About The Study: This systematic review and meta-analysis indicates that differences exist between adjunctive atypical antipsychotics in the treatment of major depressive disorder with respect to overall efficacy and acceptability, which should be simultaneously considered. The absence of adequate and well-controlled studies documenting maintenance efficacy of adjunctive atypical antipsychotics in major depressive disorder remains a knowledge gap.
Corresponding Author: To contact the corresponding author, Roger S. McIntrye, MD, email roger.mcintyre@bcdf.org .
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(10.1001/jamapsychiatry.2026.0658)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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JAMA Psychiatry