Research on type 2 diabetes and its management. Covers nerve pain, early onset, BMI trajectories, and treatment side effects.
A large US study published in The BMJ found that GLP-1 receptor agonists used to treat type 2 diabetes and obesity may also help lower the risk of addiction to various substances. The study associated GLP-1 receptor agonists with reduced risks of adverse outcomes such as overdoses and drug-related emergency department visits and deaths...
Researchers found that GLP-1 medications are effective at reducing the risk of developing substance use disorders across all major addictive substances, including a 14% reduced risk for developing any substance use disorder. The study also showed significant reductions in severe harm, including overdose and death, among patients with p...
A large observational study found that sleeping 7 hours and 18 minutes per night may help prevent insulin resistance and type 2 diabetes. However, weekend catch-up sleep can increase the risk of impaired glucose metabolism in those who sleep beyond this threshold every night.
A Pennington Biomedical researcher published an editorial on the benefits of fruit intake for vascular health, citing a study on increasing fruit intake with avocados and mangos. The findings suggest that diets rich in fruits can improve nutrient status and health outcomes, aligning with the goals of the Food Is Medicine initiative.
Researchers found that individuals with type 2 diabetes who used GLP-1 receptor agonists in combination with healthy lifestyle habits had a substantially lower risk of major adverse cardiovascular events. Lifestyle habits that reduced cardiovascular risk included healthy eating, regular physical activity, and good stress management.
A new study by Harvard T.H. Chan School of Public Health and the Department of Veterans Affairs Boston Healthcare System found that using GLP-1 receptor agonists in combination with adhering to healthy lifestyle habits significantly reduces cardiovascular risk among individuals with type 2 diabetes. The study showed that these two stra...
A survey of 1,998 US adolescents aged 10-19 found nearly 1 in 3 have diabetes or prediabetes. Waist-to-height ratio emerged as the strongest independent predictor of these conditions.
A new study found that adding one avocado and a cup of mango to daily meals and snacks for eight weeks improved vascular function among adults with prediabetes, while also reducing diastolic blood pressure. The Avocado-Mango diet showed significant increases in flow-mediated dilation and nutrient-dense nutrients without changes in calo...
Syzygium jambolanum extracts demonstrate significant protective and antidiabetic effects, improving glycaemic control and metabolic health. The study reveals a systemic protective effect beyond glucose lowering alone.
The ESE and ESPE have launched a landmark Joint Clinical Practice Guidance to support structured and effective transition of young people with endocrine conditions. The Guidance provides practical, evidence-based recommendations to ensure continuity, safety and quality of care during this critical phase in a patient's life.
Researchers developed an oxygen-delivering gel to heal chronic wounds that fail to heal for more than a month. The gel conforms to the wound's shape and provides continuous oxygen levels, helping transform nonhealing wounds into normal injuries.
A study from Lund University found that a climate-friendly diet rich in plant-based foods like wholegrains, legumes, fruit, and vegetables leads to better nutritional status compared to traditional diets. Despite lower meat consumption, most participants achieved sufficient amounts of key vitamins and minerals.
A nationwide cohort study found that semaglutide initiators had a significantly higher risk of developing nonarteritic anterior ischemic optic neuropathy compared to sodium-glucose cotransporter-2 inhibitor initiators. The absolute risk was low, but clinicians and patients should be aware of this rare but evident increased risk.
University of Pittsburgh scientists discovered a way to fight insulin resistance and diabetes by protecting a special type of immune cell in fat tissue. By improving insulin sensitivity in mice, the research reveals a potential new treatment path for type 2 diabetes that could supplement GLP-1 drugs.
A new global study finds that physical inactivity is a significant driver of diabetes complications, with up to 10% of cases potentially preventable. The research emphasizes the need for tailored approaches to promote physical activity among people with diabetes, particularly addressing social and gender inequalities.
Researchers found that subtle changes in retinal blood vessel geometry triggered by postural shifts can predict disease progression. Abnormal increases in arteriolar tortuosity and changes in venular branching behavior were linked to higher or lower likelihood of retinopathy progression.
A recent study published in JAMA Internal Medicine found that oral semaglutide has a potential benefit in reducing heart failure events among people with type 2 diabetes and existing heart failure. The data support the use of oral semaglutide as a treatment option for these patients.
A study co-led by UMass Amherst researchers identified hundreds of genes and proteins linked to Type 2 diabetes, many not captured by blood samples alone. The research found that genetic diversity across populations is crucial for identifying disease drivers.
A global genomics study reveals that genetic variants influence gene activity and protein abundance in multiple tissues, not just blood samples. This analysis identifies causal evidence for 676 genes linked to type 2 diabetes.
A randomized controlled trial found that contingent discount financial incentives on medication expenses can improve glycemic control and encourage engagement with ongoing monitoring among patients with poorly controlled type 2 diabetes. After six months, the intervention group showed greater improvements in long-term blood sugar level...
