Articles tagged with Nephropathies
A new study by Korea University researchers reveals that switching to besifovir may improve patient kidney and bone health for long-term hepatitis B treatment. The study showed that patients who switched to besifovir had higher estimated glomerular filtration rate indicating improved kidney function and higher hip and spine bone densit...
A new study suggests that paricalcitol may help manage chronic kidney disease (CKD) in dogs by reducing renal secondary hyperparathyroidism and proteinuria. The treatment showed promise in stabilizing proteinuria, but raised questions about potential long-term effects on CKD progression.
Researchers at the University of Oklahoma are using a new $2 million grant to study the mechanisms of polycystic kidney disease (PKD), a family of genetic disorders causing clusters of cysts on the kidney. By identifying genes and proteins responsible for PKD, they aim to develop novel therapies.
Patients with chronic kidney disease are at risk of neurological issues after cardiac surgery due to complex interactions among functional status, general anesthesia, and surgical trauma. Cognitive dysfunction is a significant concern for quality of life and overall prognosis.
A new method combines traditional histopathology with spatial transcriptomics data to improve understanding of chronic kidney disease lesions at the cellular and molecular levels. This approach has the potential to identify new biomarkers and therapeutic strategies for patients.
A new medication approved to treat type 2 diabetes and kidney disease also significantly reduces the risk of heart attacks and strokes among these patients. Sotagliflozin, a sodium-glucose cotransporter inhibitor, blocks proteins that help control blood sugar levels and has been shown to reduce cardiovascular events by 23%.
Aging cats with chronic kidney disease (CKD) have lower levels of key kidney transporter genes, leading to impaired waste removal. Monitoring these transporters and toxin buildup may help detect CKD early and improve treatment options.
University of Birmingham researchers have been awarded a grant to study the mechanisms driving early cardiac dysfunction in CKD. The study aims to identify interventions that can reverse or prevent heart disease in its earliest stages.
Researchers at Boston Medical Center have identified six new biomarkers that could detect kidney injury faster and with more sensitivity. These biomarkers can be measured in the urine and may offer a more sensitive approach than existing standards for monitoring kidney health.
A recent study found a positive association between smoking and CKD risk in observational studies, but Mendelian randomization analysis revealed no direct causal link. Researchers propose that diabetes and hypertension may mediate the relationship.
A cohort study found COVID-19 accelerates kidney function decline, particularly in hospitalized patients. Early monitoring and optimized management of chronic kidney disease can help prevent complications.
A study from Tulane University found that a low-protein diet in one generation can lead to lower birthweights and smaller kidneys in offspring across multiple generations. The findings suggest that food scarcity or malnutrition may result in decades of adverse health outcomes.
Research finds that Streptococcus mutans's collagen-binding protein may induce hematuria and IgA deposition in kidney disease, suggesting a potential pathogenic role. The study suggests a link between oral pathogens and renal lesions.
Researchers found that individuals with chronic kidney disease, Type 2 diabetes, or both are at increased risk of cardiovascular disease, with the risk predicted to occur up to 28 years earlier than in those without these conditions. The study aimed to better understand the effects of cardiovascular-kidney-metabolic syndrome on CVD risk.
A nationwide study in Japan reveals an increasing trend of overweight and obesity among patients with incident end-stage kidney disease (ESKD), mirroring the global obesity epidemic. Underweight individuals remain prevalent, presenting a dual challenge for public health strategies.
The new biosensor detects symmetric dimethylarginine in urine, providing a more accurate indicator of kidney health than creatinine. It can identify mild kidney impairment and offers a reliable alternative to blood tests, enabling timely interventions and potential long-term outcomes.
Researchers found a specialized low-salt, fasting-mimicking diet (LS-FMD) slows deterioration of kidney structures and function in rodents with chronic kidney disease. In humans, the diet reduced proteinuria and improved endothelial function in patients with chronic kidney disease.
Researchers developed an AI-based method to analyze kidney lesions in female patients with Alport syndrome, predicting renal prognosis and guiding treatment interventions. The approach uses a modified stain and deep learning to detect basement membrane lesions, showing a positive correlation with proteinuria concentration.
Researchers have made breakthrough in developing artificial kidney tissue from scratch, which could reduce the need for dialysis and transplantation. The study discovered a potential governor of kidney growth, tiny mechanical stress waves, to understand how nature builds the organ.
A new study from the University of Texas at Arlington suggests that analyzing RNA in urine can show changes in cell types, revealing early signs of cancer and other diseases. This method could help clinicians detect problems earlier when they are more easily treated without invasive procedures.
