Articles tagged with Type 2 Diabetes
The American Heart Association's 2025 statistics report shows an increase of over 10,000 cardiovascular disease-related deaths in the US, with a slight decrease in age-adjusted death rates. Rising kidney disease, hypertension, and obesity are contributing to these trends.
Researchers found that new habits can begin forming within about two months, but can take up to 335 days to establish. The study also identified factors that influence successful habit formation, including frequency, timing, and enjoyment.
A trial published by The BMJ found that combining dapagliflozin with moderate calorie restriction led to higher rates of diabetes remission compared to calorie restriction alone. This study provides a practical strategy for achieving remission in patients with early type 2 diabetes.
A large population-based analysis found that genetic variants in the GLP1R gene are associated with cardiometabolic traits and behavioral changes, such as risk-taking behavior and anxiety. These findings suggest that any observed behavioral changes with GLP1RA medications are unlikely to be a direct result of the medication.
A recent study found that effective pediatric obesity treatment is associated with lower incidences of mortality in young adulthood. The treatment was also linked to reduced long-term morbidity, such as type 2 diabetes, dyslipidemia, and hypertension.
A study identified unique microbiome signatures associated with Nonalcoholic Fatty Liver Disease (NAFLD), allowing for precise diagnoses and new therapeutic approaches. These signatures predict bacterial metabolites and are linked to the development of NAFLD, providing insights into disease mechanisms.
A study published in JAMA Pediatrics found that childhood obesity treatment can reduce the risk of serious health problems such as type 2 diabetes, hypertension, and dyslipidaemia in young adults. However, it did not have a lasting impact on depression and anxiety, which remained unchanged regardless of treatment outcomes.
A study published in Nature Metabolism found that four percent of Greenland's Inuit population has a gene variant that increases their risk of type 2 diabetes by tenfold. Exercise has been shown to increase insulin sensitivity in these individuals, suggesting it may be an effective way to reduce their risk of developing the disease.
A study found that intestinal bacterium Bacteroides vulgatus and its metabolite pantothenic acid regulate sugar preference by activating the GLP-1-FGF21 hormone axis, providing a promising strategy for diabetes prevention.
A new study identifies three molecular clusters in women who develop type 2 diabetes after gestational diabetes, pointing to potential precision-medicine approaches. The clusters are driven by pancreatic beta-cell dysfunction, insulin resistance, or a combination of both.
The Lancet Commission on Clinical Obesity proposes a new model for diagnosing clinical obesity based on objective measures of illness at the individual level. The proposal aims to settle the ongoing dispute around the idea of obesity as a disease, providing a medically coherent framework for diagnosis.
A new study identifies molecular mechanisms of the progression from gestational diabetes to type 2 diabetes, finding reduced levels of sphingolipids in blood and a mutation in gene CERS2 linked to risk. The discovery could lead to new therapies and interventions to reduce the risk of this progression.
A large international study of GLP1-RA users and dipeptidyl peptidase-4 inhibitors (DPP-4i) found no evidence that GLP1-RA use is associated with an increased risk of thyroid cancer. The study, published in the Thyroid journal, analyzed data from 92,497 GLP1-RA users and 2,484,408 DPP-4i users.
Researchers found that carrots can enhance the body's ability to regulate blood sugar and positively influence the composition of gut bacteria. The study used mice with type 2 diabetes and found improved glucose tolerance after consuming carrot powder.
A new AI-based algorithm can parse three of the four most common Type 2 diabetes subtypes using data from continuous blood glucose monitors. The technology could help individuals take preventative measures by identifying prediabetes warning signs and adjusting dietary or exercise habits accordingly.
Researchers from Kumamoto University identified SerpinA1 as a key regulator in combating obesity and enhancing glucose metabolism. The study found that activating brown adipose tissue could pave the way for innovative treatments for diabetes and metabolic disorders.
A new study from Tufts University estimates that sugary drinks contribute to 2.2 million new type 2 diabetes cases and 1.2 million new cardiovascular disease cases annually worldwide. Regular consumption leads to weight gain, insulin resistance, and metabolic issues tied to these diseases.
A recent study has uncovered the crucial role of enzyme G6PC2 in regulating blood sugar levels by controlling glucagon secretion from pancreatic alpha cells. Genetic variations in G6PC2 impact its expression in alpha cells, and inhibiting this enzyme may provide a new therapeutic strategy for type 2 diabetes.
Participants in the National Diabetes Prevention Program saved approximately $5,000 in medical costs over two years due to reduced hospitalizations, outpatient visits, and emergency room visits. Additionally, they showed a lower probability of developing diabetes compared to non-participants.
A recent study by the University of Helsinki found that placentas from fresh embryo transfers are smaller on average compared to those from frozen embryo transfers. The researchers also identified altered gene function and DNA methylation in ART-conceived children, particularly in relation to metabolism and growth.
