Articles tagged with Nephropathies
A five-day course of inorganic nitrate significantly reduces contrast-induced nephropathy rates, improves three-month renal function, and lowers one-year major adverse cardiac events. The trial also shows improved kidney outcomes at three months compared to placebo.
A team of researchers from Aarhus University has developed a simple measurement of protein in the urine that can predict which individuals are at high risk of rapid progression of chronic kidney disease. The study found that patients with newly diagnosed mild to moderate chronic kidney disease within three years have a 15% risk of rapi...
Researchers optimized polygenic risk scores using ancestrally diverse genomic data to improve accuracy across diverse populations. The recalibrated tests provided a more accurate assessment of disease risk for individuals with varied ancestral backgrounds.
Research found that boosting weekly total physical activity by just over an hour is associated with a 33% lower risk of progression to chronic kidney disease. The study also showed that longer bouts of moderate-intensity exercise, even those below 10 minutes, contribute to better outcomes.
Researchers discovered a mutation in the APOA4 gene causing chronic kidney disease by analyzing DNA from affected families. The mutation leads to unstable and aggregated APOA4 protein depositing in the kidney, resulting in progressive kidney disease.
Researchers found that participants who achieved diabetes remission through weight loss had a 40% lower rate of cardiovascular disease and 33% lower rate of chronic kidney disease. The study, led by Professor Edward Gregg, monitored over 5,000 patients for 12 years.
Chronic kidney disease and cardiovascular disease significantly worsen prognosis for severely burned patients. The study analyzed data from 1,193 patients and found that nearly half did not survive their burns with impaired kidney function. Researchers highlight the need to integrate these findings into burn treatment scores.
A large study found that individuals who frequently add salt to their food are more likely to develop chronic kidney disease. The researchers suggest that reducing salt consumption could be a valuable strategy for lowering the risk of this condition.
Researchers at Johns Hopkins Medicine have identified six protein markers that can predict and manage acute kidney injury (AKI), a condition marked by serious inflammation. The study's findings offer hope for non-invasive assessments of AKI, potentially reducing the need for invasive kidney biopsies.
A large cohort of adolescents found high BMI in late adolescence is associated with early CKD in young adulthood. High-normal BMI and severe obesity also increased the risk of developing CKD.
A clinical trial found that the ketogenic diet improved kidney function in patients with polycystic kidney disease, contradicting the long-held belief that it's a genetic disease. The study suggests that controlling the condition through dietary changes can lead to better health outcomes.
The American College of Physicians has published a new clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C virus in chronic kidney disease. The guideline includes recommendations for expanding treatment with sofosbuvir-based regimens to patients with CKD glomerular filtration rate categor...
Research suggests visfatin stimulates membrane raft clustering, leading to NLRP3 inflammasome activation and podocyte injury. The study highlights the role of membrane raft redox signaling in visfatin-induced inflammation and kidney damage.
A pharmacist-led intervention has been shown to improve medication adherence among Latinos with type 2 diabetes, leading to significant reductions in blood sugar levels. The study found that patients who interacted with a pharmacist had an average 0.45% reduction in blood sugar, while systolic blood pressure remained unchanged.
A study by UC San Francisco researchers found that patients with acute kidney injury on outpatient dialysis may not need lifelong treatment if they have the potential to recover. The study tracked data from over 1,700 patients and showed that approximately three-quarters of those who recovered kidney function discontinued dialysis with...
A new study published in Obesity found that fitness and preventing weight gain may be more important than weight loss for preventing chronic kidney disease in obese adults. Weight gain was associated with a higher risk of developing chronic kidney disease, while low physical fitness was linked to rapid kidney function decline.
A new study from Aarhus University found that acute kidney injury causes significant cell death in kidneys, which then spreads to healthy tissue over several days. This finding may increase the risk of patients developing chronic kidney damage and highlights the need for timely intervention measures.
In a cohort study of 2,055 patients with glomerular diseases, COVID-19 vaccination did not worsen kidney damage or affect proteinuria. The data support vaccination for COVID-19 in patients with glomerular disease.
A USC Stem Cell-led mouse study reveals that lowering testosterone can improve the resilience of male kidneys by reducing their vulnerability to disease. The researchers also found that three months of calorie restriction has a similar effect, suggesting new potential treatments for kidney diseases.
A study found that longer duration of type 2 diabetes is associated with decreased brain structure and increased white matter hyperintensities. Despite this, cognition was not affected, highlighting the need for early screening for cognitive disorders in diabetic patients.
