Research on type 2 diabetes and its management. Covers nerve pain, early onset, BMI trajectories, and treatment side effects.
A new study suggests that marbling of fat inside muscles is a strong indicator of poor health, including obesity, Type 2 diabetes, and neuromuscular disorders. The research found that intramuscular fat acts as a physical barrier obstructing muscle healing and regeneration.
A recent study found that patients with type 2 diabetes experience worse financial outcomes, including below-prime credit scores and medical debt in collections. Nearly two-thirds of diabetes patients were estimated to have an adverse financial outcome, compared to half of other patients. The findings highlight the importance of screen...
A study assessing the Enhanced Primary Care Diabetes model found that Black patients were less likely to meet diabetes care goals, despite more frequent nurse touchpoints. Younger age, insulin use, and fewer initial medication counts were associated with slower progress.
A new web-based tool, Coverage Checker, helps Michigan physicians navigate diabetes coverage and prior authorization. The tool shows care team members which insurance policies cover guideline-directed medical therapy and continuous glucose monitors, and the prior authorization steps required.
Patients with type 2 diabetes experience more severe financial difficulties compared to those without the condition. The study emphasizes the importance of considering patient financial health when treating type 2 diabetes, particularly for vulnerable populations.
A large study suggests that GLP-1 receptor agonists may have a lower cumulative risk of developing dementia compared to metformin. The findings indicate that these drugs could be prioritized in future clinical guidelines for the treatment of type 2 diabetes.
A new study found that exposure to PFAS, a class of synthetic chemicals, may increase the risk of developing type 2 diabetes. Higher levels of PFAS were associated with a significantly greater risk of developing T2D in the future.
Researchers have discovered a non-autoimmune form of type 1 diabetes prevalent in young people in Sub-Saharan Africa, differing from the typical autoimmune pattern seen in other regions. The study's findings also suggest an ancestral or genetic link between this subtype and African ancestry in the US.
A recent study published in JAMA Network Open found that glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment was associated with reduced all-cause mortality among older patients with cancer and type 2 diabetes. The survival benefit persisted across various subgroups, including age, sex, and cancer type.
A new study found that consuming pistachios every night for 12 weeks altered bacteria in the gut of adults with prediabetes, increasing beneficial short-chain fatty acids like butyrate. The changes may offer long-term health benefits, potentially slowing Type 2 diabetes development or reducing inflammation.
A new study suggests that erythritol, commonly used in low-carb products, can alter the function of brain microvascular endothelial cells, leading to increased risk of stroke. The sugar substitute was found to constrict blood vessels and reduce the production of natural clot-busting compounds.
Researchers identified TMEM9B-AS1, a long non-coding RNA that regulates cellular functions, as significantly reduced in skeletal muscles of people with type 2 diabetes. Its absence disrupts protein production, leading to muscle weakness and loss.
A new Leicester study found that women with type 2 diabetes are nearly twice as likely as men to have hidden heart damage, according to researchers. The study used advanced MRI scans and data from four studies conducted at the NIHR Leicester Biomedical Research Centre.
A recent study published in Nature reveals that weight loss triggers the breakdown and recycling of fats called lipids, potentially leading to improved health outcomes. Weight loss also clears out senescent cells, which are ageing and damaged cells that accumulate in tissues, reducing inflammation and scarring.
A study of 679 patients found that longer GLP-1RA treatment, not having diabetes, and higher body fat were associated with better weight reduction. Higher muscle mass and metabolic rate also contributed to successful weight loss in patients with overweight or obesity.
A study of 168,547 postmenopausal women found that excess weight is associated with a 31% higher risk of breast cancer in those with cardiovascular disease. Higher BMI also increases the risk in women without cardiovascular disease, although to a lesser extent.
A Cornell University study found that people with more copies of the AMY1 gene have higher salivary amylase activity, which may be protective against Type 2 diabetes. Researchers suggest that a higher copy number may lead to earlier insulin release and lower blood glucose levels.
A new study confirms that intensive lifestyle modification is more effective than metformin in preventing the onset of Type 2 diabetes. The health benefits from lifestyle intervention persisted for over 20 years, with participants experiencing a reduced risk of developing diabetes compared to those on metformin.
A new study found that the newer generation of effective diabetes medications are not reaching enough patients. The study analyzed data from over 40,000 records and found that only 20% of patients with type 2 diabetes were taking GLP-1 drugs within a year of diagnosis, and less than 15% were taking SGLT2 drugs.
A clinical trial found that semaglutide, a Type 2 diabetes drug, improved blood sugar levels and weight loss in adult Type 1 diabetes patients who use automated insulin delivery systems. The study showed that 36% of patients taking semaglutide achieved target blood glucose levels and lost at least 5% of their body weight.