A new Northwestern Medicine study reveals how metformin lowers glucose levels by targeting mitochondrial complex I in cells. The drug also improves COVID outcomes and reduces inflammation, suggesting that mitochondrial complex I inhibition may be a unifying mechanism behind its diverse effects.
A new study found significant disparities in the use of obesity-management medications among different racial and ethnic groups. People of Asian, Black, and Hispanic descent were significantly less likely to use these medications compared to whites, even after adjusting for income, education, health insurance coverage, and clinical need.
A recent study from the University of Missouri found that peripheral chemoreceptors are overactive in adults with type 2 diabetes, leading to increased cardiovascular risk. While high doses of oxygen reduced chemoreceptor activity, it did not improve glucose tolerance or insulin sensitivity.
Two independent studies from University of Southern Denmark confirm that patients with type 2 diabetes who take Ozempic are at increased risk of developing damage to the optic nerve, leading to severe and permanent loss of vision. The risk doubles compared to those not taking Ozempic.
Researchers have identified three major pathomechanisms of MASLD: hepatic genetic component, metabolic de novo lipogenesis, and adipose tissue dysfunction. These subtypes have distinct risk factors for cardiovascular disease and type 2 diabetes. Novel pharmacological approaches may facilitate targeted therapies for each subtype.
The five-year national research study will examine the effectiveness of medically tailored meals in reducing gestational diabetes and Type 2 diabetes prevalence among pregnant and postpartum women from historically marginalized communities. Nearly 1,000 participants will be assessed for maternal health outcomes.
Scientists explore low glycemic index (Low GI) rice varieties to counter the growing diabetes epidemic in Asia, with potential health benefits and economic opportunities for farmers. Developing Low GI milled rice can reduce blood sugar spikes and support better glycemic control.
Researchers from the University of Georgia found that involving local leaders and churches can improve health outcomes in rural communities. The Diabetes Prevention Program was implemented across rural Georgia, with a focus on establishing healthy habits and social engagement.
A new study published in Lancet Gastroenterology and Hepatology found that a combined screening approach can detect liver damage in people with type 2 diabetes. The method involves elastography, an ultrasound-based technique, which was found to be willing to be adopted by most patients. Early detection of liver fibrosis is crucial, as ...
Empagliflozin was associated with a 22% lower risk of diabetic retinopathy progression in patients with early-stage non-proliferative DR. The study found that empagliflozin may be beneficial in slowing down progression to more advanced stages of DR in type 2 diabetes patients.
Mount Sinai researchers have made significant progress in understanding how human beta cell regenerative drugs work, potentially leading to a cure for diabetes. The study suggests that these drugs may be able to induce lineage conversion in human pancreatic islets, providing a new source of beta cells.
Researchers at Lund University Diabetes Centre have mapped out differences in the atherosclerotic process in people with type 2 diabetes. The study found that high blood sugar levels can lead to reduced ability to form protective connective tissue in atherosclerotic plaques, increasing cardiovascular risk.
A long-term US study found that eating five servings of dark chocolate a week reduces the risk of type 2 diabetes by 21% compared to those who rarely or never eat chocolate. In contrast, milk chocolate consumption was not significantly associated with type 2 diabetes risk.
A new study from Harvard T.H. Chan School of Public Health found that consuming at least five ounces of dark chocolate per week may lower the risk of developing type 2 diabetes by up to 21%. Dark chocolate's rich polyphenols are believed to offset the negative effects of saturated fat and sugar on weight gain and diabetes.
A Brazilian study of 89 father-mother-baby triads found that paternal overweight is linked to lower birth weight and may influence the baby's health in adulthood. The research suggests that fathers should prioritize healthy habits during pregnancy to support fetal development.
Researchers from the University of Eastern Finland found that high-dose vitamin D supplements over five years had no impact on type 2 diabetes development among those without prediabetes. The Finnish Vitamin D Trial revealed no statistically significant difference in disease incidence between groups receiving different doses of vitamin D.
Researchers found that certain cancer treatments, such as immune checkpoint inhibitors, can trigger damaging levels of inflammation in the heart and increase risk of heart disease. This is because these treatments interfere with immune regulation in the heart's largest blood vessels.
A machine learning algorithm developed by researchers at Aarhus University can identify patients at high risk of involuntary admission within six months. The study, based on electronic health record data, suggests that the algorithm can improve targeted treatment and prevention in psychiatric services.
A clinical study found increased permeability of the small intestine and inflammation in the gut, linked to higher body weight and insulin resistance. The researchers emphasize the need for further investigations into carrageenan's effects on human health.
Researchers found a novel link between aortic stenosis and insulin resistance, with certain biomarkers increasing the risk of the disease. The study's findings suggest that managing metabolic health could be a new approach to reduce the risk of AS and improve cardiovascular health in aging populations.
