Could GLP1RA drugs lower high iron levels?
Researchers found that liraglutide alters iron metabolism, decreasing liver iron storage and circulation. The study suggests a potential new therapeutic option for patients with hereditary hemochromatosis.
Type 2 Diabetes
Articles tagged with Type 2 Diabetes
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New guideline details how to manage CVD risk before, during & after noncardiac surgery
The 2024 guideline provides comprehensive recommendations for assessing cardiovascular disease risk and managing patients taking SGLT2-inhibitors. It also highlights the importance of judicious screening and evidence-based management of cardiovascular conditions before, during, and after noncardiac surgery.
UNDER EMBARGO: Mount Sinai study identifies link between prediabetes during adolescence and young adulthood with the likelihood of adverse pregnancy outcomes
A Mount Sinai study links prediabetes among young people with a higher likelihood of gestational diabetes and hypertensive disorders during pregnancy. The findings highlight the need for clear clinical guidance on screening and counseling youth with elevated blood glucose levels.
A simple blood test warns of possible cardiometabolic complications for children with obesity
A study from the University of Copenhagen detected lipid biomarkers in obese children that indicate a higher risk of developing type 2 diabetes, liver, and heart disease later in life. A one-year lifestyle intervention lowered these biomarkers, demonstrating the importance of early intervention for children with obesity.
Widely used test for gestational diabetes misses 70% of cases
A Kobe University study found that the widely used casual blood glucose testing method for screening pregnant women with gestational diabetes mellitus misses 70% of cases. The researchers recommend using more reliable tests to prevent pregnancy complications and type II diabetes in mothers and children.
Research assesses impact of weight loss and blood sugar control in Type 2 Diabetes
A study found that every 1% decrease in BMI leads to a 4% reduction in cardiovascular risk. Blood sugar control also lowers the risk of chronic kidney disease independently of weight change.
Researcher awarded $600,000 grant to study therapeutics to mitigate obesity-linked diabetes
A researcher at Georgia State University has received a grant to evaluate the therapeutic potential of a new small molecule in obesity-linked diabetic models. The study aims to assess the efficacy and mechanisms of this new molecule in improving pancreatic islet cell function and mitigating adiposity.
Study reveals key predictors for achieving and sustaining blood glucose control and weight loss with tirzepatide in adults with type 2 diabetes
The SURPASS-4 trial found that tirzepatide improved blood glucose control and weight loss in adults with type 2 diabetes. Higher doses of tirzepatide and female patients were associated with better long-term outcomes, including reduced risk of cardiovascular events.
Large-scale population analysis confirms reassuring safety profile of tirzepatide
A large-scale population analysis confirms tirzepatide's similar gastrointestinal tolerability to other GLP-1 medications without increased risk of diabetic retinopathy, medullary thyroid cancer, or pancreatitis. Researchers analyzed real-world evidence from the FDA adverse event reporting system database and found that tirzepatide has...
Semaglutide’s cardiovascular benefits are maintained in people with impaired kidney function
The study found that semaglutide was effective in preventing heart attacks and other major adverse cardiovascular events as well as death in adults with impaired kidney function. The results showed a significant reduction in cardiovascular disease risk with semaglutide, even among those with poor kidney function.
Tirzepatide associated with greater weight loss in women than men
A post-hoc analysis of the SURMOUNT trials found that tirzepatide consistently reduced body weight in both males and females, but women experienced greater weight loss with up to 24.6% reduction compared to 18.1% for men. The safety profile was broadly similar by sex, but females were more likely to experience nausea and vomiting.
Lower diligence level linked to higher cardiovascular disease risk in type 2 diabetes
Research published in BMJ Open Diabetes Research & Care found a significant association between lower diligence levels and higher cardiovascular disease risk in people with type 2 diabetes. Adopting a healthy lifestyle remains beneficial regardless of diligence level.
New research shows new class of once-weekly insulin as effective as daily injections for patients with type 2 diabetes
A new class of once-weekly insulin, efsitora, is noninferior to daily insulin injections in controlling high blood sugar levels. The study found that efsitora reduced Hb1Ac by 1.26% and was associated with a lower rate of hypoglycaemia compared to daily insulin.
Individuals with complications of diabetes are at higher risk of gum disease, Danish study finds
A Danish study published in The Journal of Dental Research found that individuals with diabetes complications are at higher risk of gum disease. Periodontitis was more common among those with microvascular complications such as retinopathy and neuropathy.
