Articles tagged with Nephropathies
Researchers used human-induced pluripotent stem cell-derived kidney organoids to model nephronophthisis, revealing the Hippo signaling pathway's role in fibrosis. Inhibiting this pathway with drugs like verteporfin shows promise as a treatment option.
A recent FAU Engineering study leverages quantum computing to enhance the accuracy of chronic kidney disease (CKD) diagnosis. The research team developed and compared two automated systems: Classical Support Vector Machine (CSVM) and Quantum Support Vector Machine (QSVM). CSVM achieved remarkable 98.75% accuracy, while QSVM reached 87....
Researchers at University of Utah Health have found that AKI is triggered by ceramides, which cause serious injury by damaging kidney mitochondria. Using a backup drug candidate, the team was able to preserve mitochondrial integrity and prevent kidney injury in mice.
A new study estimates that about 14% of adults worldwide have chronic kidney disease, with 1.5 million deaths in 2023. Early detection and treatment are crucial to prevent severe interventions like dialysis and transplantation.
Researchers investigated GnT-V, a cancer-related glycosylation enzyme, and found its selectivity relies on protein structure and subcellular trafficking. Two enzymes, metalloproteases, were identified as major substrates in the kidney.
The study found CKD affects nearly 800 million worldwide, with diabetes and high blood pressure driving the greatest loss of healthy years. Access to kidney replacement therapies remains limited, highlighting the need for preventive measures and equitable care.
A new study reveals that a large gap between two common kidney function tests may indicate future disease, particularly among older adults. The research found that over a third of hospitalized participants had a significant difference in their creatinine and cystatin C readings, which can predict serious health problems.
A randomized clinical trial has shown that rituximab is effective in preventing relapses and reducing the need for corticosteroids in adults with relapsing nephrotic syndrome. The study involved 66 adult patients treated with either rituximab or a placebo, with impressive results at the 49-week follow-up.
A new study from the University of Cincinnati College of Medicine calls for more extensive nephrology fellowship training on reproductive health. Females with CKD face increased risks of high-risk pregnancies, preeclampsia, and preterm births, yet their contraceptive use remains relatively low.
Researchers developed a scalable method to produce human kidney organoids, combining them with pig kidneys outside the body for transplantation. The transplanted organs functioned normally and showed no signs of damage or toxicity.
A simple blood test is being developed to detect acute kidney injury hours faster, allowing for earlier intervention and better management of chronic kidney disease. The test uses patented DNA aptamers to directly investigate structural kidney damage.
Researchers found that over 30% of children referred for Alport syndrome testing at age 3 already required therapeutic intervention, highlighting the potential benefits of early detection. The study suggests introducing a urine testing system may enable intervention before kidney dysfunction onset.
Researchers have discovered that APOL1 mutations impair mitochondrial function in podocytes, leading to impaired kidney filtering. This finding could explain why inflammation triggers the onset of AMKD in patients, paving the way for targeted treatments.
A study published in Mayo Clinic Proceedings found that shift workers have a 15% higher risk of developing kidney stones, especially younger workers and those with low levels of manual labor. Lifestyle factors such as BMI, fluid intake, and smoking habits significantly contribute to the occurrence of kidney stones.
Researchers at Mayo Clinic found that transplanting patients' own stem cells into their veins can help prevent inflammation and vein narrowing in patients with end-stage kidney disease. This could extend the time before dialysis is required, reducing healthcare costs and improving patient outcomes.
A new study by the University of Arizona found that heat exposure and toxic metal exposure can increase signs of kidney injury in agricultural workers. The study suggests that providing mandatory breaks, water, electrolyte replacement, and restrooms nearby can help prevent heat-related illnesses and kidney damage.
Researchers at the University of Copenhagen discovered two new ciliary proteins that regulate cell communication and may lead to the development of new treatments for chronic diseases. The study found that defective cilia can disrupt signaling in almost all tissues and organs, leading to various diseases.
The Alliance for Clinical Trials in Oncology will host a public webinar showcasing key findings from the 2025 ASCO Annual Meeting. Researchers will discuss latest information on colorectal, squamous cell, and renal cell cancers.
Researchers used AI models with integrated clinical and claims data to predict chronic kidney disease (CKD) progression to end-stage renal disease (ESRD). The study found that the models outperformed single data source models and reduced racial bias. The findings can inform likelihood and management of CKD, supporting targeted interven...
USC Stem Cell scientists have developed a blueprint for generating specific kidney cell types on demand, holding immense value for preclinical studies of new therapeutics and congenital kidney diseases. The team successfully created lab-grown proximal tubule cells that can absorb sugar and protein, respond to chemotherapy drugs, and pr...
