Articles tagged with Nephropathies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Chronic kidney disease, linked to heat exposure and dehydration, is expected to surge globally as temperatures rise. Climate change also threatens to increase cardiovascular disease, Lyme disease, and other illnesses in vulnerable communities.
The study found a significant increase in pre-emptive kidney transplants covered by Medicaid in states that expanded the program, with a 66% rise compared to non-expansion states. Medicaid-covered living-donor kidney transplants also increased, particularly in expansion states.
A recent study by Mayo Clinic researchers found that over 2.3 million adult patients in the US are likely treated too intensively for their blood sugar levels, resulting in thousands of preventable hospitalizations and emergency department visits. This excessive treatment is linked to increased risk of hypoglycemia and other complicati...
Researchers at Children's Hospital Los Angeles create an in vitro model of the human kidney glomerulus that filters blood and removes toxins. The breakthrough could lead to better understanding of chronic kidney disease mechanisms and development of new treatments.
Researchers found that self-diagnosis using the internet can lead to successful diagnoses of rare inherited conditions like autosomal dominant tubulointerstitial kidney disease (ADTKD). The study received over 665 referrals from 1996 to 2017, with positive genetic testing results in 27% of cases.
A new study published in PLOS Medicine found that women who developed pre-eclampsia during pregnancy were nearly five times more likely to develop end stage kidney disease (ESKD) than those who did not. The study analyzed data from over 1 million healthy women and revealed a significant association between pre-eclampsia and ESKD risk.
A study of 812 ADPKD patients found that 9% had undiagnosed brain aneurysms, with those with hypertension and smoking more likely to have aneurysms. The overall rupture rate was approximately 5 times higher than in the general population.
Researchers found that cold snare polypectomy with continuous anticoagulant use does not increase bleeding risk, showing non-inferiority and even superiority over traditional methods. The study suggests that this procedure can be a safer alternative for patients taking blood thinners.
The UBI trial found that sodium bicarbonate treatment delayed progression of chronic kidney disease, reducing the risk of death by 57% and hospitalizations. The study also showed a significant delay in creatinine doubling time, translating to a relative risk reduction of 64%.
A multicenter trial found that linagliptin reduced albuminuria but had no significant effect on eGFR or cardiovascular risk in patients with diabetes. The study also suggested that stratifying patients with nephrotic-range proteinuria could lead to better outcomes.
Chronic kidney disease (CKD) is associated with increased cardiovascular risk due to high LDL-C levels. PCSK9 inhibitors like evolocumab and alirocumab have shown promise in reducing cardiovascular events, but more research is needed to prove their efficacy and safety in CKD patients.
A new essay published in Annals of Internal Medicine argues that physicians often have to make difficult decisions when faced with extreme political pressures. The author shares a personal story about caring for a pregnant woman who was forced to carry a baby without a brain, highlighting the need for compassion over 'choice' in patien...
Researchers have identified protective factors that play a strong role in preventing diabetic kidney disease. The study found that certain enzymes, including PKM2, are present in people with good kidney function and may be used as biomarkers and targets for personalized clinical intervention.
A study published in the New England Journal of Medicine suggests that climate change may be contributing to a mysterious epidemic of chronic kidney disease among agricultural workers. The researchers found that heat exposure and heavy labor are common factors in the disease, which is also linked to toxins such as glyphosate and lead.
A Swedish study found that preterm and early term birth are strong risk factors for the development of chronic kidney disease from childhood into mid-adulthood. Preterm birth interrupts kidney development, leading to fewer nephrons forming and an increased risk of high blood pressure and progressive kidney disease.
A new study found that consuming a nutrient-rich plant-based diet may help protect against chronic kidney disease (CKD) development. Participants with the highest adherence to a healthy plant-based diet had a lower risk of developing CKD compared to those with low adherence.
A study of 1.4 million adults in England found that socioeconomically deprived individuals are 68% more likely to develop advanced chronic kidney disease than the least deprived, experiencing poorer health outcomes and quality of life. The research recommends targeted interventions to engage disadvantaged groups through improved screen...
Scientists at Joslin Diabetes Center discovered a group of 17 inflammatory proteins associated with diabetic kidney disease progression. These Kidney Risk Inflammatory Signature (KRIS) proteins, including TNF receptors, are indicative of systemic inflammation and may serve as drug targets to prevent and treat end-stage renal disease.
Trodusquemine has shown promise in stimulating heart muscle regeneration in mice after an artificially induced heart attack, and slowing heart and skeletal muscle degeneration in a mouse DMD model. Novo Biosciences aims to develop a dosing regimen for juvenile DMD patients and define toxicity in juvenile animal models.