A significant proportion of American adults suffer from absolute and functional iron deficiency, which can lead to adverse health outcomes. The study highlights the importance of screening strategies for iron deficiency, as it is a common issue that may be overlooked or undertreated.
A study published in Nature Communications found that one in eight newborn babies has a genetic protection against jaundice. The researchers identified a specific gene variant that codes for an enzyme linked to increased bilirubin metabolism, providing an opportunity for personalized medicine.
A new study estimates nearly 10.5 million U.S. adults have A-Fib, a three-fold increase from previous estimates. Early detection and treatment can reduce its adverse outcomes.
A study published in Kidney International Reports identified mutations in the IFT140 gene as a potential cause of polycystic kidney disease in patients without a family history. The findings suggest that these patients may be underdiagnosed due to mild symptoms and atypical kidney characteristics.
Researchers have identified key cellular interactions and microenvironments that contribute to the development of chronic kidney disease (CKD) after acute kidney injury (AKI) in mice. The study, published in Nature Communications, provides new insights into how damaged cells interact within disease-promoting microenvironments.
A new study published in Neurology found that acute kidney injury is associated with an increased risk of developing dementia. The study analyzed data from over 300,000 individuals and found a 49% higher risk of dementia overall, with significant increases for specific types of dementia such as Lewy body dementia and vascular dementia.
The Northwestern University Transplant Access Program (AATAP) has supported nearly 300 patients, with over 50 receiving a kidney or liver transplant. The program focuses on the needs of Black Americans, addressing structural and institutional barriers to access.
A five-year randomized control trial found that diets high in fruits and vegetables lower blood pressure, reduce cardiovascular risk, and improve kidney health. The study also suggests that incorporating fruits and vegetables into treatment plans can be more effective than traditional medication approaches.
A recent study published in ESC Heart Failure found that kidney dysfunction can be used as a criterion to stratify patients requiring implantable defibrillators. The research identified two key independent predictors for the risk of sudden cardiac death: left ventricular ejection fraction and estimated glomerular filtration rate.
A study found that both short and long sleep durations are associated with a higher risk of microvascular disease in individuals recently diagnosed with type 2 diabetes. Short sleep duration, especially among older adults, was linked to a significantly increased risk of blood vessel damage.
Researchers study droughts, wildfires, and precipitation changes across the US Southeast and globally. The Great Salt Lake's drying exacerbates regional droughts, while a Maui wildfire is linked to atmospheric patterns.
Researchers at USC Keck School of Medicine discovered that a low-salt diet can stimulate kidney regeneration and repair in mice by targeting the macula densa region. This finding holds promise for developing a new therapeutic approach to treat chronic kidney disease, which affects millions worldwide.
A new study published in Menopause suggests a significant association between chronic kidney disease and tooth loss in postmenopausal women. The study found that lower kidney function is linked to fewer teeth, indicating the need for attention to both oral and bone health in this population.
A groundbreaking study has uncovered a significant breakthrough in the diagnosis and monitoring of kidney diseases associated with nephrotic syndrome. Researchers identified anti-nephrin autoantibodies as a reliable biomarker for tracking disease progression, opening new avenues for personalized treatment approaches.
Chronic kidney disease patients at a US-based academic medical center experienced significant sex disparities in primary care management. Females received poorer care compared to males, highlighting the need for further examination of these differences.
Researchers have identified 12 new quinoline and isoquinoline alkaloids with anti-inflammatory properties and the ability to reduce renal fibrosis in cell cultures. These findings could provide a lead for developing treatments for chronic kidney disease, according to the study published by the American Chemical Society.
A five-day course of inorganic nitrate significantly reduces contrast-induced nephropathy rates, improves three-month renal function, and lowers one-year major adverse cardiac events. The trial also shows improved kidney outcomes at three months compared to placebo.
The USC CIRM ASCEND Center will offer organoids, single-cell analysis, and spatial transcriptomics services to the California research community. The center aims to facilitate collaboration, technology transfer, and a competent workforce in personalized medicine.
A team of researchers from Aarhus University has developed a simple measurement of protein in the urine that can predict which individuals are at high risk of rapid progression of chronic kidney disease. The study found that patients with newly diagnosed mild to moderate chronic kidney disease within three years have a 15% risk of rapi...
Researchers optimized polygenic risk scores using ancestrally diverse genomic data to improve accuracy across diverse populations. The recalibrated tests provided a more accurate assessment of disease risk for individuals with varied ancestral backgrounds.
