Articles tagged with Nephropathies
Patients with chronic kidney disease are at a higher risk of experiencing complications when hospitalized, including longer hospital stays and mortality. The study found that potentially preventable hospital-acquired complications are linked to an elevated risk of early death in these patients.
Scientists at Joslin Diabetes Center have found that healthy individuals with diabetes develop protective enzymes against damage from high blood sugar levels. The researchers identified an enzyme called PKM2 and showed that activating it can stop abnormalities in mouse podocytes and delay diabetic kidney disease progression.
Research on osteoporosis medications in patients with chronic kidney disease (CKD) found mixed results regarding benefits and harms. Bisphosphonates may slow BMD loss but effects on fractures and safety are unclear. More research is needed to determine the best options for patients across CKD spectrum.
A recent Yale-led study found that marathon running can cause short-term kidney injury in runners, with 82% of participants showing signs of Stage 1 Acute Kidney Injury after the event. The researchers attribute this to sustained rises in core body temperature, dehydration, and decreased blood flow to the kidneys.
A preclinical study has established a link between gene variants in African American populations and kidney disease risk. The G1 and G2 APOL1 variants, found almost exclusively in West African descent individuals, cause human-like kidney disease when expressed in filtering cells.
Researchers at Maastricht University Medical Center found that omitting standard intravenous hydration during contrast material procedures for patients with compromised renal function has no added value and may even lead to negative consequences. Omitting this treatment could prevent complications and save millions of euros in care costs.
A randomized crossover trial found that limiting sodium intake reduced systolic blood pressure by an average of 11mmHg and excess fluid retention. The study suggests that simple dietary advice may help slow the progression of chronic kidney disease.
Researchers at King's College London have found that patients with early stages of kidney disease and type 1 diabetes have lower levels of the protective 'anti-ageing' hormone Klotho. This discovery could lead to the development of new treatments to prevent kidney disease in patients with type 1 diabetes.
A new study has found that skin sodium content is strongly correlated with left ventricular hypertrophy in patients with chronic kidney disease. Reducing skin sodium through dietary restriction or medications may help protect the heart in these patients.
A recent study published in Annals of Emergency Medicine found no association between intravenous contrast media and acute kidney injury. The research, which analyzed five years of records, showed that the probability of developing acute kidney injury was higher for patients receiving unenhanced CT scans.
A study at Columbia University Medical Center found that a missing CRKL gene causes kidney and urinary tract defects in people with DiGeorge syndrome. The team analyzed genomic data from over 2,600 children with congenital anomalies of the kidney and urinary tract.
SGLT2 inhibitors demonstrate renoprotective effects by reducing intraglomerular pressure, hyperfiltration, and improving renal function in patients with diabetes. Additionally, these drugs modulate the renin-angiotensin axis, which may contribute to their observed benefits.
A study found that decreased blood levels of soluble klotho were linked to an increased likelihood of experiencing kidney function decline in elderly adults. Higher klotho levels may help preserve kidney function.
A phase 3 trial found that oral ferric citrate significantly boosted hemoglobin levels in patients with chronic kidney disease, correcting anemia. The treatment effect was seen as early as 1-2 weeks after starting treatment and was durable.
A study published in Nature Medicine identifies bone marrow-derived immature myeloid cells as the source of suPAR, a reliable marker for chronic kidney disease. Elevated suPAR levels have been linked to future chronic kidney disease, potentially enabling early intervention and prevention of recurrence after transplant.
A study found that type 1 diabetes patients with elevated albumin in their urine had triple the risk of life-threatening kidney and cardiac disease compared to those with normal levels. Copeptin levels were significantly higher in these patients, suggesting a new potential target for therapies.
A study reveals that the liver is the primary source of Apol1, a protein linked to kidney disease, and finds a significant association between APOL1 gene variants and increased risk in individuals of recent African ancestry. The findings provide new insights into the biology of Apol1 and its potential role in health and disease.
A simple saliva test for salivary urea nitrogen showed high accuracy in diagnosing kidney disease in adults in Malawi. The test also predicted patients' risk of early death, highlighting its potential to improve treatment outcomes.
Amit X. Garg, a renowned nephrologist, is being honored by the American Society of Nephrology for his groundbreaking research on living kidney donation and kidney health analytics. His work has led to improved understanding and treatment of kidney diseases, including E. coli O157:H7 poisoning and acute kidney injury.
A clinical trial conducted by Wayne State University and Henry Ford Hospital found that a family psychoeducation consultation reduced 30-day all-cause hospital readmissions from 32% to 18%. The intervention improved patient health outcomes and reinforced the need for Integrative Behavioral Care.