A study published in the Clinical Journal of the American Society of Nephrology found that pruritus affects 24% of patients with non-dialysis chronic kidney disease. Patients with pruritus reported poorer mental and physical quality of life, depression, and restless sleep.
A recent study found that kidney disease can trigger cognitive impairment even in its early stages, affecting approximately one in two patients. The cognitive decline is not age-related and worsens with declining kidney function.
A new global study, Global Kidney Health Atlas (GKHA), is released on April 12 at the World Congress of Nephrology, detailing country and region breakdowns of global kidney health. The study highlights disparities in treatment access due to social, economic, and political factors, resulting in over 2 million deaths annually worldwide.
A researcher at Children's National Hospital has received a $2 million NIH grant to study new approaches to treating kidney disease linked to the APOL1 risk allele. The team plans to use a Drosophila model to identify potential therapeutic targets and test compounds for effective treatment.
A new study reveals that chronic kidney disease of undetermined causes (CKDu) is present in rural India, particularly in Southern areas, and shares similar risk factors as in Central America and Sri Lanka. The disease affects mainly working-age populations and has a faster clinical evolution compared to traditional CKD.
A recent study found that very few smartphone apps related to chronic kidney disease (CKD) are highly rated by both patients and physicians. The study suggests that patient opinions on app quality correlated poorly with physician ratings and consumer ratings from iOS and Android app stores.
A new study finds that occupational heat exposure is linked to a decline in kidney function and chronic kidney disease (CKD) in artisanal brick makers in Nicaragua. The researchers found 12.1% of the sample had stage 3-5 CKD, with risk factors including operating ovens, less education, older age, and inadequate water intake.
Researchers at Wake Forest Institute for Regenerative Medicine have made breakthroughs in treating chronic kidney disease with cell therapy. Amniotic fluid-derived stem cells injected into diseased kidneys showed improvement in kidney function and structural recovery after 10 weeks, reducing damage to capillary clusters.
A new study has found a strong association between secondhand smoke exposure and the development of chronic kidney disease. Even brief periods of exposure, such as less than 3 days per week, were linked to a higher risk of CKD, with a 66% increased risk compared to those with no exposure.
Researchers at Clemson University developed a targeted nano therapy that destroyed calcium buildup in arteries without causing side effects. The therapy mimics a human's chronic kidney disease and has the potential to benefit thousands of patients.
Researchers found patients taking proton pump inhibitors (PPIs) were 28.4 times more likely to develop chronic kidney disease compared to those taking histamine-2 receptor antagonists. PPIs were also linked to higher rates of acute kidney injury, end-stage renal disease, and unspecified kidney impairment.
A new study by Loyola Medicine and colleagues reveals that only 21.8% of non-dialysis-dependent chronic kidney disease patients use statins, despite being at high risk for cardiovascular disease.
A study examining barriers to exercise among dialysis patients reveals that fatigue and weakness are major obstacles. Patients would like to improve their energy, strength, and quality of life through exercise, with most preferring aerobic and resistance training at home.
A study combining technology with healthcare provider perceptions identifies nonadherent patients better than doctors' perceptions alone. Pharmacy refill data shows that combining provider reports and pharmacy data leads to the most balanced sensitivity and negative predictive power.
A study of 3003 African-American adults found that consuming a pattern of soda, sweetened fruit drinks, and water was associated with a higher risk of developing chronic kidney disease. The researchers were surprised to see that water as part of this beverage pattern was linked to a higher risk of CKD.
A systematic review and meta-analysis found that CoQ10 supplementation significantly reduced total-cholesterol, malondialdehyde, and creatinine levels in patients with chronic kidney disease. The treatment did not affect other metabolic markers, suggesting a potential therapeutic benefit for CKD patients.
Researchers aim to evaluate a low dose blood-thinning medication for people with advanced kidney disease, a condition affecting over 30.5 million globally. The five-year trial will also investigate the safety of this medication in reducing heart attacks, strokes and deaths.
Chronic kidney disease (CKD) is characterized by progressive loss of kidney function, which can be attributed to faulty cellular energy sensing. Researchers have identified a link between decreased AMPK activity and CKD progression, highlighting a potential therapeutic target for treatment.
A new study by American Society of Nephrology examined 281,233 patients with diabetes and CKD in 130 VA facilities. The findings point to areas where care might be improved and standardized among facilities.
Researchers discovered a new pathway to enhance kidney self-repair by reprogramming the body's metabolism. The 'lift and push' process involves shifting glucose from energy production to repair damaged cells, resulting in improved lifespan for injured animals.