A new study from Queen Mary University of London has identified the genetic drivers of early onset type 2 diabetes in South Asians, revealing a strong link to lower insulin production and unfavorable body fat distribution. The research also sheds light on treatment responses, highlighting the need for precision medicine approaches.
A study of 49 million patients in England found that routine screening for cardiometabolic conditions like obesity and high blood pressure dropped sharply during the pandemic. Blood pressure measurements remained lower than pre-pandemic levels as of March 2024, particularly among lower socioeconomic groups.
A new study led by Weill Cornell Medicine found that tirzepatide reduced the risk of diabetes in obese and prediabetic patients by more than 90% after 176 weeks. The treatment also showed significant weight loss and improved blood sugar control.
Researchers discovered Inceptor's role in regulating insulin homeostasis and its potential to improve beta cell function. By blocking Inceptor, the receptor can refill beta cells' insulin stores and enhance insulin release.
Researchers found that GLP-1 receptor agonists reduced the risk of kidney failure by 16% and worsening of kidney function by 22%. The combined reduction in risk was 19%, showing a clear benefit on kidney protection. This study expands current knowledge about this class of drugs, highlighting their role in treating patients with chronic...
A study published in PLOS ONE found that adults diagnosed with type 2 diabetes at a younger age are more likely to develop dementia. The researchers analyzed data from over 1,200 U.S. adults and found a graded association between age at diagnosis and dementia risk.
Research suggests that lifestyle modifications and metformin do not improve atrial fibrillation (AFib) burden or progression when compared to standard care. In contrast, weight loss and exercise resulted in decreased AFib symptoms in patients with the condition.
Studies published in JACC found that anti-obesity drugs such as tirzepatide and semaglutide improved cardiac structure and function, as well as reduced cardiac risk biomarkers with lifestyle interventions. These findings suggest that these treatments may have a transformative impact on cardiovascular health beyond weight loss.
A recent study found that intensive systolic blood pressure reduction approaches can significantly reduce the risk of major cardiovascular events in adults with Type 2 diabetes. Lowering systolic blood pressure to less than 120mmHg led to a reduced risk of heart attack, stroke, and death from cardiovascular disease.
A global study found that diabetes rates have more than doubled since 1990, reaching 828 million adults worldwide. However, many low- and middle-income countries struggle to provide adequate treatment, resulting in a staggering 59% of adults with diabetes not receiving the care they need.
Researchers found semaglutide and liraglutide substantially decrease AUD hospitalization risk compared to approved medications. Clinical trials are needed to confirm these findings and explore their efficacy in treating AUD.
Scientists have discovered a new weight loss drug target that increases calorie-burning and lowers appetite without causing nausea. The discovery could lead to a new therapy for millions of people with obesity and type 2 diabetes.
A large cohort study found that young adults with type 2 diabetes ages 20-39 who had low incomes were more likely to die prematurely. The study highlights the need for socioeconomic support to address income-related health disparities among younger individuals.
Researchers discovered genetic variation in sucrose digestion affects sugar consumption and preference. Individuals with complete SI gene deficiency consumed less sucrose-rich foods than those with partial functionality.
Metformin, a widely prescribed diabetes drug, may increase risks of obesity and diabetes in newborns when given to pregnant women. The study found that the drug accumulated in the fetal kidneys, liver, and other organs, leading to growth restriction, which has been linked to an elevated risk of obesity and insulin resistance in childhood.
A new system combining high-speed video and an AI algorithm can detect high blood pressure and Type 1 or Type 2 diabetes from subtle changes in blood flow, potentially leading to early detection and treatment. The technology is still in its preliminary stages but holds promise for non-invasive monitoring of health at home.
Researchers found that individuals with chronic kidney disease, Type 2 diabetes, or both are at increased risk of cardiovascular disease, with the risk predicted to occur up to 28 years earlier than in those without these conditions. The study aimed to better understand the effects of cardiovascular-kidney-metabolic syndrome on CVD risk.
Research suggests that GLP-1 receptor agonists and SGLT2 inhibitors, commonly prescribed for Type 2 diabetes or weight loss, may lower the risk of heart attack and recurrent stroke in adults who have had an initial stroke. The study analyzed data from over 7,000 adults with ischemic strokes between 2000 and 2022.
A preliminary study found that neighborhoods previously subjected to redlining had higher rates of heart disease, Type 2 diabetes, and cardiovascular risk factors due to reduced access to healthy foods. Researchers analyzed data from over 11,000 U.S. Census tracts across 38 states, controlling for population size.
Researchers identified disturbances in glucose regulation after delivery in women who have had gestational diabetes, despite comparable clinical measurements. Continuous monitoring using wearable devices revealed disrupted blood sugar rhythms and internal clocks, suggesting a need for appropriate follow-up.