Articles tagged with Nephropathies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers found that smaller declines in estimated GFR are strongly associated with subsequent risk of end-stage renal disease. A new definition of kidney disease progression could shorten clinical trials and improve treatment outcomes.
A new study suggests revising the definition of kidney disease progression used in clinical trials could shorten trial length and encourage more trials. This revised definition, based on a decline in estimated kidney function, carries higher risks for end-stage renal disease and mortality but is common enough to facilitate testing.
A new UCLA-led study found that depression is linked to a far greater chance for early death among adults 65 and older with diabetes, compared to those without depression. The researchers suggest that depressed individuals are less likely to adhere to their prescribed medications and lifestyle changes.
A study found that walking can significantly improve survival rates and reduce the need for dialysis among patients with stage 3-5 chronic kidney disease. Patients who walked regularly were 33% less likely to die and 21% less likely to require dialysis compared to non-walkers.
Researchers found that pravastatin significantly slowed the growth of kidney cysts in children and young adults with ADPKD, reducing progression of kidney disease. The study's results suggest early intervention may be key to preventing long-term complications of ADPKD.
A study found that low birth weight and maternal conditions like diabetes and overweight/obesity are associated with an increased risk of childhood kidney disease. Researchers suggest that modifying these factors could help protect children's kidney health and reduce the incidence of CKD.
A study by Lynn Butler and colleagues found that cytomegalovirus infection inhibits erythropoietin production, leading to lower red blood cell counts. The researchers suggest targeting CMV as a potential treatment for anemia in patients with kidney disease.
Researchers found that rheumatoid arthritis patients have a 1 in 4 chance of developing chronic kidney disease over a 20-year period, compared to the general population's 1-in-5 risk. Patients should work to keep blood pressure under control and avoid medications damaging to the kidneys.
The updated guidelines emphasize a multidisciplinary approach to care, targeting growth, neurocognitive development, quality of life, and risk for complications. Children's Mercy Hospital has led the Chronic Kidney Disease in Children study, identifying factors that lead to kidney disease progression in children.
A study published in the Journal of the American Society of Nephrology found that moderate exercise, such as walking, can improve immune function and reduce inflammation in patients with chronic kidney disease. Six months of regular walking was shown to decrease immune cell activation and markers of systemic inflammation.
A study found that poor quality of life in African Americans with chronic kidney disease is associated with increased risks of disease progression and heart problems. The research suggests that improving quality of life may help protect patients' health, highlighting the need for better management of kidney disease-related health issues.
A receptor called B7-1 is expressed by kidney cells during the progression of diabetic nephropathy, and targeting this receptor with abatacept helps to maintain kidney function in mice. The study suggests that clinical trials should be designed to test abatacept in diabetic patients.
The American Society of Nephrology warns that dwindling medical research funding is hindering progress in kidney disease and other medical studies. With 20 million Americans affected by chronic kidney disease, the need for continued clinical advances is pressing.
A recent study found that warfarin treatment is associated with a lower risk of death, heart attack, or stroke without an increased risk of bleeding for patients with established cardiovascular disease and atrial fibrillation. The study included over 24,000 patients with kidney function measured through serum creatinine levels.
A study of 267 CKD patients found that 69.3% experienced at least one hazardous event related to their outpatient care, with hypoglycemia and falling/severe dizziness being common complications.
A new study in the Journal of Consumer Research found that people are more motivated to engage in healthy behavior when they're feeling depleted. Consumers tend to prefer products with safety features more when they're low on energy.
Scientists at the University of Nottingham are developing non-invasive measurements using magnetic resonance imaging (MRI) to assess blood flow and oxygenation in the human kidney. The goal is to improve monitoring and treatment for chronic kidney disease, which can be caused by health conditions like diabetes and high blood pressure.
A new guideline from the Canadian Society of Nephrology recommends delaying dialysis for asymptomatic adults with chronic kidney disease, citing improved quality of life and cost savings. The 'intent-to-defer' strategy avoids the burden of early start, while still closely monitoring patients.
A single dose of rituximab significantly reduces kidney relapses in children and young adults with frequently-replapsing idiopathic nephrotic syndrome, allowing for discontinuation of standard immunosuppressive medications. The treatment is also well-tolerated and improves kidney function.
Panel members of the Institute of Medicine's Eighth Joint National Committee opposed relaxing systolic blood pressure targets to 150 mmHg, citing insufficient evidence. The decision may reduce antihypertensive treatment intensity, potentially reversing declines in cardiovascular disease mortality rates.
