Articles tagged with Nephropathies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers analyzed data from a nationwide study of over 5,200 adults and found that African Americans have faster rates of decline in kidney function compared to white Americans. Hispanic participants also showed faster declines, but with varying effects by country of origin.
A study by Elizabeth Hedgeman and colleagues found that earlier nephrologist care is associated with lower ESRD incidence and improved patient outcomes. Patients who received recommended care were in better health, more prepared for dialysis, and had a 40% lower risk of death during the first year after developing ESRD.
A study found that pomegranate juice reduced inflammation and oxidative stress, leading to fewer hospitalizations due to infections. It also improved cardiovascular risk factors, suggesting better heart health for hemodialysis patients.
The Halpin Foundation-ASN Research Grant has enabled researchers to study the PCP pathway's role in regulating podocyte architecture and nephrin organization. This finding establishes a mechanism for the regulation of foot processes in membranous nephropathy.
The American Society of Nephrology (ASN) is convening a Summit on the Nephrology Workforce to address the growing crisis in kidney care. The summit aims to increase interest in nephrology careers, particularly among underrepresented minorities and women.
A study found that starting dialysis earlier in advanced kidney disease was associated with a greater risk of death. Patients who began dialysis early had a higher mortality rate compared to those who started later, especially those with lower albumin levels.
A new registry based on electronic health records could help physicians improve care for patients with mild to moderate chronic kidney disease. The registry, developed at the Cleveland Clinic, houses information on 57,276 CKD patients and has been validated as reliable for tracking disease progression.
Chronic kidney disease patients who don't adhere to high blood pressure medications are more likely to have sub-optimal blood pressure control. Improving medication adherence can greatly improve outcomes for these patients.
A new study has found a strong association between low birth weight and poor growth rate in children with chronic kidney disease (CKD). The research, published in the Clinical Journal of the American Society of Nephrology, analyzed data from over 400 children with CKD and found that those born with lower birth weights were more likely ...
A study found that measuring three biomarkers in a single blood sample can improve physicians' ability to identify patients at high risk of developing CKD. The biomarkers included homocysteine, aldosterone, and B-type natriuretic peptide.
Research highlights that kidney disease patients' blood pressure management needs are not one-size-fits-all, with age, race, and diabetes affecting mortality risk. The rate of kidney function decline also significantly impacts patient prognosis, suggesting a need for tailored strategies to protect kidney function.
Patients with higher muscle mass tend to live longer if they have kidney disease, according to a recent study. Researchers found that increased mid-arm muscle circumference was associated with improved mental health scores and longer survival rates.
A national study found that keeping blood pressure at 130/80 mm Hg reduced the risk of disease progression by 27 percent for patients with proteinuria. However, intensive lowering of blood pressure in all African-Americans did not slow disease progression.
A study found that malnutrition and inflammation status are key to understanding the effects of high cholesterol on kidney disease patients. Patients with malnutrition and/or inflammation had an inverse relationship between cholesterol levels and cardiovascular events, unlike those without these conditions.
Researchers found that mice treated with chromium picolinate had lower levels of albuminuria compared to untreated diabetic mice. The supplement reduced inflammation by affecting IDO, IL-6, and IL-7, suggesting a potential therapeutic effect.
A recent study suggests that aggressively treating hypertension in African Americans with kidney disease can significantly decrease the number of patients who lose kidney function and require dialysis. The study found a 25% reduction in end-stage kidney disease among those with protein in their urine.
A study of 5037 European hemodialysis patients found that fluctuating hemoglobin levels do not increase the risk of mortality. Patients with consistently low hemoglobin levels had a higher risk of dying, however.
Researchers have identified a rare form of kidney disease linked to a genetic mutation in the innate immune system, causing progressive kidney malfunction and blood in urine. The condition, named CFHR5 nephropathy, has been found in over 100 people of Cypriot descent and is potentially serious but can be detected through DNA testing.
Researchers identify a genetic mutation in the immune system causing chronic kidney disease in Cypriot families, with symptoms including blood in the urine and progressive kidney malfunction. The mutation dates back to a single common ancestor over 16 generations ago.
Research shows that community poverty is linked to lower rates of arteriovenous fistula use among newly diagnosed dialysis patients in poorer communities. This suggests that targeted interventions are needed to improve pre-dialysis care for these patients.
