Articles tagged with Nephropathies
Researchers from the University of Pennsylvania identified three novel cell populations and understood how kidney disease develops at a single-cell level. They found that specific cell types convert to each other, leading to conditions like chronic kidney disease, which affects about 14 percent of Americans.
A new study suggests that multidisciplinary care programs for patients with mild to moderate chronic kidney disease (CKD) are likely to be cost-effective. The study estimates that such programs add 0.23 quality-adjusted life years over usual care, with a cost of $51,285 per QALY gained.
A recent VA study found that over 30% of diabetic veterans had prior signs of chronic kidney disease. The results highlight the importance of early detection and screening for CKD in at-risk populations. Researchers propose broadening screening among patients with increased risk of CKD to prevent organ damage.
Patients with non-dialysis chronic kidney disease (CKD) who performed combined exercise showed greater increases in muscle mass and strength compared to those doing aerobic exercise alone. The study found that combining both modes of exercise led to significant health benefits, including increased cardiorespiratory fitness.
Researchers found that high glucose levels are associated with a higher risk of heart attack and kidney dysfunction in people with prediabetes. The study suggests that identifying and treating this group can lead to significant reductions in cardio-metabolic risks.
An analysis of published studies found that children with CKD had lower intellectual functioning compared to children in the general population, particularly those on dialysis. Deficits were evident for attention, memory, and executive function domains.
Children with chronic kidney disease (CKD) experience deficits in academic skills, visual and verbal memory, and executive function, according to a new study. The analysis of 34 studies found that CKD patients have an average IQ 10 points lower than healthy children, with those on dialysis showing an even greater decline.
A US researcher has received a grant to investigate the role of ALCALM in lupus, a complex autoimmune disease. The study aims to understand how ALCALM drives the immune system to attack healthy tissues, and potentially find new treatments or even a cure for lupus.
Researchers explore mechanisms protecting animals from chronic kidney disease, such as naked mole rats' longevity and hibernation adaptations. Biomimetics collaboration could lead to novel therapeutic approaches and improved human health.
A recent study has found that people over 65 with chronic kidney disease and atrial fibrillation are at increased risk of stroke when taking blood thinners. The researchers estimate that half a million UK adults fall into this category, highlighting the need for cautious prescribing practices.
A study by Kaiser Permanente and University of Washington found that patients with chronic kidney disease who receive implantable cardioverter defibrillators experience a significantly increased risk of subsequent hospitalization. The use of ICDs was associated with a 49% increased risk of hospitalization for heart failure and a 25% in...
Scientists at Joslin Diabetes Center found a connection between eye damage and cardiovascular disease in people with type 1 diabetes, suggesting shared biological mechanisms. The study also showed that kidney disease was not necessarily linked to cardiovascular disease, challenging previous assumptions.
Researchers from ColoradoSPH identified new risk factors for a mysterious kidney illness affecting farm workers worldwide. The study found that access to water, rest, and shade reduces the rates of kidney disease onset and injury severity.
A new study by Boston University researchers confirms the link between chronic kidney disease and increased risk of blood clots, identifying specific tryptophan metabolites as key players. The findings provide a promising approach for risk stratification and potential treatment strategies for CKD patients.
A group of articles highlights the factors threatening job satisfaction and high-quality care delivery among nephrology specialists. Experts propose measures to improve professional lives, including fellowship training reform, practice transformation, and creating a stronger community of nephrologists.
A study found that undocumented immigrants with emergency-only dialysis were more likely to die after three and five years, as well as spend more days in the hospital. The study highlights the need for states to consider the human and economic toll of providing access to less-than-standard dialysis for these patients.
A new therapeutic paradox targets thrombo-vascular complications in kidney disease by boosting a regulatory protein called STUB1, which interacts with tissue factor to trigger clotting. This approach may offer an alternative to standard heparin treatment while maintaining a balance between pro-clotting and anticoagulant factors.
A recent study published in PLOS Medicine reveals that HIV patients are at a higher risk of both chronic kidney disease and cardiovascular disease. The research found that nearly 11% of patients experienced both conditions within one year of each other.
Research highlights the need for better nutritional management in chronic kidney disease, where high protein diets may have deleterious impacts on kidney health. A low protein, low salt diet may slow progression and help patients defer dialysis initiation.
A phase 3 trial found tolvaptan slows the rate of decline in kidney function in patients with autosomal dominant polycystic kidney disease. The condition affects millions in the US and has no cure. The drug targets a mechanism contributing to cyst growth, potentially delaying transplant or dialysis need.
