Articles tagged with Type 2 Diabetes
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A new study found that AI tool accurately captures details in just three minutes from a body scan, highlighting the potential of using AI to repurpose data from routine scans. Visceral adipose tissue volume and fat deposits in muscle are strongly associated with diabetes and cardiovascular disease risk.
A new study published in Diabetes, Obesity and Metabolism found that weight loss treatments, including medication and surgical procedures, may help lower the risk of obesity-related cancers in people with obesity and type 2 diabetes. The study analyzed data from over 180,000 people and found a significant reduction in cancer incidence ...
A 'light-touch' EHR referral strategy successfully connected patients with prediabetes to community-based DPPs, with 122 out of 577 referred patients enrolling. The strategy was used by 30% of targeted clinicians and accounted for over half of all referrals.
The SURPASS-PEDS trial shows that tirzepatide significantly improves HbA1c levels, BMI, and fasting glucose in children aged 10-17 years with type 2 diabetes. The study demonstrates sustained improvements over a year-long period, making it a potential safe and efficacious treatment option for youth-onset type 2 diabetes.
A UK Biobank study suggests that people with type 2 diabetes progress to additional chronic conditions at a faster rate than those without the condition. The study found that individuals with T2D experience a 60% higher risk of new disease diagnosis compared to those without T2D.
A new study published in Pharmaceutics found that semaglutide provides powerful protection against diabetic retinopathy, a condition that can lead to sight loss. The study suggests that GLP-1 receptor agonists enhance retinal cells' defences against damage in diabetes-like conditions.
A diet rich in wholegrains, fruits, and vegetables while limiting red meat and sugary drinks may help prevent type 2 diabetes and reduce greenhouse gas emissions. Higher adherence to this planetary health diet was associated with a 32% lower incidence of type 2 diabetes and 18% lower greenhouse emissions.
A large community-based study has found that individuals with type 2 diabetes are at a doubled risk of developing sepsis, particularly among younger adults and men. The study identified several modifiable risk factors, including smoking, high blood sugar, and complications of diabetes.
A systematic review and meta-analysis of 18 trials found GLP-1 RAs significantly improved glycemic and weight outcomes in children and adolescents with type 2 diabetes or obesity. However, gastrointestinal adverse effects warrant attention in long-term management.
Women with type 2 diabetes taking oral hormone replacement therapy are at a higher risk of developing pulmonary embolism and heart disease. Transdermal HRT, on the other hand, appears safer, reducing cardiovascular risk by up to 25%.
A new study analyzing real-world data from over 4 million adults found that cannabis users face almost four times the risk of developing type 2 diabetes within five years compared to non-users. The study suggests that long-term metabolic effects of cannabis use may be linked to insulin resistance and unhealthy dietary behaviors.
Two large-scale clinical trials found that a higher dose of semaglutide significantly improves weight loss and related health outcomes in adults with obesity. The study revealed an average weight loss of nearly 19% in those receiving the higher dose, compared to 10% with the standard dose or placebo.
Research from Sweden, Norway, and Finland shows smoking significantly raises type 2 diabetes risk across all subtypes, with severe insulin-resistant diabetes (SIRD) being the most affected. Heavy smokers face greater risks, especially those with genetic predispositions.
A new European study of over 45,000 individuals aged 50-plus found a significant association between diabetes and depression, with individuals having diabetes increasing their risk of developing severe depressive symptoms by 48%, regardless of country. Conversely, those with high depressive symptoms had a 15% higher odds of developing ...
Researchers found genetic peptides called alpha-defensins that shape gut bacteria, producing healthier microbiomes and reducing insulin resistance. This discovery suggests personalized treatments can be tailored to individual genes, offering new hope for addressing chronic diseases like obesity and diabetes.
A 14-year study highlights the importance of diagnosing and treating obstructive sleep apnea in people with type 2 diabetes. The research suggests that continuous positive airway pressure (CPAP) treatment can reduce mortality risk by up to 26%.
A cohort study found GLP-1 RAs offer body mass index-dependent cardiovascular benefits and consistent kidney protection for type 2 diabetes patients. The study suggests BMI stratification is crucial for guiding treatment decisions.
Researchers at the University of Gothenburg found that semaglutide reduced both cocaine use and relapse in rats, with motivation to keep taking cocaine decreasing by 52%. The study suggests that semaglutide may blunt cocaine's ability to raise dopamine levels in the brain.
Researchers found 22 previously unknown genetic variants associated with type 2 diabetes by considering participants' hormone levels. The analysis suggests that sex hormone levels interact with genes to increase the risk of developing the disease.
Researchers discovered a brain-liver circuit that connects stress with increased glucose production, potentially linking to type 2 diabetes. Long-term elevations in glucose can cause hyperglycemia and increase the risk of developing type 2 diabetes.
