Research on type 2 diabetes and its management. Covers nerve pain, early onset, BMI trajectories, and treatment side effects.
A systematic review and meta-analysis of 40 studies found that people with type 2 diabetes are 53% more likely to develop Alzheimer's disease. The review estimated that 4.7 out of 1000 people with type 2 diabetes will develop Alzheimer's in a year.
A new study reveals that the decline in thermogenic fat activity with age may explain why older people feel the cold more. The research suggests that restoring thermogenic fat activity could help understand and treat age-related metabolic problems, including obesity and type 2 diabetes.
Researchers found that parathyroid hormone and abaloparatide boosted bone formation in diabetic mice without increasing resorption, producing net bone gain. Osteocytes mediate this anabolic effect, offering a new strategy for improving tooth retention and dental implant success in diabetic patients.
The Endocrine Society establishes the Jesse Roth Award to recognize outstanding research in hormone action, diabetes, or metabolism. C. Ronald Kahn is the inaugural winner, who will deliver a lecture at ENDO 2027 and receive an honorarium and travel grant.
Researchers review how AI enhances continuous glucose monitoring to enable predictive, personalized diabetes management, improving glycemic outcomes and prioritizing high-risk patients. Machine learning models forecast individualized responses to meals, enabling tailored dietary and physical activity guidance.
Researchers review evidence on obesity drugs, finding potential benefits for brain function, especially for those with type 2 diabetes or obesity. They call for clinical trials to track cognitive abilities and emphasize the importance of monitoring older patients.
SLAS Technology journal Volume 41 features research on type 2 diabetes treatment, computational intelligence, and nanofiber engineering. The journal aims to advance life sciences discovery through education, knowledge exchange, and global community building.
Diabetic foot ulcers cause pain despite numbness, with patients experiencing unpredictable and severe discomfort. Patients struggle to manage their daily lives due to sleep disturbances and lack of pain recognition from healthcare staff.
A randomized controlled trial found that adding sleep coaching to a diabetes prevention lifestyle program helped participants sleep better and feel less sleepy during the day, leading to greater weight loss. Falling asleep earlier was associated with about 1.3 pounds of weight loss over eight weeks, independent of sleep duration.
Researchers found that sotagliflozin reduces excessive platelet activation, a process that can lead to dangerous blood clots that block flow to the heart and brain. The drug also makes platelets less likely to stick together and form blood clots, potentially lowering the risk of heart attack and stroke.
A study found that endocrinologists who scored higher on the American Board of Internal Medicine's Longitudinal Knowledge Assessment were more likely to prescribe key diabetes drug classes following a treatment guidelines update. The study analyzed Medicare claims data from 2017 to 2022 and included 1,061 endocrinologists caring for 17...
A long-term study found that 58% of participants assigned to metabolic-bariatric surgery achieved diabetes remission, compared to 3% on medical and lifestyle management. Researchers identified factors associated with remission, including shorter diabetes duration and greater early weight loss.
A new guide, Football for Diabetes, adapts football training for people with type 2 diabetes or prediabetes, focusing on individual abilities and enjoyment. The 12-week training programme combines warm-up, ball exercises, and small-sided games to benefit physical and mental well-being.
Researchers propose targeting G protein-coupled receptors to slow aging, exploring AI, systems biology, and digital twins for therapy design. The approach could work alongside senolytic, metabolic, and regenerative strategies.
Researchers propose novel therapies to rebalance GPCR signaling, potentially extending healthy years of life and delaying multiple age-related diseases. This network-level approach could give rise to personalized treatments and complement emerging longevity strategies.
A new study by Klick Labs reveals complex patterns in voice recordings that are associated with Type 2 diabetes. The research used 14,759 voice recordings from 461 adults, analyzing spectrograms and identifying acoustic patterns related to diabetes. The study achieved balanced accuracy of 71.3 percent for women and 72.4 percent for men.
Researchers discovered a protein called Miro1 linked to insulin resistance in muscle, offering a potential new target for future diabetes treatments. Removing Miro1 restored muscle response to insulin in preclinical models, while exercise reduced protein levels in people with Type 2 diabetes.
A new documentary reveals a nutritional method helping people improve and reverse type 2 diabetes. Nearly a dozen physicians and researchers share their research and scientific evidence demonstrating the diet's effectiveness.
A team of researchers found that carbonic anhydrase VIII (CA8) coordinates insulin secretion and hepatic glucose production in mice with type 2 diabetes. The study reveals that CA8 plays a crucial role in regulating metabolic functions in the liver and pancreas.
Researchers found that eating olive oil before carbohydrates reduces early blood glucose levels and slows gastric emptying in mice, while also increasing early secretion of glucagon, GIP, and GLP-1. These beneficial effects were retained in mice with type 2 diabetes and severe insulin deficiency.
