Researchers have solved the structure of F1Fo ATP synthase, shedding light on its rotation mechanism and permeability transition pore formation. The fully resolved structure reveals the c-ring is plugged by two lipids, one from each side of the membrane.
The NIH has augmented the Health and Aging Brain Among Latino Elders (HABLE) Study to include additional biomarkers, including positron emission tomography (PET) imaging, to better understand Alzheimer's disease in Mexican Americans. The study will help identify health disparities and potential treatments for the condition.
A new study from Cornell University finds that Facebook anniversaries, like birthdays, prompt users to reflect on time and patterns in their lives. This tradition stems from newspapers' 'on this date' lists, which encourage people to put time into perspective by remembering significant events.
A new study reveals that environmental factors drive migration, particularly in regions with middle incomes and agriculture. Climate change impacts vary by hazard type and context, with changing temperatures having the strongest effect.
A Florida State University team recommends classifying algae by DNA and then by ecological traits to improve understanding of algal species. This new approach could help mitigate the effects of algal blooms and coral reef destruction, as well as inform conservation efforts.
Scientists at CUNY ASRC develop morphing crystals that convert water evaporation into powerful motions, offering a clean source of energy for mechanical devices. The materials are biocompatible, biodegradable, and cost-effective, with potential applications in robotics and micro-machines.
A recent study reveals significant genetic diversity among Four-eyed turtles, highlighting the importance of genetic screenings to prevent extinction. The research emphasizes the need for stricter laws and regulation in releasing confiscated animals back into the wild.
A new white paper from the Society for Healthcare Epidemiology of America provides targeted screening and decolonization strategies to prevent Staphylococcus aureus infections in critically ill infants. The guidance balances infection prevention with the need for skin-to-skin contact with parents and siblings.
Researchers at Ohio State University have discovered that RNA nanoparticles exhibit elastic and rubbery properties, enabling them to target tumors by slipping through tumor blood vessels. The particles are also excreted from the body quickly via urine, reducing toxicity.
Researchers developed a virtual reality training program to educate the public on administering naloxone, reversing opioid overdoses. The 9-minute VR training was found to be just as effective as an in-person training in increasing knowledge and confidence among participants.
Researchers at Washington University School of Medicine have developed an experimental imaging agent called Galuminox that detects inflammation via positron-emission tomography (PET) scans. The agent has shown promise in imaging inflammation in the lungs of mice with acute lung injury, and its potential uses include cancer treatment an...
A team of Indian and Japanese physicists have overturned the six-decade old notion that giant magnetic fields in plasma evolve from small scales. Instead, they originate at macroscopic scales defined by the boundaries of electron beams, leading to a new understanding of magnetic fields in astrophysical scenarios and laser fusion.
Researchers analyzed 12 voluntary REDD+ projects in the Brazilian Amazon and found that they overestimated reduction of deforestation and carbon emissions. Decreasing deforestation trends during early stages of REDD+ projects may explain why these projects resulted in less avoided deforestation than expected.
Researchers at the University of Warwick have developed a training tool to reduce motion sickness susceptibility by over 50% using visuospatial exercises. This method has shown promise in both driving simulators and on-road experimentation, with potential applications in autonomous vehicles and other domains.
People with underlying endocrine diseases are at higher risk of developing severe COVID-19 and experiencing worse outcomes. COVID-19 is also associated with long-term effects on the hormone system, including weight loss and muscle mass loss.
A new study finds that massive volcanism sent great waves of carbon into the oceans thousands of years ago, but human emissions are now three to eight times faster. The consequences for life on land and in the water could be catastrophic.
Researchers distinguish between brain activities of right-handers and left-handers using functional near-infrared spectroscopy, revealing asymmetry in response to passive touch stimulations. The study may have implications for brain-computer interfaces, rehabilitation robotics, and cognitive enhancement treatments.
Researchers at Sechenov University study immune reactions to develop an effective vaccine against SARS-CoV-2. The key finding is that vaccines should induce high-affinity neutralizing antibodies targeting ACE2, while avoiding eosinophilic complications.
Researchers at the University of Leeds have visualised the structure of amylin fibrils, a key player in type 2 diabetes, and discovered an intricate architecture that makes some sequences more prone to aggregation. This finding suggests a potential explanation for the rapid onset of disease in individuals with early-onset type 2 diabetes.
Researchers from the University of Würzburg have developed a method to convert nitrogen to ammonium at room temperature without using transition metals. The key to this process is the use of boron and water, which enables sequential reactions that bring the team close to producing ammonia.
