A large international study found that spironolactone, a medication for high blood pressure and heart failure, does not reduce the risk of heart-related death or hospitalizations in people with kidney failure receiving dialysis. The study also showed an increased risk of severe hyperkalaemia.
Researchers developed a technical framework for green wheat production, including soil, root zone, and canopy systems. The study found that combined application of organic fertilizer and mineral fertilizer can increase soil organic carbon sequestration efficiency by 26% and wheat yield by 15.1%.
Chinese researchers have developed a green high-yield and high-efficiency technology system for rice production, balancing yield and ecology. The new technology improves nitrogen use efficiency by 8.1%–21.3%, reduces greenhouse gas emissions, and enhances soil fertility.
Researchers developed a device and platform to measure Parkinson's disease symptoms quantitatively and reproducibly. The technology allows clinicians to guide treatments remotely and has been shown to be easy to use by patients.
A new study by Imperial College London has found that areas with higher levels of social deprivation and increased transport density have a higher suicide risk. The study analyzed data from 2002-2022 and found significant variations in regional suicide risks, with the highest risk in the North-East of England and the lowest in London.
A new study reveals that households with solar panels can increase their returns by selling surplus power directly to their neighbours through peer-to-peer energy sharing. This approach helps stabilize the electricity grid and negotiates a better price for households compared to traditional grid export arrangements.
The winner of the 2025 BMC journals Image Competition is a photograph of two male saigas sparring on the banks of a steppe lake. The image, taken by Andrey Giljov, showcases the unique characteristics of saiga antelopes and their survival strategies.
Cancer Research UK scientists have found that pre-cancer cells develop faults in autophagy, a cell recycling process. This discovery may help predict or reverse the start of pancreatic cancer, a difficult-to-treat disease linked to 6,900 deaths in the UK every year.
A new study published in Pharmaceutical Research suggests that planaria, harmless flatworms, react to brain medicines similarly to rodents. This could lead to the development of treatments for schizophrenia and hallucinations, reducing the number of mice and rats used in early medical research.
Experts recommend SGLT-2 and GLP-1 diabetes drugs for adults with high cardiovascular and kidney risk, but not those at low risk. The guidelines emphasize weight loss alongside medication for adults with obesity.
A new method measures leg movement variability to diagnose dystonia in children with cerebral palsy, enabling swift and accurate treatment. The study also identifies brain cells linked to dystonia, suggesting early intervention targeting these processes could prevent or treat the condition.
Researchers develop biodegradable polyurethane using natural polymer lignin and captured carbon dioxide, reducing energy consumption and toxic chemicals. The material is strong, heat-resistant, and easily processed, making it a promising alternative to petroleum-based plastics.
The Huntsman Cancer Institute is launching new clinical trials to explore how theranostics can help more patients. Theranostics combines diagnostics and therapeutics to deliver targeted radiation directly to cancer cells, offering a powerful approach to finding and treating cancer.
The 66th Supplement to the Check-list of North American Birds includes significant updates to bird species classification, including new species splits for Myiarchus nuttingi, Vireo gilvus, and Larus argentatus. These changes reflect detailed analysis of sound recordings and other data.
A team of FSU chemists has developed a new form of X-ray materials that can meet the needs of large-area applications. They created amorphous films by combining non-crystalline organic molecules with metal halides, enabling efficient conversion of X-rays into electrical signals for image generation.
Research from UBCO reveals that Canadian-grown wheat, canola, and peas have significantly lower carbon footprints due to conservation tillage and soil storage. These practices help soils act as carbon sinks rather than sources, resulting in lower emissions.
Researchers developed a one-time gene editing treatment that restored hearing and balance in adult mice with DFNA41, a genetic form of progressive deafness. The therapy successfully disabled the harmful mutation while preserving the normal gene, leading to long-term hearing and balance restoration.
Insilico Medicine has completed IND-enabling studies for ISM8969, an orally available NLRP3 inhibitor targeting inflammation and neurodegenerative disorders. The drug candidate demonstrated favorable PD/PK profiles and dose-dependent efficacy in motor functions in animal models.
A new study will investigate whether low levels of the lung protein CC16 in childhood can predict who will develop early chronic obstructive pulmonary disease (COPD) later in life. The five-year study aims to identify children at risk for early COPD and potentially intervene to prevent lung disease.
Researchers have identified a key synergistic role for two epigenetic markers involved in programming cell fate. Turning off these markers causes genes to over-activate, disrupting normal cell development. This discovery may indicate a new target for treating some types of leukemia with drugs already in clinical trials for other cancers.