Time-restricted eating improves blood sugar control in adults at risk of type 2 diabetes regardless of time of day
A randomized crossover trial found that restricting eating to an 8-hour window improved daily time spent in normal blood glucose range and reduced fluctuations in blood glucose levels. The benefits were evident within three days, even without restricting calories.
Individuals with type 2 diabetes are at higher risk of asthma – and vice versa
A study of 17 million individuals reveals a reciprocal relationship between asthma and type 2 diabetes, with asthma increasing T2D risk by 83% and T2D increasing asthma risk by 28%. Shared factors like hypertension and dyslipidaemia are associated with both conditions.
Voice analysis can screen people for type 2 diabetes with high accuracy, study finds
Researchers developed an AI model using 25 seconds of a person's voice to detect type 2 diabetes, distinguishing between individuals with high accuracy. The model showed strong performance, especially in females aged 60 or older and those with hypertension, aligning with the American Diabetes Association risk score.
Reduced heart rate fluctuations due to disruption of the body’s internal clock may double risk of death in people with diabetes
Research links impaired circadian heart rate fluctuations to microvascular disease and increased long-term risk of cardiovascular mortality in people with diabetes. Disrupted daily heart rate variations are associated with a doubled risk of dying from cardiovascular causes.
Innovative semaglutide hydrogel could reduce diabetes shots to once a month
Researchers have developed a semaglutide hydrogel that could reduce diabetes shots to once a month, improving drug adherence and quality of life. The hydrogel's slow release of semaglutide over one month was found to be well-tolerated in laboratory rats with no inflammatory reactions.
Insulin resistance is linked to over 30 diseases – and to early death in women, study of people in the UK finds
A study of 500,000 UK participants found insulin resistance associated with higher risk of 26 conditions, such as sleep disorders and pancreatitis, and lower risk of five diseases, including anaemia and Parkinson's disease. Insulin resistance also linked to increased mortality risk in women.
Is a low-carb diet a nutritious diet? Yes, new study shows
A new study in Frontiers in Nutrition found that well-constructed low-carb eating patterns can meet and sometimes exceed nutrient needs. The study assessed three different 7-day low-carb meal plans, which safely exceeded nutrient needs for vitamins A to K, thiamin, riboflavin, niacin, folate, and vitamins B6 and B12.
GLP-1 receptor agonist use and risk of suicide death
A cohort study found no association between GLP-1 receptor agonist use and increased risk of suicide death or related disorders in patients with type 2 diabetes. The study included mostly patients with type 2 diabetes.
Virginia Tech researchers develop tool to assess healthy hydration recommendations
Researchers in human nutrition developed an innovative tool to assign a healthy hydration recommendation score to governments, promoting water and discouraging sugary beverages. The study analyzed 93 countries with dietary guidelines, finding that 48 had complementary messages encouraging water and reducing sugary beverage intake.
Does low lipoprotein(a) increase the risk of diabetes? New research suggests it does not
Researchers used genetic method Mendelian randomization to show high levels of fasting insulin cause reduction in Lp(a), rather than the other way around. Low Lp(a) is unlikely to be a risk factor for type 2 diabetes, independent of pre-existing hyperinsulinaemia and insulin resistance.
Mankai reduces post-meal sugar levels in diabetics
A clinical trial found that consuming Mankai after meals can significantly lower blood sugar levels in patients with type 2 diabetes. The study showed a 20% reduction in post-meal blood sugar levels and faster return to baseline levels in about two-thirds of participants.
new diabetes research in Scientific Reports links blood glucose levels and voice
A new study published in Scientific Reports confirms a linear relationship between blood glucose levels and voice fundamental frequency, suggesting potential for voice-based glucose monitoring. Researchers at Klick Labs used vocal biomarkers and AI to detect Type 2 diabetes with high accuracy.
A healthy lifestyle may counteract diabetes-associated brain ageing
A comprehensive brain imaging study found that diabetes and prediabetes are associated with accelerated brain ageing, with brains appearing 0.5-4 years older than chronological age. A healthy lifestyle may help counteract this effect, with associations attenuated among people with high physical activity.
Bats are surviving and thriving on nothing but sugar
Scientists discovered the highest natural blood sugar levels in mammals, found in a species of bats that can survive on a diet rich in sugars. The study's findings suggest that these bats have evolved unique strategies for glucose regulation, which may hold potential for managing metabolic diseases in humans.
Individuals with type 2 diabetes who are at higher risk of certain cancers could be identified by a simple blood test, Danish study suggests
A simple blood test could identify individuals with type 2 diabetes who are at a higher risk of certain cancers. The study found that higher levels of pro-inflammatory cytokine interleukin-6 were associated with an increased risk of obesity-related cancers.
