Researchers predict that changes in brain chemicals and synaptic connections are necessary for recovery from cocaine addiction. Excessive glutamate production in the pleasure center can cause permanent damage, making it challenging for the brain to regulate itself.
Biomimetic nanoparticles are degraded by cathepsin L when entering human cells, compromising their potential to deliver therapeutic proteins. Researchers have developed methods to measure nanoparticle location and state, aiding the design of nanodevices that overcome this degradation.
A survey of nearly 4,500 general surgery residents found that most are satisfied with their training and relationships with faculty and peers. However, they also reported concerns about their clinical skills, family life strain due to work stress, and need for additional specialty training to be competitive in the job market.
A recent study has identified gene variants for glaucoma in a black population, which could lead to future treatments or a cure for the disease. The finding is significant as it explains nearly one-third of the genetic risk for glaucoma and could provide a more accurate and earlier diagnosis.
Research shows that spontaneous preterm birth rates are rising alongside medically-induced preterm births in Scotland, with maternal complications playing a decreasing role. The study suggests that reducing both types of preterm births is crucial for improving infant survival rates.
Researchers at Ohio State University have developed a mathematical model of ischemic wound healing, simulating both non-ischemic and ischemic wounds. The model predicts that ischemic wounds will heal in about 20 days, but only 25% will be healed by then.
The Field Museum has received a three-year grant to establish new conservation landscapes in Amazonian Peru. The project aims to secure legal protection for high-priority forests and indigenous territories, while also promoting sustainable management and financing through the REDD voluntary carbon market.
Researchers at the University of Gothenburg have discovered nine new bristleworm species that feed on dead whales, highlighting a previously unknown food source in marine ecosystems. The study reveals these specialized organisms play a significant role in nutrient cycling and ecosystem balance.
A team of researchers has discovered a compact way to produce infrared light using a miniscule tunnel in a stack of gold and silica layers. This tiny, tunable light source could be the precursor to a new component for light-based chips. String theorists have also developed a toolkit of equations to measure the predictions of string the...
Research at the University of Cincinnati found that individuals with the CHEK2*1100delC gene variant are more susceptible to developing cancer, particularly in women. The study suggests a stronger link between the gene and breast cancer in females compared to males.
Researchers analyzed 86 patients with nasal fractures, finding no significant difference in revision rates or patient satisfaction between closed and open treatments when done correctly. A treatment algorithm based on fracture type and degree of septal deviation can help surgeons choose the best approach for each individual case.
New research finds that adding cetuximab to chemotherapy reduces the risk of death from advanced non-small cell lung cancer by 13%, while also slowing disease progression and increasing the chance of tumor shrinkage. The study, which included over 2,000 patients, also found a 10% improvement in progression-free survival.
Researchers at Duke University have made significant progress in developing a portable, easy-to-use diagnostic device that can reveal who is infected with an upper respiratory virus before symptoms appear. The device uses advanced genomic and statistical tools to detect changes in gene expression, known as a 'signature' of infection.
Katsura Asano's research aims to understand protein building pathways in eukaryotic cells, which can play a role in cancer and chronic diseases. The study uses yeast as a model organism due to its similar protein-building process to human cells.
A multicenter study found drug-eluting stents to be effective in treating patients with chronic total occlusions, with low rates of major adverse cardiac events. The study also showed that certain drug-eluting stents, such as SES and EES, had a lesser rate of angiographic restenosis compared to others.
Researchers discovered a link between declining financial skills and the development of Alzheimer's disease. Participants with mild cognitive impairment (MCI) who showed poorer money management abilities were more likely to progress to dementia.
Scientists have developed a new antigen that induces protective antibodies capable of blocking infection by genetically-diverse HIV strains. The chemically-activated antigen differs from previous vaccines and stimulates the production of broadly-neutralizing antibodies.
Researchers at Johns Hopkins Medicine have identified a distinct set of white blood cells called regulatory T cells that play a crucial role in wound repair after serious lung injury. The study found that these cells can be sped up or slowed down, either aiding or hindering healing in severely damaged lung tissue.
A new technique for reconstructing the palate after tonsil cancer surgery has been shown to maintain patients' ability to speak clearly and eat most foods. The technique, developed at Michigan Medicine, separates the mouth from the nasal cavity and closes during swallowing, allowing patients to recover their complex throat functions.
A recent study published in Archives of Surgery found that individuals with ethanol in their bloodstreams are less likely to die following a moderate to severe head injury. The study analyzed data from 38,019 patients and found a significant decrease in mortality rates among those with alcohol in their bloodstreams.
