Articles tagged with Nephropathies
A new study published in The Lancet found that calcium supplements may increase the risk of heart disease and death in patients with kidney disease. Patients who took non-calcium based treatments had a lower risk of death compared to those who took calcium supplements, highlighting the potential dangers of long-term use.
A strong association was found between worse kidney function and medication-resistant hypertension in individuals with moderate chronic kidney disease. Black patients and those with a larger waist circumference, diabetes, and a history of heart attacks or strokes were more likely to have resistant hypertension.
Research found that low birth weight and prematurity are linked to low nephron numbers, increasing the risk of high blood pressure and chronic kidney disease. The study suggests clinicians use birth weight as a parameter for screening patients.
A new study presented at Heart Failure 2013 found that ambulatory levosimendan improved event-free survival by 50% compared to placebo in patients with end-stage heart failure. However, it failed to show significant improvements in functional capacity and quality of life.
A study published in the Journal of the American Society of Nephrology found that LDL cholesterol is not a reliable indicator of heart disease risk in patients with kidney disease. Patients with very low kidney function were more likely to have a heart attack, regardless of their LDL levels.
A national study estimates 2.9 million Canadian adults have chronic kidney disease, a risk factor for death and significant healthcare burden. High blood pressure and diabetes are more common among those with chronic kidney disease.
Cinacalcet has little to no effect on mortality in patients with end-stage kidney disease, but may prevent surgical parathyroidectomy. The treatment also comes with significant side effects, including hypocalcemia and nausea. The study suggests that routine cinacalcet therapy is not warranted.
Scientists found that inhibiting epoxide hydrolase with tAUCB and activating PPARγ with rosiglitazone had synergistic effects on cardiometabolic syndrome, reducing cardiovascular risk factors and kidney disease progression.
A study has found that slower walking speed is associated with increased mortality risk in kidney disease patients. The research suggests that lower extremity physical performance tests may help identify those at higher risk of premature death.
People with apple-shaped bodies are more likely to develop kidney disease due to lower kidney function, lower kidney blood flow, and higher blood pressure within the kidneys. Treatments that reduce kidney blood pressure may be beneficial for these individuals.
Research suggests that individuals with an apple-shaped body distribution may experience lower kidney function and higher blood pressure within the kidneys, increasing their risk of developing kidney disease. Treatments that reduce kidney blood pressure could be beneficial for these individuals.
Individuals who are overweight starting in early adulthood are twice as likely to have chronic kidney disease at age 60 to 64 years. Larger waist-to-hip ratios during middle age are also linked with chronic kidney disease at the same age. Avoiding excess weight gain could prevent many cases of chronic kidney disease, with over one-thir...
A study found that individuals with chronic kidney disease who adhered to a healthy lifestyle had a greater likelihood of surviving over a 13-year period. Nonsmoking was associated with the greatest survival benefits.
A recent study found that suboptimal kidney response to the hormone FGF-23 may increase risks for kidney disease patients, particularly those with lower urinary phosphorus levels. The study suggests that resistance to FGF-23's hormonal actions in the kidney may identify novel aspects of kidney dysfunction.
A recent study found that African Americans with kidney disease who experience large fluctuations in blood pressure are nearly three times more likely to die prematurely. Monitoring and addressing these day-to-day changes may improve health outcomes.
Researchers at the University of Manchester have identified a molecular basis for tissue-specific immune regulation in eye and kidney diseases. A common genetic alteration in complement factor H (CFH) is associated with AMD, while a different mutation is linked to rare kidney disease aHUS.
Adding fruits and vegetables to the diet has been shown to reduce metabolic acidosis and kidney injury in late-stage chronic kidney disease patients. One-year plasma total carbon dioxide levels increased in both groups, indicating a lessening of metabolic acidosis.
A study found that among individuals with diabetes, those with both diabetes and kidney disease have a mortality rate of 31.1%, compared to 11.5% for those with diabetes but without kidney disease. Preventing and treating kidney disease in diabetics may be crucial to reducing mortality risk.
A study published in the Canadian Medical Association Journal found that women with hypertensive disorders during pregnancy are at higher risk of chronic kidney disease and end-stage renal disease. The study analyzed data from over 26,000 women in Taiwan and found an increased risk of end-stage renal disease among those with preeclamps...
Researchers at the University of Tübingen found that spironolactone reduces vascular calcification in klotho-hypomorphic mice, a model for chronic kidney disease. This treatment also increases the life span of these mice. The findings have implications for treating cardiovascular mortality in CKD patients.
