Articles tagged with Type 2 Diabetes
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Researchers have identified three major pathomechanisms of MASLD: hepatic genetic component, metabolic de novo lipogenesis, and adipose tissue dysfunction. These subtypes have distinct risk factors for cardiovascular disease and type 2 diabetes. Novel pharmacological approaches may facilitate targeted therapies for each subtype.
The five-year national research study will examine the effectiveness of medically tailored meals in reducing gestational diabetes and Type 2 diabetes prevalence among pregnant and postpartum women from historically marginalized communities. Nearly 1,000 participants will be assessed for maternal health outcomes.
Researchers from the University of Georgia found that involving local leaders and churches can improve health outcomes in rural communities. The Diabetes Prevention Program was implemented across rural Georgia, with a focus on establishing healthy habits and social engagement.
A new study published in Lancet Gastroenterology and Hepatology found that a combined screening approach can detect liver damage in people with type 2 diabetes. The method involves elastography, an ultrasound-based technique, which was found to be willing to be adopted by most patients. Early detection of liver fibrosis is crucial, as ...
Mount Sinai researchers have made significant progress in understanding how human beta cell regenerative drugs work, potentially leading to a cure for diabetes. The study suggests that these drugs may be able to induce lineage conversion in human pancreatic islets, providing a new source of beta cells.
Empagliflozin was associated with a 22% lower risk of diabetic retinopathy progression in patients with early-stage non-proliferative DR. The study found that empagliflozin may be beneficial in slowing down progression to more advanced stages of DR in type 2 diabetes patients.
Researchers at Lund University Diabetes Centre have mapped out differences in the atherosclerotic process in people with type 2 diabetes. The study found that high blood sugar levels can lead to reduced ability to form protective connective tissue in atherosclerotic plaques, increasing cardiovascular risk.
A long-term US study found that eating five servings of dark chocolate a week reduces the risk of type 2 diabetes by 21% compared to those who rarely or never eat chocolate. In contrast, milk chocolate consumption was not significantly associated with type 2 diabetes risk.
A new study from Harvard T.H. Chan School of Public Health found that consuming at least five ounces of dark chocolate per week may lower the risk of developing type 2 diabetes by up to 21%. Dark chocolate's rich polyphenols are believed to offset the negative effects of saturated fat and sugar on weight gain and diabetes.
A Brazilian study of 89 father-mother-baby triads found that paternal overweight is linked to lower birth weight and may influence the baby's health in adulthood. The research suggests that fathers should prioritize healthy habits during pregnancy to support fetal development.
Researchers from the University of Eastern Finland found that high-dose vitamin D supplements over five years had no impact on type 2 diabetes development among those without prediabetes. The Finnish Vitamin D Trial revealed no statistically significant difference in disease incidence between groups receiving different doses of vitamin D.
Researchers found that certain cancer treatments, such as immune checkpoint inhibitors, can trigger damaging levels of inflammation in the heart and increase risk of heart disease. This is because these treatments interfere with immune regulation in the heart's largest blood vessels.
A machine learning algorithm developed by researchers at Aarhus University can identify patients at high risk of involuntary admission within six months. The study, based on electronic health record data, suggests that the algorithm can improve targeted treatment and prevention in psychiatric services.
A clinical study found increased permeability of the small intestine and inflammation in the gut, linked to higher body weight and insulin resistance. The researchers emphasize the need for further investigations into carrageenan's effects on human health.
Researchers found a novel link between aortic stenosis and insulin resistance, with certain biomarkers increasing the risk of the disease. The study's findings suggest that managing metabolic health could be a new approach to reduce the risk of AS and improve cardiovascular health in aging populations.
A new study from Queen Mary University of London has identified the genetic drivers of early onset type 2 diabetes in South Asians, revealing a strong link to lower insulin production and unfavorable body fat distribution. The research also sheds light on treatment responses, highlighting the need for precision medicine approaches.
A study of 49 million patients in England found that routine screening for cardiometabolic conditions like obesity and high blood pressure dropped sharply during the pandemic. Blood pressure measurements remained lower than pre-pandemic levels as of March 2024, particularly among lower socioeconomic groups.
A new study led by Weill Cornell Medicine found that tirzepatide reduced the risk of diabetes in obese and prediabetic patients by more than 90% after 176 weeks. The treatment also showed significant weight loss and improved blood sugar control.
Researchers discovered Inceptor's role in regulating insulin homeostasis and its potential to improve beta cell function. By blocking Inceptor, the receptor can refill beta cells' insulin stores and enhance insulin release.
Researchers found that GLP-1 receptor agonists reduced the risk of kidney failure by 16% and worsening of kidney function by 22%. The combined reduction in risk was 19%, showing a clear benefit on kidney protection. This study expands current knowledge about this class of drugs, highlighting their role in treating patients with chronic...