This study highlights significant disparities in preoperative hemodialysis timing among patients with end-stage kidney disease, impacting surgical outcomes. The findings suggest a need to address equity in surgical care for these patients, particularly those from disadvantaged backgrounds.
Researchers at the University of Zurich have used AI to uncover the underlying cellular mechanism behind kidney disease in cystinosis. They identified a causal association between mTORC1 protein regulation and the disease, highlighting a promising therapeutic target.
A new study has identified 16 new locations in the genome linked to immunoglobulin A (IgA) nephropathy, a common kidney disease. The research confirms an earlier hypothesis that the immune system plays a key role in driving the disease and provides potential drug targets for treatment.
A new patient-guided intervention using telemedicine has been shown to improve symptoms of fatigue, pain, and depression in dialysis patients. The Technology Assisted Stepped Collaborative Care (TĀCcare) trial found significant improvements in energy levels and pain severity that persisted for six months after treatment.
A new study suggests that increased exposure to air pollution may be associated with first hospital admissions for acute kidney injury. The research found a link between PM2.5, NO2, and O3 exposure and an increased risk of AKI, even at low annual exposures.
A Japanese study reveals significant birth cohort effects on ESKD requiring RRT, with increased risk for men born in the 1940-60s and women born in 1930–40s. Poor environmental conditions during World War II may contribute to this trend.
A study of over 43,000 adults found that parathyroidectomy has no estimated effect on long-term kidney function in older adults. However, early treatment may preserve kidney function in patients younger than 60 years old.
A study by Johns Hopkins Medicine researchers found that certain biomarkers in urine and blood can predict the risk of developing chronic kidney disease (CKD) in patients with acute kidney injury (AKI). Higher levels of KIM-1, MCP-1, and TNFRI were associated with a increased risk of CKD progression.
People with recent atrial fibrillation diagnosis have a 13% higher risk of developing dementia. A stronger link is seen in younger patients and those without chronic kidney disease. The study's findings may lead to important clinical and public health implications.
A study found that cystatin C-based eGFR was strongly correlated with creatinine-based eGFR and that 27% of patients would be classified as having a more severe chronic kidney stage based on cystatin C test results. The use of cystatin C can lead to changes in CKD staging, which can impact clinical management.
Researchers analyzed electronic health record data from over 7.1 million children to identify risk factors associated with a faster decline in kidney function, including disease origin, proteinuria, hypertension, and younger age. The study found that certain attributes are linked to a more rapid decline in kidney function, providing va...
A new review paper aims to educate medical professionals on diagnosing and treating rat lungworm disease, which is expected to spread globally due to climate change. Early diagnosis and treatment are critical in reducing the risk of complications such as long-term disability.
Two new studies found that dialysis facilities owned by nephrologists may provide better care, with patients receiving home dialysis more often. Additionally, a shorter interval between dialysis and surgery was associated with improved post-surgery survival rates.
A new technique analyzing urine extracellular vesicles can detect changes in the kidneys earlier than conventional methods and predict renal function decline. This method has the potential to develop new urine tests that can catch the disease earlier, as well as similar tests for other diseases.
A new study has shown that SGLT-2 inhibitors, a type of diabetes medication, can decrease cardiovascular risk in adults with chronic kidney disease. The meta-analysis included results from 13 major clinical trials and found a 28% lower risk of worsening kidney disease and death from cardiovascular disease.
Researchers identified seven distinct subpopulations of kidney resident macrophages, each with unique transcriptomic signatures and functions. These subpopulations are associated with different portions of the nephron and have distinct roles in protecting the kidney from infection and maintaining tissue health.
A new study found that only around half of older adults with hypertension regularly check their blood pressure at home. Those who received a healthcare provider's recommendation to do so were three and a half times more likely to monitor their blood pressure regularly.
Studies investigate lifestyle interventions to achieve nutritional ketosis and its impact on chronic illness, sleep, and cardiovascular disease in the military. Researchers aim to understand how ketogenic diet, ketone-based beverages, and their effects on clinical outcomes will benefit soldiers' health.
A prespecified subgroup analysis of East Asian adults with lupus nephritis found that belimumab added to standard therapy improved kidney outcomes significantly. The study also showed no new safety concerns were raised in the subgroup.
Researchers identified differences in PTK activity between normal and cancer kidney tissue, with Src family kinases and PI3K pathways exhibiting high activity. Ex vivo treatment of clear cell RCC with TKIs revealed that tivozanib and cabozantinib were more potent inhibitors than sunitinib or pazopanib.