A comprehensive epidemiological study found that people who had COVID-19 are at increased risk of developing certain inflammatory diseases of the airways, such as asthma and chronic sinusitis. Vaccination against SARS-CoV-2 virus appears to reduce this risk.
Washington State University researchers developed an AI model that can accurately identify everyday activities from smartwatch data, achieving an accuracy rate of 78%. This breakthrough has potential applications in assessing cognitive health, rehabilitation, disease management, and surgical recovery.
Researchers designed over 36 million compounds using generative AI algorithms and computationally screened them for antimicrobial properties. The top candidates show promise against Neisseria gonorrhoeae and Staphylococcus aureus (MRSA) by novel mechanisms that disrupt bacterial cell membranes.
Researchers discovered S100A12 and MCEMP1 as biomarkers for both ankylosing spondylitis and myocardial infarction, showing robust diagnostic performance. These genes are linked to chronic systemic inflammation and acute coronary thrombo-inflammation, making them potential targets for risk stratification and repurposing existing drugs.
Researchers have recorded the sliteye shark for the first time on the Great Chagos Bank, highlighting the ecological importance of the archipelago's Marine Protected Area. The discovery provides new insights into deepwater seagrass habitats and their role in supporting marine biodiversity.
Researchers at KIER developed a carbon cloth-based electrode that maintains stable performance under high current conditions, enabling efficient seawater electrolysis and producing hydrogen. The new electrode achieved a 25% reduction in overpotential and demonstrated continuous operation for over 800 hours.
An ethnobotanist from the Pataxó Hã-Hã-Hãi Indigenous Land in Brazil has revived ancestral healing knowledge to treat diseases like parasitic worms, diabetes, and hypertension. He discovered 43 medicinal plants used for these diseases, with 79% consistent with recent scientific literature.
The American Heart Association's new guideline recommends combining healthy lifestyle behaviors, such as a heart-healthy diet, with early medication treatment to lower blood pressure. The guideline also provides updated guidance on medication options and recommends using the PREVENT risk calculator to estimate cardiovascular disease risk.
Scientists have successfully synthesized a new type of molecular carbon allotrope, cyclo[48]carbon, which can be studied at room temperature. The molecule is stabilized by threaded macrocycles, increasing its stability and making it possible for spectroscopic characterization in solution.
The study reveals that WIPF1 plays a crucial role in regulating extravillous trophoblast (EVT) invasion and podosome formation, which is impaired in recurrent spontaneous abortions (RSA). WIPF1's interaction with ACTN4 and WASL facilitates lamellipodia formation and enhances EVT migration and invasion.
Researchers at UC San Diego developed a computational method to determine omega positions of lipids in complex biological samples. This breakthrough makes omega position information accessible even for lipids in low concentrations, significantly advancing lipid research.
A new report from the Microbiology Society argues that vaccine deployment can slow AMR emergence. The UK Government is called upon to remove barriers and incentivize public-private collaboration for vaccine development.
A systematic review of 96 papers across 17 years found that researchers consider sharing findings a moral obligation, yet this happens frequently and unpredictably. The review highlights the need for future research on disseminating health research results to study participants.
Researchers have developed three green technologies to increase rice yield while reducing resource consumption. These include AWMD irrigation, a nitrogen fertilizer application technology, and a water-nitrogen coupling regulation technology that optimizes soil moisture and nutrient content. Trials have shown significant improvements in...
Researchers trained GAMES to generate accurate SMILES combinations, enhancing computer-aided drug design and accelerating discovery. The model combines LoRA and QLoRA techniques to reduce hardware and energy needed.
New research shows that family ostracism can significantly impair leadership effectiveness and reduce customer service performance. Leaders experiencing family exclusion may adopt a 'laissez-faire' leadership style, characterized by passivity and disengagement, ultimately affecting customer outcomes.
A new study warns that Ireland's proposed climate targets prioritize methane emission privileges for wealthy nations over poorer countries' development, undermining the transition to a sustainable and equitable food system. This approach could lock-in current inequalities in the global food system by reducing the need to curtail or off...
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
CISD1 expression linked to poor clinical outcomes, increased stemness levels, and tumor aggressiveness in multiple cancers. The gene's role in cellular bioenergetics also highlights its potential as a prognostic marker.
Weill Cornell Medicine researchers Dr. Anna Nam and Dr. Maria Cecilia Lira have been awarded prestigious Pew fellowships to support their innovative cancer and biomedical science research. Dr. Nam is investigating the genetic determinants of Hodgkin lymphoma, while Dr. Lira aims to develop novel therapies for brain tumors.
