Researchers found that overexpressing 14-3-3 proteins can make tumors resistant to chemotherapy. The study, led by Julián Cerón and Simó Schwartz Jr., reveals a key role for the par-5 gene in DNA damage response and genomic stability.
A study has identified an antitumor molecule originating from a cancer-causing gene that inhibits pro-cancer action of the oncogene. The finding could lead to discovering other oncogenes and anti-oncogenes, contributing to tumor development.
A study led by Dr. Manel Esteller has completed the first epigenome in Europe, shedding light on the activity of genes and tissues in complex diseases like cancer. The research found that a patient with a rare genetic disease had an epigenomic defect causing fragility of chromosomes and immune deficiency.
A new study has identified a gene expression fingerprint associated with low sperm fertilizing capacity, predicting male infertility. The research used RNA profiling to analyze semen samples from 68 donors and found significant differences in gene expression between fertile and infertile individuals.
Scientists at IDIBELL have found a new checkpoint in cell cycle control through the joint action of two proteins, RPL11 and RPL5, which disrupts ribosomal biogenesis. This leads to the activation of p53 protein and cell cycle arrest.
Researchers from IDIBELL have discovered a new mechanism in cell division regulation through protein Zds1. This finding has significant implications for developing targeted and direct therapies against cancer by understanding the molecular mechanisms of mitosis.
Researchers at IDIBELL discovered that combining two mTOR inhibitors can stop liver cancer growth and destroy tumor cells. A clinical trial is underway to evaluate the efficacy of this combination in humans.
The study found that overactivation of RANK signalling pathway promotes tumour stem cells, increasing tumour growth and metastasis in human breast epithelial cells. High levels of RANK protein are associated with poor prognosis tumours and basal type tumours.
Researchers identified peroxiredoxin 2 as a key protein in predicting pulmonary metastases in breast cancer patients. The protein protects tumor cells from oxidative stress and promotes growth and proliferation in the lung. Modulating PRDX2 levels may provide a new therapeutic approach to prevent lung metastases.
The new IT application BootstRatio, developed by IDIBELL researchers, allows online statistical analysis of gene-expression data. It uses resampling techniques to generate a hypothetical distribution and provides comprehensible results for scientists.
A study of a rare neurodegenerative disease has uncovered a mechanism that destabilizes the homeostatic balance of brain cells, leading to fluid accumulation. The discovery identifies a protein GlialCAM as an ion channel subunit regulating chloride ions and potentially paving the way for new treatments.
Research reveals that BRG1 gene mutations render tumor cells unresponsive to hormones like retinoic acid and steroids, leading to continued growth and spreading.
Cancer cells losing cadherin-11 protein spread to nearby organs and structures like lymph nodes. Researchers propose recovering protein activity could slow tumour growth and decrease metastases.
Researchers from IDIBELL have discovered that human NK cells play a crucial role in rejecting porcine chondrocytes. By understanding this process, they aim to develop a method to reduce rejection and enable successful xenotransplantation of pig cartilage cells.
A new questionnaire has been designed to assess individual differences in bilinguals when changing languages. Research identifies several factors contributing to language switching, including proficiency, context, and unconscious changes. The study's findings suggest that bilingualism may have cognitive benefits, but more research is n...
A new treatment for alveolar rhabdomyosarcoma has been discovered by IDIBELL researchers, using 2-deoxyglucose to inhibit glucose metabolism and cause cell death in tumor cells. The molecule is similar to those used in PET imaging techniques and shows low toxicity at high doses.
A large-scale study has found that intrauterine devices (IUDs) may protect against cervical cancer. The research involved over 20,000 women from different countries and revealed a significant reduction in cervical cancer risk among IUD users.
Researchers have identified a mechanism that explains how cancer cells change their appearance and progress from a solid state to a semiliquid mass. The study found that microRNA-200S inactivation leads to this transformation, allowing tumour cells to evade natural defences and invade neighbouring organs.
The study identifies thousands of sites of DNA methylation in a large set of physiological and pathological tissues, providing insight into human body processes and disease. The research may lead to finding the unknown origin of metastasis and developing more effective therapies.
Researchers at IDIBELL found that Nutlin-3a stimulates the p53 pathway, inducing apoptosis and cellular senescence in brain cancer cells. This study suggests MDM2 antagonists may be new therapeutic options for glioblastoma treatment.
Researchers at IDIBELL have identified a small molecule called enoxacin that inhibits tumor growth by activating the 'dark genome' and microRNA molecules, offering new potential for cancer treatment. The study's findings open up new directions for anti-tumor therapy targeting microRNA as a therapeutic target.