Articles tagged with Nephropathies
Researchers at Niigata University identified a novel Ca²⁺-independent mechanism of nephrotic syndrome caused by direct stimulation of Ephrin-B1. The study shows that Ephrin-B1 activation leads to podocyte injury through the Cdc42-calcineurin pathway, which affects nephrin and Ephrin-B1 expression.
Researchers from Fondazione Telethon and TIGEM identified a novel biological mechanism for Lowe syndrome and demonstrated piclidenoson's effectiveness in correcting kidney cell function. The findings provide a promising new therapeutic strategy for this rare genetic disorder.
A global switch to potassium-enriched salt could prevent nearly three million deaths and ten million new cases of cardiovascular and kidney disease each year. Potassium-enriched salt, which replaces some sodium chloride with potassium chloride, addresses both high blood pressure and sodium intake issues.
A survey of 97 US health clinics found that most conduct basic screening for CKM syndrome, but far fewer use guideline-recommended tools like CKM staging framework and PREVENT equations. The study highlights opportunities to improve patient care by better incorporating these tools into clinical practices.
Chronic kidney disease in China has seen rising prevalence, with 156 million people affected in 2023, largely driven by type-2 diabetes and hypertension, with obesity remaining a significant risk factor, and a disparity between men and women in disease burden
The MEDA-PKD platform uses real-time data from clinical practice and research to provide insights for personalized care. The platform has demonstrated medically relevant insights, such as slowing down kidney function loss with tolvaptan treatment.
A new analysis of US national health data found that inflammation increases across the stages of cardiovascular-kidney-metabolic syndrome, with the largest increase at the earliest stage. Average hs-CRP nearly doubled between stage 0 and stage 1, crossing the 2 mg/L threshold commonly used to signal increased cardiovascular risk.
A UK study found that women with pregnancy complications, including gestational diabetes and high blood pressure, face an elevated risk of developing cardiometabolic-renal conditions in subsequent years. The study, which followed over 1.4 million women, identified associations between postnatal depression and an increased risk of four ...
A multicentre study found patients with a rare inherited form of lupus may continue to accumulate organ damage even when disease activity appears to have declined. Long-term monitoring and more sensitive biomarkers are needed to detect ongoing subclinical inflammation and organ injury.
A new study published in the Journal of Vascular and Interventional Radiology found that kidney-sparing embolization is associated with lower rates of acute kidney injury and in-hospital mortality compared to nephrectomy in patients with high-grade kidney injuries. The study analyzed 849 cases and found that embolization reduced in-hos...
A new study reveals metabolic-associated kidney disease among young girls and women, and those without heat exposure in Nicaragua. The research found a greater prevalence of poor kidney health among young girls and women than previously known, and risk factors for kidney disease are present at younger ages.
A study of 1.6 million patients found that the risk of developing chronic kidney disease or heart failure increases substantially over time after a type 2 diabetes diagnosis. Early, proactive management is crucial to reduce the risk of serious complications.
The PKD Foundation has awarded a two-year grant to support research by USC Stem Cell faculty member Zhongwei Li, aiming to develop lab-made tissue for autosomal recessive polycystic kidney disease (ARPKD) research. The project will utilize organoids and assembloids to model the disease and test potential treatments.
Researchers found that frailty is associated with a higher risk of cognitive impairment in men with mild to moderate CKD, but not in women. Men with frailty had more than twice the risk of developing cognitive impairment compared to non-frail men.
Dr. Katherine Tuttle's pioneering work has transformed the treatment of chronic kidney disease, reducing risks of kidney failure and cardiovascular events. Her research has established SGLT2 inhibitors and GLP-1 receptor agonists as breakthrough therapies for CKD and cardiovascular-kidney-metabolic syndrome.
Researchers at the University of Münster have found that using biomarkers to identify high-risk patients can significantly reduce the risk of kidney damage after major surgery. The approach has great potential to help sepsis patients too, and the team is working to incorporate these findings into international guidelines for the treatm...
Researchers analyzed 8.1 million emergency department visits to identify the most at-risk patients during heat waves, offering a near-real-time opportunity to implement protective measures. The study suggests that delays in identifying those most at-risk are no longer necessary, and timely evidence is increasingly essential for effecti...
Txn1 mutant rats exhibit severe kidney deterioration, with hallmarks of human CKD, including oxidative stress, mitochondrial dysfunction, and inflammation. The study identifies a link between chronic thioredoxin deficiency and CKD progression, suggesting promising therapeutic approaches.
The global burden of chronic kidney disease in women has grown, with 359 million cases in 2021, driving increasing mortality rates and disability-adjusted life years. Postmenopausal women and women of reproductive age are particularly vulnerable to metabolic and behavioral drivers that can be modified to reduce risk.
