Articles tagged with Nephropathies
Children with chronic kidney disease experience prolonged hospital stays (30% longer) and increased hospital expenses ($8,755 vs. $5,016). They also have a higher risk of in-hospital mortality, with a 50% increase compared to other chronic conditions.
Researchers found that using the race multiplier correction factor for Black patients with chronic kidney disease can lead to delayed referrals and critical conversations about dialysis. Removing this factor could reclassify up to one-third of Black patients to a more severe stage of CKD.
Researchers developed a risk-scoring calculation that adds blood and urine measures of kidney disease to the current standard method for assessing cardiovascular disease risk. The study found that adding these measures can result in large increases in cardiovascular disease-risk estimates among patients with severe kidney disease.
A study of US hospitals found that children with chronic kidney disease (CKD) experience longer hospital stays and incur higher healthcare expenses due to the complexity of their medical needs. Further investigation is needed to understand the healthcare needs of this population.
Two newer diabetes medications can significantly reduce the risk of heart disease, cardiovascular events, and end-stage kidney disease. They also lower blood pressure and slow chronic kidney disease progression.
A recent study found that being physically active can significantly reduce the risk of developing chronic kidney disease (CKD). The study, which followed over 15,000 middle-aged adults for 24 years, showed that even moderate physical activity can lower the risk of CKD by up to 11%.
Researchers developed a tailored education system called 'Your Path to Transplant' that increases patient knowledge and readiness to pursue kidney transplant. The program, tested on over 800 patients, showed significant improvements in transplant preparedness and living donor transplant rates.
A large-scale clinical trial has shown that lanthanum carbonate does not reduce the risk of cardiovascular disease developing in patients with chronic kidney disease. High phosphate levels are a common problem in kidney disease and linked to cardiovascular disease, but the study found no benefit from the medication.
A systematic review of over 100 studies found that a more vegetable-rich diet, higher potassium intake, and reduced salt consumption can lower the risk of chronic kidney disease. Adhering to these recommendations could reduce the risk by 14-22%.
A 25-year analysis of PGT for kidney diseases in the Netherlands shows that 65% of couples with at least one successful cycle experienced live births without kidney disease. The study highlights the importance of counseling patients on their reproductive options to make informed choices.
Researchers at Children's Hospital Los Angeles are investigating cellular damage and repair in chronic kidney disease and Alport syndrome. Their studies aim to identify molecules that trigger injury in kidney cells, with potential applications for medications and treatments.
Obesity, as measured by body mass index and abdominal fat content, is associated with an increased risk of heart disease and progression of kidney disease in patients with chronic kidney disease. Lower physical fitness levels are also linked to a higher cardiovascular risk.
A decision support system within the EHR system significantly increased provider awareness of CKD among primary care providers. The study demonstrated that implementation of such a system can lead to improved processes of care, including blood pressure management and medication prescribing.
A large clinical trial, CKD-FIX, found that allopurinol does not prevent worsening of kidney disease. The study showed no difference in kidney function decline between the treatment and placebo groups.
Researchers analyzed EMPA-REG OUTCOME trial data to investigate impact of initial 'eGFR dip' on kidney outcomes. Diuretic use and higher KDIGO risk category were predictive factors for 'eGFR dip', but no significant impact on risk reduction
Researchers have discovered a link between exposure to certain environmental chemicals and an increased risk of chronic kidney disease. The study analyzed data from 46,748 US adults and found that elevated levels of seven chemicals were associated with markers of kidney disease.
A nationwide intervention to replace regular salt with potassium-enriched salt substitutes in China could prevent nearly half a million cardiovascular deaths per year. The blood pressure lowering effects of salt substitution were estimated to prevent around 460,000 cardiovascular disease (CVD) deaths each year.
A study has uncovered a mechanism explaining how genetic mutations lead to nephrotic syndrome, a rare genetic kidney disorder. The researchers found that disruptions in the recycling of cell membranes cause abnormal kidney cell structure and function.
A study found housing insecurity is associated with a 3.2-fold higher odds of albuminuria, a sign of kidney disease, but not rapid kidney function decline. Housing insecurity was linked to delayed healthcare visits and compromised health in urban-dwelling adults.
Researchers found that African Americans with kidney disease have higher rates of uncontrolled blood pressure when measured at home. Participants with masked hypertension had worse physical functioning than those with controlled hypertension.
Studies have shown that chronic kidney disease (CKD) patients are more susceptible to salt-induced hypertension. A recent study published in Kidney International found a link between the immune system and salt sensitivity in CKD, with TNF-α triggering high blood pressure.