A clinical trial led by Tohoku University has found that lubiprostone can prevent the decline of renal function in patients with chronic kidney disease. The study evaluated the effects of lubiprostone on kidney function and found that it improves mitochondrial function, which exerts a renoprotective effect.
Researchers discovered that immune hubs in the kidney create a unique metabolic environment, accumulating glutathione to counter oxidative stress. Blocking this process prevents TLS formation or causes existing structures to shrink. Urine glutathione levels can serve as a non-invasive biomarker for TLSs and disease progression.
Researchers found that a molecule produced by gut bacteria can cause inflammation, scarring and fibrosis in the kidneys, a major complication of diabetes. Corisin, a small peptide, attaches to albumin in the blood and targets the delicate kidney structures, accelerating aging and cell death.
A study analyzing Global Burden of Diseases data from 204 countries and territories found a rising global incidence of urolithiasis over the past three decades, with notable sex disparities. The disease burden is highest in males, particularly in Southeast Asia, whereas females show a higher vulnerability to the increase in risk factors.
Research from Dresden and Heidelberg demonstrates that estrogen protects the kidneys against ferroptosis, a major cause of acute kidney damage. Estradiol increases resistance to ferroptosis by intercepting harmful radicals and activating a genetic program to prevent damage.
Elevated cdc42 activity is a critical initiation event leading to proteinuria in nephrotic syndrome. Suppression of cdc42 activity could be a promising therapy.
Researchers developed a serum proteomics-based prediction model to identify biomarkers involved in ADPKD progression. The study identified 29 proteins linked to immune system, fat transport, and metabolism, which can predict kidney function decline rate. This breakthrough could lead to more accurate and earlier diagnosis of ADPKD.
A recent study published by Fujita Health University found that poor oral health can increase the risk of lifestyle-related diseases such as diabetes and heart disease. The researchers examined 118 individuals aged 50 or above and found significant links between oral function test results and blood test results.
A novel model reveals that local Ang II regulation plays a crucial role in maintaining kidney function balance. The study found that damaged kidneys compensate for the loss of function by increasing blood pressure and reducing glomerular atrophy.
A new study found that the newer generation of effective diabetes medications are not reaching enough patients. The study analyzed data from over 40,000 records and found that only 20% of patients with type 2 diabetes were taking GLP-1 drugs within a year of diagnosis, and less than 15% were taking SGLT2 drugs.
A national survey of 1,000 American adults found that stress (43%) and lack of sleep (39%) are major contributors to a short attention span. The study also identified digital devices as a significant factor, with 35% of respondents citing it as a contributing factor.
QUT researchers create novel composite traits from UK Biobank data, identifying 50,000 biomarkers that outperform eGFR in detecting CKD. Their approach uncovers genetic signals missed by traditional methods.
Long-term data from the Phase 1/2 study of zigakibart demonstrate sustained proteinuria remission, stable kidney function, and a reassuring safety profile in patients with IgA nephropathy. The treatment also led to reductions in serum immunoglobulins, consistent with APRIL pathway inhibition.
Researchers at CRCHUM have discovered a crucial biomarker, miR-423-5p microRNA, to predict kidney function and diagnose chronic renal failure. The breakthrough could lead to early diagnosis, targeted approaches, and improved treatment options for millions of patients worldwide.
A modified surgical face mask can detect chronic kidney disease by analyzing the wearer's breath, showing high sensitivity for CKD-related metabolites. The sensor accurately identifies patients with CKD 84% of the time and those without 88% of the time.
The American Heart Association funds research teams to investigate how risk factors for cardiovascular and kidney diseases impact women differently. The project aims to understand the biological significance of certain life cycles and societal factors on disease development.
A large US cohort study found SARS-CoV-2 infection associated with adverse postacute kidney outcomes in children and adolescents, especially those with chronic or acute kidney disease. Long-term monitoring is recommended for these patients.
The SUMMIT trial shows tirzepatide reduces the risk of cardiovascular death or worsening heart failure in patients with obesity, chronic kidney disease, and heart failure, while improving kidney function. Researchers found significant improvements in both patient groups with and without chronic kidney disease.
A new study by Korea University researchers reveals that switching to besifovir may improve patient kidney and bone health for long-term hepatitis B treatment. The study showed that patients who switched to besifovir had higher estimated glomerular filtration rate indicating improved kidney function and higher hip and spine bone densit...