A new study published in the Journal of the American Heart Association found that residents in U.S. coastal counties near ocean waters with high concentrations of microplastics are at higher risk for Type 2 diabetes, coronary artery disease, and stroke. The study analyzed data from 152 counties and found a significant association betwe...
A landmark review highlights how diabetes alters bone microarchitecture and increases fracture risk in people with type 2 diabetes, despite normal or elevated bone mineral density. The authors advocate for updated diagnostic tools, including a revised TBS algorithm, to more accurately reflect bone quality in individuals with central ob...
The University of Gothenburg, AstraZeneca, Knut and Alice Wallenberg Foundation, and Region Västra Götaland are partnering to tackle metabolic disorders. The SEK 200 million initiative aims to deepen understanding of obesity's mechanisms and develop effective treatments.
A new study finds that a lower-sodium DASH-style diet can produce clinically meaningful reductions in blood pressure for adults with type 2 diabetes. The study, which modified the original DASH diet for people with type 2 diabetes, achieved a 5-point reduction in systolic blood pressure, resulting in lower risks of stroke, cardiovascul...
A University of Oxford study found that an intensive low-energy diet programme significantly improved eating disorder symptoms in people with type 2 diabetes and excess weight at risk of developing eating disorders. The programme showed benefits persisting six months after completion.
A new study from the University of Colorado Anschutz Medical Campus shows that primary care clinics can effectively introduce continuous glucose monitors (CGMs) into their practices. The study found that both self-guided and virtual CGM initiation services were successful, regardless of clinic size or diabetes expertise.
The CONFIDENCE trial demonstrates that combination therapy with finerenone and empagliflozin leads to significantly greater reductions in albuminuria than either agent alone. The study shows a 52% median reduction in urinary albumin-to-creatinine ratio, achieving the ADA-recommended target for 70% of patients.
Researchers have discovered a key marker, FXYD2, that identifies functional maturity and heterogeneity of stem cell-derived islet organoids. This breakthrough enables quality control for production of transplantable islets, advancing the field toward safer and more effective islet replacement therapies.
A new study published in Nature Medicine suggests that individual differences in blood sugar responses to various carbohydrates can indicate specific metabolic health subtypes. These subtypes are associated with different levels of insulin resistance or beta-cell dysfunction, which can contribute to prediabetes and Type 2 diabetes.
Researchers developed a new approach to identify healed diabetic foot ulcers at risk of reopening based on trans-epidermal water loss measurements. High TEWL values were linked to increased wound recurrence and shorter time to recurrence, suggesting functional skin barrier defects are a critical factor in wound healing.
A NIH-funded study has identified trans-epidermal water loss as a reliable predictor of diabetic foot ulcer recurrence. Participants with high TEWL were 2.7 times more likely to experience wound recurrence, highlighting the importance of skin barrier function in wound healing.
Researchers found that an inexpensive HIV drug can improve vision in patients with diabetic macular edema (DME) more effectively and at a lower cost than existing treatments. The drug, lamivudine, is taken orally and may represent a game-changing option for millions of patients worldwide.
Researchers have uncovered unique molecular fingerprints for insulin sensitivity, challenging traditional binary classification of people with type 2 diabetes. These signatures can help identify individuals at risk earlier than current methods, paving the way for personalized treatments and precision medicine.
Sustained midlife weight loss was associated with lower chronic disease incidence and decreased all-cause mortality. The study's findings suggest that maintaining a healthy weight during middle age can have long-term health benefits.
Scientists have created a vascularized organoid model of hormone-secreting cells in the pancreas, promising to improve diabetes research and cell-based therapies. The model, developed by Max Delbrück Center researchers, contains greater numbers of mature beta cells and secretes more insulin than non-vascularized counterparts.
A new protocol has been developed to establish a safer standard for medication use during breastfeeding. The study focuses on the concentration of prednisolone and metformin in breast milk and infant plasma, addressing a significant knowledge gap in human lactation studies.
A study found that children exposed to higher levels of air pollution experienced rapid weight gain and higher BMI by age 13, leading to increased insulin resistance in their mid-20s. The study suggests early interventions can help reduce the risk of chronic disease.
The American Heart Association has awarded nearly $1.2 million in planning grants to 12 researchers testing the efficacy of food is medicine interventions, such as produce prescriptions and medically tailored groceries. The grants support clinical trial protocols to develop and test these approaches for treating chronic diseases like c...
A study published in the Journal of Clinical Investigation finds that excessive activity in certain brain neurons is responsible for elevated blood sugar in diabetic mice. Targeting these neurons may lead to diabetes remission, but not necessarily obesity reversal.
A new USC-led study found a significant link between type 2 diabetes and cortical thickness in older adults from various populations. The researchers discovered that individuals with T2DM exhibited thinner cortex, particularly in temporal and parietal regions critical for memory and cognitive function.
