Researchers have designed a compound that shows promise as a potential therapy for fragile X syndrome, a genetic condition causing mental retardation, infertility, and memory impairment. The molecule improves RNA splicing process and minimizes repeat-associated defects in cells.
Cardiac injury leads to rapid morphological changes, including enlargement and fibrous growth tissue formation. Advanced stages of remodeling have begun by day seven following injury. This research provides insights into the coordinated events of cardiac pathology and possible intervention targets.
Tropical Storm Michael formed on Sept 4 with winds of near 40 mph, struggling to intensify like sister storms Leslie and Isaac. Remnants of Isaac blanket the US east coast, while Leslie heads towards Bermuda, larger in size than Michael.
A multinational group of authors has found a strong association between Southeast Asian ovalocytosis and protection against malaria caused by Plasmodium vivax. The study suggests that P. vivax malaria may have contributed to shaping the unique host genetic adaptations in Asian and Oceanic populations.
A recent meta-analysis by researchers at Moffitt Cancer Center found that breast cancer patients who received chemotherapy had slight cognitive impairments in verbal and visuospatial abilities. The study suggests that these deficits can be managed through awareness and compensatory strategies, improving daily life for affected individu...
A new study finds that out-of-pocket spending on healthcare in the last five years of life can account for a significant proportion of an individual's household assets. More than three-quarters of households spent at least $10,000 on healthcare costs, with some individuals contributing as much as their total household assets.
The Wildlife Conservation Society and partners are calling on governments to take urgent action to save shark and ray species from over-fishing for international trade. Currently, only a handful of species are listed under CITES, but numerous others qualify for protection.
A study by UC San Diego researchers identified LIN28 protein binding sites in 25% of human transcripts, causing widespread alternative splicing changes that can result in cancer or other diseases. The discovery suggests that LIN28 itself should be a therapeutic target for diseases.
Researchers found that ovarian cancer cells hijack surrounding tissues by activating the HOXA9 gene, which induces TGF-β production and stimulates tumor growth. Blocking TGF-β expression reduced tumor growth, suggesting potential therapeutic targets for treating ovarian cancer.
Researchers will investigate how sulforaphane in broccoli affects prostate tissue gene expression and metabolism in men at risk of developing prostate cancer. The study aims to provide evidence that diets rich in cruciferous vegetables or sulforaphane can reduce the likelihood of metastatic cancer.
Rice University researchers have developed a nanoreactor theory to predict graphene formation, which can advance the material's quality and electronic properties. The team found that the shape of the graphene edge pattern is dictated by the most efficient use of energy, with skewed edges growing fastest.
A hybrid chicken known as the Kuroiler is being introduced in rural Uganda to improve productivity and provide economic benefits to local families. The project aims to increase returns from family flocks and reduce poverty among hundreds of thousands of households.
Researchers at Caltech have determined the dominant mechanism of cobalt catalysts, which involves a key reactive intermediate gaining an extra electron. This finding illuminates the road to developing better catalysts and suggests a route to creating extremely active iron catalysts.
Tropical Storm John existed for only one day, intensifying from a depression to a storm and weakening back into a depression. NASA's Aqua satellite observed convection and cloud top temperatures, but these features diminished as the storm moved north into cooler waters.
A study of 46,201 adults found that HIV-positive men on antiretroviral therapy were 31% more likely to die than women, despite similar treatment responses. The researchers suggest that the observed differences may be due to background differences in mortality between men and women in the South African population.
Researchers at the University of Sheffield have uncovered the origins and trading routes of ancient obsidian tools in Syria. The study reveals that exotic obsidian artefacts originated from a volcano three times farther away than expected, providing new insights into changing Bronze-Age economics and geopolitics.
A new method uncovered a way cancer cells use HER3 to drive tumor progression despite treatment with HER1 and HER2 inhibitors. Researchers found HER3 could be up to 10 times more effective than HER2 in recruiting accessory proteins that promote cancer growth and metastasis.
A centralized prescription network, PharmaNet, implemented in British Columbia pharmacies reduced inappropriate prescriptions for opioid analgesics and benzodiazepines. The study found a 33-49% reduction in potentially inappropriate prescriptions for opioids and benzodiazepines in patients on social assistance and seniors.
Vitamin D supplements did not improve cholesterol levels, according to a new study conducted at The Rockefeller University Hospital. Researchers found that correcting vitamin D deficiencies with high doses of oral vitamin D supplements had no effect on cholesterol levels in the short term.