Recent guidelines call for lower target blood pressure levels in CKD patients, but a critical review finds the data is not definitively supported by scientific evidence. The author suggests that doctors should make individualized decisions about blood pressure control for their patients with kidney disease.
Chronic kidney disease patients with depression are more likely to be hospitalized, progress to long-term dialysis treatments or die within a year compared to those without depression. Depression is associated with poorer health outcomes, including higher rates of hospitalization, dialysis, and mortality.
Despite high rates of sexual dysfunction among CKD patients, little is known about effective treatments. The review found that drug treatment was helpful for male patients with erectile dysfunction but few studies evaluated safety and side effects in CKD patients.
Mayo Clinic researchers discovered chronic mild kidney injury in the kidneys of healthy adults, increasing with age. The study, published in Annals of Internal Medicine, highlights the need for new tests to detect mild kidney disease more accurately.
A randomized trial found that high-dose B-vitamin therapy accelerated kidney function decline and increased cardiovascular events in patients with type 1 or 2 diabetes. The study suggests that B-vitamin therapy may not be an effective treatment for slowing disease progression, and potentially poses risks for these patients.
A new study by Johns Hopkins Medicine reveals that black children with chronic kidney disease have more severe anemia than white children, even when treated equally. The research suggests that genetic variations may be at play and could require tailored treatment guidelines.
Researchers found that only a small percentage of children with abnormal urine dipstick results actually developed chronic kidney disease. The high cost of the test, estimated at $3.47 per patient, made it an ineffective screening method. The study validated American Academy of Pediatrics recommendations to discontinue routine screening.
A global study of over 65,000 individuals has identified more than a dozen genes associated with chronic kidney disease. The researchers found that common genetic variations in these genes were more frequent in people with poor kidney function or chronic kidney disease.
Researchers at Nationwide Children's Hospital developed a mouse model of vesicoureteral reflux, a condition that can lead to chronic kidney disease. The study found that these models lacked the protein fibroblast growth factor receptor 2 (Fgfr2), which is involved in tissue and organ development.
Many kidney diseases are caused by single gene defects, providing opportunities for diagnosis and treatment. The discovery of causative genes enables personalized medicine and the development of targeted therapies.
A new clinical prediction index can calculate survival for patients with end-stage kidney disease, helping clinicians and patients decide between transplantation or dialysis. The index has been proven to accurately predict mortality among eligible patients.
A study found that up to 42% of people with undiagnosed diabetes and nearly 18% of those with prediabetes have chronic kidney disease. This suggests a significant number of individuals may be at risk for worsening kidney disease, emphasizing the need for earlier screening and timely medical care.
A new study found that automated laboratory reporting of estimated glomerular filtration rate (GFR) was associated with a significant increase in first-time visits to a kidney specialist, especially among older or female patients and those at increased risk of late detection of kidney disease. The rate of visits increased by 68% for pa...
Avosentan significantly reduces urinary protein loss in people with type 2 diabetes and kidney disease, but also causes serious side effects such as pulmonary edema and congestive heart failure. Lower doses of avosentan may have a more favorable risk/benefit ratio for patients.
The ACCOMPLISH study shows that initial treatment with benazepril plus amlodipine reduces CKD progression more effectively than benazepril plus hydrochlorothiazide. This benefit was seen in patients at high risk for cardiovascular events.
Researchers found that even mild low potassium levels increase the risk of death in heart failure patients with chronic kidney disease. The study suggests routine monitoring and maintaining safe potassium levels to mitigate poor outcomes.
Researchers found that even mild to moderate kidney disease can lead to physical, emotional, intellectual, and social challenges in children. Children with chronic diseases currently do not qualify for special education until their scores decline dramatically. Early attention to quality-of-life issues is crucial.
A study found that end-of-life care falls short for kidney disease patients, with many lacking adequate support and education. Patients expressed a desire for help planning for the future, pain management, and psychosocial support, but these services were not routinely integrated into their care.
A study of 1,243 male US veterans with moderate-to-advanced chronic kidney disease found that both high and low blood calcium levels increased the risk of dying prematurely. High calcium levels were linked to a 31% increased risk, while low levels resulted in a 21% higher mortality rate.
Researchers found that darbepoetin alfa had no significant impact on cardiovascular problems or death rates in patients with chronic kidney disease and anemia. However, the study revealed a notable increase in stroke risk among those taking the drug, compared to placebo group members.
