Articles tagged with Nephropathies
A nationwide study of 13,000 Americans found that nearly 60% of the elevated risk of end-stage renal disease (ESRD) in African Americans may be attributed to low vitamin D levels. Researchers also discovered that vitamin D deficiency contributes significantly to the increased risk of ESRD among African Americans compared to whites.
Recent medical school graduates are more likely to refer CKD patients for preemptive kidney transplantation, which can improve patient outcomes. The study suggests that educating veteran physicians about the benefits of preemptive transplantation may increase early referrals.
Researchers found that patients with higher kidney function at the time of transplant did not have a significant advantage in terms of long-term health. However, they did require less dialysis and were less likely to experience kidney rejection after transplantation.
A long-term follow-up study found that lifestyle intervention and metformin therapy can persistently delay the onset of type 2 diabetes for at least 10 years. The studies showed a significant reduction in diabetes incidence rates, with lifestyle intervention delaying onset by about 4 years and metformin by 2 years compared to placebo.
A study has found that coronary angiography does not harm kidney function in advanced chronic kidney disease patients, enabling better transplant decisions. The test detected coronary artery disease in some patients, making them unsuitable for transplantation until their heart complications were addressed.
For kidney disease patients, regular physical activity may prolong life and reduce mortality risk. A recent study found that active patients were 56% less likely to die than inactive counterparts.
A study found that male diabetics with higher eosinophil counts in their blood have a stronger link to diabetic nephropathy and increased risk of heart disease. Anti-inflammatory treatments used for allergies may also benefit male patients with diabetes.
A Monash University study has identified the role of microscopic antennas in the kidney's repair process, shedding light on a potentially fatal disease. The research, led by Dr. James Deane, showed how hair-like structures called cilia change their length in response to injury, amplifying signals that turn off the repair process.
A study published by the American Society of Nephrology found that weight loss through diet and exercise can reduce proteinuria and slow down kidney function decline in obese patients with kidney disease. Surgical interventions also show promise in normalizing kidney filtration rates.
The ERC is funding top researchers, including Sanna Lehtonen's group, to study the development of albuminuria and diabetic nephropathy. They aim to identify novel drug leads to treat insulin resistance and combat early stages of kidney disease.
Researchers at UT Southwestern Medical Center found a significant link between depression and early-stage chronic kidney disease, with 57 out of 272 participants identified as depressed. The study suggests that depression screening should be considered for patients in the early stages of chronic kidney disease.
Scientists have developed a new mouse model of X-linked nephrogenic diabetes insipidus, a severe kidney disease. The model shows that selective EP4 receptor agonists alleviate the symptoms of the disease, suggesting these compounds as potential therapeutics.
Researchers found 44 genes up-regulated in CKD patients, including 11 involved in oxidative phosphorylation. Elevated reactive oxygen species (ROS) levels were also detected, suggesting a vicious circle of respiration dysregulation that contributes to CKD.
Researchers identify a genetic mutation in the renin gene as a cause of inherited kidney disease, characterized by anemia and progressive kidney disease. The discovery provides insight into the role of renin in blood pressure regulation and offers potential treatment options.
A new approach to statistical analysis shows that a higher dose of dialysis can lead to longer survival times for patients with advanced kidney disease. The study found no significant effect with conventional methods, contradicting previous conflicting results.
A study found that chronic kidney disease (CKD) has a significant impact on the quality of life of patients, particularly women, diabetics, and those with heart problems. The study suggests that medical care for CKD patients should include strategies to lessen the negative impact of CKD on quality of life.
Researchers analyzed data from studies on type 1 diabetes to find that intensive treatment can significantly reduce the risk of complications. The study showed improved outcomes in patients treated with more intensive therapy.
A recent study found that 'enhanced' fresh meat products often contain high levels of phosphorous and potassium not listed on food labels. This can be problematic for kidney disease patients who must limit these substances to avoid premature death.
A new laboratory test called urine neutrophil gelatinase associated lipocalin (NGAL) has been found to help predict acute kidney injury (AKI) in intensive care patients. NGAL levels are also higher in patients with HIV-associated nephropathy, a complication of HIV affecting African Americans and black Africans.
A daily dose of sodium bicarbonate slows the decline of kidney function in patients with advanced chronic kidney disease, reducing the rate of progression by about two-thirds. Patients taking baking soda also experience improvements in nutrition and are less likely to develop end-stage renal disease.