A pilot program in rural New Mexico promoted patients' active involvement in their daily care, leading to modest improvements in clinical measures. The intervention also showed significant benefits in mental health quality of life and reduced CKD risk factors.
Researchers at NYIT are investigating the process of molecular calcification to develop a new therapy for vascular calcification. The study will validate theories on phosphatase enzyme activity and test a compound known as SBI-425 as a potential treatment.
Researchers analyzed data from 28 papers involving over 1,300 participants and found no evidence linking high protein diets to kidney disease in healthy individuals or those at risk of kidney disease. A high-protein diet can actually increase kidney function, making it a safe and important tool for muscle health across the lifespan.
Researchers have successfully developed kidney tissue that exhibits the early stages of congenital kidney disease using iPS cells from a patient with a nephrin mutation. The study found that repairing the nephrin mutation can normalize abnormalities and may lead to the development of effective drugs for kidney disease.
Adults with chronic kidney disease have a higher likelihood of receiving opioid prescriptions and using them, suggesting a link to the national opioid epidemic. Multiple comorbid conditions, including pain-causing and non-pain-related conditions, are associated with increased prescription opioid use in patients with CKD.
A phase II clinical trial found that sparsentan significantly reduces proteinuria by 45% in patients with focal segmental glomerulosclerosis (FSGS), a rare kidney disorder. The study also suggests potential implications for other kidney diseases characterized by proteinuria.
A new study found that Medicaid expansion led to a significant decrease in mortality rates among patients with end-stage kidney disease. In states that expanded Medicaid, the number of deaths within a year of starting dialysis decreased by 0.8 percentage points compared to non-expansion states.
Researchers have found that intensive blood pressure lowering does not necessarily lead to true kidney disease, but rather benign reductions in kidney blood flow. This major advancement challenges current clinical standards for diagnosing and monitoring chronic kidney disease.
A comprehensive national registry for pediatric chronic kidney disease (CKD) is essential to improve lifespan and quality of life. The study emphasizes the importance of identifying children at risk, with high mortality rates among those requiring renal replacement therapy.
The Dartmouth Institute has received a $3.5 million grant to test preventative interventions for acute kidney injury (AKI) in patients undergoing cardiac catheterization. The study aims to evaluate the effectiveness of virtual learning collaboratives with and without automated surveillance reporting.
Researchers found that patients taking full-dose allopurinol for gout flares had a lower risk of developing Stage 3 Chronic Kidney Disease (CKD) compared to non-users. The use of allopurinol may be beneficial in reducing kidney disease risk, contrary to previous concerns.
A large multi-ethnic study found that high circulating levels of an inflammatory marker are linked to long-term decline in kidney function. The study suggests a novel marker, soluble TNFR-1, is strongly related to kidney function decline over time.
Researchers found that extending specialized care to patients with advanced kidney disease before their kidneys fail could save the US healthcare system more than $1 billion annually. Improving care coordination among these patients is crucial for reducing costs and improving health outcomes.
Researchers identified specific genes and cells associated with CKD, including the adaptor protein DAB2 in the TGF-β pathway. Further experiments confirmed that reducing DAB2 expression protected mice from CKD. The findings could inform treatment options for this complex disease.
Researchers found that vitamin B complex supplementation improved blood glucose regulation and kidney function in children with type-1 diabetes. The study suggests that simple supplementation may be a safe and cost-effective strategy for early protection of kidney function.
Researchers found a relationship between high FGF23 levels and structural compromise in the brain, particularly in the frontal lobes, which control learning and complex cognitive functions. Elevated FGF23 levels were also associated with increased disconnection in the brain, indicating problems with brain health in those areas.
Exposure to PFAS has been linked to worse kidney function and other signs of kidney damage in studies analyzing all relevant research. The analysis points to the need for further research on the effects of PFAS on kidney health.
A new study suggests that moderate caffeine consumption may help reduce the risk of death for individuals with chronic kidney disease. Participants who consumed more caffeine had a nearly 25% lower risk of mortality over a median follow-up period of 60 months.
A study published in Canadian Medical Association Journal found that patients with acute critical illness without pre-existing kidney disease are at increased risk of developing chronic kidney disease and end-stage renal disease. The study also shows that these patients have a higher risk of death.
A new study published in PLOS ONE suggests that polluted air may be a threat to your kidneys, increasing the risk of chronic kidney disease. Air pollution contains fine particulate matter (PM2.5), which can cause serious health effects when inhaled regularly.
A study published in the Journal of the American Society of Nephrology found that black and Hispanic veterans with chronic kidney disease are more likely to progress to advanced kidney disease despite equal access to nephrologist care. Genetic or environmental factors, such as APOL1 mutations, may be central to these disparities.