Researchers have discovered a new function of the protein Syndecan-4, which plays an essential role in various diseases like cancer. The discovery sheds light on how proteins' shapes and forms affect cell behavior and mechanics.
Dr Andrew Benson and Dr Nick Devereux's research reveals the evolutionary history of the universe, explaining galaxy shapes and numbers. Their 'Lambda Cold Dark Matter' model suggests that dark matter haloes drive galaxy evolution, with elliptical galaxies resulting from multiple mergers.
A new study argues that a stable climate, rather than climate change, played a crucial role in the emergence of agriculture in the Near East. The research suggests that farming communities chose crops that functioned within the normal east Mediterranean rainfall pattern, allowing for sustainable farming practices during drought years.
A recent study published in the British Medical Journal found that angiotensin receptor blockers (ARBs) are associated with a significant decrease in Alzheimer's disease and dementia occurrence. Patients taking ARBs had up to a 50% lower chance of developing dementia compared to those on other medications.
A recent study challenges the claim that caffeine aggravates tinnitus, finding no significant improvement in symptoms from caffeine abstinence. Instead, participants experienced increased symptoms during acute withdrawal phases.
Two nurses, Ellen Makar and Sandra Ng, have been selected as emerging leaders in nursing informatics through the Alliance for Nursing Informatics (ANI) program. They will participate in a mentorship opportunity and complete various projects to develop their skills.
A new study found that rural males are 47% more likely to die from injuries than their urban counterparts, while rural females face a 33% higher risk of injury-related mortality. The disparity is attributed to various factors such as unintentional suffocation in infants and suicide among older adults.
Scientists have discovered a protein that can restore motor function in rats with impaired mobility after a stroke, with administered directly to the brain showing 99% regain. The intranasal method also demonstrates significant behavioral improvements and regenerative anatomical process.
A new study published in JAMA found that a platelet-rich plasma injection did not significantly improve pain or activity levels in patients with chronic Achilles tendinopathy. The study included 54 patients who received either a PRP injection or a saline placebo, and found no significant difference between the two groups after 24 weeks.
Researchers created super-strong collagen with improved stability, which could treat conditions like arthritis by mimicking natural collagen. The new collagen holds together at high temperatures and has a similar three-dimensional structure to natural collagen.
New analysis of US population data confirms a link between Bisphenol A (BPA) exposure and cardiovascular disease in adults. Higher BPA concentrations were associated with heart disease, as well as abnormal liver enzyme concentrations.
A new study published in the Journal of the National Cancer Institute found that having multiple family members with pancreatic cancer significantly increases an individual's risk of developing the disease. Relatives with a relative diagnosed under 50 years old are at a ninefold higher risk than the general population.
A researcher has used motion-sensitive night cameras to capture the first known instance of a cricket functioning as an orchid pollinator. The 'raspy' cricket is also entirely new to science and has been found to be a surprisingly efficient pollinator, with higher rates of pollination and fruit set in certain orchid species.
A recent study suggests that retreating patients with non-small cell lung cancer who initially responded to gefitinib treatment could lead to additional partial responses and stable disease. The overall disease control rate was 66.7 percent in the retreatment group, offering hope for patients who have failed initial chemotherapy.
A 93-gene signature associated with EGFR mutations in tumors from lung cancer patients was found to be a favorable prognostic marker for early stage lung cancer. The signature is also linked to drug sensitivity to erlotinib and gefitinib in non-small cell lung cancer cell lines.
Researchers confirm high levels of PCBs in IHSC sediments, sparking concerns about dredging's environmental impact. The study highlights the need for further investigation into the effects of dredging on sediment PCB levels and potential health hazards to humans.
Researchers found that educated individuals and professionals report more work interference with personal life, highlighting the 'stress of higher status'. Long hours also contribute to work-life imbalance, but only among those with control over their schedules.
Phase II study results of ASA404 showed improved overall survival in patients with squamous and non-squamous NSCLC compared to chemotherapy alone. The drug's unique mechanism of action inhibits tumor blood flow, providing a potential new treatment option for limited options.
Cancer cells co-opt the fat metabolism pathway to produce free fatty acids, promoting aggressive behaviors and potentially linking obesity to cancer progression. This discovery offers a new target for treating malignant cancers and preventing cancer progression.
Research from the University of Pittsburgh Graduate School of Public Health found that high blood pressure is associated with white matter abnormalities in the brain, which can lead to dementia. Women who had hypertension at age 65 were more likely to develop dementia eight years later.