A study of 3725 participants with chronic kidney disease found that depressive symptoms were associated with a higher risk of early death in white individuals, but not in black individuals. Treatment of depressive symptoms may help lower this risk.
The global burden of chronic kidney disease attributable to air pollution is estimated to be over 10.7 million cases per year, with varying impacts by geography. Air pollution may contribute to the rising incidence of CKD worldwide, particularly in Central America and South Asia.
A dose-dependent inverse association was found between caffeine consumption and early death in patients with chronic kidney disease. The study, presented at ASN Kidney Week 2017, suggests that advising patients to drink more caffeine may reduce mortality.
Longtime advocates Paul T. Conway and Richard Knight received the ASN's President's Medal for their significant contributions to the fight against kidney diseases, including improving access to treatment and increasing funding for research and treatment innovations.
A study found that Canadian nephrologists generally recommend follow-up kidney evaluations for most patients with acute kidney injury but only a minority receive these evaluations. The disparity between recommendations and actual practices may be attributed to various factors, including patient age and pre-existing conditions.
A study published in PLOS Medicine found that using cystatin C with creatinine to estimate GFR for chronic kidney disease diagnosis resulted in increased healthcare costs without improved risk prediction. The test led to a higher number of patients being reclassified to more advanced CKD, requiring more frequent monitoring and referrals.
A new study led by NYU School of Medicine found that Hispanic and Asian women in Manhattan have a higher prevalence and severity of lupus than white women. The study also showed significant disparities in kidney disease among these demographic groups.
Research finds that Asian dust is associated with an increased likelihood of acute myocardial infarction, especially in patients with chronic kidney disease. The study analyzed data from Kumamoto University Hospital and found a significant association between Asian dust exposure and the onset of acute myocardial infarction.
Researchers found that high levels of suPAR are a reliable predictor of kidney damage in children, similar to adults. The protein is associated with increased risk of kidney loss and progression in children with mild to moderate kidney disease.
A new prediction tool has been developed to identify elderly patients at greatest risk of acute myocardial infarction during Asian dust storms. The tool, based on a simple scoring system, takes into account various pre-existing conditions and can help prevent AMI in high-risk patients.
A recent study of healthy young adults found no association between marijuana use and change in kidney function over time or albumin in the urine. Further research is needed to assess the effects of marijuana on older adults and patients with kidney disease.
A study found that individuals with poor kidney function had a higher risk of developing lower respiratory tract infections, urinary tract infections, and sepsis. The relative proportion of these infections increased as kidney function decreased.
A Massachusetts General Hospital study found that deficits in the sense of smell are common among patients with serious kidney disease and correlate with poor nutrition. A proof-of-concept trial of a potential treatment for these olfactory deficits showed promising results.
A specially designed exercise program improved blood vessel health and exercise capacity in chronic kidney disease patients. Patients also reported improvements in their everyday quality of life as a result of becoming more active.
A new study published in the New England Journal of Medicine found that canagliflozin significantly reduced the risk of both cardiovascular disease and kidney disease in people with type 2 diabetes. The drug was shown to lower blood sugar levels and also provide protection against heart failure and renal decline.
A new study found that higher body fat was linked with increased risk of developing chronic kidney disease. Waist circumference and BMI were shown to provide similar information on risk as more direct measures of different types of body fat, indicating these simple measures may be reliable for assessing an individual's risk.
Patients with chronic kidney disease are at a higher risk of experiencing complications when hospitalized, including longer hospital stays and mortality. The study found that potentially preventable hospital-acquired complications are linked to an elevated risk of early death in these patients.
Scientists at Joslin Diabetes Center have found that healthy individuals with diabetes develop protective enzymes against damage from high blood sugar levels. The researchers identified an enzyme called PKM2 and showed that activating it can stop abnormalities in mouse podocytes and delay diabetic kidney disease progression.
Research on osteoporosis medications in patients with chronic kidney disease (CKD) found mixed results regarding benefits and harms. Bisphosphonates may slow BMD loss but effects on fractures and safety are unclear. More research is needed to determine the best options for patients across CKD spectrum.
A recent Yale-led study found that marathon running can cause short-term kidney injury in runners, with 82% of participants showing signs of Stage 1 Acute Kidney Injury after the event. The researchers attribute this to sustained rises in core body temperature, dehydration, and decreased blood flow to the kidneys.
A preclinical study has established a link between gene variants in African American populations and kidney disease risk. The G1 and G2 APOL1 variants, found almost exclusively in West African descent individuals, cause human-like kidney disease when expressed in filtering cells.