Scientists have developed a method to create functional kidney units from patient cells, allowing for the study of human kidney diseases and potential therapeutic agents. The research enables in vitro studies of kidney pathophysiology and nephrotoxicity, with the ultimate goal of developing bioengineered kidneys for regenerative medicine.
A new study found that reducing sodium intake significantly reduced albuminuria and blood pressure in patients with chronic kidney disease. The combination of paricalcitol and a low sodium diet resulted in the lowest albuminuria levels in patients, indicating a strong reduction in kidney function decline and heart benefits.
Researchers at UC San Diego School of Medicine developed a bioinformatics framework that identified key proteins significantly altered in patients with diabetic kidney disease. The 'MetBridge Generator' framework revealed the protein MDM2 played a key role in disease progression, and its potential as a therapeutic target was discovered.
Research found no association between allopurinol use and increased risk of chronic kidney disease (CKD) Stage 3 or higher in gout patients with normal kidney function. Allopurinol may be beneficial for preventing renal decline, suggesting its safe use in managing gout symptoms.
A study published in Mayo Clinic Proceedings found a persistent decline in kidney function after an individual's first case of kidney stones. This decline was linked to higher levels of cystatin C and urine protein, both associated with increased risk of chronic kidney disease.
African genetic variants associated with increased risk of albuminuria and low glomerular filtration rate among Hispanic/Latino adults, highlighting the importance of ancestry in kidney disease risk, researchers say.
Research at the University of Montreal found that high urea levels impair insulin secretion and blood glucose regulation in chronic kidney disease. A mouse model study demonstrated similar reductions in insulin secretion and poor glucose control when urea was increased.
A large study found that maintaining intermediate levels of high-density lipoprotein (HDL) cholesterol may help people live longer. The study, which included 1.7 million US male veterans, discovered a U-shaped relationship between HDL-C and mortality risk, with low and high levels being associated with higher risks.
A study of US adults with diabetes found that overall diabetic kidney disease prevalence remained stable from 1988 to 2014, while albuminuria declined and reduced estimated glomerular filtration rate (eGFR) increased. The prevalence of reduced eGFR was higher among younger and non-Hispanic white populations.
A study published in American Journal of Kidney Diseases found that following a DASH-style diet can lower the risk of developing chronic kidney disease over two decades. The diet, which emphasizes whole grains, fruits, vegetables, and low-fat dairy, was also shown to reduce blood pressure and cardiovascular disease risk.
A study by University of Washington researchers found that the prevalence of diabetic kidney disease has remained relatively stable over 30 years, but its clinical manifestations have changed significantly. Albuminuria rates decreased, while reduced glomerular filtration rate increased.
Researchers found that patients with nonfunctional adrenal tumors have a significantly higher risk for developing diabetes compared to those without the condition. The study suggests that these tumors may warrant more clinical attention and should be considered an independent risk factor for diabetes.
A study has identified D-amino acids as potential biomarkers for predicting chronic kidney disease (CKD) progression. Elevated levels of D-Serine and D-Asparagine in CKD patients are associated with a higher risk of end-stage kidney disease, highlighting the potential for improved treatment and novel therapy options.
Researchers investigated the impact of vitamin D on vascular access outcomes in patients with chronic kidney disease, revealing potential benefits for reducing RAAS activity. Vitamin D deficiency has been linked to cardiovascular diseases, including CKD and ESRD-related complications.
The study reveals that errors in cell adhesion and inhibition cause two types of kidney cyst formation, which can lead to a significant increase in kidney size. The researchers used advanced computer simulations to identify the potential new drug target and confirmed its accuracy using real human cells.
African Americans with diabetes are at increased risk of stroke, coronary heart disease, and cardiovascular mortality. The study found that assessing kidney function can help identify individuals with elevated cardiovascular risks.
A study found that gut bacterial metabolites can accumulate in patients with chronic kidney disease, leading to an increased risk of cardiovascular disease and premature death. The accumulation of phenylacetylglutamine was particularly associated with poor health outcomes.
A nationwide study found that obese young adults are at risk for chronic kidney disease due to undetected albuminuria, with Mexican Americans and blacks showing higher rates. The study suggests that healthcare providers should test for kidney damage in obese young adults, emphasizing the importance of prevention through lifestyle changes.
A simple public health intervention helped prevent many cases of chronic kidney disease (CKD) in Pakistan by training community health workers and general practitioners on healthy lifestyle advice. After 7 years, individuals with the combined intervention had preserved kidney function, while those who received usual care experienced a ...
Patients with chronic kidney disease (CKD) are at a higher risk of experiencing hospital-acquired complications when hospitalized. A study of 536,549 adults found that CKD patients were 19% more likely to experience complications than those with normal kidney function, with the risk increasing as CKD severity worsened.