A new type of sirolimus-eluting stent successfully demonstrated greater neointimal suppression and vessel wall integrity compared to paclitaxel-eluting stents. This study, presented at the TCT scientific symposium, confirms the superiority of the sirolimus-eluting stent for treating coronary artery disease.
Researchers found exceptionally low rates of complications and stable gradient release after one-year follow-up. Multiple vascular access sites are feasible, but periprocedural complications are considerable due to the high-risk patient population.
The OceanScope Working Group aims to collect high-resolution data on ocean interior dynamics and its impact on climate. Representatives from academia, industry, and government agencies are working together to establish a global network of ocean observation platforms on commercial ships.
A minimally invasive procedure called CT-guided tube pericardiostomy has been found to be just as effective as surgical drainage in treating pericardial effusion, with a significant cost savings of 89%. This treatment method spares patients from recovery time and reduces the risk associated with invasive surgery.
A study published in PNAS found that adolescent rats exposed to alcohol showed a bias towards uncertain rewards, while control group rats made more informed decisions. This research suggests a causal link between early heavy drinking and later adult decision-making impairments.
Researchers have identified a potential link between B cells and spinal cord injury, suggesting that therapies targeting these immune cells may improve recovery outcomes. In a separate study, scientists developed an assay to distinguish harmful from harmless BRCA1 mutations, which could help identify patients at risk of breast cancer.
Critically ill patients in ICUs can benefit from mild physical therapy exercises to reduce muscle wasting and promote recovery. The new approach involves introducing muscle-strengthening exercises early into treatment plans, with patients exercising while on ventilators and other life-support equipment.
Preliminary analysis of blood samples from trial participants suggests that the 2009 H1N1 influenza vaccine generates an immune response that is expected to be protective against the virus in most children between 10-17 years old. Younger children had a less robust early response to the vaccine.
A team of researchers led by Dr. Alon Monsonego has created a humanized mouse model that responds specifically to an A-beta-peptide vaccine, reducing plaque and inflammation in the brain. The study provides a basis for developing individualized immunotherapeutic approaches to Alzheimer's disease.
Researchers at Ohio State University have identified B cells as a key player in worsening spinal cord injury outcomes, but also found that removing or inhibiting these cells may help improve recovery. The study suggests potential new therapeutic targets for minimizing injury and promoting repair after traumatic spinal cord injury.
This article provides practical guidance for diagnosing adult asthma, including occupational asthma, using patient history, physical examination, and definitive diagnostic testing like spirometry. The goal is to accurately diagnose or exclude the possibility of asthma and treat patients accordingly.
Research shows consumers develop specific rules for sharing personal data online, influencing retailers' data mining practices. Understanding these rules is crucial to improving online experiences and products.
A new study from the University of Gothenburg reveals that middle-aged women with large abdominal fat cells are at higher risk of developing type 2 diabetes. The study uses waist circumference divided by body height as a predictor, suggesting a simpler and faster way to identify those at risk.
Researchers found that whole-brain radiotherapy did not extend lives or improve independence in patients with limited brain metastases and stable cancer. However, it slowed cancer progression by five weeks and reduced the risk of brain-related deaths.
Researchers at the University of Edinburgh have identified a protein that enables sections of so-called junk DNA to be cut and pasted within genetic code. This finding could speed up the development of gene therapies by allowing scientists to control the process of DNA transposition.
A new study found that switching post-menopausal women with early breast cancer to exemestane after two or three years of tamoxifen improves disease-free survival and overall survival. The study involved 4,724 postmenopausal women who were followed for an average of 91 months.
Researchers developed a modified catheter with side holes and slits to reduce the force of contrast material exiting the end hole. The study found a nine to 30 percent reduction in velocity and a more cloud-like dispersal of contrast material, resulting in improved patient safety.
Researchers found Hummer owners frame themselves as moral protagonists, using American foundational myths to defend their consumption choices against critics. They believe representing a bastion against anti-American discourses earns them the moral high ground.
Firms in energy-intensive industries invest regardless of regulatory enforcement due to social pressure and internal synergies. Economic logic also plays a role, as firms that expect to reap early benefits or recognize internal synergies are more likely to invest sooner.
A new study found that people tend to mimic their thin companion's portion sizes, but adjust their behavior when they think their friend is obese. Eating with someone of the same weight as oneself has little impact on food choices.