A new UCSF-led study reveals that body mass index significantly increases the risk of developing chronic kidney disease, even before other obesity-related diseases emerge. Healthy kidneys play a vital role in various bodily functions, and the research emphasizes the importance of intervening early in life with obese patients.
A recent study published in the Journal of the American Society of Nephrology found that increased physical activity can slow the progression of kidney disease in patients. The researchers discovered that each 60-minute increment in weekly physical activity was linked with a 0.5% slower decline per year in kidney function.
The American College of Physicians recommends clinical and administrative changes to deter prescription drug abuse while maintaining patient access to treatment. The guidelines advocate for physician, patient, and public education on the harms of medical and nonmedical use of prescription drugs.
A new study found that consuming more vegetable protein is associated with a 14% lower risk of death in kidney disease patients. The study, which analyzed data from 1,104 CKD patients, suggests that increasing vegetable protein intake may help prolong survival among those with chronic kidney disease.
Researchers developed a saliva test for diagnosing acute kidney injury, found Mediterranean diet linked to reduced risk of chronic kidney disease, and explored mindfulness meditation's benefits on blood pressure in patients with kidney disease. Initiating dialysis can cause significant burdens and loss of independence in elderly patients.
A new testing approach can better detect parathyroid hormone imbalances in end-stage kidney disease patients, which are linked to higher mortality rates. The study found that patients with higher levels of non-oxidized parathyroid hormone had a lower risk of death.
A new study reverses the prevailing theory on diabetic kidney disease, finding that elevated glucose levels do not cause the condition but rather suppressing mitochondrial activity. The researchers discovered that boosting beneficial AMPK activity through lifestyle changes or drug activation can reduce kidney disease severity.
Researchers identified 13 metabolites that are significantly different in patients with diabetes and chronic kidney disease compared to healthy controls. Twelve of the metabolites are linked to mitochondrial function, suggesting suppressed mitochondria as a fundamental characteristic of diabetic kidney disease.
A new analysis finds that patients with chronic kidney disease are being prescribed statins inappropriately, despite no proven benefit. The study recommends lower dosages for early-stage kidney disease to minimize risks such as muscle pain and diabetes.
The study found that measuring cystatin C in the blood strengthens the association between kidney function and risks of death and end-stage renal disease. Kidney function stages categorized by cystatin C were better at reflecting future risk than those based on creatinine estimates.
The use of blood levels of cystatin C strengthens the association between kidney function and risks of death and end-stage renal disease. Cystatin C allows for better staging and risk classification of chronic kidney disease, potentially leading to targeted management and improved patient outcomes.
A study published by the American Society of Nephrology found that a structured exercise and lifestyle program can improve fitness, body composition, and heart function in patients with kidney disease. The program was safe for patients with multiple health issues, including diabetes and high blood pressure.
Research published in Annals of Internal Medicine suggests that low diastolic blood pressure may be a significant risk factor for mortality in patients with CKD. A study of over 651,000 veterans found that those with diastolic blood pressures below 70mmHg had higher mortality rates compared to those within the recommended range.
Eating a healthy diet has been found to lower the risk of chronic kidney disease (CKD) and mortality among patients with type 2 diabetes. Moderate alcohol intake also reduced the risk of CKD, while high sodium intake was not associated with increased risk.
The Mount Sinai Hospital is launching the first-ever genetic testing program in primary care settings to identify genetic risk for kidney disease in patients with hypertension. This $3.7 million grant will provide genomic information to individualize treatment, testing, and monitoring, with a focus on African Americans who are four to ...
A new study published in The Lancet found that calcium supplements may increase the risk of heart disease and death in patients with kidney disease. Patients who took non-calcium based treatments had a lower risk of death compared to those who took calcium supplements, highlighting the potential dangers of long-term use.
A strong association was found between worse kidney function and medication-resistant hypertension in individuals with moderate chronic kidney disease. Black patients and those with a larger waist circumference, diabetes, and a history of heart attacks or strokes were more likely to have resistant hypertension.
Research found that low birth weight and prematurity are linked to low nephron numbers, increasing the risk of high blood pressure and chronic kidney disease. The study suggests clinicians use birth weight as a parameter for screening patients.
A new study presented at Heart Failure 2013 found that ambulatory levosimendan improved event-free survival by 50% compared to placebo in patients with end-stage heart failure. However, it failed to show significant improvements in functional capacity and quality of life.
A study published in the Journal of the American Society of Nephrology found that LDL cholesterol is not a reliable indicator of heart disease risk in patients with kidney disease. Patients with very low kidney function were more likely to have a heart attack, regardless of their LDL levels.