Researchers at Maastricht University Medical Center found that omitting standard intravenous hydration during contrast material procedures for patients with compromised renal function has no added value and may even lead to negative consequences. Omitting this treatment could prevent complications and save millions of euros in care costs.
A randomized crossover trial found that limiting sodium intake reduced systolic blood pressure by an average of 11mmHg and excess fluid retention. The study suggests that simple dietary advice may help slow the progression of chronic kidney disease.
Researchers at King's College London have found that patients with early stages of kidney disease and type 1 diabetes have lower levels of the protective 'anti-ageing' hormone Klotho. This discovery could lead to the development of new treatments to prevent kidney disease in patients with type 1 diabetes.
A new study has found that skin sodium content is strongly correlated with left ventricular hypertrophy in patients with chronic kidney disease. Reducing skin sodium through dietary restriction or medications may help protect the heart in these patients.
A recent study published in Annals of Emergency Medicine found no association between intravenous contrast media and acute kidney injury. The research, which analyzed five years of records, showed that the probability of developing acute kidney injury was higher for patients receiving unenhanced CT scans.
A study at Columbia University Medical Center found that a missing CRKL gene causes kidney and urinary tract defects in people with DiGeorge syndrome. The team analyzed genomic data from over 2,600 children with congenital anomalies of the kidney and urinary tract.
SGLT2 inhibitors demonstrate renoprotective effects by reducing intraglomerular pressure, hyperfiltration, and improving renal function in patients with diabetes. Additionally, these drugs modulate the renin-angiotensin axis, which may contribute to their observed benefits.
A study found that decreased blood levels of soluble klotho were linked to an increased likelihood of experiencing kidney function decline in elderly adults. Higher klotho levels may help preserve kidney function.
A phase 3 trial found that oral ferric citrate significantly boosted hemoglobin levels in patients with chronic kidney disease, correcting anemia. The treatment effect was seen as early as 1-2 weeks after starting treatment and was durable.
A study published in Nature Medicine identifies bone marrow-derived immature myeloid cells as the source of suPAR, a reliable marker for chronic kidney disease. Elevated suPAR levels have been linked to future chronic kidney disease, potentially enabling early intervention and prevention of recurrence after transplant.
A study found that type 1 diabetes patients with elevated albumin in their urine had triple the risk of life-threatening kidney and cardiac disease compared to those with normal levels. Copeptin levels were significantly higher in these patients, suggesting a new potential target for therapies.
A study reveals that the liver is the primary source of Apol1, a protein linked to kidney disease, and finds a significant association between APOL1 gene variants and increased risk in individuals of recent African ancestry. The findings provide new insights into the biology of Apol1 and its potential role in health and disease.
A simple saliva test for salivary urea nitrogen showed high accuracy in diagnosing kidney disease in adults in Malawi. The test also predicted patients' risk of early death, highlighting its potential to improve treatment outcomes.
Amit X. Garg, a renowned nephrologist, is being honored by the American Society of Nephrology for his groundbreaking research on living kidney donation and kidney health analytics. His work has led to improved understanding and treatment of kidney diseases, including E. coli O157:H7 poisoning and acute kidney injury.
A clinical trial conducted by Wayne State University and Henry Ford Hospital found that a family psychoeducation consultation reduced 30-day all-cause hospital readmissions from 32% to 18%. The intervention improved patient health outcomes and reinforced the need for Integrative Behavioral Care.
Scientists have developed a method to create functional kidney units from patient cells, allowing for the study of human kidney diseases and potential therapeutic agents. The research enables in vitro studies of kidney pathophysiology and nephrotoxicity, with the ultimate goal of developing bioengineered kidneys for regenerative medicine.
A new study found that reducing sodium intake significantly reduced albuminuria and blood pressure in patients with chronic kidney disease. The combination of paricalcitol and a low sodium diet resulted in the lowest albuminuria levels in patients, indicating a strong reduction in kidney function decline and heart benefits.
Researchers at UC San Diego School of Medicine developed a bioinformatics framework that identified key proteins significantly altered in patients with diabetic kidney disease. The 'MetBridge Generator' framework revealed the protein MDM2 played a key role in disease progression, and its potential as a therapeutic target was discovered.
Research found no association between allopurinol use and increased risk of chronic kidney disease (CKD) Stage 3 or higher in gout patients with normal kidney function. Allopurinol may be beneficial for preventing renal decline, suggesting its safe use in managing gout symptoms.