Researchers found that short-term stress enhances anti-tumor activity in mice, with fewer developing skin cancer and lower tumor burden. The stressed mice showed increased levels of immune-activating genes, suggesting a longer-term enhancement of immunity.
Researchers found that scientists combine model-based cognitive problem-solving with creativity to develop a better understanding of the system under investigation. This approach allows scientists to build real-world models and make predictions, leading to novel problem solutions.
A multicenter study found that drug-eluting stents are safe and effective in patients with diabetes, with low acute complications. The study showed a lower rate of restenosis for certain stent types, such as SES, BES, and EES.
A recent study published in General Hospital Psychiatry found that depressive symptoms and antidepressant treatment are associated with fetal growth changes, shorter gestations, and neonatal irritability. The research highlights the need for pregnant women to receive adequate care and support to mitigate these risks.
A large cohort study of 456,930 contrast doses found only 522 cases of adverse effects, most being mild and non-severe. The study suggests that contrast agents are safe to use and essential for diagnosis, with the advent of new agents improving their safety profile.
Researchers have developed an assay to distinguish between harmful and harmless BRCA1 mutations, providing a way to identify women with increased breast cancer risk. This breakthrough has immense clinical potential for early prevention and treatment strategies.
A large-scale clinical trial aims to determine if high doses of coenzyme Q10 can slow Parkinson's disease progression. Studies have shown that Parkinson's patients have impaired mitochondrial function and low levels of coenzyme Q10, which can be protected by the enzyme.
The Regenstrief Institute has developed technologies to enable rapid, secure bi-directional exchange of health information between clinical sources and public health organizations. This allows for efficient sharing of information on emerging risks and outbreak detection.
The HORIZONS-AMI trial showed that bivalirudin therapy significantly reduces major bleeding and cardiac death in patients with ST-segment myocardial infarction (STEMI) who have disease of the left anterior descending (LAD) artery. In high-risk STEMI patients, bivalirudin also provides the greatest mortality benefit.
Two Australian research studies reveal that 50% of people over 30 do not have sufficient risk factor information recorded, and only 20% with high risk receive all recommended treatments. Indigenous healthcare sites show better patient management, with 44% prescribed appropriate medicines.
Researchers explore image-guided interventional radiology procedures as a central role in treating DVT. These techniques aim to eliminate blood clots completely, potentially improving patient outcomes and preventing long-term complications. A national clinical trial is underway to confirm the effectiveness of this approach.
A new study published in the Journal of the American College of Cardiology found that public smoking bans can significantly reduce the risk of heart attacks, especially among younger individuals and nonsmokers. The study suggests that banning smoking in public places and workplaces can prevent up to 154,000 heart attacks each year.
Researchers at Southern Methodist University develop a four-week program to teach asthmatics how to better control their condition by changing the way they breathe. The study aims to reduce both the expense and suffering associated with chronic asthma, with promising results in limiting severity and frequency of attacks.
Investors tend to view stocks with shorter up-and-down movements as less risky, a phenomenon known as the 'run-length effect'. This bias is influenced by education level and trading experience, leading to systematic biases in risk perceptions that can impact market prices.
Scientists have discovered a potential therapeutic strategy for reversing rheumatoid arthritis and osteoporosis by manipulating the levels of NF-κB p100, a key inhibitory protein. The study found that increasing NF-κB p100 levels can limit bone destruction and inflammation in both diseases.
A study by University of Alberta researchers found that language commonly used in instant messaging has no effect on children's spelling abilities. In contrast, using language variations may require concentration and attention, suggesting its potential benefits in educational contexts.
Researchers found that the brain uses local motion signals to learn global motion, contradicting previous assumptions. The study published in Journal of Vision suggests that local motion processes are more important for task-relevant perceptual learning of global motion than previously thought.
Researchers at the University of Iowa discovered a way to deliver therapeutic molecules directly into brain cells using the blood-brain barrier. They found that unique alterations in the blood vessels surrounding brain cells can target specific diseases, allowing for non-invasive treatment of lysosomal storage diseases.
A study found that minimal training can significantly improve first responders' speed and effectiveness when inserting laryngeal masks during life-saving CPR or mouth-to-mouth. Regular refresher courses are recommended to maintain skills, as proficiency declines after six months of non-use.
Researchers found that incidental mood is generally not incorporated into memory-based judgments made after the mood has passed. However, if the mood effects are 'locked in,' such as through real-time evaluations, participants' memories can be influenced.