Research found that people with learning disabilities in the UK have a faster progression to severe type 2 diabetes and are at higher risk of dying from the condition. They also tend to have better overall blood glucose control compared to those without learning disabilities.
Researchers found that diabetes directly affects the heart's structure and energy production in humans for the first time. Diabetes causes distinct molecular changes to heart cells and structural changes to the muscle, particularly in patients with ischaemic cardiomyopathy.
Human cells use a synchronized traffic control system to monitor nutrient levels and precisely control cellular energy balance, blood sugar levels, and energy management. This finding offers promising new targets for treating diabetes and cancer.
A Kobe University study found that metformin reduces copper and iron levels and increases zinc levels in patients with type 2 diabetes. This suggests a possible mechanism for the drug's beneficial effects beyond lowering blood sugar levels.
A new investigational drug, ION224, shows promise in treating metabolic dysfunction-associated steatohepatitis (MASH), a serious form of fatty liver disease. By targeting the DGAT2 enzyme, the drug helps reduce fat buildup and inflammation, two major drivers of liver damage.
The Pennington Biomedical Research Center has opened a new Endocrinology and Diabetes Clinic in Baton Rouge, providing specialized care for patients managing diabetes and endocrine disorders. The clinic is led by Dr. Timothy Gilbert, who brings nearly 20 years of private practice experience to the region.
A Mediterranean-style diet, along with reduced caloric intake and moderate physical activity, has been shown to lower the risk of type 2 diabetes by 31%. The study found that participants in the intervention group lost an average of 3.3 kilograms and reduced their waist circumference by 3.6 centimeters.
A new study found that younger men with type 2 diabetes are more likely to experience worse cardiovascular disease and mortality outcomes compared to those with type 1 diabetes. In contrast, women with type 1 diabetes face poorer health outcomes across all ages, particularly due to longer exposure to high blood sugar levels and less ag...
A new study from the Indian Institute of Science (IISc) reveals that glucose uptake is poorly managed in β-cells from people with Type 2 diabetes, leading to reduced insulin secretion. Restoring proper GLUT trafficking could slow disease progression and personalize therapies, according to the researchers.
Researchers developed a first-trimester blood test that accurately predicts gestational diabetes risk, using just seven biomarkers. The test's strong ability to distinguish high-risk from low-risk pregnancies could enable early interventions and reduce long-term health burdens.
A study found that almost 50,000 adults with prediabetes and 30,000 with type 2 diabetes lived in the same households as index cases. The researchers analyzed electronic health records to identify household members with diabetes risk factors, including obesity and abnormal blood fats.
Researchers at the University of Sydney have discovered a new biological pathway that may help explain why people with type 2 diabetes are more prone to developing blood clots. A protein called SEC61B was found to disrupt calcium balance inside platelets, making them more likely to form clots.
A new study published in JAMA Network Open reveals that patients with type 2 diabetes prescribed semaglutide or tirzepatide are at increased risk of nonarteritic anterior ischemic optic neuropathy and other optic nerve disorders. The overall risk is low, but highlights the need for close monitoring of these conditions.
Cohort study finds GLP-1 receptor agonist use associated with modestly increased risk of incident diabetic retinopathy; however, those with preexisting DR experience fewer sight-threatening complications. Regular screening and monitoring recommended for all T2D patients on GLP-1 RAs.
A new study found that self-reported physical activity is associated with reduced risk of all-cause mortality and major adverse cardiac events in individuals recently diagnosed with type 2 diabetes. Higher levels of physical activity were linked to lower risks of cardiovascular disease and death, even after adjusting for other risk fac...
An international research team has identified epigenetic biomarkers that can predict which individuals with type 2 diabetes are at risk of cardiovascular disease. The study used DNA methylation as a way to identify these biomarkers in blood, and found over 400 sites with altered DNA methylation.
A recent study published in The BMJ found that consuming three weekly servings of French fries is associated with a 20% increased risk of developing type 2 diabetes. In contrast, eating similar amounts of boiled, baked, or mashed potatoes does not substantially increase the risk. Replacing potatoes with whole grains was also linked to ...
A new study found that consuming three servings of French fries weekly increased the risk of developing type 2 diabetes by 20%. In contrast, baked, boiled, or mashed potatoes were not significantly associated with T2D risk. Swapping any form of potato for whole grains may lower the risk of T2D, with a 4% reduction in risk estimated.
This review synthesizes evidence highlighting immune aging as a critical accelerator of type 2 diabetes pathogenesis. Chronic low-grade inflammation, organelle stress pathways, and the ominous octet framework contribute to metabolic-inflammatory vortex, disrupting β-cell function and insulin signaling.