Researchers found that higher testosterone levels reduced risk, while increased estradiol levels increased cardiovascular risk in male participants. In contrast, women with diabetes showed no significant link between hormone levels and cardiovascular outcomes.
A produce prescription program improved nutrition security among Medicaid patients with diabetes, increasing it from 23.2% to 38.7%. The program also improved food security, with 42.9% of participants reporting secure access to healthy foods after completion.
A randomized clinical trial found that a smart speaker-based intervention significantly improved mental distress, quality of life, and diabetes self-care among older adults with type 2 diabetes. This easily implemented self-management strategy may enhance health outcomes in this population.
A modelling study suggests that preventing high blood glucose from turning into type 2 diabetes with lifestyle changes could result in a 67% reduction in greenhouse gas emissions. Well-controlled type 2 diabetes management could cut CO2 emissions by 21%, adding nearly 2 extra years of life.
Researchers discovered a probiotic strain, Bifidobacterium animalis subsp. lactis B960, that enhances the glucose-lowering effects of glibenclamide with minimal degradation. This combination therapy reduces fasting blood glucose levels and improves pancreatic function while alleviating hepatotoxicity.
A comparative effectiveness study found that SGLT2 inhibitors were associated with a lower risk of chronic kidney disease and acute kidney injury compared to GLP-1 receptor agonists. These findings suggest that SGLT2 inhibitor treatment may be an effective strategy for preventing kidney disease in individuals with type 2 diabetes.
Researchers identified metabolites associated with type 2 diabetes risk, revealing genetic and lifestyle factors that influence these metabolites. A unique signature of 44 metabolites improved prediction of future risk of type 2 diabetes beyond traditional risk factors.
A new study from Karolinska Institutet reveals that long-term type 2 diabetes can cause red blood cells to become directly harmful to blood vessels. The researchers found that microRNA-210 plays a crucial role in this process, and its levels in red blood cells may serve as a biomarker for early detection of cardiovascular complications.
Researchers mapped nearly 400 genetic regions regulating circulating proteins, identifying 18 with a likely causal link to T2D. These findings provide new insights into disease biology and could lead to earlier and more accurate diagnoses, as well as treatments tailored to African populations.
A new study has identified unique protein signatures linked to ethnicity and changes in physical activity, which may influence cardiometabolic health. The research found that South Asian individuals may face a higher risk of cardiometabolic disorders due to distinct immune, inflammatory, and metabolic pathways.
Researchers discovered that natural light exposure improves blood glucose levels and reduces variability in people with type 2 diabetes. The study also found that melatonin levels increased and fat oxidative metabolism improved when participants were exposed to natural light.
A large population-based study found that SGLT-2 inhibitors reduced the risk of diabetic foot problems compared to GLP-1 receptor agonists. The difference was mainly due to fewer cases of nerve damage in the feet among SGLT-2 inhibitor users.
A recent study by University of Eastern Finland found that prediabetes has increased significantly in Finnish children living with overweight or obesity, rising from 11% to 50% over two decades. The study suggests a potential link between maternal overweight and the rise in child prediabetes prevalence.
A large cohort study found that statins significantly reduce the risk of death and major cardiovascular events in adults with type 2 diabetes. The findings challenge long-standing uncertainty about whether patients at low risk benefit from preventive statin therapy, suggesting that the drugs may have broader protective value.
A major review in Frontiers in Science highlights how unsustainable food systems contribute to both health and climate crises. Experts examine evidence-based strategies to tackle industrial food systems promoting overconsumption and environmental pressures.
A comprehensive review highlights the urgent need to transform unsustainable food systems, which drive both obesity and environmental harms. The authors recommend subsidies for healthy foods, taxes on unhealthy products, and restrictions on aggressive marketing to address these twin crises.
Researchers found that the healthy Nordic diet was more effective in reducing blood glucose levels and improving body weight, inflammation, and lipid profile compared to other diets. The study also showed that participants lost weight despite being allowed to eat as much as they wanted from recommended foods.
Using GLP-1 receptor agonists may lower the risk of vertebral compression fractures and related surgical interventions in people with type 2 diabetes. The study suggests that these medications have a bone-protective effect, offering benefits for patients.
A recent study found that home-delivered groceries can significantly improve blood sugar control among adults with type 2 diabetes who experience food insecurity. The program provided culturally relevant, medically tailored groceries and education materials, leading to a clinically meaningful reduction in hemoglobin A1c levels.
Researchers from The University of Osaka found that blood sugar migration to saliva in individuals with type 2 diabetes causes an imbalance in the oral microbiome, leading to cavity development. Improved glycemic control reduces this imbalance and the risk of tooth decay.