A study published in PLOS ONE found that adults diagnosed with type 2 diabetes at a younger age are more likely to develop dementia. The researchers analyzed data from over 1,200 U.S. adults and found a graded association between age at diagnosis and dementia risk.
Research suggests that lifestyle modifications and metformin do not improve atrial fibrillation (AFib) burden or progression when compared to standard care. In contrast, weight loss and exercise resulted in decreased AFib symptoms in patients with the condition.
Studies published in JACC found that anti-obesity drugs such as tirzepatide and semaglutide improved cardiac structure and function, as well as reduced cardiac risk biomarkers with lifestyle interventions. These findings suggest that these treatments may have a transformative impact on cardiovascular health beyond weight loss.
A recent study found that intensive systolic blood pressure reduction approaches can significantly reduce the risk of major cardiovascular events in adults with Type 2 diabetes. Lowering systolic blood pressure to less than 120mmHg led to a reduced risk of heart attack, stroke, and death from cardiovascular disease.
A global study found that diabetes rates have more than doubled since 1990, reaching 828 million adults worldwide. However, many low- and middle-income countries struggle to provide adequate treatment, resulting in a staggering 59% of adults with diabetes not receiving the care they need.
Researchers found semaglutide and liraglutide substantially decrease AUD hospitalization risk compared to approved medications. Clinical trials are needed to confirm these findings and explore their efficacy in treating AUD.
Scientists have discovered a new weight loss drug target that increases calorie-burning and lowers appetite without causing nausea. The discovery could lead to a new therapy for millions of people with obesity and type 2 diabetes.
A large cohort study found that young adults with type 2 diabetes ages 20-39 who had low incomes were more likely to die prematurely. The study highlights the need for socioeconomic support to address income-related health disparities among younger individuals.
Researchers discovered genetic variation in sucrose digestion affects sugar consumption and preference. Individuals with complete SI gene deficiency consumed less sucrose-rich foods than those with partial functionality.
Metformin, a widely prescribed diabetes drug, may increase risks of obesity and diabetes in newborns when given to pregnant women. The study found that the drug accumulated in the fetal kidneys, liver, and other organs, leading to growth restriction, which has been linked to an elevated risk of obesity and insulin resistance in childhood.
A preliminary study found that neighborhoods previously subjected to redlining had higher rates of heart disease, Type 2 diabetes, and cardiovascular risk factors due to reduced access to healthy foods. Researchers analyzed data from over 11,000 U.S. Census tracts across 38 states, controlling for population size.
A new system combining high-speed video and an AI algorithm can detect high blood pressure and Type 1 or Type 2 diabetes from subtle changes in blood flow, potentially leading to early detection and treatment. The technology is still in its preliminary stages but holds promise for non-invasive monitoring of health at home.
Researchers found that individuals with chronic kidney disease, Type 2 diabetes, or both are at increased risk of cardiovascular disease, with the risk predicted to occur up to 28 years earlier than in those without these conditions. The study aimed to better understand the effects of cardiovascular-kidney-metabolic syndrome on CVD risk.
Research suggests that GLP-1 receptor agonists and SGLT2 inhibitors, commonly prescribed for Type 2 diabetes or weight loss, may lower the risk of heart attack and recurrent stroke in adults who have had an initial stroke. The study analyzed data from over 7,000 adults with ischemic strokes between 2000 and 2022.
Researchers identified disturbances in glucose regulation after delivery in women who have had gestational diabetes, despite comparable clinical measurements. Continuous monitoring using wearable devices revealed disrupted blood sugar rhythms and internal clocks, suggesting a need for appropriate follow-up.
The University of Washington School of Medicine has released a flagship AI-ready dataset for a type 2 diabetes study, featuring a diverse range of participants and novel measures. The dataset includes environmental sensor data, survey responses, eye-imaging scans, and traditional biologic variables.
Researchers found that AI tools can link genetic variations with diseases like diabetes without considering the complexity of genetics. A new statistical method can reduce false positives, but proxy information studies also introduce misleading correlations, warns Qiongshi Lu.
A new study finds that restricting sugar consumption in utero and early childhood significantly reduces the risk of midlife chronic diseases like Type 2 diabetes and hypertension. Low sugar intake by mothers before birth and continued restriction after birth increased health benefits.
A recent NIH study found that young people with severe obesity who underwent weight-loss surgery between ages 15 and 18 continued to see significant improvements in health outcomes, including reduced type 2 diabetes, hypertension, and abnormal cholesterol levels. The study, known as Teen LABS, suggests that bariatric surgery may offer ...
Researchers developed a screening technique to filter out low-quality data in wearable sensors, improving the performance of smartwatches for noninvasive blood glucose estimation. The approach enhances accuracy by discarding data with high phase errors and approximating missing values.