Researchers have discovered over 30 species of invertebrates and 100 single-celled organisms at the East Stoke Fen nature reserve. The findings highlight the importance of protecting 'cryptic biodiversity', which helps natural ecosystems recover from environmental change.
USGS scientists identify Northern Pintail birds with genetic variations closely related to Eurasian influenza viruses, highlighting the need for targeted surveillance efforts. The study proposes refining priority species lists based on genetic analysis to reduce time and effort in surveillance sampling.
A study found that people who follow more complex diets are more likely to drop out due to perceived difficulty. The researchers suggest choosing a diet plan with fewer rules and easier monitoring to increase long-term adherence.
Researchers found that decitabine increased activity of genes in cancer cells, leading to complete responses and improved survival times. The study suggests decitabine as a potential first-line treatment for older leukemia patients with limited options.
Scientists discovered that Gata5 gene cooperates with Gata4 to direct the heart's normal structure formation during early development. This finding contributes to understanding how heart defects may occur in humans.
A recent study published in the European Heart Journal found that cocaine use is a growing public health problem in Europe, with 3.1% of sudden deaths related to the drug. The study revealed that even small amounts of cocaine can be toxic due to individual variations in body mass index, age, and other factors.
A new study has found that patients with specific oncogenic rearrangements of the anaplastic lymphoma kinase (ALK) gene in their tumors respond significantly to an ALK-inhibitor therapy. The study suggests a paradigm shift in cancer drug development, allowing for more targeted treatments.
A study published in PLoS ONE found a correlation between DNA methylation and heart failure, suggesting that environmental factors may play a key role in the development of the disease. The researchers compared DNA from diseased hearts with healthy hearts and found distinct 'marks' on the genome
A new research project will sequence and annotate the sunflower genome to locate genes responsible for agriculturally important traits. The goal is to develop a hybrid variety of sunflower that can thrive in challenging environments, making it suitable for subsistence agriculture in Africa and North America.
Researchers discovered that human chromosomes can reorganize their territories surprisingly quickly, taking up to 15 minutes to complete, when transitioning from proliferation to quiescence. This rapid process is driven by an energy-driven mechanism involving nuclear actin-myosin motor function.
The American College of Physicians has issued a position paper to guide ethical relationships among patients, physicians, and caregivers. The paper outlines four primary principles for physicians to consider when collaborating with patients and caregivers, including respect for patient dignity and effective communication.
Researchers found that custom videogames improved hand function and forearm bone health in teens with hemiplegic cerebral palsy. The games were designed to be used remotely, reducing costs and increasing accessibility to rehabilitation therapy.
Researchers have discovered genetic differences in pediatric brain tumors that can help explain tumor development and potentially lead to targeted treatments. The study identified a subset of malignant astrocytomas with specific genetic alterations, which may enable more individualized care for children with brain cancer.
Researchers found a 'longevity gene' associated with slower cognitive decline and reduced risk of dementia and Alzheimer's disease. The CETP gene variant alters protein function, leading to higher HDL cholesterol levels and increased protection against age-related illnesses.
A new technology could increase wind turbine efficiency by up to 30-40% at lower wind speeds, opening up new geographic areas for wind power. The circulation control aerodynamic technique will be applied to wind turbine blades, allowing for simpler designs and increased power production.
Neuroscientists and computer scientists identified how the brain arranges noun representations, using a neural Rosetta Stone. The three basic features of the brain's dictionary concern physical interaction, eating, and shelter or enclosure. This discovery has implications for treating psychiatric and neurological illnesses.
A University of Leeds research project aims to develop new treatments for multiple myeloma patients, using techniques such as injecting cements into the spine. The study seeks to improve quality of life for patients suffering from this incurable bone marrow cancer.
A study published in the Journal of Neuroscience found a link between loss of smell function and amyloid protein accumulation in the brain, potentially serving as an early diagnostic tool for Alzheimer's disease. Researchers suggest that olfactory dysfunction may be used to detect the disease prior to substantial brain degeneration.
Researchers have identified a fast-acting compound, benzylquinolone carboxylic acid (BQCA), that improves cognitive function impairments in mice with progressive Alzheimer's disease. BQCA works by boosting weak signals of the M1 muscarinic acetylcholine receptor and inhibiting production of amyloid beta, a marker of the disease.
