About The Study: In this study, conducted when surgical and pharmacological weight-loss interventions were nearly nonexistent, sustained midlife weight loss compared with persistent overweight was associated with a decreased risk of chronic diseases beyond type 2 diabetes and decreased all-cause mortality.
Corresponding Author: To contact the corresponding author, Timo E. Strandberg, MD, PhD, email timo.strandberg@helsinki.fi .
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(doi:10.1001/jamanetworkopen.2025.11825)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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