chronic gastrointestinal damage caused by radiotherapy, reducing radiation-induced inflammation in the digestive system. This contradicts long-held clinical recommendations that advise a restricted fibre diet for cancer patients undergoing radiotherapy treatment.
A new study by Lancaster University found that Welsh-medium school pupils consistently score lower than their English-speaking counterparts in standardised tests. Despite attending schools with wealthier families and having more access to resources at home, these pupils still fail to match the academic performance of their peers.
A NOAA study shows that elevated carbon dioxide concentrations slow down shellfish gill cilia, reducing feeding and filtration rates in blue mussels. This affects ecosystem services like energy and growth in marine ecosystems.
Genetic and immunological analyses reveal inherited immunodeficiency in patients with severe COVID-19, impairing anti-viral response. The study identifies 13 critical genes associated with the disease, paving the way for personalized treatment and prevention.
The SPARC reactor concept leverages scientific progress in magnetic confinement fusion and high-temperature superconductor technology to achieve a compact, high-field DT burning tokamak. Seven peer-reviewed articles provide a comprehensive physics basis for the design.
Scientists study tree rings to reveal how Arctic dimming kills trees and limits growth due to reduced sunlight from industrial pollution. The research found massive tree mortality associated with the Norilsk mining complex in northern Siberia.
A new study suggests that the gut microbiome plays a role in how prostate cancer patients respond to oral therapies like abiraterone acetate. The research found that bacteria in the gut metabolize the drug, leading to an increase in beneficial organisms with anti-cancer properties.
Researchers found that species-rich sites can lead to biased measurements of biodiversity change. A systematic approach is needed to prevent such biases and ensure accurate conclusions. The study emphasizes the importance of choosing representative sampling sites to inform conservation efforts.
Researchers from VA Boston Healthcare System and Boston University School of Public Health used machine learning to explore streamlining the diagnostic tool for PTSD. They found that six questions could be cut from the SCID-5 while maintaining accuracy, with different questions being more or less important for male and female veterans.
Researchers linked an outbreak to a source patient who likely spread the virus through the air conditioning system, contradicting long-held assumptions about COVID-19 transmission. The study's findings support the importance of wearing face masks in indoor spaces with poor ventilation.
Researchers used data from fishing technology company ReelSonar to model angler movements and predict where aquatic invasives may spread. The study found that anglers who fish frequently in the same area are more likely to transport invasive species.
A landmark special issue collaboration between Kew and New Phytologist Foundation highlights the global roadmap for protecting and sustainably using plants and fungi. The research emphasizes the importance of collaboration and recognizes the threats to plant and fungal diversity, highlighting a critical need for conservation efforts.
A new TB vaccine developed by Dartmouth's Geisel School of Medicine has shown promising results in a Phase 2 trial, inducing immune responses against the disease. The vaccine was safe and well-tolerated, with minimal local reactions, and may prevent TB disease by inducing a favorable immune response.
A team of Penn State researchers has integrated water purification technology into a sea water electrolyzer, which uses an electric current to split apart the hydrogen and oxygen in water molecules. This new method can make it easier to turn wind and solar energy into a storable and portable fuel.
A new study by the University of Pennsylvania School of Nursing demonstrates the potential of mobile technology in improving recovery from serious traumatic injuries. The research showed that mobile health monitoring was feasible and acceptable for tracking biometric indicators of physical activity and sleep among Black men recovering ...
Scientists discover that stressed liver cells quickly become senescent after hemorrhagic shock, a condition that accounts for 30-40% of trauma-related deaths. This rapid transition to senescence may help prevent organ failure, but drugs targeting senescent cells can be lethal in the context of injury.
Researchers created a novel Drosophila-based disease model for Pitt-Hopkins syndrome (PTHS), which is caused by mutations in the TCF4 gene. The model reveals that certain substances can enhance learning and locomotor abilities in PTHS patients, suggesting potential therapeutic options.
Researchers from Università di Bologna found evidence of genetic isolation between two morphotypes of Parazoanthus axinellae, suggesting they may belong to different species. The study's findings have significant implications for biodiversity conservation in the Mediterranean Sea.
In a study published in PNAS, researchers found that when participants were informed they could return some of the money they had overreported, they forgot their past cheating behavior more accurately. This 'unethical amnesia' allowed them to restore their reputation, making it more acceptable for future moral breaches.