A new paper suggests that COVID-19 policy makers can improve transparency and accountability by learning from the aviation industry. The research emphasizes the importance of assurance cases to explain model assumptions and their limitations, enabling policymakers to critically review decisions.
Researchers discovered how the brain processes bright and contrasting light, enabling robots to team with humans. The study's findings reveal principles that can guide modeling toward correct mechanisms for reconstructing 3D shape in real-world luminance.
Researchers are enrolling 250-325 households to study how SARS-CoV-2 is spread within families, and whether children contribute to transmission. The two-year study aims to provide information for limiting family transmission and optimizing COVID-19 vaccination strategies.
Researchers at University of Pittsburgh isolated the smallest biological molecule to date that neutralizes SARS-CoV-2. The tiny antibody component, known as Ab8, is 10 times smaller than a full-sized antibody and has been shown to be highly effective in preventing and treating SARS-COV-2 infection in mice and hamsters.
NASA uses infrared data from the Aqua satellite to analyze low-pressure areas developing in the eastern Atlantic Ocean. The data reveals cloud top temperatures as cold as minus 63 degrees Fahrenheit, indicating strong storms capable of heavy rain.
The University of Louisville will establish a Center for Cancer Immunology and Immunotherapy to develop and improve cancer treatments that utilize the immune system. Researchers will focus on advancing strategies to use the immune response to fight cancer, with the goal of saving lives through immunotherapies.
A comprehensive international study found that pregnancy can delay the onset of multiple sclerosis (MS) by more than 3 years. The study used a global database of over 70,000 MS patients and suggested that pregnancy may reduce abnormal immune system activity that causes MS.
Researchers found Botox short-term use in low doses does not cause significant bone loss, while higher doses were associated with reduced bone density. Long-term studies are needed to track potential cumulative effects.
A randomized, double-blind trial found that turmeric supplements were more effective in reducing knee pain in patients with osteoarthritis compared to a placebo. The study also showed no adverse events and reduced medication usage, but highlighted the need for larger, longer-term trials.
Researchers found genetic markers protecting against migraines' chronification, enabling personalized prevention therapies for at-risk individuals. The study identified polymorphisms in the pain receptor TRPV1, which may help detect those prone to chronic migraine.
Research shows that appointing a new leader just before an election leads to a higher turnover of MPs across Europe. The study analyzed statistics from 251 parties between 1945 and 2015, finding that the proportion of new and re-elected MPs is almost 5 percentage points higher for parties with a new leadership.
Researchers found that immune cells surrounding the brain produce a molecule called IL-17, which is then absorbed by neurons and appears to be necessary for normal behavior. The findings suggest that elements of the immune system affect both mind and body.
Researchers found that full-face readings provide greater accuracy than targeting only the inner canthi region for fever screening with IRTs. The study evaluated over 500 individuals and reported excellent IRT performance with clear correlations to oral temperature baseline data.
The team used terahertz-frequency light to probe the vibrational modes of lysozyme, discovering that its glassy and fractal nature explains the anomalously large vibrations. The study may lead to improvements in industrial glass manufacturing by understanding disordered materials.
A Bayesian modeling framework can estimate population in each 100-m grid cell with an overall error rate of 67 people per hectare. This approach may be suitable for conflict-affected or remote areas where regular census surveys are not feasible.
Scientists have discovered a potential effective treatment for Frontotemporal Dementia (FTD) using Ursodeoxycholic Acid, an already approved liver medication. The drug has been shown to increase protective proteins in neurons and prevent cell death, offering new hope for patients.
Newly hatched tortoises preferentially orient toward face-like representations, which may be an evolutionary leftover from a common ancestor of mammals, birds, and reptiles. This exploratory behavior could play a role in learning and development.
Researchers used CRISPR-Cas9 to remove endogenous germline in recipients, allowing for donor-derived spermatogenesis. The approach shows promise for improving livestock and conserving endangered species.
Researchers detected hydroxylated polychlorinated biphenyls (OH-PCBs) in the fetal brain of a Japanese macaque, revealing their transfer from maternal blood. The study suggests that OH-PCB concentrations may exceed levels that induce adverse effects on neurodevelopment, highlighting the need for further research on human exposure risks.
Researchers at Colorado State University found a genetic mutation associated with dogs having hypothyroidism being less likely to develop T-zone lymphoma. The study suggests that a region of chromosome 8 linked to thyroid hormone regulation may play a crucial role in the development of the disease.