Researchers have found that an anti-Alzheimer's drug can halt the growth of Barrett's oesophagus and even destroy mutant tissue, providing a potential cure for oesophageal cancer. The study, published in Disease Models & Mechanisms, offers new hope for therapy in heartburn-related cancer.
Researchers identified three microRNAs linked to chemoresistance in small cell lung cancer, affecting up to 15-30% of patients who are resistant to first-line therapy. The study provides new insights into predicting patient response to treatment and designing targeted therapies.
A new study published in PLOS Medicine found that British American Tobacco strategically influenced the European Union's framework for evaluating policy options, leading to a system that prioritizes business interests over public health. The study analyzed internal BAT documents and interviewed policymakers to reveal the extent of toba...
Edzani, once a powerful cyclone, has lost its 'roundness' and become asymmetrical. The storm's convection is decreasing, indicating further weakening.
Researchers at Florida Institute of Technology are awarded a four-year, $1.024 million NIH grant to continue their studies on cell growth regulation and its implications for human health. The funding will support the development of novel inhibitors that could be used to combat antibiotic-resistant bacterial diseases and treat cancer.
Research suggests that certain adaptations that once benefited humans may now be helping such ailments persist in spite of advancements in modern culture and medicine. Evolutionary perspectives integrated into medical curricula could help future physicians understand health problems from an evolutionary perspective.
A new analysis led by UC Davis expert Arthur Shapiro reveals that climate change and habitat loss are devastating butterfly populations, with lowland species being hit hard. The study's findings also show that 'ruderal' butterfly species, often considered insignificant, are declining faster than other species.
Researchers have discovered a genetic variant associated with aggressive prostate cancer, which may help identify men at risk of developing the disease. The study found that this genetic marker was present in 25% more men with aggressive disease than those with slow-growing disease.
The college has received a $20,000 grant from the Pennsylvania Coastal Zone Management Program to further study contaminants in Presque Isle State Park's recreational waters. Researchers aim to quantify hazardous chemicals like Triclosan and Fluoxetine to ensure water quality and public health
Mears will research real-time modeling and information exchange to maximize efficiency in machining systems. The project aims to improve manufacturing quality and productivity nationwide.
A large national study from Brandeis University found that intellectual activities undertaken regularly can make a difference in maintaining memory. Those with low education who engaged in reading, writing, attending lectures, doing word games or puzzles regularly had memory scores similar to people with more education
The National Salt Reduction Initiative proposes targets to reduce sodium levels in packaged and restaurant foods by 25% over five years. The initiative aims to decrease the nation's salt intake by 20% and prevent thousands of premature deaths.
Prof. Michael Gurevitz's research isolates genetic sequences for neurotoxins in scorpion venom and develops methods to produce and manipulate toxins for restricted toxicity in certain insects or mammals. This work paves the way for a new, ecologically sound pest control method.
Researchers have developed an algorithm and open source tool that reduces current software testing time by 300 times, increasing the efficiency of software testing across systems. The 'Just Enough Testing' project aims to re-use test results across different systems, reducing testing time for single systems.
Researchers at Texas A&M AgriLife Communications discovered that mango polyphenols can prevent or stop growth of certain breast and colon cancer cells. The study found that the fruit's antioxidants had a significant impact on these specific types of cancer, with some cell lines undergoing programmed cell death.
The program aimed to reduce child mortality by at least 25% in 11 west African countries but found no significant acceleration in child survival. Coverage for effective treatment interventions and nutritional status showed mixed results, with decreases in some areas but not others.
Research in Social Psychological and Personality Science suggests that women's fascination with true crime stems from a desire to learn strategies for prevention and survival. The study found that women are more likely to be drawn to true crime books than men, as they seek to understand warning signs and escape tips.
A study examines the effect of FDA safety warnings on atypical antipsychotics prescribed to patients with dementia, revealing a decline in usage among the elderly population. The findings highlight the need for improved risk communication between physicians and patients.
A new study found that bifocal glasses can slow the progression of nearsightedness in children. The treatment was more effective than single-vision lenses and had a significant role in preventing the development of very high pathologic myopia.
Researchers have identified a set of proteins related to the malaria parasite that can serve as new drug targets. The discovery uses a plant-based model, Arabidopsis, to understand how these proteins normally function, which could lead to the development of more effective antimalarial drugs.
Researchers question the safety of gene therapy targeting I-1c in treating heart failure after finding it can cause abnormal heartbeats and sudden death. Additionally, a study reveals that certain anticancer drugs can cause heart failure by triggering PDGFR-beta signaling in heart muscle cells.