A recent study found that exposure to fine particulate matter is associated with a higher degree of albuminuria and a higher risk of developing chronic kidney disease. The study suggests that efforts to improve air quality may yield health benefits, including reducing rates of chronic kidney disease.
Researchers have discovered that contaminated groundwater in Balkan villages is a significant source of human exposure to aristolochic acids, potent kidney toxins. The discovery highlights the urgent need for weed control measures to reduce the incidence of Balkan endemic nephropathy.
A comprehensive evaluation of existing quality metrics for kidney disease reveals that less than half are highly valid, with nearly half related to dialysis management. The study proposes refinements and new metrics to better reflect the spectrum of kidney care delivery, aiming to improve the accuracy of quality measurement.
A new study reveals chronic kidney disease is a leading cause of death globally, resulting in an estimated 1.23 million deaths in 2017. The disease's impact varies widely across countries, with some nations experiencing rates nearly 15 times higher than others.
Researchers have successfully isolated kidney stem cells from urine, expressing markers similar to bone marrow-derived mesenchymal stem cells and renal stem cell markers. The isolated cells can differentiate into various kidney cell types, including proximal- and distal-tubules and podocytes.
Researchers identified coronary microvascular dysfunction as a precursor to later heart disease and possible death in patients with chronic kidney disease. The study found that CMD was associated with abnormal mechanics of the left ventricle and clinical risk of adverse cardiovascular outcomes.
A new study found that between 15-22 out of every 100 Indian patients with mild-to-moderate CKD had significant impairment in at least one domain of quality of life. Lower income, poor education, and female gender were associated with lower quality of life scores.
High levels of protein in urine shortly after an episode of acute kidney injury are associated with increased risk of kidney disease progression. The study suggests that measuring urine protein levels can help identify patients at highest risk and guide appropriate referrals to reduce adverse health outcomes.
A University of Tsukuba study reveals that histamine, a key factor in inflammation, can control the severity of cardiorenal syndrome in mice. Histamine agonist drug prevents further damage in a mouse model of cardiorenal dysfunction, showing protective changes in gene expression.
A recent study found that a significant proportion of children with chronic kidney disease (CKD) are prescribed medications that may be toxic to their kidneys. Among the studied population, 71% of those with CKD and 50% without received at least one potentially nephrotoxic medication over an average follow-up period of 3.3 years.
The American Society of Nephrology has honored five individuals for their outstanding contributions to kidney disease research, education, and clinical practice. Mitchell Rosner received the Robert G. Narins Award for his work in education and teaching, while Toshiro Fujita was recognized for his groundbreaking research on hypertension.
An observational study of nearly 16,000 older adults with chronic kidney disease (CKD) found that higher doses of the muscle relaxant baclofen were associated with a greater risk of hospitalization due to encephalopathy. The study suggests that patients with CKD may need closer monitoring when prescribed baclofen.
A new risk calculator tool predicts accurate five-year risk of chronic kidney disease based on variables like age, hypertension, and diabetes status. The tool enables healthcare providers to identify patients at high risk and benefit from preventive interventions.
A new study used data from over 5 million people to develop equations predicting the five-year risk of reduced estimated glomerular filtration rate (eGFR), a key indicator of chronic kidney disease. The findings can help identify individuals at increased risk and potentially prevent or manage the condition.
Researchers investigated the effect of vitamin D and omega-3 supplements on chronic kidney disease (CKD) development or progression in adults with type 2 diabetes. The study found no significant difference in CKD progression between supplementation groups.
A study examining clinical trial data found that sleep problems and fatigue significantly impact the cognitive function and behavior of children with chronic kidney disease. The research highlights the importance of assessing sleep problems and fatigue in these children to improve their emotional-behavioral and neurocognitive outcomes.
Researchers have developed a non-invasive method to visualize kidney disease in live animals using genetically modified mice. They found that a promising chemical found in citrus fruit, G-Hes, reduces inflammation in the kidneys when fed to mice with kidney disease.
Chronic kidney disease patients are at an increased risk of heart attacks, congestive heart failure, stroke, and other adverse cardiovascular events. The study found that chronic kidney disease is associated with a 95% higher risk of heart attack during the follow-up period.
A study by JAMA Network found a potential association between ACE inhibitors and ARBs and an increased risk of suicide among individuals with hypertension, diabetes, and chronic kidney disease. The observational study analyzed data from over 200,000 patients to identify any possible links between these medications and suicidal behavior.