A team of international researchers has detected phosphine gas in Venus' clouds, a potential biosignature indicative of life. The finding is significant as it rules out natural non-biological processes that could produce the same amount of phosphine.
Researchers found that heroin use alters the expression of the FYN gene, which regulates Tau production and is associated with neurodegenerative diseases like Alzheimer's. The study suggests that FYN inhibitors may be a promising therapeutic tool for opioid addiction.
A recent Oregon State University study found that disease-spreading mosquitoes are more abundant in human-impacted areas than in protected national parks. The study suggests that modifying habitats may be a more effective strategy for reducing disease-carrying mosquito populations.
Researchers at HSE University have discovered microRNA molecules that can bind to coronavirus genomes, slowing down their replication and potentially allowing the virus to delay an active immune response. The study found four families of human miRNAs with binding sites for all seven types of human coronaviruses, including SARS-CoV-2.
A new study found that depression is associated with increased inflammation and metabolic changes, but not anxiety. The research used blood samples from over 300 people with depression and anxiety to identify biochemical markers, revealing distinct patterns of lipid metabolism and immune system involvement.
Astronomers have detected a Jupiter-sized planet, TOI-1899 b, orbiting a low-mass star, providing insights into the formation of giant planets. The discovery was made possible by the Habitable-zone Planet Finder spectrograph and offers a unique opportunity to study the properties of warm Jupiters.
A study published in American Political Science Review found that Facebook political ads were more partisan and less negative than TV ads in the 2018 campaign season. Social media was a more practical option for many candidates due to its affordability, with nearly 6,000 candidates using only Facebook ads.
In the early 20th century, José Carlos Amaringo Chico rose to power as an Ashaninka shaman-chief, driven by his unwavering belief in transformation and immortality. He took a strong anti-slavery stance, fueling social liberation movements and achieving a peaceful transition with Seventh Day Adventist missionaries.
A large-scale clinical trial has shown that lanthanum carbonate does not reduce the risk of cardiovascular disease developing in patients with chronic kidney disease. High phosphate levels are a common problem in kidney disease and linked to cardiovascular disease, but the study found no benefit from the medication.
Scientists studied giraffe and elephant foraging patterns in Kenyan savannas to understand how megaherbivores impact vegetation. They found that these animals prefer flat ground while feeding, leading to reduced damage on Acacia mellifera trees on steep slopes.
The report highlights a failure in global preparedness during the COVID-19 pandemic, emphasizing governance failures. Experts recommend strategies to re-center governance, including reforming international regulations and increasing funding for the WHO.
Scientists have introduced a new finding about hydrogen sulfide, producing superconducting structures at relatively high temperatures. The discovery uses stoichiometric H3S produced by heating elemental sulfur with excess hydrogen under pressure.
The University of North Texas Health Science Center has received a $45 million grant to study health disparities in Alzheimer's disease among multi-ethnic populations. The research aims to understand the biological framework of the disease in Mexican Americans, who develop Alzheimer's 10 years earlier than non-Latino whites.
Studies published in the Journal of Experimental Medicine found that sticky webs of DNA released from immune cells cause much of the tissue damage associated with severe COVID-19. Blocking the release of these DNA webs could be a new therapeutic target for managing severe forms of the disease.
A global study found that over 90% of conventionally farmed soils are thinning, with many having lifespans of less than a century. However, soils managed with conservation techniques tend to have longer lifespans, and certain practices like converting arable land to forest can help extend soil lifespan.
Research from the University of Kent found that TRESK plays a crucial role in regulating the brain's central circadian clock. Lowering TRESK levels disrupted the biological rhythm, causing the clock to lose its day-night association.
A team of researchers at KIT demonstrated that DNA damage can occur up to 30 DNA building blocks away from the entry point of UV radiation. This finding has significant implications for understanding DNA photodamage and its role in skin cancer.
Researchers successfully increased the catalytic activity of Rubisco in rice by transferring RbcS from C4 plant sorghum. This led to a 1.5-fold increase in catalytic rate and improved photosynthetic ability under high CO2 conditions. Further research is needed to apply this strategy to other major crops.
Researchers at Boston University School of Medicine aim to create new breast tumor models that represent women with comorbidities like diabetes, which can lead to improved outcomes in survival. The project's goal is to address the unmet clinical need for better treatment options for these patients.
Researchers found that older people without cognitive problems who experience a fall may have already begun neurodegeneration leading to Alzheimer's dementia. The study suggests that falls in this population are linked to brain changes that can be prevented with environmental modifications.