A new smartphone-based system improved blood pressure control, reduced medication errors, and increased patient engagement among patients with chronic kidney disease. The system provided personalized feedback and alerts to clinicians, leading to better patient outcomes.
A retrospective study found that young women undergoing PCI for acute coronary syndrome experience higher rates of adverse cardiovascular events and bleeding risks compared to men. The study highlights the importance of objectively assessing all risk factors when prescribing antiplatelet therapy.
Research suggests that climate change and resulting water shortages are linked to an increase in chronic kidney disease caused by dehydration and heat stress. The study found that rural hot communities are disproportionately affected, with risks increasing for cognitive dysfunction, malnutrition, and other conditions.
A new study found that achieving ideal cardiovascular health factors, such as healthy blood pressure and cholesterol, is associated with a reduced risk of new-onset kidney disease. The study included 14,832 adults aged 45-64 and followed them for an average of 22 years to develop chronic kidney disease.
UTA professor Paul Fadel receives a four-year NIH grant to study high sympathetic nerve activity in patients with chronic kidney disease and its link to ADMA, a natural occurring chemical in the body. The goal is to develop a treatment to lower sympathetic nerve activity and prevent dialysis, improving patient outcomes.
A new thematic issue of The Open Urology & Nephrology Journal reports on the association between hyperuricemia and kidney disease. Chronic inflammation is a common link between the two conditions, with research exploring its role in uric acid excretion and progression of renal disease.
Chronic kidney disease affects over a third of cats over 10 years old, causing significant quality of life compromise. The ISFM Consensus Guidelines provide practical diagnostic and treatment options, including dietary management and antihypertensive medication use.
Patients with chronic kidney disease and periodontitis have a significantly higher all-cause mortality rate compared to those with chronic kidney disease alone. The study analyzed data from 13,734 participants and found an increased risk of death at 10 years for individuals with both conditions.
A recent study found two genetic mutations in the SLC19A3 gene to be strongly associated with reduced risk of diabetic retinopathy and nephropathy. These mutations, which prevent high blood sugar damage to tiny blood vessels, have significant implications for diabetes prevention and treatment.
The American College of Physicians recommends using either cognitive behavioral therapy or second-generation antidepressants to treat adults with major depressive disorder. Both treatments are found to be similarly effective for treating depression, and physicians should consider a discussion with the patient about treatment effects, a...
New research published in Respirology suggests a significant link between sleep apnea and an increased risk of developing chronic kidney disease. Adults with sleep apnea were found to have a 58% higher risk of developing the condition over a 3.9-year follow-up period.
A ketoanalogue-supplemented vegetarian very low-protein diet was found to slow disease progression in patients with advanced CKD. The study suggests that this type of nutritional intervention could be used to postpone dialysis initiation in compliant patients.
A study found that high levels of mitochondrial DNA in the blood are associated with a lower risk of developing chronic kidney disease (CKD). The researchers analyzed data from over 9,500 participants and discovered that individuals with higher mitochondrial DNA copy numbers had a 25% lower risk of CKD compared to those with lower levels.
A study in JCI Insight identifies Dickkopf-3 as a driver of renal fibrosis in chronic kidney disease. DKK3 expression is elevated in stressed tubular epithelia and associates with profibrotic T cell responses, leading to interstitial fibrosis and impaired kidney function.
The USRDS annual data report reveals a decline in deaths among dialysis and transplant patients, while prevalence of end-stage kidney disease continues to rise. Home dialysis use has increased, offering improved quality of life, but awareness of kidney disease remains low.
The NHS Health Check programme effectively identifies people at risk of cardiovascular incidents and helps diagnose conditions like type 2 diabetes, high blood pressure, and chronic kidney disease. The study found that the programme prevented 2,500 cases from treatment following the check over its first five years.
A large cohort study found proton pump inhibitors associated with a higher risk of developing chronic kidney disease. The study suggests that up to 70% of PPI prescriptions may be without an appropriate indication, and discontinuing therapy without symptoms could prevent CKD in long-term users.
The study found substantial variation in CKD prevalence across European countries, ranging from 3% to 17%, which may be due to factors other than diabetes, hypertension, and obesity. The findings could guide future projections of the CKD burden in Europe and inform prevention and disease management strategies.
Researchers found a 15-20% reduction in hospitalization risk for heart failure or death among patients with cardiac resynchronization therapy compared to those with implantable cardioverter defibrillators. The treatment is associated with improved outcomes, but further studies are needed.
Researchers have identified a simple, non-invasive test to identify patients at risk of chronic kidney disease progression by measuring epidermal growth factor levels in urine. Decreased epidermal growth factor protein is an early sign of diminishing kidney function and pinpoints the at-risk patient population.