A recent study published in the Journal of the American Society of Nephrology found that carotid endarterectomy surgery significantly reduces the risk of future strokes in patients with chronic kidney disease. The procedure was shown to be safe and effective, without increasing the risk of death from surgical complications.
A new clinical tool helps determine if kidney disease patients on dialysis are likely to die within the next few months. The model considers a doctor's estimate of prognosis, nutritional status, age, and additional illnesses or conditions.
A new study finds that US per capita food waste has increased by about 50% since 1974 to over 1400 Calories per person per day, equivalent to 150 trillion Calories per year. This excessive energy content contributes significantly to freshwater consumption and fossil fuel emissions.
A study found that nearly 40% of children with chronic kidney disease have masked hypertension, which increases the risk of heart problems. Children with masked hypertension are four times more likely to develop left ventricular hypertrophy, a common consequence of untreated hypertension.
A study found that one-third of children with CKD have masked hypertension, which increases the risk of left ventricular hypertrophy and heart disease. Children with masked hypertension are four times more likely to develop LVH, highlighting the need for regular blood pressure monitoring outside the clinic.
Declining kidney function increases the risk of heart failure and premature death. Treatments that slow kidney function decline may safeguard heart health by stabilizing it in the normal range before kidney disease develops.
A study found that small increases in phosphorus are associated with higher coronary artery calcification and an increased risk of heart disease. Participants with lower kidney function were also more likely to have progressive CAC.
A clinical study found that cutting back on processed and fried foods, high in AGEs, reduces inflammation and restores natural defenses. The 'AGE-less diet' reduced blood AGE levels and improved biomarkers of vascular function by 60%, even in people with kidney disease.
Researchers have identified a new molecular pathway and class of molecules that can prevent potassium buildup in the bloodstream, which can cause fatal cardiac arrest. This discovery could lead to the development of new drugs to treat hyperkalemia, a condition affecting 8% of hospitalized patients.
Researchers found that oral activated charcoal lessens atherosclerotic lesions in experimental mice with kidney damage. This effect appears to be related to reduced inflammation in the blood vessels, regardless of treatment timing or changes in blood pressure or cholesterol levels.
Women with chronic kidney disease are more likely than men to be undiagnosed, according to a new study. The study found that primary care physicians need more education on diagnosing CKD, which could lead to improved patient outcomes and cost savings.
Recent medical school graduates are more likely to refer CKD patients for preemptive kidney transplantation, which can improve patient outcomes. The study suggests that educating veteran physicians about the benefits of preemptive transplantation may increase early referrals.
Researchers found that patients with higher kidney function at the time of transplant did not have a significant advantage in terms of long-term health. However, they did require less dialysis and were less likely to experience kidney rejection after transplantation.
A nationwide study of 13,000 Americans found that nearly 60% of the elevated risk of end-stage renal disease (ESRD) in African Americans may be attributed to low vitamin D levels. Researchers also discovered that vitamin D deficiency contributes significantly to the increased risk of ESRD among African Americans compared to whites.
A long-term follow-up study found that lifestyle intervention and metformin therapy can persistently delay the onset of type 2 diabetes for at least 10 years. The studies showed a significant reduction in diabetes incidence rates, with lifestyle intervention delaying onset by about 4 years and metformin by 2 years compared to placebo.
A study has found that coronary angiography does not harm kidney function in advanced chronic kidney disease patients, enabling better transplant decisions. The test detected coronary artery disease in some patients, making them unsuitable for transplantation until their heart complications were addressed.
For kidney disease patients, regular physical activity may prolong life and reduce mortality risk. A recent study found that active patients were 56% less likely to die than inactive counterparts.
A study found that male diabetics with higher eosinophil counts in their blood have a stronger link to diabetic nephropathy and increased risk of heart disease. Anti-inflammatory treatments used for allergies may also benefit male patients with diabetes.
A Monash University study has identified the role of microscopic antennas in the kidney's repair process, shedding light on a potentially fatal disease. The research, led by Dr. James Deane, showed how hair-like structures called cilia change their length in response to injury, amplifying signals that turn off the repair process.
A study published by the American Society of Nephrology found that weight loss through diet and exercise can reduce proteinuria and slow down kidney function decline in obese patients with kidney disease. Surgical interventions also show promise in normalizing kidney filtration rates.