A new study found that neuroticism is linked to increased brain activity during pain anticipation in individuals with irritable bowel syndrome (IBS). This heightened emotional response may exacerbate chronic pain conditions. Physicians should consider a patient's mental state when determining treatment regimens.
Developed by Cardiff University, the test identifies a wound type based on its gene signature with an initial accuracy rate of 98%. It has the potential to transform service provision and provide the right treatment at the earliest possible opportunity.
Researchers discovered that mast cells release protein MCPT4, degrading Gila monster venom helodermin, reducing morbidity and mortality. This mechanism also applies to scorpion venom, providing a natural defense against deadly toxins.
Researchers have discovered a protein called ubiquitin ligase Nedd4L as a new regulator of cystic fibrosis. Mice lacking Nedd4L in the lung developed cystic fibrosis-like disease, highlighting a promising therapeutic target. Enhancing Nedd4L function or inhibiting ENaC may alleviate symptoms of the disease.
Researchers discovered proteins and genetic material from the 1918 influenza virus in specimens from 37 soldiers, including four who died between May and August 1918. The findings suggest that the virus did not undergo a dramatic change during the pandemic, contributing to unusually high mortality.
A new image-guided technique may enable more stroke patients to be successfully treated, particularly those living far from specialist medical care. Researchers found no difference in recovery time or 90-day survival rates between patients receiving treatment within six hours of symptom onset.
A new study provides clear evidence that many primitive bird species survived right up until the time of the Chicxulub meteorite impact. The team identified and dated a large collection of bird fossils representing various species, showing diversity in size, beak structure, and other features.
A study reveals that tumors can disable the T cell–attracting protein CCL2 by modifying it with reactive nitrogen species, keeping T cells out. Scientists are now developing RNS-blocking drugs to restore T cell function and potentially enhance cancer treatment.
A study published in mBio reveals that the 2009 H1N1 pandemic flu virus causes more extensive damage to lung tissues than seasonal flu, making it more susceptible to bacterial infections like pneumonia. This damage compromises the protective epithelial cells, allowing bacteria to thrive and increase mortality.
Researchers challenged online gamers to predict the structure of a protein-cutting enzyme from an AIDS-like virus using the game Foldit. The players successfully generated accurate models, which were refined and determined to be correct within days.
Researchers investigated 50-million-year-old clam shells and wood from Antarctica, finding a climate rhythm resembling El Niño and La Niña in the South Pacific Ocean. The results indicate that global warming may not disrupt the ENSO climate rhythm above the South Pacific Ocean.
A UBC journalism project documents severely constrained access to morphine globally, revealing bureaucratic hurdles and the impact of the war on drugs. The Pain Project showcases stories of patients struggling with pain and caregivers who have fought against intractable systems.
A multidisciplinary approach using laser technology has been successfully employed to fabricate tiny scaffolds for cell delivery and growth in damaged neural tissue. This study demonstrates the potential of direct laser writing in tissue engineering, enabling precise control over scaffold design and structure.
A University of Melbourne study found that doctors failed to properly explain complications risks in over 70% of medical negligence cases. The study analyzed nearly 2000 claims and found that surgical procedures were the primary source of complaints.
The American College of Physicians advocates for a seventh ACGME/ABMS general competency on cost-conscious care. Meanwhile, research on Bisphenol A (BPA) exposure in relation to diabetes remains inconclusive. Additionally, local incidence data may improve the diagnosis of strep throat, which affects millions worldwide each year.
Researchers discovered a new class of molecules inhibiting white blood cell recruitment to sites of inflammation in the body. This breakthrough offers a more targeted approach to treating diseases like Inflammatory Bowel Disease (IBD).
Researchers found that EVLT and HLS are effective treatments for varicose veins, with similar rates of clinical recurrence. However, EVLT was associated with more adverse effects and improved hemodynamics, while HLS had a lower rate of saphenofemoral vein recurrences.
A recent study found that depression is a significant barrier to preventive health screening among Latina breast cancer survivors. The research revealed that Hispanic breast cancer patients are more depressed than their non-Hispanic counterparts and have lower rates of screening for colorectal and ovarian cancers.
Scientists have observed water's retardation of dynamism in biological enzyme substrate compounds, which acts like an 'adhesive' to control metabolic processes. This finding has implications for future drug design and development of medicines.
Researchers at UCSF found that bone marrow cells used to treat human hearts after a heart attack are impaired due to inflammation caused by the attack. This discovery may lead to new therapeutic approaches to improve treatment outcomes for heart attack patients.