A Mayo Clinic study found that diets rich in calcium and potassium can help prevent recurrent symptomatic kidney stones. Patients who experienced a first-time stone were more likely to experience recurrence if their diet was low in these nutrients.
A study found that widely-used kidney function tests are inaccurate for predicting kidney disease in African populations, suggesting a significant underestimation of kidney disease prevalence. The creatinine-based test was shown to be less effective due to unique biological characteristics in African populations, while the cystatin C t...
A study published in The American Journal of Medicine found that regular physical activity can substantially reduce the risk of chronic kidney disease in individuals from lower socioeconomic backgrounds. Participants with higher levels of fitness showed a significantly lower risk of developing the disease, even among those with low soc...
A cross-sectional study found significant differences between estimated glomerular filtration rate (eGFR) and directly measured GFR (mGFR), highlighting the importance of considering uncertainty in eGFR calculations. Researchers suggest renaming eGFR as a population average GFR to improve accuracy.
Researchers found that invasive therapy for non-ST segment elevation myocardial infarction in patients with CKD is associated with lower mortality and reduced risk of cardiac events. The study challenges the dominant practice of offering medical management instead of invasive therapy for this population.
A recent review article highlights the crucial role of macrophages in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The study suggests that targeting specific signaling pathways and altering macrophage activation can prevent renal fibrosis and CKD. Therapeutic strategies such as clodronate liposomes an...
A retrospective cohort study found that poor continuity of care is associated with increased health care use and sub-optimal prescribing of guideline-recommended medications in patients with CKD. Strengthening patient-provider relationships and guiding physicians on recommended prescribing can help mitigate these issues.
A study found that general practitioners use ultrasound for exploratory purposes, outside of formal training areas, raising concerns about appropriate use and scanning competency. Meanwhile, lung ultrasounds may enable primary care physicians to prescribe antibiotics directly, reducing radiation exposure and saving time.
A qualitative study of Black veterans with chronic kidney disease reveals feelings of anger and resentment towards racist encounters in healthcare. Participants expressed a strong sense of distrust in the healthcare system, highlighting the need for increased awareness and action to address racism.
Scientists have created cilia-free human pluripotent stem cells that exhibit symptoms of ciliopathy, such as polycystic kidney disease. These cells can be used to study the cause of these diseases and guide therapy development.
A team of researchers has identified two transcription factors, AP-2α and AP-2β, that regulate distinct segments of the distal nephron in the mammalian kidney. The study sheds light on the molecular mechanisms underlying urinary concentration and its implications for treating kidney diseases.
Researchers at Massachusetts General Hospital identified genes that play a crucial role in maintaining healthy kidney repair, including FANCD2 and Rad51. Activating a DNA repair mechanism may help preserve kidney function in people with chronic kidney disease.
A new study used a virtual population to simulate a clinical trial examining kidney damage in Black Americans. The model predicted kidney damage and showed that adding drug therapy and reducing salt intake could stop the damage, improving heart sizes as well.
A systematic review of 41 studies found that patients with advanced kidney disease who forgo dialysis have improved survival rates and quality of life. The study also showed a significant reduction in healthcare resource utilization and end-of-life care expenses.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that obesity may increase the risk of end-stage kidney disease in women with type 2 diabetes. Managing blood pressure and sugar levels is not enough to slow progression, emphasizing the need for weight management.
Researchers have developed a gel that improves the formation of arteriovenous fistulas, a vital connection site for kidney failure patients undergoing dialysis. The gel helps reduce intimal hyperplasia and vein narrowing, leading to better blood flow and increased success rates.
Researchers developed a new compound based on Nobel Prize-winning discoveries that raised hemoglobin levels in patients with kidney disease undergoing dialysis and those not on dialysis. The oral medication was found to be as safe and efficacious as conventional treatment for anemia, offering a transformative approach to patient care.
Researchers created novel frog models to replicate polycystic kidney disease, allowing for real-time observation of disease processes. AI analysis enabled rapid assessment of disease in the tiny animals.
Researchers discovered an important mediator of thrombosis in CKD patients, the IDO enzymatic pathway, which can be targeted for therapeutic purposes. Current antithrombotic agents fail to target this pathway, predisposing patients to increased risk of bleeding.
Researchers found significant variations in guideline-recommended chronic kidney disease care delivery based on race and ethnicity. The study highlights the need for targeted interventions to address these disparities and improve health outcomes for diverse patient populations.