A systematic review and meta-analysis found that GLP-1 receptor agonists probably have little or no effect on the risk of thyroid, pancreatic, breast, or kidney cancer in patients with type 2 diabetes or overweight/obesity. However, longer-term studies are needed to clarify potential risks or benefits for other obesity-related cancers.
A study published in Environmental Endocrinology found that teens with higher blood levels of PFAS before bariatric surgery had smaller improvements in blood sugar over five years. This could lead to the metabolic benefits of the surgery fading within a decade.
The UCF Health Mobile Health Clinic provides free high-quality healthcare services to underserved communities, serving as a real-world classroom for medical and nursing students. The clinic aims to reduce preventable conditions and improve long-term health through comprehensive screenings, chronic disease monitoring, and education.
A large study found that people with type 1 and type 2 diabetes have a higher risk of sudden cardiac death, particularly in younger adults. The research also showed that sudden cardiac death contributes to shorter life expectancy for those with diabetes.
A research team at Max-Planck-Gesellschaft found that pregnant mice exposed to fatty food smells developed more pronounced obesity and insulin resistance in their offspring. The brains of the offspring showed similarities to those of obese adult mice, suggesting a potential link between maternal diet and child health.
A nationwide observational study from SWEDEHEART reveals that patients with type 1 diabetes have a significantly higher risk of stent complications compared to those without diabetes. The study emphasizes the need for adapted treatment and follow-up strategies for this patient group.
Researchers at University of Cologne identify p35-mediated CDK5 hyperactivity as a central mechanism limiting nerve regeneration in diabetes. Targeted interventions using peptides restore nerve fiber growth, leading to significant motor and sensory improvements.
Researchers used MRI 3D mapping to analyze changes in gluteus maximus shape over time and its association with type 2 diabetes. The study found that men showed muscle shrinkage, while women showed enlarged muscle, highlighting sex-specific differences in response to insulin tolerance.
The report emphasizes the importance of pairing research with policy partners and investing in mentorship and career advancement of Latino scientists and students. It also calls for implementing evidence-based practices, using telemedicine and AI equitably, and designing trauma-informed interventions that fit Latino family life.
Researchers identified 251 genetic variants that significantly affect circulating protein levels in Greenlanders, showing stronger genetic control over certain proteins in the Inuit population. The study uncovered 70 previously unreported associations and found links between Arctic-adapted genes and disease development.
A study comparing GLP-1 RAs found that all three drugs are relatively safe options for patients with type 2 diabetes, with minimal differences in kidney and cardiovascular risks. Liraglutide had a lower risk of all-cause mortality compared to dulaglutide.
Researchers analyzed insurance claims data from US health insurers to demonstrate the cardiovascular benefits of semaglutide and tirzepatide. Both GLP-1 drugs provide cardioprotective effects, reducing the risk of stroke and heart attack by 18% and 13%, respectively.
Researchers found that prasugrel may offer an advantage over ticagrelor for individuals with Type 1 or Type 2 diabetes and complex coronary disease. This is because the two medications are not interchangeable, and treatment with prasugrel may provide better benefits in preventing blood clots and adverse cardiac events.
A new poll finds that 65% of Americans would try a low-fat, plant-based diet to prevent type 2 diabetes or improve blood sugar control. The poll also reveals that most adults are unaware of the benefits of high fruit and vegetable intake for reducing diabetes risk.
A comprehensive analysis of 70,000 participants across 10 trials found that SGLT2 inhibitors reduced the risk of chronic kidney disease (CKD) progression by 38% and slowed eGFR decline by 51%. The treatment was beneficial for all levels of kidney function and albuminuria levels, particularly in reducing hospitalizations.
The study suggests that SGLT2 inhibitors can benefit patients with varying levels of kidney function and albuminuria. Routine use of these medications may lead to improved kidney outcomes across different patient groups.
Researchers explore the link between senescent cells and metabolic diseases, highlighting potential treatments known as senotherapeutics. Senolytics, senomorphics, and senosensitizers are interventions aimed at eliminating or suppressing senescent cells to mitigate metabolic disease.
A study found that following steps to improve cardiovascular health can reduce the risk of mild cognitive impairment and dementia among people with Type 2 diabetes. Maintaining optimal cardiovascular health may protect brain health even for individuals with a high genetic risk for dementia.
A preliminary study found that low-dose aspirin use was associated with a lower risk of major cardiovascular events, including heart attacks and strokes, among adults with Type 2 diabetes. The analysis of 11,500 individuals over 10 years showed that consistent aspirin use led to significant reductions in cardiovascular event rates.
A new observational study found that semaglutide, tirzepatide, and dulaglutide have similar gastrointestinal safety profiles among patients with type 2 diabetes. The medications were assessed in a large database of adults with T2D, who underwent treatment with these GLP-1 RA medications between 2019 and 2024.