A study analyzing national survey data found a biomarker for higher risk of heart and kidney disease in children and adolescents associated with BPA exposure. The study suggests that even low levels of BPA increase oxidative stress and inflammation, promoting protein leakage into the urine.
Retaining certain compounds normally excreted by the kidneys can cause insulin resistance in kidney disease patients. Treating mice with a prebiotic reduces these compound levels, preventing insulin resistance and related lipid abnormalities.
Blocking the endothelin receptor reduces cardiovascular risk factors in patients with chronic kidney disease independent of blood pressure. The findings suggest that blocking the receptor may provide heart-related benefits to these patients, who have a higher risk of developing heart problems due to their condition.
The most severe form of acute kidney injury has seen a significant increase in incidence rates, with deaths associated with the condition also rising. The study highlights the need for further research into the causes behind this trend and potential interventions to reduce its impact.
A study published by UCSF found that acute kidney injuries have doubled over the last decade, from 222 to 533 cases per million people. The total number of deaths associated with acute kidney injury also more than doubled during this time, from 18,000 in 2000 to nearly 39,000 in 2009.
A new study published in JAMA found that chronic kidney disease and its complications are associated with a higher risk of death regardless of age. Both low kidney function and high albuminuria were independently linked to mortality and end-stage renal disease, according to the findings.
A nationwide population-based study found that adolescents' being overweight and obese during their teenage years are linked to a higher risk of developing end-stage renal disease (ESRD) in the following 25 years. Researchers also noted an increased risk for diabetic ESRD, with risks increasing six-fold and 19-fold among overweight and...
Two new studies found that chronic kidney disease is a strong indicator of death and end-stage renal disease in patients without hypertension or diabetes. Chronic kidney disease affects 10-16% of adults globally and is associated with increased mortality risk regardless of the presence of diabetes.
A federally funded study found that children with mild to moderate kidney disease have abnormally thick neck arteries, a condition known as carotid atherosclerosis. This discovery highlights the need for aggressive monitoring and early treatment to prevent later heart attacks and strokes.
The American Society of Nephrology has identified five recommendations for reducing unnecessary medical interventions, including avoiding routine cancer screening and administering erythropoiesis stimulating agents in chronic kidney disease patients. By implementing these guidelines, healthcare costs can be lowered and patient care imp...
A systematic review and meta-analysis found that renal transplantation offers the best treatment option for improving quality of life in people with late-stage chronic kidney disease. In contrast, home-based automated peritoneal dialysis provides a better quality of life than continuous ambulatory peritoneal dialysis.
A new test can measure an individual's propensity for calcification in their blood, identifying those at increased risk of vascular calcification and potential heart disease. The test may also provide a basis for treatment monitoring in patients who receive calcification inhibitors.
The American College of Physicians (ACP) advises against routine screening for chronic kidney disease in asymptomatic adults due to insufficient evidence supporting its benefits. Commercial screening tests can also inflate healthcare costs and undermine physician efforts to provide cost-conscious care.
Scientists at Joslin Diabetes Center have identified the biological mechanisms by which glucagon-like peptide-1 (GLP-1) protects against kidney disease, including its ability to inhibit the signaling pathway of angiotensin II. The study suggests that effective therapeutic agents could be developed to enhance GLP-1R on the endothelium, ...
A recent study found that gout and hyperuricemia affect 8.3 million and 43.3 million Americans, respectively, with high rates of related medical disorders like hypertension, chronic kidney disease, and obesity.
A large-scale Canadian study has found that patients with chronic kidney disease are at comparable risk of future coronary events to those who have previously suffered a heart attack. This could lead to targeted treatment for high-risk individuals, including the use of statins to reduce 'bad' fats in the bloodstream.
A low-carbohydrate high-protein diet has been found to be safe for healthy obese patients' kidney function and fluid balance, unlike a low-fat diet. However, additional studies are needed to evaluate its effects in individuals with pre-existing kidney disease or other health conditions.
A study found that off-pump coronary artery bypass surgery is likely safer than on-pump surgery for chronic kidney disease patients, cutting down on kidney injuries after heart surgery. CKD patients undergoing on-pump surgery were more than three times as likely to die or need dialysis compared to those who received off-pump surgery.
A minimally invasive procedure called renal denervation disrupts overactive sympathetic nerves, lowering blood pressure in CKD patients with hypertension. The study found no worsening of kidney function, indicating the procedure is safe for those with CKD.
The American College of Physicians (ACP) has released a tip sheet on screening and treatment of chronic kidney disease, concluding that regular screening offers no clear benefits. In contrast, preexposure prophylaxis (PrEP) is effective in preventing HIV infection among high-risk men who have sex with men (MSM). The ACP also notes that...