A recent study published in Circulation: Heart Failure found that women aged 18-55 receiving aggressive care for heart attacks with cardiogenic shock had significantly lower survival rates compared to men. The study revealed disparities in treatment, including reduced use of coronary angiography and mechanical pump therapy.
A recent study shows that most older women with breast cancer can safely undergo surgery, reducing the gap in survival rates between older and younger women. The research found that surgery is generally well-tolerated and offers slightly lower survival rates for those who don't have it.
Quinoline and its derivatives have diverse chemical and pharmacological properties. The new water-mediated synthetic method offers environmentally friendly and regioselective transformations. This innovation provides an alternative route for the synthesis of quinolines, minimizing waste and improving efficiency.
The pathoconnectome is a map of how eye disease alters retinal circuitry, offering insights into other neurodegenerative diseases like Alzheimer's and epilepsy. The research findings provide fundamental rules on how neural networks are rewired by disease, paving the way for new therapies.
A study of comet motions reveals a second alignment plane in our solar system, dubbed the 'empty ecliptic.' The newly discovered plane is where comets' farthest points (aphelia) tend to converge, challenging models of Solar System formation. Long-period comets' orbits show two peaks near the well-known ecliptic and empty ecliptic planes.
A OU-led study integrates omics data into ecosystem models to better predict soil carbon loss due to warming-induced adaptation in microbial communities. The findings suggest a more nuanced understanding of the ecological consequences of climate warming.
Research from University of Cambridge suggests widely-used 'mixing ventilation' systems disperse airborne contaminants evenly, potentially increasing exposure to COVID-19. The study highlights the importance of good ventilation and mask-wearing in mitigating transmission.
A new study by the RAND Corporation found that American adults have increased their alcohol consumption significantly during the pandemic, with women experiencing a 41% rise in heavy drinking episodes. The overall frequency of alcohol consumption also rose among all adults aged 30 and above.
Researchers have identified the cellular process by which Cisplatin chemotherapy causes neuronal damage, revealing that it induces senescence of peripheral neurons through overexpression of the p21 protein. This discovery provides new targets for neuroprotective treatments to alleviate or avoid the adverse effects of Cisplatin.
A laboratory study replicates common restaurant noise levels and shows that even 'normal' background noise can be unpleasant to diners. The study suggests noise management strategies, including quiet dining areas for older and noise-sensitive individuals, to improve dining experiences.
A computer brain circuit has identified a potential mechanism for impaired decision making in schizophrenia, linked to reduced activity of molecules called NDMA receptors. The model's results provide new insight that may inform future treatments for neuropsychiatric conditions.
Researchers at UC San Diego report that Kawasaki disease clusters have distinct demographic and clinical features, suggesting different triggers and genetic susceptibilities. The study's findings support the idea that KD is not a single homogenous disease, but rather a complex condition with multiple causes.
A new study published in BMC Biology found that nearly all of the mutations tested had a negative effect on fertility early in life and accelerated reproductive ageing. This suggests that mutations contributing to ageing may be more common than previously thought.
Researchers at SUTD developed a method to preheat gelatin ink, increasing its printing time and producing high-quality prints. The study found that preheated gelatin exhibited greater change in volume, allowing for size changes post-printing.
Researchers found that ordinary conversation creates a conical 'jet-like' airflow that quickly carries tiny droplets from a speaker's mouth across meters of an interior space. This can lead to the transmission of diseases like COVID-19, even in the absence of visible symptoms.
Infrared data from NASA's Terra satellite revealed Typhoon Kujira's strongest storms and coldest cloud top temperatures, indicating potential heavy rainfall. The storm's maximum sustained winds were near 65 knots on Sept. 29.
A new study found that China's aerosol pollution reduction efforts have caused warming in northern latitudes, potentially masking some effects of global warming. The research suggests that the reductions in particulate pollution may have unmasked around 0.1 degrees Celsius of greenhouse-gas-induced warming.
Researchers discovered a fungal virus that converts a deadly fungal pathogen into a beneficial endophytic fungus in rapeseed plants. The transformed fungus boosts the plant's immune system, leading to increased weight, root growth, and resistance to diseases.
A new study reveals that cannabis data is lacking on lesser-known compounds, but machine learning can help fill the knowledge gap. By analyzing a dataset of over 17,600 cultivars, researchers found that only 1.4% of strains had complete data on THC and CBD, highlighting the need for standardization in product labeling.