A phase 3 study found canagliflozin significantly reduced HbA1c levels in children with type 2 diabetes, outperforming placebo. The medication also showed a favorable safety profile, with minimal risk of hypoglycemic events.
A study found that semaglutide and liraglutide use are associated with a higher risk of nonarteritic anterior ischemic optic neuropathy in older patients with type 2 diabetes. The GLP-1 receptor agonists showed varying levels of risk, with liraglutide posing the greatest threat.
A large meta-analysis of over 800,000 participants shows that high adherence to the Mediterranean Diet, Alternative Healthy Eating Index, and Dietary Approaches to Stop Hypertension reduces type 2 diabetes risk across diverse ethnic groups. These three diets have been recommended for general health and their potential benefits were fou...
A UNLV study uses an mRNA cocktail to selectively route to the pancreas, reducing the risk of immune responses and side effects. The breakthrough offers new hope for treating pancreas-related diseases, including cancer and diabetes.
A new study suggests that marbling of fat inside muscles is a strong indicator of poor health, including obesity, Type 2 diabetes, and neuromuscular disorders. The research found that intramuscular fat acts as a physical barrier obstructing muscle healing and regeneration.
A recent study found that patients with type 2 diabetes experience worse financial outcomes, including below-prime credit scores and medical debt in collections. Nearly two-thirds of diabetes patients were estimated to have an adverse financial outcome, compared to half of other patients. The findings highlight the importance of screen...
A study assessing the Enhanced Primary Care Diabetes model found that Black patients were less likely to meet diabetes care goals, despite more frequent nurse touchpoints. Younger age, insulin use, and fewer initial medication counts were associated with slower progress.
A new web-based tool, Coverage Checker, helps Michigan physicians navigate diabetes coverage and prior authorization. The tool shows care team members which insurance policies cover guideline-directed medical therapy and continuous glucose monitors, and the prior authorization steps required.
Patients with type 2 diabetes experience more severe financial difficulties compared to those without the condition. The study emphasizes the importance of considering patient financial health when treating type 2 diabetes, particularly for vulnerable populations.
A large study suggests that GLP-1 receptor agonists may have a lower cumulative risk of developing dementia compared to metformin. The findings indicate that these drugs could be prioritized in future clinical guidelines for the treatment of type 2 diabetes.
A new study found that exposure to PFAS, a class of synthetic chemicals, may increase the risk of developing type 2 diabetes. Higher levels of PFAS were associated with a significantly greater risk of developing T2D in the future.
Researchers have discovered a non-autoimmune form of type 1 diabetes prevalent in young people in Sub-Saharan Africa, differing from the typical autoimmune pattern seen in other regions. The study's findings also suggest an ancestral or genetic link between this subtype and African ancestry in the US.
A recent study published in JAMA Network Open found that glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment was associated with reduced all-cause mortality among older patients with cancer and type 2 diabetes. The survival benefit persisted across various subgroups, including age, sex, and cancer type.
A new study found that consuming pistachios every night for 12 weeks altered bacteria in the gut of adults with prediabetes, increasing beneficial short-chain fatty acids like butyrate. The changes may offer long-term health benefits, potentially slowing Type 2 diabetes development or reducing inflammation.
A new study suggests that erythritol, commonly used in low-carb products, can alter the function of brain microvascular endothelial cells, leading to increased risk of stroke. The sugar substitute was found to constrict blood vessels and reduce the production of natural clot-busting compounds.
Researchers identified TMEM9B-AS1, a long non-coding RNA that regulates cellular functions, as significantly reduced in skeletal muscles of people with type 2 diabetes. Its absence disrupts protein production, leading to muscle weakness and loss.
A new Leicester study found that women with type 2 diabetes are nearly twice as likely as men to have hidden heart damage, according to researchers. The study used advanced MRI scans and data from four studies conducted at the NIHR Leicester Biomedical Research Centre.
A recent study published in Nature reveals that weight loss triggers the breakdown and recycling of fats called lipids, potentially leading to improved health outcomes. Weight loss also clears out senescent cells, which are ageing and damaged cells that accumulate in tissues, reducing inflammation and scarring.
A study of 679 patients found that longer GLP-1RA treatment, not having diabetes, and higher body fat were associated with better weight reduction. Higher muscle mass and metabolic rate also contributed to successful weight loss in patients with overweight or obesity.
A study of 168,547 postmenopausal women found that excess weight is associated with a 31% higher risk of breast cancer in those with cardiovascular disease. Higher BMI also increases the risk in women without cardiovascular disease, although to a lesser extent.
A Cornell University study found that people with more copies of the AMY1 gene have higher salivary amylase activity, which may be protective against Type 2 diabetes. Researchers suggest that a higher copy number may lead to earlier insulin release and lower blood glucose levels.