Researchers at Linköping University have discovered two 'pleiotropic' genes influencing comb size, bone growth and egg production in domestic chickens. The study reveals the genetic basis for the correlation between comb size and increased egg-laying.
Researchers found that patients at hospitals with longer resuscitation attempts have a higher likelihood of immediate survival and survival to discharge. However, the study does not recommend an optimal duration for resuscitation, emphasizing the need for careful clinical judgment.
A new fungal species, Hebelomagriseopruinatum, has been officially classified as a novel species after discovery on Zealand in Denmark. The fungus has been found to coexist intimately with plants, similar to edible fungi like chantarelles and truffles.
Researchers at the University of Texas at Austin have developed a simulation model to study how planets form from protostellar disks. The models simulate key factors such as turbulence and temperature, which affect planet formation, providing insights into the conditions most favorable for planetary birth.
A meta-analysis of over 60 randomized controlled trials found no statistically significant increased risk of any type of cancer with biologic response modifiers in patients with rheumatoid arthritis. The study included 29,423 patients and followed them for at least 24 weeks.
Researchers highlight RNA's self-assembling properties, but also discuss challenges such as stability and targeting in therapeutic applications. The article provides a detailed review of the field, discussing its potential for treating various diseases.
A by-product of biofuel manufacture can power microbial fuel cells to generate electricity cheaply and efficiently. Researchers have successfully used Distillers Dried Grain with Solubles (DDGS) as a feedstock for the bacteria, producing a reliable source of renewable energy.
Researchers have identified a conserved class of genes responsible for the development of double flowers in plants like Thalictrum thalictroides. This discovery sheds light on the evolutionary history of flowering plants and their ability to coevolve with pollinators.
Researchers have developed a method to make flexible lithium-ion battery components from discarded silicon, which can prolong their usefulness. The new material is made by creating nanowires from high-value but hard-to-recycle silicon and then encasing them in an electrically conducting copper and ion-conducting polymer electrolyte.
Researchers identified brain regions involved in affective aggression in mice, which may be similar to those affected in humans. The study's findings could lead to the development of novel approaches to treat chronic affective aggression.
New data reveals galaxies formed and fully illuminated the universe by 750 million years old, ending sooner than expected. The epoch of reionization lasted less than 500 million years and was triggered by monster galaxies with over a billion stars.
A study reveals that most electronic waste in Spain is uncontrolled, with only 2.55 kg out of 13.86 kg collected and processed correctly under the Integrated Waste Management System (SIG). The majority of manufacturers are not registered in the system, leading to significant payment evasion.
A study examining the length of resuscitation efforts after in-hospital cardiac arrest found that hospitals attempting longer resuscitations had higher survival rates. The duration of resuscitation attempts varied widely between hospitals, with those attempting longer efforts having a greater chance of successful revival and discharge.
Researchers at Children's Hospital of Philadelphia have discovered two gene variants that increase the risk of neuroblastoma and promote its progression. These variants in HACE1 and LIN28B genes were found to exert opposite effects, with low expression of HACE1 and high expression of LIN28B correlating with worse patient survival.
A framework for point-of-care testing is proposed to address barriers in low- and middle-income countries. The authors emphasize the importance of focusing on point-of-care programs rather than technology itself.
A new study reports that Medicare payment reforms mandated in the Affordable Care Act have great potential to lower costs without harming patients. The researchers found that previous payment reforms caused a steep downtick in postacute care costs immediately after implementation, but expenses quickly resumed their upward trend.
The Stanford study analyzed 237 studies comparing organic and conventional foods, finding no significant difference in health benefits or nutrient content. Organic produce had a lower risk of pesticide contamination, but pesticide levels were generally within safe limits.
The International Commission on Zoological Nomenclature (ICZN) has passed an amendment allowing purely digital publications to meet its requirements. This change aims to speed the process of publishing biodiversity information, improve access, and reduce the 'taxonomic impediment' hindering cataloguing. The new rules open the door to e...
A study using cardiac magnetic resonance imaging in Iceland found that unrecognized heart attacks (UMI) were associated with an increased risk of death. The prevalence of UMI was higher than previously suspected, especially among individuals with diabetes.
A study found that using regional PACS networks for inter-hospital image transfer reduces repeat imaging rates, associated costs, and radiation exposure. The results showed a lower repeat rate of 17%, resulting in lower charges and less radiation exposure.
Research found that Tasmanian devils with fewer bites are more likely to develop Devil Facial Tumour Disease (DFTD), a fatal infectious cancer. The study suggests that boosting natural selection of less aggressive devils could help reduce the spread of the disease and save the species from extinction.