A national study estimates 2.9 million Canadian adults have chronic kidney disease, a risk factor for death and significant healthcare burden. High blood pressure and diabetes are more common among those with chronic kidney disease.
Cinacalcet has little to no effect on mortality in patients with end-stage kidney disease, but may prevent surgical parathyroidectomy. The treatment also comes with significant side effects, including hypocalcemia and nausea. The study suggests that routine cinacalcet therapy is not warranted.
Scientists found that inhibiting epoxide hydrolase with tAUCB and activating PPARγ with rosiglitazone had synergistic effects on cardiometabolic syndrome, reducing cardiovascular risk factors and kidney disease progression.
A study has found that slower walking speed is associated with increased mortality risk in kidney disease patients. The research suggests that lower extremity physical performance tests may help identify those at higher risk of premature death.
People with apple-shaped bodies are more likely to develop kidney disease due to lower kidney function, lower kidney blood flow, and higher blood pressure within the kidneys. Treatments that reduce kidney blood pressure may be beneficial for these individuals.
Research suggests that individuals with an apple-shaped body distribution may experience lower kidney function and higher blood pressure within the kidneys, increasing their risk of developing kidney disease. Treatments that reduce kidney blood pressure could be beneficial for these individuals.
Individuals who are overweight starting in early adulthood are twice as likely to have chronic kidney disease at age 60 to 64 years. Larger waist-to-hip ratios during middle age are also linked with chronic kidney disease at the same age. Avoiding excess weight gain could prevent many cases of chronic kidney disease, with over one-thir...
A study found that individuals with chronic kidney disease who adhered to a healthy lifestyle had a greater likelihood of surviving over a 13-year period. Nonsmoking was associated with the greatest survival benefits.
A recent study found that suboptimal kidney response to the hormone FGF-23 may increase risks for kidney disease patients, particularly those with lower urinary phosphorus levels. The study suggests that resistance to FGF-23's hormonal actions in the kidney may identify novel aspects of kidney dysfunction.
A recent study found that African Americans with kidney disease who experience large fluctuations in blood pressure are nearly three times more likely to die prematurely. Monitoring and addressing these day-to-day changes may improve health outcomes.
Researchers at the University of Manchester have identified a molecular basis for tissue-specific immune regulation in eye and kidney diseases. A common genetic alteration in complement factor H (CFH) is associated with AMD, while a different mutation is linked to rare kidney disease aHUS.
Adding fruits and vegetables to the diet has been shown to reduce metabolic acidosis and kidney injury in late-stage chronic kidney disease patients. One-year plasma total carbon dioxide levels increased in both groups, indicating a lessening of metabolic acidosis.
A study found that among individuals with diabetes, those with both diabetes and kidney disease have a mortality rate of 31.1%, compared to 11.5% for those with diabetes but without kidney disease. Preventing and treating kidney disease in diabetics may be crucial to reducing mortality risk.
A study published in the Canadian Medical Association Journal found that women with hypertensive disorders during pregnancy are at higher risk of chronic kidney disease and end-stage renal disease. The study analyzed data from over 26,000 women in Taiwan and found an increased risk of end-stage renal disease among those with preeclamps...
Researchers at the University of Tübingen found that spironolactone reduces vascular calcification in klotho-hypomorphic mice, a model for chronic kidney disease. This treatment also increases the life span of these mice. The findings have implications for treating cardiovascular mortality in CKD patients.
A study analyzing national survey data found a biomarker for higher risk of heart and kidney disease in children and adolescents associated with BPA exposure. The study suggests that even low levels of BPA increase oxidative stress and inflammation, promoting protein leakage into the urine.
Retaining certain compounds normally excreted by the kidneys can cause insulin resistance in kidney disease patients. Treating mice with a prebiotic reduces these compound levels, preventing insulin resistance and related lipid abnormalities.
Blocking the endothelin receptor reduces cardiovascular risk factors in patients with chronic kidney disease independent of blood pressure. The findings suggest that blocking the receptor may provide heart-related benefits to these patients, who have a higher risk of developing heart problems due to their condition.
The most severe form of acute kidney injury has seen a significant increase in incidence rates, with deaths associated with the condition also rising. The study highlights the need for further research into the causes behind this trend and potential interventions to reduce its impact.
A study published by UCSF found that acute kidney injuries have doubled over the last decade, from 222 to 533 cases per million people. The total number of deaths associated with acute kidney injury also more than doubled during this time, from 18,000 in 2000 to nearly 39,000 in 2009.