Researchers at Hebrew University of Jerusalem have made a breakthrough in harnessing DNA molecules for disease detection and electronics. They developed a highly-reliable method to measure electric currents passing through individual DNA molecules, finding that the current flows along the backbone rather than base-pairs.
Researchers discovered a potential way to prevent long-lasting brain damage in newborn children by targeting the histamine H2 receptor. A protein known as the histamine H2 receptor inhibits the formation of mature oligodendrocytes, leading to improved recovery from hypoxia-ischemia in mice treated with cimetidine.
A computer model shows that SARS-CoV-2 spike protein's superantigenic features interact with human T cells, leading to a 'cytokine storm' and severe inflammation. Researchers found similarities between this region and bacterial proteins causing toxic shock syndrome.
A new study found that China's success in reducing air pollutants such as sulphur dioxide, black carbon, and organic carbon may exacerbate global warming. The reductions, achieved through stringent measures, led to notable public health benefits but also changed the radiative forcing of the earth's temperature.
A large cohort of COVID-19 patients was analyzed using VirScan technology, revealing epitopes recognized by a large fraction of patients and cross-reactivity with other human coronaviruses. The study also found sex differences in antibody responses and a machine learning model that accurately classified SARS-CoV-2-infected patients.
Researchers successfully synthesized hetero-steroid-amino acid conjugates using microwave-assisted Ugi-4-CR reactions. This method improves yields and reaction rates, offering a promising approach for synthesizing novel hybrid molecules.
Researchers found that speech can spread salivary and mucus droplets for at least a meter in front of a speaker, potentially transmitting viruses like coronavirus. Using lip balm, the researchers reduced the droplet size, suggesting a possible mitigation strategy.
Physicists have directly observed nutation in magnetic spins, a phenomenon 1000 times faster than precession. This discovery has significant implications for data centers and digital storage, paving the way for more efficient technologies.
Researchers found vessel traffic and whale vocalizations contribute to ambient sound, with fluctuations by month and seasonal peaks. The study establishes a baseline for understanding the impact of human-made noise on the sanctuary's ecosystem.
An international research team found large diamonds and nanodiamonds in ureilite meteorites, suggesting they formed through massive impact events rather than continuous pressure in planetary precursors. The discovery challenges existing theories and provides insights into the extreme forces that shaped the early solar system.
A George Mason University study found that mental illness is a significant predictor of veteran suicide, while social determinants of health can predict but not cause it. The study used EHR data from over five million veterans and recommends focusing on medical issues such as antidepressant use to improve risk modification efforts.
Native broadleaf trees planted in upland areas can absorb rainwater more efficiently, reducing peak river flow and flood risk. This nature-based solution is an effective and natural flood management tool that can be maximized with careful placement.
Researchers found that catalase can regulate cytokine production, protect alveolar cells from damage, and repress SARS-CoV-2 virus replication in rhesus macaques. The study suggests a potential therapeutic solution for hyperinflammation caused by COVID-19.
A study revealed that over 4,000 reptile species are in global trade, with 3/4 not covered by international regulations. Most traded species are endangered or range-restricted, especially from Asia.
Researchers at Vanderbilt University have created a wearable exosuit that reduces lower back muscle fatigue in individuals working in physically demanding fields. The exosuit applies assistive forces to relieve strain on muscles and spine, reducing injury risks and improving safety for frontline workers.
A team of NUS researchers has developed a solution to address the long-standing challenge of uniform switching mechanism in memristors, a key component of organic and molecular electronics. The breakthrough demonstrates homogeneous molecular switching with less than 7 nanometre spatial resolution.
A Mayo Clinic study found that patients with large polycystic kidneys can have their diseased kidneys removed laparoscopically at the same time as a kidney transplant, without compromising kidney function. The dual surgery approach has been shown to be a safe and viable option for these patients.
A new study found that chain pharmacies in West Virginia are more likely to stock emergency contraception than independent pharmacies. The researchers also found that many pharmacies have inadequate knowledge about the effectiveness of Plan B and can be intimidating for customers seeking it.
Researchers analyzed blood samples from 232 COVID-19 patients using VirScan to identify 800 sites of the virus that the immune system can recognize, known as epitopes. The team detected a range of antibody frequencies against various epitopes, with some recognized by 79% of COVID-19 patients.