Research found that boosting weekly total physical activity by just over an hour is associated with a 33% lower risk of progression to chronic kidney disease. The study also showed that longer bouts of moderate-intensity exercise, even those below 10 minutes, contribute to better outcomes.
Researchers discovered a mutation in the APOA4 gene causing chronic kidney disease by analyzing DNA from affected families. The mutation leads to unstable and aggregated APOA4 protein depositing in the kidney, resulting in progressive kidney disease.
Researchers found that participants who achieved diabetes remission through weight loss had a 40% lower rate of cardiovascular disease and 33% lower rate of chronic kidney disease. The study, led by Professor Edward Gregg, monitored over 5,000 patients for 12 years.
Chronic kidney disease and cardiovascular disease significantly worsen prognosis for severely burned patients. The study analyzed data from 1,193 patients and found that nearly half did not survive their burns with impaired kidney function. Researchers highlight the need to integrate these findings into burn treatment scores.
A large study found that individuals who frequently add salt to their food are more likely to develop chronic kidney disease. The researchers suggest that reducing salt consumption could be a valuable strategy for lowering the risk of this condition.
Researchers at Johns Hopkins Medicine have identified six protein markers that can predict and manage acute kidney injury (AKI), a condition marked by serious inflammation. The study's findings offer hope for non-invasive assessments of AKI, potentially reducing the need for invasive kidney biopsies.
The American College of Physicians has published a new clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C virus in chronic kidney disease. The guideline includes recommendations for expanding treatment with sofosbuvir-based regimens to patients with CKD glomerular filtration rate categor...
A large cohort of adolescents found high BMI in late adolescence is associated with early CKD in young adulthood. High-normal BMI and severe obesity also increased the risk of developing CKD.
A clinical trial found that the ketogenic diet improved kidney function in patients with polycystic kidney disease, contradicting the long-held belief that it's a genetic disease. The study suggests that controlling the condition through dietary changes can lead to better health outcomes.
Research suggests visfatin stimulates membrane raft clustering, leading to NLRP3 inflammasome activation and podocyte injury. The study highlights the role of membrane raft redox signaling in visfatin-induced inflammation and kidney damage.
A new study published in Obesity found that fitness and preventing weight gain may be more important than weight loss for preventing chronic kidney disease in obese adults. Weight gain was associated with a higher risk of developing chronic kidney disease, while low physical fitness was linked to rapid kidney function decline.
A pharmacist-led intervention has been shown to improve medication adherence among Latinos with type 2 diabetes, leading to significant reductions in blood sugar levels. The study found that patients who interacted with a pharmacist had an average 0.45% reduction in blood sugar, while systolic blood pressure remained unchanged.
A study by UC San Francisco researchers found that patients with acute kidney injury on outpatient dialysis may not need lifelong treatment if they have the potential to recover. The study tracked data from over 1,700 patients and showed that approximately three-quarters of those who recovered kidney function discontinued dialysis with...
A new study from Aarhus University found that acute kidney injury causes significant cell death in kidneys, which then spreads to healthy tissue over several days. This finding may increase the risk of patients developing chronic kidney damage and highlights the need for timely intervention measures.
A USC Stem Cell-led mouse study reveals that lowering testosterone can improve the resilience of male kidneys by reducing their vulnerability to disease. The researchers also found that three months of calorie restriction has a similar effect, suggesting new potential treatments for kidney diseases.
In a cohort study of 2,055 patients with glomerular diseases, COVID-19 vaccination did not worsen kidney damage or affect proteinuria. The data support vaccination for COVID-19 in patients with glomerular disease.
A study found that longer duration of type 2 diabetes is associated with decreased brain structure and increased white matter hyperintensities. Despite this, cognition was not affected, highlighting the need for early screening for cognitive disorders in diabetic patients.
This study highlights significant disparities in preoperative hemodialysis timing among patients with end-stage kidney disease, impacting surgical outcomes. The findings suggest a need to address equity in surgical care for these patients, particularly those from disadvantaged backgrounds.
Researchers at the University of Zurich have used AI to uncover the underlying cellular mechanism behind kidney disease in cystinosis. They identified a causal association between mTORC1 protein regulation and the disease, highlighting a promising therapeutic target.
A new study has identified 16 new locations in the genome linked to immunoglobulin A (IgA) nephropathy, a common kidney disease. The research confirms an earlier hypothesis that the immune system plays a key role in driving the disease and provides potential drug targets for treatment.