A new study has discovered a link between delayed puberty and an increased risk of developing type 2 diabetes in boys. According to the research, adolescent boys who experience delayed puberty are 37% more likely to develop type 2 diabetes in early adulthood, regardless of their weight or socio-economic status.
Researchers identified six risk groups for cardiometabolic complications in older people without type 2 diabetes, with a special high-risk group characterized by inflammation and insulin resistance. The study emphasizes the need for precise early detection and prevention strategies.
Researchers at Pennington Biomedical found that mitochondrial fragmentation can bypass defects in mitophagy to sustain skeletal muscle quality control in patients with Type 2 Diabetes. This adaptation helps maintain mitochondrial function despite impaired mitophagy.
A new MRI technique measures a person's 'functional age' of their heart, revealing how unhealthy lifestyles add years to their heart's aging process. This method has the potential to transform heart disease diagnosis and offer a lifeline to millions by catching problems early.
New findings from multiple studies demonstrate the significant benefit of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on cardiovascular outcomes like heart failure, acute myocardial infarction, and peripheral artery disease. GLP-1RA use has been associated with a lower risk of all-cause mortality in patients with type 2 diabetes.
A recent study published in Diabetes Care found that persistently high blood sugar and insulin resistance significantly increased the risk of worsening functional and structural heart damage during adolescence to young adulthood. The study showed a five-fold increase in prediabetes prevalence among adolescents, with females being dispr...
A combination of bazedoxifene and conjugated estrogens reduces obesity-related changes in rats, including fat cell accumulation and insulin resistance. The treatment also increases beneficial gut microbes and improves metabolic health, making it a promising alternative to tamoxifen for women at high breast cancer risk.
A Kobe University team developed a DNA base editing technology that enables precise control over microorganism genetic content without using template DNA from other organisms. They successfully applied this technique to industrially important Lactobacillus strains, creating safer probiotics for people with type 2 diabetes.
A study published in JAMA found that metformin reduced knee arthritis pain over six months in patients with symptomatic knee osteoarthritis and overweight or obesity. The treatment was shown to have a moderate effect on pain reduction, with the metformin group reporting a 31.3 point decrease compared to the placebo group.
A study published in JAMA Neurology found that GLP-1RAs and SGLT2is may have neuroprotective effects for people with Type 2 diabetes and those without diabetes. These findings suggest that these medications may slow the rate of cognitive decline in Alzheimer’s patients.
The research aims to bridge the translational gap between animal and human studies, exploring how obesity impacts decision-making around food. The team will measure brain chemical activity while participants consume sugary drinks and complete emotion-related tasks.
A new American Heart Association scientific statement emphasizes the importance of multidimensional sleep health in reducing cardiometabolic risks. The statement reviews evidence on the relationship between sleep and various health factors, including body fat, blood sugar, cholesterol, and blood pressure.
Researchers used ULM to monitor pancreatic microvasculature in a rat model, tracking microbubble trajectories and quantifying vascular parameters. Anti-cytokine immunotherapy showed significant improvements in vascular structure and function, suggesting its potential to restore β-cell function.
A recent study found that parental metabolic traits, particularly those of the mother, can significantly affect a child's cardiometabolic health. The research showed that mothers have a greater impact on blood sugar and cholesterol levels in their children, while fathers' genes play a stronger role in insulin function over time.
A new study analyzed health data of over 100,000 adults and found that two food additive mixtures were associated with a higher incidence of type 2 diabetes. The mixtures contained emulsifiers, sweeteners, and colourings commonly found in ultra-processed foods.
A French cohort study of over 100,000 adults found that mixtures of common food additives, including aspartame and carrageenan, were associated with a slightly increased risk of type II diabetes. The study suggests that these additives may have adverse effects on glucose metabolism.
A large-scale epidemiological study found that higher muscle strength is associated with a lower risk of type 2 diabetes, even in individuals with high genetic susceptibility. The study highlights the importance of maintaining or improving muscle strength as a key strategy for preventing T2D.
Research reveals that GLP-1RAs and SGLT2i medications significantly reduce the risk of Alzheimer's disease and related dementias in people with type 2 diabetes. No significant difference was found between these two treatments.
Researchers Schmidt and Selvin will explore the connections between cardiovascular disease and diabetes, with a focus on large white blood cells and wearable continuous glucose monitors. Their work aims to develop new treatment therapies and improve health outcomes for people with diabetes.
A Texas A&M University study found that online diabetes self-management programs significantly reduced hemoglobin A1c levels in participants with Type 2 diabetes, regardless of intervention type or delivery mode. The interventions showed long-lasting benefits, particularly for older adults and those with better baseline health.