Research suggests that different α-synuclein aggregate conformations lead to distinct pathologies in neurodegenerative diseases. Suzuki et al. found that α-synuclein fibrils (-) inhibit proteasome activity, leading to accumulation of phosphorylated α-synuclein and ubiquitinated proteins.
The Washington COVID-19 biorepository has expanded its sample types to include convalescent plasma, enabling diagnostics developers to accelerate the development and validation of quality diagnostic products. This move aims to improve the performance of antibody assays and facilitate the verification of tests for global markets.
Physicists discovered that individual light-harvesting nanotubes with disordered molecular structures transport light energy in the same way. The result is attributed to the linkage of molecules, which averages out small differences, resulting in similar optical properties.
Researchers at MUSC are using new technologies to conduct remote smoking cessation clinical trials, reaching smokers in rural areas and beyond. With electronic consent and smartphone-enabled devices, participants can complete trials from home, providing more representative data.
Researchers developed a new approach to study color perception in fruit flies, enabling simultaneous brain imaging and visual stimulation. The study found strain-specific sensitivities to colors among the fruit flies, with orange-eyed flies exhibiting increased sensitivity in the green range.
A study published in mBio found that past infections with coronaviruses, including the common cold, can induce long-lasting immunity against COVID-19. The research also showed cross-reactivity between memory B cells that target SARS-CoV-2 and those targeting other betacoronaviruses.
A repeated testing protocol for COVID-19 among patients with cancer was examined in a quality improvement study. The study found that asymptomatic cancer patients can be safely screened for COVID-19 without increasing the risk of infection.
A multicenter observational study found that sitagliptin improved survival rates in diabetic patients hospitalized with COVID-19 pneumonia. The study also showed reduced inflammation and improved clinical outcomes. A new randomized, placebo-controlled trial is now enrolling patients to confirm the findings.
A new study reveals that sleeping less is associated with being seen as more masculine and positively judged by society, while women are not subjected to the same effects. The research suggests that this stereotype can have detrimental consequences on mental and physical health, as well as contribute to aggressive behavior.
A new mobile app, Genopo, developed by Garvan Institute of Medical Research, makes genomics more accessible to remote or under-resourced regions and the hospital bedside. The app enables fast, real-time genomic analysis on a smartphone, opening possibilities for point-of-care testing and unlocking information in DNA or RNA.
A new study published in eLife suggests a link between unexplained miscarriages and how women perceive men's body odor. Women with a history of uRPL were found to have an altered perception and brain response to male body odors, including improved ability to identify their spouse by smell.
Researchers discovered pine needle fibers are better at shedding water than circular fibers, retaining less moisture. This evolution is advantageous as it prevents photosynthesis from being blocked by rainwater.
Researchers at University of Cincinnati discover sphingosine, a natural element, can interfere with SARS-CoV-2 binding to human cells, preventing infection. The study suggests sphingosine could be used as a nasal spray to prevent or treat COVID-19.
Researchers found evidence of widespread forest fires during the Cretaceous period, burning up to 40% of global forests, even in wet regions. This discovery sheds light on how Earth's history might behave under future global climate change.
Research led by Durham University found that massive collisions could have stripped the early Earth of up to 60% of its atmosphere, leading to the Moon's creation. The study developed a new method for predicting atmospheric loss from any collision, which could aid in understanding the Moon's origins and other giant impacts.
Researchers tested anoles' bones for responsiveness to mechanical stress, finding it didn't drive evolutionary divergence; instead, simple genetic changes likely led to repeated traits.
A University of Colorado Boulder astrophysicist is searching the light coming from a distant magnetar, PSR J1745-2900, for signs of dark matter. The scientist hopes to detect the faint signals of an axion particle transforming into light.
A major national study found that oral antibiotics are as effective as intravenous antibiotics in killing Pseudomonas aeruginosa, a common germ causing chronic lung infection in CF patients. This means CF patients with a new infection can be treated at home and saved from hospital admissions.
Researchers at UT Health San Antonio discovered that childhood chemotherapy changes the function of cells that repair heart injury, leading to increased risk of heart failure in survivors. The study found that damage to these cells may contribute to late effects seen in childhood cancer survivors when they become adults.
A Rutgers University study found that patients with generalized epilepsy are at a higher risk of developing obstructive sleep apnea compared to those with focal epilepsy. Treatment of OSA may improve seizure control and overall health for these patients.
A team of researchers from the University of Southern California discovered a highly fragmented network pattern within the Panama Papers, which makes it challenging to infiltrate or take down. The study revealed that this system is robust due to its disconnectedness, making it difficult for national or international bodies to intervene.