A study published in the Journal of the Endocrine Society found that people with type 2 diabetes who sleep longer may be at a higher risk of developing or worsening diabetic kidney disease. Longer sleep duration was particularly associated with an increased risk among older adults and those with existing kidney damage.
A new 16-week clinical trial found that a low-fat vegan diet reduced liver fat by a third and improved insulin function in adults with type 2 diabetes. The study, which measured liver fat, muscle fat, visceral fat, and tissue AGE accumulation, showed that healthy eating can reverse underlying mechanisms driving the disease.
A UK study found that women with pregnancy complications, including gestational diabetes and high blood pressure, face an elevated risk of developing cardiometabolic-renal conditions in subsequent years. The study, which followed over 1.4 million women, identified associations between postnatal depression and an increased risk of four ...
A clinical trial found that feijoa powder improved systolic blood pressure in people with prediabetes, which was an unexpected finding in a study designed to test its effects on weight loss and blood sugar control. Larger trials are needed to confirm these results and fully understand the potential benefits of feijoa powder.
Mauritius has systematically monitored type 2 diabetes using the 2-hour oral glucose tolerance test, showing a 61% increase in prevalence between 1987 and 2009, but a 11% decrease between 2009 and 2021. The country's multisectoral approaches to prevention and management may hold the key to reversing the epidemic, according to the study.
Researchers found that a low-energy diet combined with structured exercise can reverse early onset type 2 diabetes in approximately half of participants. The study, which included 96 participants aged 18-45, showed significant improvements in blood sugar control, fitness, and muscle mass.
The phase 2b study evaluates the safety and efficacy of eloralintide in combination with tirzepatide, resulting in substantial weight loss and improvements in blood sugar control. The study demonstrated substantial weight loss and reduction in glycated haemoglobin (HbA1c) across different dosing combinations.
The ACHIEVE-4 study shows orforglipron pills offer superior weight loss and blood sugar control compared to insulin glargine, but with a higher gastrointestinal adverse event rate. Non-inferiority for cardiovascular safety and superiority for weight reduction were demonstrated.
The Novo Nordisk Foundation has renewed its $53 million commitment to the Broad Institute's Center for Genomic Mechanisms of Disease. This funding will accelerate research into the genetic and biological mechanisms underlying type 2 diabetes and obesity, with the goal of identifying new therapeutic targets. The center will expand on it...
Women are more likely to experience weight loss and improved blood sugar control with GLP-1 RAs, but face higher rates of side effects and unequal access to treatment worldwide. Extensive research is needed to address these disparities and optimize treatment for women in various domains.
Retatrutide demonstrates substantial weight loss and improved blood sugar control in adults with overweight and type 2 diabetes, with 47% of participants losing at least 20% of their starting weight. The treatment also improves cardiometabolic risk factors and reduces inflammation.
Researchers aim to identify biological mechanisms behind insulin resistance and develop therapeutic strategies. The study focuses on skeletal muscle tissue from lean and obese individuals, exploring protein modifications that distinguish insulin-sensitive from insulin-resistant muscle.
A new AI-based tool uses speech analysis to detect type 2 diabetes in just 20 seconds, with high accuracy rates. The model performed well across different sexes and ages, but had lower performance on recordings from Black participants and those with heart disease, high blood pressure, or obesity.
A study of 2 million adults in Ontario, Canada, found that moving from a high-poverty to a lower poverty neighbourhood significantly lowers the risk of developing type 2 diabetes. Individuals who moved experienced a 57% lower risk compared to those who remained in the same high-poverty area.
A new study found that consuming red meat linked to a 63% higher risk of developing type 2 diabetes due to Neu5Gc, a non-human sugar found in red meat. Higher levels of Neu5Gc were associated with greater risk, even after adjusting for other factors.
Researchers have identified a unique 'bacterial signature' that flags individuals at risk of type 2 diabetes, even if their blood sugar levels are normal. The study analyzed data from over 200,000 adults and found that changes in the gut microbiome can be detected before the onset of diabetes.
A new study suggests that eating a diet low in ultra-processed foods and exercising regularly can reduce the risk of type 2 diabetes, even in those with a strong genetic predisposition. The analysis of data on tens of thousands of people found that those who followed these habits were up to 70% less likely to develop the condition.
A new post-hoc analysis of the ATTAIN-1 and -2 studies found significant and similar weight reductions for women of different menopausal status, with up to 14% body weight loss and 12.5cm waist circumference reduction
A study of 1.6 million patients found that the risk of developing chronic kidney disease or heart failure increases substantially over time after a type 2 diabetes diagnosis. Early, proactive management is crucial to reduce the risk of serious complications.
A study of over 6 million people found that individuals diagnosed with type 2 diabetes before the age of 20 were more likely to have ADHD (14%) and autism (5.7%) compared to those without T2D. This suggests that healthcare systems may need to consider the needs of neurodivergent people when providing care for early-onset T2D.