Mental health and chronic diabetes complications strongly linked both ways, study finds
Researchers found that people with chronic diabetes complications are up to three times more likely to have a mental health condition, while those with mental health disorders are up to two and a half times more likely to experience sustained diabetes complications. The study highlights the importance of screening for both risk factors.
FAMU-FSU College of Engineering research shows how insulin, zinc and pH can block harmful protein clumps linked to Type 2 diabetes
Researchers led by Ayyalusamy Ramamoorthy find that insulin, zinc and pH levels work together to inhibit the buildup of protein clumps contributing to Type 2 diabetes. The study offers promising avenues for innovative treatments and may revolutionize treatment approaches.
Role of bitter polyphenols in the regulation of blood sugar
Researchers find that unabsorbed dietary polyphenols can reduce the risk of type II diabetes by regulating blood glucose levels and appetite through secretion of gastrointestinal hormones. Polyphenol-mediated binding and activation of T2R promotes the release of incretins, which regulate insulin secretion and food intake.
Proposed risk factor tool finds heart failure rates are higher among American Indian adults
A new risk prediction scale specifically for American Indian adults found elevated heart failure rates compared to other population groups. The analysis identified Type 2 diabetes status, kidney damage, and high blood pressure as major modifiable determinants of developing heart failure over 5-10 years.
Type 2 diabetes increased by almost 20% over a decade
A new study from the University of Georgia found that type 2 diabetes prevalence increased by almost 20% between 2012 and 2022, affecting all sociodemographic groups. Non-Hispanic Black people were particularly hard hit, with a diabetes prevalence rate of just under 16%.
Red and processed meat consumption associated with higher type 2 diabetes risk, study of two million people finds
A recent study analyzing data from 1.97 million participants found that consuming 50g of processed meat a day increases type 2 diabetes risk by 15%, while eating 100g of unprocessed red meat daily raises the risk by 10%. Poultry consumption was also associated with a higher risk, but to a lesser extent.
New molecular insights into bariatric surgery's impact on obesity and type 2 diabetes
Researchers found distinct molecular responses in skeletal muscle following bariatric surgery between obese individuals and those with additional T2D. Obesity individuals showed improvements in metabolic health, while T2D participants had limited changes.
Females’ and males’ muscles differ in sugar and fatty acid handling
A new study found that females' and males' muscles handle glucose and fatty acids differently, but regular physical activity cancels out these differences and triggers similar beneficial metabolic changes in both sexes. This research has important implications for preventing type 2 diabetes.
Posttraumatic stress disorder and type 2 diabetes outcomes in veterans
A cohort study found that PTSD is a modifiable risk factor for a modest reduction in microvascular complications in veterans with comorbid PTSD and type 2 diabetes. The study suggests further research is needed to confirm findings in non-Veterans Health Administration settings.
Significant link found between heme iron, found in red meat and other animal products, and type 2 diabetes risk
A new study found a significant association between higher heme iron intake and type 2 diabetes risk. Participants with the highest heme iron intake had a 26% higher risk of developing T2D than those in the lowest intake group. The researchers also identified key metabolic biomarkers associated with this increased risk.
Possible explanation for link between diabetes and Alzheimer's
A new study by Umeå University found that people with type 2 diabetes have difficulty eliminating beta-amyloids, which may contribute to Alzheimer's disease. The researchers suggest that preventing or managing type 2 diabetes could reduce the risk of cognitive decline.
Looking to boost your heart health? Try a baked potato
A recent study by Neda Akhavan found that baked potatoes can help lower blood sugar and improve body composition in adults with Type 2 diabetes. The study, which involved 24 participants, showed a modest decrease in fasting blood glucose levels and improvements in waist circumference and resting heart rate.
The long-lasting impact of war on global diabetes prevalence
A new study by the Complexity Science Hub estimates that the ongoing war in Ukraine could lead to up to 180,000 additional cases of type 2 diabetes worldwide due to supply chain disruptions and food shortages. Malnutrition during early pregnancy is also linked to increased risk of developing diabetes later in life.
Type 2 diabetes can be prevented by diet and exercise even in individuals with a high genetic risk
A new study from the University of Eastern Finland shows that a healthy diet and regular exercise can reduce the risk of type 2 diabetes even in individuals with a high genetic risk. Lifestyle changes significantly improved glucose metabolism and reduced the prevalence of type 2 diabetes, regardless of genetic risk.
Gestational diabetes does not increase risk of breast cancer, large Danish study finds
A large Danish study published in Diabetologia found no association between gestational diabetes and an increased risk of breast cancer. The study included over 708,000 women and followed them for a median of 11.9 years to examine the link between the two conditions.