A study published in the Clinical Journal of the American Society Nephrology found that dialysis does not affect the heart health of kidney disease patients who have had a heart attack. Researchers identified predictors of high risk, such as potassium levels and patient condition severity.
Researchers have identified the protein ILK as promoting growth of aggressive rhabdomyosarcoma cells and suppressing ERMS cell growth. A therapy targeting ILK may provide a tailored approach for treating the lethal form of RMS, ARMS.
Two studies in the American Journal of Pathology demonstrate stromal caveolin-1 as a prognostic marker for breast cancer progression, correlating with reduced metastasis levels. Additionally, researchers have identified novel biomarkers for chronic kidney disease progression, predicting progressive renal fibrosis and glomerular filtrat...
A new study shows that overnight dialysis is a viable alternative for patients with irreversible kidney disease, offering improved health outcomes and reduced healthcare burden. The long-term results of this therapy were found to be well-tolerated by most patients, with lower rates of anemia and reduced levels of urea in their blood.
A study found that hypoglycemia may account for some portion of excess heart-related deaths in CKD patients. Patients with CKD and diabetes are at highest risk of developing hypoglycemia, which can lead to severe health complications.
A study analyzing Medicare data found that increasing preventive care measures, such as influenza vaccines and blood glucose monitoring, correlates with lower heart disease incidence in CKD patients. These measures can slow disease progression and improve overall health outcomes.
A study published in Clinical Journal of the American Society Nephrology found that patients with more knowledge about dialysis are more likely to use permanent vascular access. The researchers also identified factors associated with lower knowledge, including age, education level, and race.
Researchers have identified multiple chromosomal regions associated with genes influencing variation in proteinuria, particularly in the setting of diabetes or hypertension. The study's findings suggest that genetic variation likely accounts for part of the increased risk of kidney disease in American Indians.
A study of 298 black and 945 white male patients found that blacks with moderate and advanced chronic kidney disease lived longer than whites once they reached later stages. Blacks had a lower prevalence of cardiovascular disease, which contributed to their better survival rates.
A study published in the Journal of the American Society of Nephrology found that enzyme replacement therapy with agalsidase alfa slows kidney function decline in men with Fabry disease. The therapy showed promise when initiated early, particularly for those with higher initial kidney function.
A study suggests that combining glomerular filtration rate (GFR) and urinary albumin levels can predict which patients with chronic kidney disease will develop end-stage renal disease. This combination test could help identify patients at high risk of serious kidney trouble.
Studies found that partial correction of severe anemia with erythropoietin improves heart structure, while normalization of hemoglobin levels reduces fatigue in kidney disease patients. However, treating to a normal hemoglobin level may cause harm and is not recommended for all patients.
A study from the American Chemical Society reports that proteins from garden peas show promise in fighting high blood pressure and chronic kidney disease. The researchers found a 20% drop in blood pressure in rats with polycystic kidney disease when fed small daily doses of pea protein hydrolysate.
A study found that proteinuria levels are higher in children with low glomerular filtration rates and non-Caucasian race, suggesting genetic or environmental factors. The study also found that patients taking renin-angiotensin system antagonizing drugs had lower levels of proteinuria compared to those not on these medications.
A commonly used questionnaire for measuring quality of life in ADPKD patients is not sensitive enough to detect physical and mental problems. The study found links between patient characteristics and physical scores, but no significant difference in quality of life scores compared to the general population.
A new study by Kaiser Permanente researchers found that chronic kidney disease independently increases the risk of ischemic stroke in patients with atrial fibrillation. Kidney function may provide an additional clue about how to best assess stroke risk and decide upon the best prevention strategy for patients with AF.
High-flux hemodialysis reduces the risk of premature death in patients with CKD by eliminating large toxins. Patients with diabetes showed a significant survival benefit from high-flux dialysis, while benefits were not observed in all patient groups.
A study found that chewing gum with a phosphate-binding ingredient can help maintain proper phosphate levels and prevent cardiovascular disease in dialysis patients. Salivary phosphate levels decreased significantly after two weeks of chewing, while blood phosphate levels also showed a notable reduction.
A study found that individuals with high urinary protein levels are at increased risk of developing kidney disease. Screening for albuminuria in the general population or high-risk groups could help prevent kidney function loss and related health issues.
Researchers discovered that many processed and fast foods contain phosphorus additives, which can be just as dangerous for patients with advanced kidney disease as naturally high-phosphorus foods. Studies found that avoiding these additives significantly lowers phosphorus levels among patients.