Researchers from NUS and Harvard T.H. Chan School of Public Health found that breastfeeding significantly reduces cardiovascular disease risk among women with type 2 diabetes and gestational diabetes. A healthy Mediterranean diet with low persistent organic pollutant exposure also lowers the risk of GDM.
Researchers developed an algorithm that splits obesity into 5 separate diagnostic profiles with contrasting risk of developing obesity complications. This can help clinicians identify individuals who need early interventions, improving disease prediction and treatment.
The use of GLP-1 receptor agonists (GLP-1RAs) and SGLT2 inhibitors in people with type 1 diabetes has significantly increased between 2010 and 2023. This trend is driven by their benefits in weight management and cardiorenal protection, but caution is advised due to concerns about euglycemic diabetic ketoacidosis.
A low-carbohydrate diet may improve beta-cell function in people with type 2 diabetes, allowing them to better manage their disease and possibly discontinue medication. The study found that participants on a low-carb diet showed significant improvements in acute and maximal beta-cell responses compared to those on a high-carb diet.
Researchers from UT Arlington sequenced RNA genes of pythons, discovering conserved pathways in humans that are activated uniquely by these snakes. This knowledge helps explain intestinal regeneration and metabolism changes, offering potential therapeutic targets.
A new study from the University of Washington found that lower-income households decreased their purchases of sweetened beverages by nearly 50%, while higher-income households reduced purchases by 18%. The tax was implemented in four U.S. cities and resulted in a significant decline in consumption among lower-income households.
Researchers found that ultra-processed foods, including diet options, bring distinct risks for people with type 2 diabetes. Consuming more ultra-processed foods is closely linked with higher blood sugar levels, while a diet rich in minimally processed or unprocessed foods improves control.
A large study of over 3 million pregnancies found no association between paternal metformin use and risk of congenital malformations. The findings provide reassurance for clinicians in making informed treatment decisions when selecting metformin for men with type 2 diabetes who plan to have children.
A recent study analyzing data from the ANCORS-YW study found that overweight and obese women in this region are at a higher risk of hypertension and cardiovascular disease. Researchers recommend tailored preventive strategies, including lifestyle modification programs and socioeconomic support, to address this public health challenge.
A retrospective cohort study of children and adolescents found a higher risk of developing type 2 diabetes after COVID-19 infection compared to other respiratory infections. The study suggests potential long-term effects on glucose regulation.
A new treatment strategy combining ReCET and semaglutide has been shown to eliminate insulin therapy in 86% of type 2 diabetes patients, improving sensitivity to endogenous insulin. The novel procedure, which employs electroporation, is compliance-free and disease-modifying, addressing ongoing patient adherence issues.
A new study from Karolinska Institutet found that people with type 2 diabetes have lower levels of the protein creatine kinase, leading to impaired mitochondrial function and energy production. This impairment may contribute to poorer energy metabolism in individuals with type 2 diabetes.
A systematic review and meta-analysis found that weight-loss surgery reduces pancreatic cancer risk among individuals with obesity by 44%, and among those with both obesity and type 2 diabetes by 79%. The study suggests that metabolic-bariatric surgery may play a crucial role in reducing the risk of pancreatic cancer.
Studies discovered that DNA sequence changes associated with diabetes predisposition alter pancreatic cell stress response, leading to reduced insulin production and increased cell death. The findings point toward a druggable target, MAP3K5, which may help prevent or treat type 2 diabetes in high-risk individuals.
A Carnegie Mellon University-led team is developing a bioelectronic implant called ROGUE that can produce a year's supply of treatment for chronic diseases like Type 2 diabetes and obesity. The device will offer continuous, adjustable therapy deployment via a minimally invasive procedure.
A clinical trial found time-restricted eating improved blood sugar regulation and reduced markers of metabolic dysfunction in adults with metabolic syndrome. Participants who followed a customized eight-to-ten-hour eating window saw significant improvements compared to standard treatments.
A recent study found that limiting food consumption within a 10-hour window per day improved key indicators of heart health in adults with metabolic syndrome. The study demonstrated significant reductions in blood sugar and cholesterol levels, as well as lower levels of hemoglobin A1c, a marker of long-term blood sugar management.
Researchers at Texas A&M University have developed a method to recharge cellular mitochondria using nanotechnology, potentially extending healthy lifespans and improving outcomes for patients with age-related diseases. The molybdenum disulfide nanoparticles stimulate mitochondrial regeneration, helping cells generate more energy.
Scientists identify PICALM as a key player in regulating glucose homeostasis and insulin signaling in adipocytes. Reduced expression of PICALM improves insulin sensitivity and glucose transport, holding promise for new therapeutic approaches for type 2 diabetes and obesity.
A study suggests that semaglutide may have therapeutic value in preventing opioid overdoses by reducing the associated risk. The results require further validation, but the findings indicate a potential benefit for patients with comorbid type 2 diabetes and opioid use disorder.