A new study suggests that paricalcitol may help manage chronic kidney disease (CKD) in dogs by reducing renal secondary hyperparathyroidism and proteinuria. The treatment showed promise in stabilizing proteinuria, but raised questions about potential long-term effects on CKD progression.
Researchers at the University of Oklahoma are using a new $2 million grant to study the mechanisms of polycystic kidney disease (PKD), a family of genetic disorders causing clusters of cysts on the kidney. By identifying genes and proteins responsible for PKD, they aim to develop novel therapies.
Patients with chronic kidney disease are at risk of neurological issues after cardiac surgery due to complex interactions among functional status, general anesthesia, and surgical trauma. Cognitive dysfunction is a significant concern for quality of life and overall prognosis.
A new method combines traditional histopathology with spatial transcriptomics data to improve understanding of chronic kidney disease lesions at the cellular and molecular levels. This approach has the potential to identify new biomarkers and therapeutic strategies for patients.
A new medication approved to treat type 2 diabetes and kidney disease also significantly reduces the risk of heart attacks and strokes among these patients. Sotagliflozin, a sodium-glucose cotransporter inhibitor, blocks proteins that help control blood sugar levels and has been shown to reduce cardiovascular events by 23%.
Aging cats with chronic kidney disease (CKD) have lower levels of key kidney transporter genes, leading to impaired waste removal. Monitoring these transporters and toxin buildup may help detect CKD early and improve treatment options.
University of Birmingham researchers have been awarded a grant to study the mechanisms driving early cardiac dysfunction in CKD. The study aims to identify interventions that can reverse or prevent heart disease in its earliest stages.
Researchers at Boston Medical Center have identified six new biomarkers that could detect kidney injury faster and with more sensitivity. These biomarkers can be measured in the urine and may offer a more sensitive approach than existing standards for monitoring kidney health.
A recent study found a positive association between smoking and CKD risk in observational studies, but Mendelian randomization analysis revealed no direct causal link. Researchers propose that diabetes and hypertension may mediate the relationship.
A cohort study found COVID-19 accelerates kidney function decline, particularly in hospitalized patients. Early monitoring and optimized management of chronic kidney disease can help prevent complications.
A study from Tulane University found that a low-protein diet in one generation can lead to lower birthweights and smaller kidneys in offspring across multiple generations. The findings suggest that food scarcity or malnutrition may result in decades of adverse health outcomes.
Research finds that Streptococcus mutans's collagen-binding protein may induce hematuria and IgA deposition in kidney disease, suggesting a potential pathogenic role. The study suggests a link between oral pathogens and renal lesions.
Researchers found that individuals with chronic kidney disease, Type 2 diabetes, or both are at increased risk of cardiovascular disease, with the risk predicted to occur up to 28 years earlier than in those without these conditions. The study aimed to better understand the effects of cardiovascular-kidney-metabolic syndrome on CVD risk.
The new biosensor detects symmetric dimethylarginine in urine, providing a more accurate indicator of kidney health than creatinine. It can identify mild kidney impairment and offers a reliable alternative to blood tests, enabling timely interventions and potential long-term outcomes.
A nationwide study in Japan reveals an increasing trend of overweight and obesity among patients with incident end-stage kidney disease (ESKD), mirroring the global obesity epidemic. Underweight individuals remain prevalent, presenting a dual challenge for public health strategies.
Researchers developed an AI-based method to analyze kidney lesions in female patients with Alport syndrome, predicting renal prognosis and guiding treatment interventions. The approach uses a modified stain and deep learning to detect basement membrane lesions, showing a positive correlation with proteinuria concentration.
Researchers found a specialized low-salt, fasting-mimicking diet (LS-FMD) slows deterioration of kidney structures and function in rodents with chronic kidney disease. In humans, the diet reduced proteinuria and improved endothelial function in patients with chronic kidney disease.
Researchers have made breakthrough in developing artificial kidney tissue from scratch, which could reduce the need for dialysis and transplantation. The study discovered a potential governor of kidney growth, tiny mechanical stress waves, to understand how nature builds the organ.
A new study from the University of Texas at Arlington suggests that analyzing RNA in urine can show changes in cell types, revealing early signs of cancer and other diseases. This method could help clinicians detect problems earlier when they are more easily treated without invasive procedures.
A significant proportion of American adults suffer from absolute and functional iron deficiency, which can lead to adverse health outcomes. The study highlights the importance of screening strategies for iron deficiency, as it is a common issue that may be overlooked or undertreated.
A study published in Nature Communications found that one in eight newborn babies has a genetic protection against jaundice. The researchers identified a specific gene variant that codes for an enzyme linked to increased bilirubin metabolism, providing an opportunity for personalized medicine.