A recent study published in PLoS ONE found that women who drink two or more cans of soda per day are nearly twice as likely to show early signs of kidney disease. The study also did not find an elevated risk for men or diet soda consumption.
A phase 3 clinical trial has shown that ferumoxytol, a novel intravenous form of iron, is effective in treating iron deficiency in CKD patients on dialysis. The study found significant improvements in hemoglobin levels compared to oral iron supplementation.
Measuring glomerular filtration rates from routine blood work may not be a cost-effective way to identify people with chronic kidney disease (CKD). The test can lead to 11,348 more false positive CKD cases than serum creatinine reporting.
A new formula estimates glomerular filtration rate (GFR) using demographic variables and biochemical markers, providing a valuable tool for pediatricians to monitor kidney function. The equation was found to be comparable with more complicated tests and superior to other recently published equations.
Researchers created a simple model to predict patients at high risk for chronic kidney disease, using an eight-point risk factor checklist. The model accurately stratifies middle-aged and older patients and has been validated across different cohorts.
Studies suggest taking phosphorus binders reduces death risk in new dialysis patients and those with less-severe CKD. The treatment could benefit a larger population of patients with pre-dialysis CKD.
A study published in JASN found that even mild increases in serum phosphorus levels are associated with cardiovascular events in people with moderate chronic kidney disease. Vascular calcification, detected by CT scans, was more common in patients with higher phosphorus levels, increasing the risk of coronary artery calcification.
Researchers at the University of Warwick have discovered that high doses of thiamine can dramatically decrease albumin excretion and reverse early-stage diabetic kidney disease. The study found that 300mg of thiamine taken orally daily for three months reduced albumin excretion by 41% in type 2 diabetes patients.
A study by the American Society of Nephrology found that patients with poor health literacy are less likely to receive kidney transplants. Roughly one-third of dialysis patients had inadequate health literacy, which hindered their ability to navigate healthcare systems and follow transplant instructions.
A study found that acute kidney injury increases the risk of end-stage renal disease among elderly patients, highlighting the importance of close monitoring and timely interventions.
The Canadian Society of Nephrology has released new guidelines to slow progression, prevent complications, and reduce mortality in chronic kidney disease patients. The guidelines encourage shared care among general practitioners and specialists.
Individuals with kidney stones are at a 60% greater risk of developing chronic kidney disease (CKD), according to a new study. Researchers recommend careful monitoring of stone formers and appropriate treatment when needed.
A newly developed equation estimates glomerular filtration rate (GFR) more accurately than the widely used Modification of Diet in Renal Disease (MDRD) Study equation, especially at higher GFR levels. The CKD-EPI equation was validated using data from over 8,000 patients and shows lower bias compared to the MDRD equation.
A clinical trial found that cognitive-behavioral therapy significantly improves depressive symptoms and quality-of-life scores in patients with kidney disease on dialysis. After three months of weekly sessions, patients showed a substantial reduction in depression and improved cognitive function.
The recently passed Medicare Improvement for Patients and Providers Act of 2008 will significantly impact nephrology practice and patient care. Key provisions include funding for CKD education sessions, bundled payment systems, and quality measures to improve efficiency and outcomes.
Researchers found improved cognitive function in transplant patients, particularly in verbal learning and memory. In contrast, dialysis patients showed declining test scores over time. The study suggests that kidney transplantation may have a beneficial effect on patients' mental function.
A study compared the survival of dialysis patients undergoing heart bypass surgery or stent placement, finding that stents offer best one-year survival but bypass surgery is superior for long-term results. The study's findings suggest that treatment choices depend on individual patient goals and risk tolerance.
Research presented at the American Society of Nephrology's Annual Meeting found African Americans with CKD caused by high blood pressure have a higher risk of progression to ESRD. The study followed 691 patients for 11 years and found they were at higher risk of progressing to ESRD than experiencing cardiovascular events.
A study of 107,693 Canadians found Aboriginal people with severe kidney disease were 43% less likely to visit a nephrologist and almost twice as likely to be hospitalized for preventable conditions. Understanding the barriers to healthcare is crucial to addressing these inequities.
The Halpin Foundation has awarded a research grant to Dr. Elena Torban, focusing on podocytes and their role in preventing proteinuria in nephrotic syndrome. This funding will support her investigation into the cell and molecular basis of this kidney disease.