Skoltech researchers propose a fast and accurate numerical method to address the low spatial resolution of EEG studies. The new approach directly backpropagates measured signals from the skin down to the cortex, increasing accuracy for source localization while speeding up processing.
A new study finds that acknowledging uncertainty in epidemiological models can increase public trust, while catastrophic messaging may undermine it. Researchers also discovered that criticism from Democrats can erode confidence in science, highlighting the need for careful communication about COVID-19 science.
Researchers found that exosomes secreted by cardiac cells derived from human induced pluripotent stem cells improved myocardial recovery and reduced arrhythmia in pigs. The treatment showed regenerative benefits equivalent to injecting living cells, without increasing the risk of tumorigenesis.
A new CDK 4/6 inhibitor, abemaciclib, has been shown to reduce the risk of breast cancer recurrence in high-risk patients with hormone receptor-positive (HR+) early-stage disease by 25%. The monarchE study found that adding abemaciclib to standard hormone therapy significantly improved patient outcomes.
A study by Cima and Clinica Universidad de Navarra has identified reparative cardiac fibroblasts that play a crucial role in repairing the heart after an infarction. These cells are activated when a patient suffers a heart attack, producing a collagen scar to prevent rupture of the ventricular wall.
Researchers found that excessive social media use is related to depression and secondary trauma, suggesting taking a break may promote well-being. Over half of respondents reported some level of depression, while more than half experienced increased hand washing and face mask use as a result of social media.
A new software tool can accurately predict motor development disorders in preterm infants based on early MRI scan data. The tool quantifies diffuse white matter abnormality (DWMA) volume, which serves as a biomarker for brain developmental issues.
Researchers at North Carolina State University have found that vitamin D deficiency during early development can disrupt the metabolic balance between growth and fat accumulation in zebrafish. The study suggests a linkage between vitamin D and metabolic homeostasis, leading to obesity and stunted growth.
New research from University of Illinois scientists suggests that crop-relevant drought should be measured by atmospheric dryness (VPD) rather than just rainfall and soil moisture. Studies found that VPD accounts for nearly 90% of changes in crop stomatal conductance and productivity.
A global study maps areas with high carbon returns from natural forest regrowth, highlighting climate's role in carbon storage. Climate change mitigation strategy: restoring degraded woody vegetation could store substantial amounts of CO2.
Researchers identified a time delay in the production of an inhibitory factor that triggers cell refractoriness to interferon treatments, suggesting strategies for enhanced therapeutic response rates.
Research by Hokkaido University scientists finds that warming waters and sea ice-free conditions in the Pacific Arctic will lead to significant changes in marine community compositions. Larger fish and invertebrates are expected to expand their ranges towards the pole, altering ecosystem structure and functions.
Lithium-rich oxides offer a promising solution for more sustainable and cost-effective batteries, made predominantly of Earth-abundant elements like manganese. The discovery reveals that the movement of elements other than oxygen is the primary cause of energy inefficiency in these materials.
A UC Riverside-led study found that the drug tofacitinib can repair permeability defects in the intestine caused by overactive immune cells. The study suggests that patients with a specific gene mutation may have a better response to this drug, improving targeting of treatments.
Key findings from TropMed20 include new research on climate-related health impacts, such as increased tick bites and fetal health risks. The conference also addresses racism in tropical medicine and explores the potential of monoclonal antibodies to combat diseases like COVID-19 and malaria.
Researchers found a connection between amino acid metabolism and joint hypermobility in autistic children, with increased levels of hydroxyproline linked to joint issues. The study suggests that amino acid balance may be an additional tool for ASD therapy.
A portable device has been created to mimic the placenta's oxygenation role for pre-term newborns in respiratory distress. The artificial lung uses a fine membrane to release carbon dioxide and uptake oxygen while protecting blood from infection, improving survival rates and reducing brain damage.
Scientists at Boston University's NEIDL and CReM developed living human lung cells from stem cells to study COVID-19's impact on the lungs. They found that NFkB pathway activation triggers deadly levels of lung inflammation, leading to a search for new therapeutics.
A new study sequenced the genomes of two millipede species, revealing vast differences in genome size due to unique gene structures. The research also identified genes involved in toxic secretion, supporting the idea that ozadene gland secretions protect against microbes and predators.