A study found that dialysis patients with deteriorating mental health have a higher risk of developing heart problems and dying prematurely. The research suggests that addressing kidney disease patients' mental health may help prevent heart complications and even death.
Researchers from Mount Sinai School of Medicine presented several studies at the American College of Cardiology's annual scientific session. One study found that aggressive statin therapy reduced fat content in coronary blockage by 22 percent, while another showed that cardiovascular disease screening can identify risk factors and symp...
A Canadian study reveals that non-cardiac co-morbidities such as COPD and chronic kidney disease are the main predictors of late mortality after TAVI, emphasizing the importance of closer patient evaluation and follow-up. The study also shows that valve performance is maintained throughout the follow-up period.
Researchers found dapagliflozin effective as an add-on for type 2 diabetes treatment, despite long-term safety data limitations and increased hypoglycemia risk. Peer mentoring improved glucose control among African American veterans through behavioral interventions. However, the use of antiplatelet therapy in patients with chronic kidn...
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that elderly people with the metabolic syndrome are at a higher risk of chronic kidney disease. Insulin resistance and high blood glucose levels were also linked to rapid decline in renal function.
A new study found that overweight and obese adults with chronic kidney disease who attempt to lose weight through diets and diet pills may cause further kidney damage. The study highlights the need for safe weight loss strategies that protect kidney function.
Daily doses of a vitamin D compound did not reduce enlargement or improve impaired functioning of the heart's main pumping chamber in patients with kidney disease and cardiac enlargement. However, the study found some evidence that paricalcitol may reduce the incidence of heart failure.
Patients with chronic kidney disease did not show significant improvement on measures of cardiac structure, function, or left ventricular mass after receiving vitamin D compound paricalcitol for up to 48 weeks. However, the study found fewer hospitalizations for cardiovascular events in the treatment group compared to placebo.
The FDA has revised labeling guidelines for erythropoiesis-stimulating agent (ESA) drugs in chronic kidney disease patients. These updates aim to minimize the risk of heart-related problems, but critics argue that they may be too conservative and not tailored to individual patient needs.
Researchers found that hydrogen sulfide decreases the production of scarring proteins in kidney cells exposed to high glucose levels. The study paves the way for future research in animal models of diabetic kidney disease.
Researchers at Case Western Reserve University School of Medicine received a $6.75 million grant to investigate the role of innate immunity in inflammatory bowel disease (IBD). They discovered a deficit in infection-fighting cells, leading to a buildup of harmful agents in the body.
A study by UC Irvine researchers found that CKD causes depletion of adhesive proteins in the intestines, leading to systemic inflammation and cardiovascular complications. The findings could lead to novel treatments to curb this inflammation and its adverse consequences.
Researchers at Stanford Medicine have discovered a pathway that reveals how podocytes, specialized epithelial cells in the kidney, can regenerate and renew themselves during normal kidney function. This finding could lead to the development of therapies to treat people with chronic kidney disease.
Two studies found that pomegranate juice can lower cholesterol, blood pressure, and the need for blood pressure medications in kidney disease patients. Meanwhile, over 15% of kidney disease patients take potentially harmful herbs or dietary supplements.
A three-year grant will fund clinical trials testing patient navigator models and electronic health record enhancements for chronic kidney disease care. The study aims to improve treatment adherence and patient outcomes.
A $3.9 million grant will enable research to identify protective factors that prevent diabetes complications in long-term insulin-dependent diabetes patients. The study aims to find biomarkers and therapeutic agents to halt diabetic retinopathy and nephropathy, which significantly impact lifespan and quality of life.
A new Medicare payment system may unfairly penalize dialysis clinics that provide care to patients with complex medical and social issues. The study found that patient characteristics, particularly adherence to prescribed treatments, significantly impact a facility's achievement of the pay-for-performance measure.
A systematic review published in The Cochrane Library found that regular exercise can improve physical fitness, walking capacity, and heart rate among people with CKD. Exercise programs can also increase muscular strength, reduce blood pressure, and enhance overall quality of life.
Researchers at Wake Forest Baptist Medical Center found no association between sickle cell trait and risk of non-diabetic or diabetic end-stage kidney disease. The study contradicts earlier findings that suggested having one copy of the sickle cell gene increased kidney disease risk.
The tip sheet highlights common barriers to depression disclosure among patients, including concerns about antidepressant prescriptions and confidentiality. It also explores the widespread use of NSAIDs by patients with chronic kidney disease, despite warnings against their use. Additionally, the article critiques long-established coro...