Type 2 diabetes and fracture risk in older women
A recent study found that type 2 diabetes significantly increases the risk of fractures in older women. The increased risk is thought to be primarily caused by impaired physical function rather than skeletal characteristics.
CT health screening can identify diabetes risk
A study found that CT scans can identify individuals at high risk of type 2 diabetes through automated analysis of various body components. The index of visceral fat showed the highest predictive performance for diabetes.
Recent insights and advances in treatment and management show promise in stemming the growing prevalence of diabetes
A recent paper surveys advances in diabetes pathogenesis and treatment, highlighting the role of genes, environmental factors, and social determinants. The study suggests that understanding these dynamics is key to developing targeted interventions to reduce diabetes risk and manage its complications.
Prediabetes remission for type 2 diabetes prevention
Experts advocate for incorporating normalization of blood sugar regulation into diabetes prevention strategies. Studies show that weight loss-induced prediabetes remission can significantly reduce the risk of developing type 2 diabetes, especially when combined with lifestyle changes.
New Cedars-Sinai study investigates shifting trends in GLP-1RA prescription
A nationwide study found a significant increase in GLP-1RA prescriptions for weight loss management, with a notable uptick since 2020. The researchers hope their findings will inform healthcare policies to ensure equitable access to these essential treatments.
Long-term sulfonylurea use linked to higher risk of low blood sugar unawareness in type 2 diabetes patients
A recent study found that long-term use of sulfonylureas increases the risk of impaired awareness of hypoglycemia in patients with type 2 diabetes. The longer the patient uses sulfonylureas, the higher the risk. Researchers suggest using newer classes of medications to reduce this risk.
Unhealthy sleep linked to diabetes in a diverse population
A large cohort of primarily low-income, Black and white adults found persistently unhealthy sleep to be significantly associated with Type 2 diabetes. The study suggests that maintaining regular sleep schedules over time may reduce the risk of adverse cardiometabolic conditions.
Paleolithic diets are not without risks
A recent UNIGE study highlights the risks of high-protein diets, also known as Paleolithic diets, which can lead to severe neurological disorders. Excess protein increases ammonium production, overwhelming the liver and potentially causing coma in severe cases.
Study finds irregular sleep patterns lead to increased risk of type 2 diabetes
A study found that irregular sleep durations were associated with a higher risk of developing type 2 diabetes, even after adjusting for various risk factors. Participants with more inconsistent sleep patterns had a 34% increased risk compared to those with regular sleep patterns.
Researchers identify key cells for blood sugar control using optogenetics
A study published in Science Advances reveals a special group of 'first responder' cells in the pancreas that trigger blood sugar response. These cells respond to glucose quicker than others, initiating the response and regulating the activity of other beta cells.
How a gene for obesity affects the brain
A study reveals that the gene SH2B1 controls feeding and energy expenditure, with mutations associated with obesity and metabolic diseases. Enhancing SH2B activity may offer a promising treatment for obesity and related conditions with fewer side effects.
Study finds short and long sleep duration associated with blood vessel damage in those recently diagnosed with type 2 diabetes
A study found that both short and long sleep durations are associated with a higher risk of microvascular disease in individuals recently diagnosed with type 2 diabetes. Short sleep duration, especially among older adults, was linked to a significantly increased risk of blood vessel damage.
Same workout, different weight loss: Signal molecule versions are key
Researchers found that mice lacking certain signal molecules produced during exercise had reduced oxygen consumption and fat burning, leading to increased susceptibility to weight gain. In humans, those producing more of these alternative versions consumed less oxygen and had lower body fat.
New scientific review shows numerous links between pulse consumption and positive health outcomes
A systematic review published in Nutrients highlights the positive health outcomes associated with pulse consumption. The study found that eating more pulses reduces the risk of type 2 diabetes and heart disease.
Metformin and other antidiabetic drugs can help reduce the risk of dementia in patients with type 2 diabetes
Researchers analyzed over 1.5 million patient records to find that metformin and SGLT-2 inhibitors lowered dementia and Alzheimer's disease risks compared to other antidiabetic drugs. The study suggests individualized treatment approaches considering patient-specific factors for optimal diabetes management.
Blood fat profiles confirm health benefits of replacing butter with high-quality plant oils
A recent study published in Nature Medicine confirms the health benefits of a diet high in unsaturated plant fats, such as the Mediterranean diet. The research used lipidomics to measure diet-related fat changes in the blood and link them to disease risk.