Researchers developed a novel method to generate variable low-noise microwaves using an optical microresonator frequency comb and a compact laser. The approach allows for significant frequency tunability and improved phase-noise levels compared to traditional methods.
Researchers at North Carolina State University developed a prototype vascular graft that combines synthetic fibers and collagen filaments to aid in regeneration of the coronary artery lining. The design showed improved strength, flexibility, and biological response compared to previous models.
Researchers developed a machine learning technique that rapidly discovered rules governing catalysts, which took humans years of difficult calculations to reveal. The team believes this will enable faster progress in designing materials for various purposes.
The new membraneless fuel cell, developed by INRS researchers, powers an LED for four hours using only 234 microlitres of methanol. The device uses selective electrodes to minimize crossover and can be optimized to use ethanol, a greener fuel.
Researchers found that spreading volcanic ash from a ship to an area of ocean floor could sequester up to 2300 tonnes of CO2, significantly cheaper than other methods. The technique is less invasive and doesn't require expensive technology or land repurposing.
Researchers discovered that nasal administration of physiological salts can effectively eliminate airborne particles from airways, reducing exhaled aerosol particles by up to 99%. The study showed significant reductions in sub-micron aerosol particles, suggesting a potential addition to Covid-19 hygiene protocols.
West Virginia University engineers have developed a new low-cost process to convert natural gas flared at industrial sites into high-value solid carbon and hydrogen. The $3 million DOE award aims to mitigate carbon dioxide emissions from shale gas production, benefiting various industries and the economy.
The SPARC project has published seven research papers outlining the physics behind the ambitious reactor design, with calculations suggesting a Q ratio of 10 or more. The device aims to achieve a 'burning plasma,' a self-sustaining fusion reaction, which is crucial for developing practical power-generating plants.
Researchers developed a new model that describes driving behavior based on a 'human' principle: managing risk below a threshold level. The model can accurately predict human behavior in various driving tasks and may be used in intelligent cars to reduce their 'robotic' feel.
Researchers developed a deep-learning model that uses big data and artificial intelligence to predict future COVID-19 case growth. The model accounts for features such as mobility, population activities, and social demographics, achieving 64% accuracy in predicting cases.
A deep learning model can quickly identify large vessel occlusions, which account for a significant proportion of ischemic strokes. The algorithm's sensitivity was found to be 100%, outperforming single-phase CTA in detecting these critical blockages.
A new Canadian study found that girls who participate in school sports activities during middle childhood show improved behaviour and attentiveness in early adolescence. The study, led by Linda Pagani, suggests that extracurricular sports can be a positive approach to promote psychological well-being and reduce ADHD symptoms in girls.
A survey study explores public preferences for COVID-19 vaccine allocation. The results show that most people prioritize vaccine distribution to high-risk groups, including seniors and individuals with chronic health conditions. This preference is expected to influence healthcare policy decisions.
A new computer modelling study suggests that simple interactions between nerve cells contribute to the development of complex brain circuits, making a precise genetic blueprint unnecessary. The findings help answer how the brain wires itself during development and may inform new ways to treat conditions that disrupt brain circuits.
Scientists at University of Bath and UCB biopharma company produce miniaturized antibodies up to five times smaller than regular ones. These tiny antibodies may bind to sites on pathogens that larger antibodies can't, offering a potential new class of treatments.
A phase 3 clinical trial found that ipilimumab improved progression-free survival by two to three times in patients with metastasized, castration-resistant prostate cancer. The treatment also showed overall survival benefits compared to the placebo arm.
A team of researchers developed a cooperative adaptive cruise control model that uses streaming data to predict the driving states of preceding vehicles, reducing congestion and traffic accidents. The model can be tested using actual connected, autonomous vehicles and could create a safer future for everyone sharing the road.
A Rutgers-led study reveals that small water droplets on plant leaves are rich in carbohydrates and proteins, essential for insect survival. This discovery has profound implications for the conservation of beneficial insects and could reduce pest problems in various crops.
A study found that non-driving-related license suspensions are given to over 90% of drivers in New Jersey, affecting low-income neighborhoods and communities of color. These suspensions disproportionately limit access to employment and healthcare, with failure to pay fines being the most common reason.
Researchers at Colorado State University developed a decision support prototype to help fire managers tailor suppression responses to local conditions. The tool addresses complexities by organizing information on ecological, social, and policy factors.