Researchers developed a high-speed 3D imaging microscope that can capture detailed cell dynamics of an entire small whole organism at once. The new system, M25, extends classical multifocus microscopy to study development, locomotion, and neuroscience in real time.
The University of Houston is expanding its behavioral health offerings with new ABA training programs, addressing growing need for behavior analysts. Salaries range from $63,000-$77,000 annually, with autism diagnoses on the rise due to improved screenings and assessments.
A partnership between Macquarie University and Lithium Universe has licensed breakthrough silver extraction technology to transform how Australia recycles solar panels. The new method extracts valuable metal without destroying the panels, addressing a growing waste problem.
Research from Dresden and Heidelberg demonstrates that estrogen protects the kidneys against ferroptosis, a major cause of acute kidney damage. Estradiol increases resistance to ferroptosis by intercepting harmful radicals and activating a genetic program to prevent damage.
Researchers found specialized immune cells, called stem-like T cells, that behave like young stem cells but instead spread disease. These immune cells were found in over 100 older patients with autoimmune diseases, such as giant cell arteritis.
A 36-year-old woman was diagnosed with non-gestational ovarian choriocarcinoma, a rare and aggressive tumor that shares symptoms with pregnancy. She received chemotherapy and showed complete response to treatment.
Researchers successfully transferred a gift-giving courtship behavior from Drosophila subobscura to Drosophila melanogaster by manipulating a single gene in insulin-producing neurons. This study represents the first example of transferring behavior between species through genetic manipulation.
A recent study reveals woefully low awareness of human papillomavirus (HPV), the HPV vaccine, and their association with cancer in the Midwestern and Southern US states. These states have seen a rise in HPV-associated cancers, making suboptimal HPV vaccination rates even more alarming.
A deep learning model successfully predicted ignition in a recent fusion experiment at the U.S. National Ignition Facility (NIF). The model's accuracy was over 70%, offering valuable guidance for researchers working on future inertial confinement fusion experiments.
Researchers developed ultrathin porous NiO nanosheets with abundant oxygen vacancies, which exhibit exceptional performance in photocatalytic CO2 reduction. The catalysts achieve high CO evolution rates and selectivity under pure CO2 atmospheres.
UGA researchers have developed a long-lasting hand sanitizer alternative called NORel that eliminates more than 97% of bacteria and fungi. The gel formula maintains effective antimicrobial activity for up to two hours after application, making it promising for high-risk environments.
A new study tracks the evolution of marine sediment layers across hundreds of millions of years, revealing insights into bioturbation's impact on ocean habitability and ecology. Bioturbation played a critical role in shaping seafloor ecosystems and regulating nutrient cycling.
Researchers propose a green production scheme to balance high yield with efficient resource utilization in corn production. The study suggests three optimization strategies: matching planting density with solar radiation, selecting compact varieties, and optimizing tillage, root systems, and canopy. Implementing these schemes can incre...
A new method for identifying genomic regulatory switches has been developed to improve crop resilience and yield in the face of climate change. The approach has identified over 3,500 individual regulatory switches associated with drought stress in maize.
Researchers identified X- and Y-linked sequences in Nautilus, indicating a more dynamic sex determination system than previously thought. The study's findings have implications for cephalopod biology and conservation.
Blum investigates how the immune system interprets what we eat, exploring mechanisms of oral tolerance and signaling that help our bodies tolerate most foods. Her research could enable new immunotherapy strategies for preventing or treating food allergies.
Researchers proposed a quantitative design theory and technical pathway for green yield increase and efficient nitrogen utilization in winter wheat. The "Three-Stage Theory" identifies key bottlenecks and recommends optimizing population structure, soil health, and root-crown interactions to overcome them.
Researchers created a high-resolution map of Panama showing the movement and intensity of Batrachochytrium dendrobatidis, a deadly fungal disease. The data reveals that higher elevations are more hospitable to the fungus, but rainy seasons bring outbreaks in lowlands.
Researchers identify B-cell lymphoma 6 (BCL6) as a key player in promoting glioma cell proliferation and progression. A novel small-molecule inhibitor YK01 targets BCL6, showing potent anti-tumor effects in GBM cells and animal models.
A study found no association between semaglutide treatment and diabetic retinopathy, but suggested a potential link to nonarteritic anterior ischemic optic neuropathy. Further research with larger sample sizes is needed to clarify this risk.