The RadiCaL study, the first randomized trial of a radiopharmaceutical in kidney cancer, found that adding radium-223 to the standard of care does not improve skeletal event-free survival. Patients who received the combination treatment lived a median of 28.3 months, compared with 19.7 months for those who received cabozantinib alone.
A study published in PLOS Medicine found that British Bangladeshi and British Pakistani individuals are more likely to develop multimorbidity, a condition where people experience multiple chronic illnesses simultaneously. The research identified sociodemographic and genetic factors that increase the risk of developing these conditions,...
Researchers found that severe periodontitis was associated with reduced kidney function and increased albuminuria, even at early stages of chronic kidney disease. Systemic inflammation partially explained this relationship, but additional biological mechanisms are also likely involved.
A new study published in Nature links casdatifan, an investigational HIF-2a inhibitor, to improved clinical outcomes in metastatic clear cell renal cell carcinoma (ccRCC) patients. Deep suppression of serum EPO correlated with higher response rates and longer progression-free survival.
A new study by NYU Langone Health researchers found that nearly half of Americans with kidney failure who are referred for transplantation never begin the process required to be considered for a new organ. The study analyzed data from over 720,000 patients and found that those who were unmarried, had severe obesity, or lived in rural a...
Researchers successfully generated rat-derived kidneys in mice using interspecies blastocyst complementation, demonstrating potential for growing transplantable human organs in larger animals. The study represents an important step toward addressing global kidney shortages.
The new clinical practice guideline provides recommendations for identifying cardiovascular-kidney-metabolic (CKM) syndrome risk earlier and taking action to protect long-term heart, metabolic, and kidney health. Lifestyle modification, including the American Heart Association's Life's Essential 8 measures, can help prevent a range of ...
The new clinical guideline identifies excess weight, especially in the abdomen, as a key driver for cardiovascular-kidney-metabolic syndrome. Nearly 9 in 10 adults in the US have at least one condition within this syndrome, which includes high blood pressure, abnormal cholesterol and metabolic conditions like diabetes and obesity.
LRBA deficiency, a rare inherited condition, impairs kidney function by disrupting water and sodium balance, leading to polyuria and electrolyte abnormalities. Treatment with desmopressin may help manage excessive urination in some patients.
In an exploratory analysis, finerenone was found to slow kidney function decline, reduce albuminuria, and lower the risk of kidney failure or substantial loss of kidney function in patients with glomerular diseases. These findings suggest a crucial role for finerenone in preserving kidney function in this population.
A study found that even low levels of particulate matter in the air increased hospitalization risk for men with kidney diseases. Men aged 19-50 were most at risk, with prolonged exposure to high concentrations increasing the risk of chronic kidney disease and acute kidney injury.
Researchers at USC have created complex lab-grown kidney models, known as human synthetic kidney organoids (hSKOs), which can mimic the filtering and urine-collecting functions of a real kidney. The team plans to study how these mini-kidney structures mature over time and test their ability to carry out key kidney functions.
A Brown University study found that expanded Medicaid coverage significantly improves one-year mortality rates for young adults with kidney failure. The researchers discovered improvements in pre-dialysis care, increased use of dialysis, and longer dialysis sessions, all leading to better long-term health outcomes.
A cluster randomized trial found comparable improvements in 6-month outcomes between intervention and control groups, indicating no independent effect of the clinical decision support system. The study suggests that other factors may be responsible for the observed benefits.
A study published in Frontiers in Ecology and Evolution found that optimal birth weight for minimal kidney damage during extreme endurance events is around eight pounds. Individuals with lower or higher birth weights may face a greater risk of kidney stress or damage.
Scientists create a novel nano-delivery system that boosts NAD+ synthesis and reduces consumption, rapidly restoring energy metabolism in damaged kidneys. The approach halts disease progression and prevents chronic kidney disease, offering a promising drug development platform for AKI and other energy metabolism disorders.
AI models can analyze complex data to predict disease progression and identify early signs of kidney damage. This allows for earlier detection and better treatment planning, making a significant impact on patient outcomes.
A study found that higher midlife cardiorespiratory fitness is strongly associated with later onset of chronic disease, lower overall disease burden, and longer life expectancy. Adults with higher fitness levels developed fewer chronic diseases and spent more years free from serious illness.
This study reveals that HDAC3 epigenetically represses RASAL1, a key antifibrotic regulator, leading to enhanced fibroblast activation and extracellular matrix deposition in renal fibrosis. Restoring RASAL1 expression or inhibiting HDAC3 activity attenuates renal fibrosis.
Scientists at Buck Institute for Research on Aging developed an orally administered small molecule that completely prevents calcium oxalate kidney stones, protects against kidney failure, and fully restores normal survival in a mouse model of Primary Hyperoxaluria Type 2. The drug candidate, N-propargylglycine (N-PPG), targets a key en...
Researchers found a clear connection between oral health and kidney health, with immune dysregulation and systemic inflammation driving the relationship. The study highlights the need for physicians to integrate oral and renal health into clinical care systems.
