The ADVOCATE study demonstrates avacopan's effectiveness in reducing corticoid use and achieving sustained remission in patients with AAV, particularly those with renal involvement. The treatment also showed improved outcomes with lower infection rates compared to standard immunosuppressive therapy.
A randomized trial found that rituximab reduces the risk of relapse by 64% compared to azathioprine, with fewer severe adverse events. The study suggests that rituximab may be a superior treatment option for patients with ANCA-associated vasculitis, particularly those with history of relapses.
A new UCL-led study found that repetitive negative thinking is linked to cognitive decline and increased risk of Alzheimer's disease. The research, published in Alzheimer's & Dementia, suggests that psychological tools like mindfulness or meditation may help reduce dementia risk.
The BLISS-LN study showed that belimumab added to standard therapy resulted in a significantly better primary renal response at 2 years, with 43% showing improvement versus 32% on placebo. Additionally, patients treated with belimumab had a 50% lower risk of experiencing renal events associated with poor prognosis.
A study by Oregon State University found that telepresence robots can enhance student engagement and expression in online classes. In contrast, instructors preferred teaching students in person, but valued telepresence robots as a remote learning solution over distance learning tools.
A new study reveals that great white sharks spend most of their time foraging just above the seabed, contrary to the common stereotype of a shark's dorsal fin above the surface. The diet of juvenile white sharks consists mainly of fish species that live on or near the seafloor.
Researchers found that pinker flamingos are more aggressive when competing for food in confined spaces. In contrast, birds fed outdoors with space to roam spend less time displaying aggression and double their foraging time.
A Phase 3 study found lumasiran to be effective in reducing 24hr urinary oxalate excretion by 65.4% and normalizing oxalate levels in patients with PH1. The treatment also showed an encouraging safety profile, with mild injection-site reactions being the most common adverse event.
A recent study analyzing data from over three million individuals found widespread sex-differential participation bias, suggesting that men and women are more likely to participate in genetic studies based on different characteristics. This bias can impact the accuracy of results and conclusions drawn from genetic association studies.
Researchers found a 50% decline in North East Atlantic plankton over the past 60 years, with tiny picophytoplankton replacing more nutritious species. This shift affects fish, seabirds, and marine mammals, threatening shelf sea food webs.
A new study by UCL and Great Ormond Street Hospital found that virus DNA can spread to nearly half of all sites sampled in a hospital ward within 10 hours. The study used artificial DNA replication to simulate how SARS-CoV-2, the virus causing Covid-19, spreads across surfaces.
A four-year study at Jodrell Bank Observatory reveals a repeating Fast Radio Burst (FRB) follows a cyclic pattern with radio bursts observed every 90 days, followed by a silent period of 67 days, repeating every 157 days. This discovery provides an important clue to identifying the origin of FRBs.
Researchers analyzed EMPA-REG OUTCOME trial data to investigate impact of initial 'eGFR dip' on kidney outcomes. Diuretic use and higher KDIGO risk category were predictive factors for 'eGFR dip', but no significant impact on risk reduction