A new analysis suggests that Earth's deep oceans can absorb enough heat to flatten the rate of global warming for periods of up to a decade. The study used computer simulations and found that ocean layers deeper than 1,000 feet are the main location of the 'missing heat' during these periods.
Despite advancements in treating STEMI patients needing emergency artery-opening procedures, delays continue to occur, particularly during transfers between hospitals. Researchers found that 34.2% of patients experienced delays, with the most frequent reasons being referral hospital delays and cardiac arrest.
A new multispectral fluorescence imaging system has been developed to localize cancer cells during surgery, enabling surgeons to detect small clusters of tumor cells that might otherwise go undetected. In a study on nine patients with ovarian cancer, the system successfully detected and removed all cancer cells in eight cases.
Experts argue that current film classification guidelines are inadequate and failing to control the impact on adolescents. Studies show a significant association between smoking depiction in films and increased risk of tobacco use among teenagers. The authors propose applying default 18 classification for all films containing smoking.
A new study by Potsdam Institute for Climate Impact Research finds that financial support for new technologies is necessary to cost-effectively protect the climate. The simulation shows that without targeted funding, high-cost reduction potential energy technologies will struggle to compete with familiar technologies.
Researchers observe helicase enzymes unzipping DNA by manipulating single molecules and observing nucleotide effects. They found ATP can cause unwinding, but only in single-molecule studies.
A Phase III trial demonstrated that the oral recombinant salmon calcitonin tablet OSTORA achieved superior efficacy to nasal calcitonin while showing equivalent safety. This offers a promising new treatment option for postmenopausal osteoporosis patients who have limited options due to side effects or poor tolerance.
A new technology developed by Purdue University researchers allows surgeons to detect small clusters of ovarian cancer cells, leading to improved removal rates. The technique uses a fluorescent imaging agent that 'homed' to cancer cells, illuminating their location during surgery.
The study reveals exactly how dynamin proteins form large assemblies that pinch off bubbles from cell membranes, allowing cells to 'eat' and compartmentalize external items. Understanding these miniature motors may enable the engineering of cells with new functions.
The 'Hacking Autism' initiative selects seven new software applications to be built by volunteer developers, aiming to improve daily life for individuals with autism. The selected apps include social stories, calendar management, medical journals, and communication tools.
Dr Nick Graham, a young researcher at James Cook University, has won the Scopus Young Researcher of the Year Award for his work on predicting fish populations in coral reefs. His research uses satellite data to study the architecture of coral reefs from space, providing valuable insights into how degraded reefs can recover.
Researchers at Brown University found that carbon nanotubes enter cells tip-first and at a 90-degree angle, often causing repeated inflammation. The team's study suggests that understanding how nanomaterials interact with cells is crucial for designing products that help cells rather than harm them.
Scientists have found that nanoparticles can cause brain injury in fish, leading to the formation of vacuoles and nerve cell death. The results may influence policy regulations on environmental protection and human safety.
A breakthrough allows scientists to assemble virtually complete genomes from DNA extracted from a single bacterial cell. This opens the door to sequencing bacteria that cannot be cultured in the lab, including those living on the planet's surface and within human bodies.
A new study found that epilepsy patients who receive additional treatment with antiepileptic drugs have a seven times lower risk of dying from a sudden unexpected death. The study suggests that the reduction in seizure frequency is the most likely explanation for this finding.
A new decision-support model developed by scientists can guide allocation of conservation funding to save more species from extinction. The model incorporates both ecological and economic information, prioritizing conservation activities based on a yearly budget.
Researchers from U of T, KAUST, and Penn State created the most efficient solar cell using collodial-quatum-dots (CQD), achieving record electrical currents and power conversion efficiency. The team's innovative approach eliminated charge traps, enabling rapid electron movement and providing a path to long-term stability.
Researchers have found that taking common medications for dementia does not cause further cognitive decline in those already suffering from the condition. The study involved 224 participants with established Alzheimer's dementia and suggests that low doses of certain medications may be safe for people with dementia.
Research from Autism Speaks Autism Treatment Network found that over half of children and adolescents with autism also have ADHD symptoms, compromising their adaptive abilities and quality of life. The study highlights the importance of identifying and treating ADHD symptoms in individuals with autism.
Researchers developed a noninvasive wireless system to measure breathing rates, alerting caregivers if breathing stops. The technique could increase surgery patient safety and reduce infant mortality by detecting sudden infant death syndrome (SIDS) without invasive monitoring.