Researchers have discovered a new biomarker for immunoglobulin A (IgA) nephropathy, which is an autoimmune disease that can lead to kidney failure. Complement pathway proteins, including CFHR1, were found to be overexpressed in patients with IgA nephropathy, suggesting a potential treatment target and diagnostic marker.
Research found that people who spend a higher proportion of their total physical activity doing vigorous activity have substantially lower risks of all eight serious health conditions. The benefits of vigorous activity remained even when the amount of time was modest.
The study developed a novel multi-task deep LASSO algorithm that identified six core clinical indicators, establishing four stable MASLD subtypes with distinct characteristics. The classification system enables targeted interventions, prioritizing fibrosis screening and aggressive cardiorenal protection for specific subgroups.
A recent study found that B-type natriuretic peptide is independently associated with chronic kidney disease progression in individuals with diabetes. Combining BNP with urinary markers such as UACR improves risk prediction, highlighting its potential role in early detection and management of kidney disease.
Researchers discovered VISTA as a critical immune checkpoint that balances immune activation and inflammation resolution during kidney injury. Administering exogenous VISTA protein shows potent protection against acute kidney injury and its progression to chronic disease.
A new study from Columbia University Vagelos College of Physicians and Surgeons has found that analyzing the APOL1 gene in Black patients with kidney disease can provide more accurate diagnoses. The study suggests that incorporating M1 into routine APOL1 genetic testing could help doctors determine the true cause of a patient's kidney ...
Researchers found elevated pTau levels in individuals with transthyretin amyloidosis and immunoglobulin light-chain amyloidosis, suggesting a new diagnostic approach for systemic amyloidosis. The findings may facilitate earlier detection and help confirm suspected cases.
ISM4808, a PHD inhibitor for chronic kidney disease-related anemia, has achieved its first milestone with successful completion of the Phase I clinical trial. The treatment stimulates endogenous erythropoietin production and improves iron utilization, offering improved efficiency and safety compared to existing treatments.
A nationwide Danish study comparing outcomes between patients treated with minimally invasive ablation and surgery found no difference in cancer progression but more frequent local recurrence of the disease following ablation. Ablation patients had shorter hospital stays and fewer complications.
A study found that COVID-19 infection significantly increases the risk of acute kidney injury, chronic kidney disease, and kidney failure in US adults. The research used machine learning models to analyze data from over three million patients, revealing a 2.3-times higher risk of acute kidney injury compared to influenza.
Researchers identified multiple microRNAs linked to disease progression and built a model to distinguish high-risk patients with CKD. The M3V2 equation significantly outperformed conventional clinical markers in predicting both kidney decline and major cardiovascular events.
The American Heart Association reports that millions of US adults with diabetes are unaware they have it, while nine in ten with chronic kidney disease do not know they have it. Regular screening can catch problems early, with approximately 80% of heart attacks and strokes being preventable.
Research reveals that podocytes in aged rats adapt by increasing volume and forming atypical junctions to compensate for loss, while exporting unnecessary cellular components into the extracellular space. The study employed array tomography to elucidate age-related structural changes, shedding light on the mechanisms of aging glomeruli.
A nationwide cohort study found that chronic kidney disease significantly heightens mortality risk, even at moderate levels, and exceeds traditional metabolic risk factors. Maintaining renal function and early detection of CKD are critical for reducing both all-cause and cardiovascular mortality.
A new study offers hope that kidney transplant patients may one day have a more effective treatment regimen. The Phase 2 pilot study showed improved kidney functioning in all patients who completed the study, with no patients experiencing rejection due to antibodies produced by the immune system.
Treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) significantly lowers risks of limb events, cardiovascular events, all-cause mortality, and kidney disease progression compared to dipeptidyl peptidase-4 inhibitors in patients with diabetes. GLP-1 RAs are preferred for secondary prevention in this high-risk population.
Salk Institute scientists discover that dietary supplementation of the amino acid methionine protects infected mice against inflammation-related wasting, blood-brain barrier dysfunction, and death. Methionine boosts kidney filtration, reducing circulating cytokine levels and improving disease outcomes.
Researchers identify circulating extracellular vesicles produced in diseased kidneys as the culprit behind toxicity in the heart. The discovery could lead to the development of a blood test to identify patients at high risk for serious heart problems and novel treatments to prevent and treat heart failure.
A comparative effectiveness study found that SGLT2 inhibitors were associated with a lower risk of chronic kidney disease and acute kidney injury compared to GLP-1 receptor agonists. These findings suggest that SGLT2 inhibitor treatment may be an effective strategy for preventing kidney disease in individuals with type 2 diabetes.
Researchers developed a highly sensitive blood test that can detect initial thrombin generation, a key trigger in blood clot formation. The test distinguishes between pathway-specific clotting abnormalities and suggests personalized treatment strategies, potentially predicting clinical outcomes.