Researchers discovered a link between gene mutations in SCN2B and SCN4B genes and cardiac arrhythmias. The study sheds light on the role of sodium V channels in maintaining heart function and may lead to new treatments for cardiac syndromes.
University students increased mobile phone use by 50% during lockdown, leading to decreased physical activity and worsened sleep quality. The study highlights the need for behavioural changes to reduce sedentary lifestyle and improve population health.
Researchers at Penn University found that autophagy, a cellular process, causes SIRT1 enzyme to degrade over time. Treating mice with an autophagy inhibitor restored SIRT1 levels, suggesting a new approach to treating age-related diseases.
Researchers from Peter the Great St. Petersburg Polytechnic University successfully created silver nanoparticles in an ion-exchanged glass using infrared nanosecond laser pulses. The nanoparticles demonstrate surface plasmon resonance, enabling signal enhancement of up to 10^6 times in Raman spectroscopy.
A new study published in Frontiers In Oncology found a negative association between beta-blocker use and survival outcomes in patients with HER2 positive advanced breast cancer. The research highlights a subgroup of patients whose survival outcomes are poorer and calls for further investigation to improve treatment outcomes.
A study found that FDA evaluations for new opioid drugs approved between 1997 and 2018 lacked systematic assessments of safety-related outcomes, particularly for chronic pain applications. The analysis revealed that trials often excluded patients who could not tolerate the drugs and failed to assess important adverse events.
Researchers at University of Würzburg developed a drug that can disarm Aurora-A kinase, a protein that causes extensive damage in cancers like leukemias and neuroblastomas. The new PROTAC substance completely degrades the Aurora protein in cancer cells, leading to cell death.
Researchers analyzed gene expression in liver, heart, and muscle tissues of aging mice to define an 'aging footprint.' This data helped identify genes and proteins controlling the aging process, which may also be relevant in human aging. The study's findings have implications for understanding age-related diseases.
Research reveals that older adults are less able to regulate body temperature and hydration during exercise in hot environments due to decreased sensitivity to elevated blood osmolality. This can lead to increased risk of heat-related injuries and adverse heart problems, highlighting the importance of staying hydrated.
Researchers found that dietary fiber-derived fatty acids activate macrophage activity against Salmonella infection by binding to apoptosis-associated speck-like protein (ASC), triggering inflammasome activation. This new mechanism provides insights into the effects of dietary fiber on the immune system.
A study from the University of Queensland found that a gene controlling inflammation increases the risk of obesity. Researchers discovered that variations in this gene lead to excessive inflammation in fat tissue, contributing to weight gain. By turning off the gene in mice, they were able to prevent weight gain and reduce diabetes risk
Researchers at Pohang University of Science & Technology developed a novel immunotherapy platform called imuGlue, which connects mussel adhesive proteins to antibodies used in immune checkpoint inhibitors.
A team of researchers has applied their model to the emergence of Southeast Asia, finding that volcanic rock provinces in the tropics are a major factor in determining CO2 levels. This discovery sheds light on our current climate crisis and provides insights into how geological processes can help mitigate its effects.
A new study suggests that high fructose intake exacerbates intestinal inflammation common to IBD, potentially worsening the condition for patients. Researchers found that a western diet, including fructose, is associated with increasing rates of obesity and diabetes, which may further increase IBD risk.
A team of scientists from Far Eastern Federal University and their colleagues developed a way to hydrogenate thin metallic glass layers at room temperature, which can expand the range of cheap, energy-efficient materials for hydrogen energy. Metallic glass has potential to replace expensive palladium in hydrogen systems.
A new study shows that clean air is achievable globally with policy interventions in multiple sectors, including environmental policies, energy and climate policies, and agricultural production system transformation. The required measures would also contribute to sustainable development and human development goals.
Researchers at the University of Texas at Austin have made a groundbreaking discovery about organoids, stem cell-based tissue surrogates that mimic organs. The team found that organoids on the edges of an extracellular matrix dome respond differently to stimuli compared to those in the center, potentially leading to misleading results.
Researchers found that working memory is not confined to one brain area but requires synchronous activity of at least two regions. Gpr12 receptors in the thalamus are essential for establishing synchrony between the prefrontal cortex and other brain areas, leading to improved working memory performance.
Researchers from KAUST analyzed fonio millet genomes to identify genes that could lead to higher yields and larger grains. The study found two genes, DeGs5-3A and DeSh1-9A, which were artificially selected for their larger grain size.