A new study published in JAMA Network Open found that Black and Hispanic patients are less likely to adhere to their diabetes medications compared to White patients. The study, which analyzed national health data from 2019, showed that extra assistance programs significantly reduced treatment gaps, particularly for high-cost treatments.
A nationwide study in Denmark found that cancer incidence is 12% higher among men with type 2 diabetes and 22% higher among women with type 2 diabetes compared to those without diabetes. Obesity-related cancers, such as colorectal and postmenopausal breast cancer, are particularly prevalent among people with type 2 diabetes.
A UK Biobank study found that higher levels of moderate-to-vigorous physical activity are associated with a substantially lower risk of developing type 2 diabetes, particularly among younger adults. Encouraging older adults to be physically active could prevent more cases of type 2 diabetes due to their high overall risk.
Researchers at Pennington Biomedical developed GVC-Calc to analyze continuous glucose monitoring data, providing a scalable and transparent approach. The platform supports batch processing, integrates individual-level data with cohort-level results, and offers consensus clinical metrics alongside exploratory measures.
Researchers identified a distinct risk profile for young adults with early-onset fatty liver disease, associated with genetic factors and metabolic conditions like type 2 diabetes. The study highlights the need for more accurate liver screening and assessment for individuals at greatest risk.
The EASD has published its first evidence-based clinical practice guideline on diabetes distress, emphasizing the importance of assessing and managing emotional burdens in adults with type 1 and type 2 diabetes. The guideline aims to improve clinical care and outcomes by incorporating a person-centered approach to diabetes care.
Researchers at UTHealth Houston developed a treatment that reverses nerve pain in diabetic mice by targeting the MMP-9 enzyme, which breaks down proteins and causes immune response. The new monoclonal antibodies selectively inhibit MMP-9 activity, regenerating nerve fibers and improving wound healing.
Women with a history of gestational diabetes in pregnancy are at a substantially increased risk of developing type 2 diabetes later in life, with a median onset age 13 years earlier than those without prior gestational diabetes. They also experience more severe disease, requiring insulin treatment more frequently.
A recent study identified three distinct BMI trajectories among people with type 2 diabetes, with stable, increasing, and decreasing trajectories associated with different comorbidities and healthcare service use. Increasing BMI was linked to a clustering of chronic diseases, while weight loss was not always indicative of better health...
A study found that SGLT2 inhibitors increase the risk of ketoacidosis in patients with type 2 diabetes who have high blood glucose, low body weight, or a history of ketoacidosis. The risk persists throughout treatment duration, highlighting the need for better support for high-risk patients.
A study published in PLOS Medicine found that women with type 2 diabetes are more likely to develop mental health conditions, while men experience more cardiovascular and renal complications. The researchers analyzed data from 28,720 men and women in the UK, revealing significant sex differences in disease trajectories.
A 10-fold increase in new case rate of type 2 diabetes in young people under 20 years old since the turn of century has led to a significant shift in the disease's demographics. The study found an accelerating trend in type 2 diabetes incidence, with a 3.8% annual increase between 2002 and 2023.
Researchers suggest that targeting tiny protein aggregates known as oligomers, which form early in the disease process, may lead to breakthroughs in treating protein-misfolding diseases. Oligomers are increasingly believed to drive cellular damage, and their early formation may be more toxic than large protein deposits.
Research shows a link between dollar store food quality and higher rates of obesity, high blood pressure, and type 2 diabetes. Traditional grocery store access is associated with better health metrics, according to a new study published in BMC Public Health.
A key molecule released during exercise, L-β-aminoisobutyric acid (L-BAIBA), has been discovered to strengthen muscles, improve exercise performance, and protect against muscle damage in type 2 diabetes. The study reveals L-BAIBA's role in muscle adaptation, metabolism, and contraction, offering promising insights for future therapies.
A new study has found that women with endometriosis are at a 46% higher risk of developing type 2 diabetes. The study analyzed nearly 3 million women over 25 years and suggests that chronic inflammation associated with endometriosis may play a role in metabolic health.
Tirzepatide has been shown to reduce the risk of heart attacks and hospitalizations due to infections in people with type 2 diabetes and obesity. The study found a relative risk reduction of about one-third, corresponding to a 36% reduced risk of infection-related hospitalization.
Researchers tracked nearly 80,000 adults with type 2 diabetes over ten years, finding those who consistently took their prescribed medication stayed free of serious heart and circulatory complications for over seven extra months. Low adherence was linked to a higher risk of cardiovascular disease, especially in younger adults.
Researchers found that people with well-controlled HIV have more fibrosis in their fat tissues, leading to insulin resistance and type 2 diabetes. The study also identified a blood marker of scarred fat, which may help predict metabolic future for individuals with HIV.
Adults with type 2 diabetes have a high risk of fragility fractures, but new research found GLP-1 receptor agonists reduce this risk by 21% compared to DPP-4 inhibitors. The largest reductions occurred in hip, femur, and spine fractures.