A study found that prescription opioids are associated with a higher risk of death and hospitalization compared to other pain medications, especially at high doses. The risk is highest among individuals with lower kidney function, who may experience reduced clearance of the active compounds from their bodies.
A study of 1,461 hospital data breaches found that 71% compromised sensitive demographic or financial information, putting patients at risk of identity theft. The breaches also revealed a lack of transparency about the types of information compromised, sparking calls for policymakers to require standardized documentation.
Researchers have uncovered 16 genetic regions linked to diabetic kidney disease, which may help identify potential targets for prevention and treatment. The study provides insights into the pathogenesis of DKD and could lead to new therapeutic strategies.
Kaiser Permanente research finds that at-home peritoneal dialysis is safe and effective for managing advanced-stage kidney disease, improving lifestyle and quality of life. The study shows a significant increase in at-home dialysis rates over 10 years, with 80% of patients remaining on it one year after starting.
Bereaved family members rate end-of-life care higher for patients who received palliative and hospice care, rather than intensive patterns of life extension. Patients treated with dialysis have more aggressive end-of-life care, which is associated with lower quality ratings.
Chronic kidney disease, linked to heat exposure and dehydration, is expected to surge globally as temperatures rise. Climate change also threatens to increase cardiovascular disease, Lyme disease, and other illnesses in vulnerable communities.
The study found a significant increase in pre-emptive kidney transplants covered by Medicaid in states that expanded the program, with a 66% rise compared to non-expansion states. Medicaid-covered living-donor kidney transplants also increased, particularly in expansion states.
A recent study by Mayo Clinic researchers found that over 2.3 million adult patients in the US are likely treated too intensively for their blood sugar levels, resulting in thousands of preventable hospitalizations and emergency department visits. This excessive treatment is linked to increased risk of hypoglycemia and other complicati...
Researchers at Children's Hospital Los Angeles create an in vitro model of the human kidney glomerulus that filters blood and removes toxins. The breakthrough could lead to better understanding of chronic kidney disease mechanisms and development of new treatments.
Researchers found that self-diagnosis using the internet can lead to successful diagnoses of rare inherited conditions like autosomal dominant tubulointerstitial kidney disease (ADTKD). The study received over 665 referrals from 1996 to 2017, with positive genetic testing results in 27% of cases.
A study of 812 ADPKD patients found that 9% had undiagnosed brain aneurysms, with those with hypertension and smoking more likely to have aneurysms. The overall rupture rate was approximately 5 times higher than in the general population.
A new study published in PLOS Medicine found that women who developed pre-eclampsia during pregnancy were nearly five times more likely to develop end stage kidney disease (ESKD) than those who did not. The study analyzed data from over 1 million healthy women and revealed a significant association between pre-eclampsia and ESKD risk.
Researchers found that cold snare polypectomy with continuous anticoagulant use does not increase bleeding risk, showing non-inferiority and even superiority over traditional methods. The study suggests that this procedure can be a safer alternative for patients taking blood thinners.
A multicenter trial found that linagliptin reduced albuminuria but had no significant effect on eGFR or cardiovascular risk in patients with diabetes. The study also suggested that stratifying patients with nephrotic-range proteinuria could lead to better outcomes.
The UBI trial found that sodium bicarbonate treatment delayed progression of chronic kidney disease, reducing the risk of death by 57% and hospitalizations. The study also showed a significant delay in creatinine doubling time, translating to a relative risk reduction of 64%.
Chronic kidney disease (CKD) is associated with increased cardiovascular risk due to high LDL-C levels. PCSK9 inhibitors like evolocumab and alirocumab have shown promise in reducing cardiovascular events, but more research is needed to prove their efficacy and safety in CKD patients.
A new essay published in Annals of Internal Medicine argues that physicians often have to make difficult decisions when faced with extreme political pressures. The author shares a personal story about caring for a pregnant woman who was forced to carry a baby without a brain, highlighting the need for compassion over 'choice' in patien...
Researchers have identified protective factors that play a strong role in preventing diabetic kidney disease. The study found that certain enzymes, including PKM2, are present in people with good kidney function and may be used as biomarkers and targets for personalized clinical intervention.
A study published in the New England Journal of Medicine suggests that climate change may be contributing to a mysterious epidemic of chronic kidney disease among agricultural workers. The researchers found that heat exposure and heavy labor are common factors in the disease, which is also linked to toxins such as glyphosate and lead.
A Swedish study found that preterm and early term birth are strong risk factors for the development of chronic kidney disease from childhood into mid-adulthood. Preterm birth interrupts kidney development, leading to fewer nephrons forming and an increased risk of high blood pressure and progressive kidney disease.