A team of gamers solved the molecular structure of a retrovirus enzyme using online game Foldit, achieving results in just three weeks. The breakthrough could lead to the development of new anti-AIDS drugs by targeting specific features on the molecule.
A new study suggests that the planet's deep oceans can absorb enough heat to flatten the rate of global warming for periods of up to a decade. The research, based on computer simulations of global climate, points to ocean layers deeper than 1,000 feet as the main location of the 'missing heat'.
Researchers analyzed gene expression profiles in pigeon crops and found genes involved in cell growth, antioxidant production, and immune response. The study reveals the mechanisms behind pigeon 'milk' production, which is essential for young pigeon squabs.
A recent study found that pregnant women who consumed low-fat yogurt with fruit daily had children more likely to develop asthma and allergic rhinitis. Milk intake during pregnancy was not linked to increased asthma risk but may offer protection.
A new study found that prescription drugs accounted for 55% of ED visits and 76% of hospital admissions, with opioid-containing pain medications being the biggest contributor. The authors attribute the increase in exposure to a greater availability and access to medications in children's homes.
The University of Pittsburgh has received a $3.54 million grant to fund translational bioengineering research that employs engineering techniques to develop healthcare improvements. The award will support research partnerships between clinicians and engineers, with the ultimate goal of accelerating new technologies into patient care.
Research reveals that immunotherapies like CTLA4 strengthen the immune system's attack on cancer by blocking proteins that prevent T cells from activating. The study also shows that these therapies can keep tumors from benefiting from IDO, an enzyme used to suppress the immune response.
Researchers found a six-fold increase in pancreatitis cases and a higher rate of pancreatic cancer among patients using sitagliptin and exenatide. The study also suggests a possible link between these drugs and an increased risk of thyroid cancer.
A new study published in Autism Research found that parental age, maternal ethnicity, and paternal age are associated with an increased risk of autism spectrum disorders (ASD) and intellectual disabilities (ID), while household income has no significant link. The research also identified demographic risk factors such as male gender and...
Researchers found that high calcium intake increases prostate cancer risk among African-American men genetically predisposed to poor calcium absorption. This study provides insight into the link between diet and disease, suggesting personalized prevention strategies may be possible in the future.
Researchers uncover the complete skull and lower jaw of a previously unknown woolly rhino species, dating back to the Pliocene epoch. The discovery sheds light on the creature's diet and adaptation to its environment, revealing it ate high-altitude grasses before adapting to lower elevations during the Ice Age.
Researchers develop a method using flashes of light to observe quantum features of large objects with unprecedented resolution. By analyzing the dynamics of such behavior, pulsed quantum optomechanics provides a path for investigating whether macroscopic mechanical objects can be used in future quantum technologies.
Researchers found that temperature affects RNA structure, hiding or showing particular sequences that influence the recognition of intronic endings. This allows for alternative protein isoforms to be generated in response to changing temperatures.
Recent studies by Sanjay Kalra demonstrate that ALS damages neurons in cognitive and behavioral areas of the brain, contradicting previous assumptions. MRI scans reveal decreased levels of neural markers NAA and increased mIns, indicating biological changes responsible for behavioral symptoms.
The SILCS Diaphragm, a single-size contoured diaphragm, has shown effectiveness rates similar to traditional diaphragms, and is easy to use and comfortable to wear. This new contraceptive method offers women more control over their reproductive health, particularly in low-resource settings.
The University of California, Riverside has received a three-year NSF grant to establish the FORWARD project, aiming to recruit, retain and develop leadership skills of women faculty in STEM disciplines. The program will also create a statewide network for professional and personal support.
New research modifies soybean seed to increase phosphorus content, improving animal nutrition and reducing feed costs. The study suggests that low phytate soybean seeds may cause low vigor seedlings, which can be easily addressed through seed treatments.
A University of Oklahoma graduate student has received the EPA's STAR Fellowship Award to develop a low-cost method for removing fluoride from drinking water in rural Ethiopian communities. Her research aims to address severe overexposure to fluoride, which can cause bone damage and tooth discoloration.
NASA satellite imagery revealed 'hot towers' around Hurricane Maria's center, indicating its inner strength and potential intensification. Cloud temperatures also showed strong convection and powerful thunderstorms, with cloud-top temperatures as cold as -63F/-52C.
Researchers identified a new type of T cell that can produce acetylcholine, a neurotransmitter that blocks inflammation. This discovery suggests a novel approach to treating inflammatory and autoimmune diseases by targeting the nerves and T cells.