A study published in JAMA Network found that increased aortic stiffness is associated with a higher risk of new hypertension. The researchers suggest that vascular stiffness may be a precursor to hypertension, rather than the result of it. The study's findings have significant implications for preventing and treating hypertension.
Researchers reconstruct 9,000-year record of delta's growth and find evidence of human impact on the entire Black Sea basin. The team finds that human deforestation and agriculture led to increased nutrient availability in the sea.
Preeclampsia is a significant risk factor for long-term health issues, including chronic hypertension and hospitalizations. The study, published in the Journal of Maternal-Fetal and Neonatal Medicine, found patients with preeclampsia had higher rates of chronic hypertension diagnosed after pregnancy.
A recent study by Hendrik De Smet investigates language change and finds that actualization processes involve small adjustments exploiting similarities between contexts. This process can lead to differences in language use over time, influencing grammatical structures.
Researchers at Vanderbilt University have developed a way to combine the photosynthetic protein from spinach with silicon to produce substantially more electrical current. The new design produces current levels nearly 1,000 times higher than previous biohybrid solar cells and has the potential to power small devices.
A study by University of Minnesota researchers found that antimicrobial growth promoters in swine alter intestinal bacteria composition, leading to accelerated growth and development. The findings suggest a possible alternative to antibiotics in animal production without compromising animal health.
A new study by the European Respiratory Society found that Christchurch residents increased their tobacco consumption following the 2010 earthquake. The study showed that 28% of non-smokers picked up the habit after the disaster, with many attributing it to anxiety and changes in lifestyle.
A recent analysis suggests that physical punishment of children can lead to increased childhood aggression and mental health issues in adulthood. The Canadian Medical Association Journal argues that emphasizing education on alternative forms of discipline is a more promising approach.
A study published in Psychology of Women Quarterly found that women who read sex-related magazine articles viewed premarital sex as less risky and were more supportive of female sexual assertiveness. The researchers also discovered a racial disparity in attitudes, with white women viewing premarital sex as less risky than women of color.
A national study of economists found significant differences in policy views between men and women, with women more likely to favor progressive taxation and less likely to support limiting government-backed redistribution policies. The study highlights the importance of including diverse perspectives in policy-making.
Researchers suggest a 'cyber war' on cancer by breaking the code of cancer cells' social behavior, similar to bacterial colonies. This approach could help prevent dormancy and reawaken cells for targeted chemotherapy attacks.
Researchers found that high F-18-FDG uptake in axillary lymph nodes before treatment can predict disease-free survival in invasive ductal breast cancer patients. A nodal SUVmax of 2.8 was identified as the optimal cutoff for predicting disease-free survival.
A new study reveals that reading sex-related magazine articles from popular women's magazines like Cosmopolitan can have empowering effects on young women's sexuality. The research found that women who read these articles were more likely to view premarital sex as a positive and less risky behavior, while also promoting female sexual a...
Researchers have found a significant association between sleep apnea and an increased risk of cancer mortality. Severe sleep apnea was linked to double the relative risk of death due to cancer in patients who spent more than 14% of their sleep with low oxygen levels.
Group Health's video-based decision aids for arthritis patients led to a sharp decline in knee and hip replacement surgeries by 38% and 26%, respectively, over six months. The cost of caring for those patients also decreased by 12-21%.
Researchers discovered two specific single-nucleotide polymorphisms in the major histocompatibility complex (MHC) linked to acute graft-versus-host disease (GVHD) and disease-free survival. A new screening protocol is being developed to better match patients and donors, with the goal of reducing GVHD incidence.
A recent study found that Magellanic penguins' high genetic variation in the MHC genome region is maintained by balancing selection, which favors heterozygous individuals with increased fitness. The study tested whether mate choice or genetic selection based on disease exposure drives this diversity.
Researchers explored the effectiveness of resveratrol in preventing head and neck cancer in Fanconi anemia patients, a rare genetic disorder affecting DNA repair. The study found that resveratrol may eliminate cancer cells in these patients by making them sensitive to certain drugs.
A study published in the Journal of the American College of Radiology found that non-invasive diagnostic imaging costs to Medicare Part B dropped significantly between 2006 and 2010. The decline was attributed to reimbursement cuts and increased education on scan utilization.
Researchers analyzed data from 29,423 adult patients and found no statistically significant increased risk of any type of cancer in those treated with biologic response modifiers. This study provides reassuring information for patients considering these therapies for their disease.