About The Study: In this individual participant data meta-analysis, positivity cutoffs converged around 18 Centiloids (data-driven) and 27 Centiloids (visual reads). Findings from a double-cutoff analysis suggest that scans in the 11 to 26 Centiloid range should be interpreted with caution depending on the context of use.
Corresponding Author: To contact the corresponding author, Ganna Blazhenets, PhD, email ganna.blazhenets@ucsf.edu .
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(doi:10.1001/jama.2026.13116)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Media advisory: This study is being published to coincide with the Alzheimer’s Association International Conference.
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