Articles tagged with Nephropathies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A multi-site landmark study found that targeting a blood pressure of 120 millimeters of mercury reduces cardiovascular disease morbidity and event rates. Adults 50 years and older also experienced reduced rates of heart attack, heart failure, stroke, and death compared to the target systolic pressure of 140 mm Hg.
A study published in JAMA found that finerenone significantly reduces albuminuria in patients with diabetes and kidney disease. The medication also shows a lower risk of hyperkalemia compared to other treatments.
Janos Peti-Peterdi, a USC kidney researcher, has made significant advances in visualizing the function of the living kidney's filter and studying kidney stem cells. He aims to find new treatments and therapies for patients with chronic kidney disease.
Researchers found that TMAO levels increase with advancing severity of kidney disease and are linked to atherosclerosis and premature death. Targeting TMAO generation by intestinal bacteria may be a novel strategy for safeguarding heart health in patients with CKD.
A study found that tailored mobile health technologies can help patients with chronic kidney disease take their medications appropriately, with a 5% error rate. The technologies were designed to provide safe and easy-to-use medication guidance for patients.
A new study by University of California, San Diego researchers has identified a pivotal player in diabetic kidney disease and a potential biomarker for diagnosing and monitoring chronic kidney disease. The study uses metabolomics analysis to clarify a central mechanism of action involving the NADPH oxidase proteins NOX1 and NOX4.
A yearlong study found that patiromer can reduce elevated blood-potassium levels and prevent life-threatening adverse events in patients with chronic diabetic kidney disease. The drug consistently maintained normal serum potassium levels over 52 weeks, with minimal discontinuation due to adverse events.
A new drug, patiromer, significantly reduced serum potassium levels in patients with diabetic kidney disease and hyperkalemia. The study found that patiromer maintained normal potassium levels over 52 weeks, with minimal discontinuations due to adverse events.
Certain ECG measures can identify individuals with chronic kidney disease at high risk of dying from heart disease. A panel of 5 common ECG parameters was found to enhance prediction of cardiovascular death in this population, suggesting potential novel interventions to prevent cardiovascular complications.
Experts identified strategies for optimizing EHRs to better manage CKD patients, including standardizing data storage and accessibility. Well-designed EHRs can monitor patient conditions, facilitate collaboration among providers, and support patient self-management.
The European Society of Cardiology has published first-ever recommendations for managing cardiac arrhythmias in patients with chronic kidney disease. The guidelines emphasize the importance of considering renal impairment when choosing antiarrhythmic strategies, drugs, and anticoagulants.
A recent study published in Hemodialysis International found that the association between poverty and kidney disease changes over time. Adults beginning dialysis are more likely to be living in a poor zip code, with rates increasing from 27.4% in 1995-2004 to 34% in 2005-2010.
Researchers have discovered a new treatment approach targeting tiny blood and lymphatic vessels inside the kidneys, which improves renal function and slows disease progression in mice. This innovative therapy may offer hope for patients with polycystic kidney disease, particularly those with rare forms of the condition.
A study found that over 90% of educational materials for kidney disease patients have literacy levels above an average patient's grade level, making it hard for them to comprehend. This can lead to poor management and higher mortality rates among those with low health literacy.
A collaborative meta-analysis found that creatinine-based eGFR and albuminuria improve cardiovascular prediction, particularly for mortality and heart failure. The assessment of albumin-to-creatinine ratio (ACR) outperformed traditional risk factors, suggesting its potential broad implications for cardiovascular risk classification.
A new study published in The Lancet reveals that ACE inhibitors and angiotensin-receptor blockers (ARBs) are the most effective treatments for preventing end-stage kidney disease in adults with diabetes. These medications, used alone or in combination, have been shown to protect kidney function in the long term.
A retrospective study found that Caucasian and Hispanic children who undergo lung transplantation are at greater risk for developing chronic kidney disease. The study also identified high tacrolimus levels and acute kidney injury as risk factors for CKD in pediatric lung transplant patients.
Researchers analyzed over 1.3 million patient records to find that mildly abnormal results on kidney function tests are the strongest risk factor for acute kidney injury. Physicians can identify high-risk patients by paying close attention to common blood and urine tests for kidney function, potentially preventing the devastating injury.
The RUBY-1 study evaluates ombitasvir/paritaprevir/ritonavir and dasabuvir in patients with stage 4 or 5 CKD and HCV GT1 infection, revealing a well-tolerated combination with rapid viral load suppression.
A study at Columbia University Medical Center found significant DNA anomalies in 31% of children with CKD, linked to neurocognitive disorders. Routine genetic screening could lead to personalized care and earlier detection of complications like diabetes and seizures.
A new assay developed by researchers can identify novel drug candidates that protect kidney cells from damage, which could lead to the development of new treatments for chronic kidney disease. The system has already identified a small molecule called pyrintegrin that effectively protected rodent kidney cells.
A study developed a risk score model to predict the likelihood of developing chronic kidney disease (CKD) in patients with HIV. The model uses nine clinical and demographic factors to assess CKD risk, with participants having low, medium, or high risk scores experiencing respective probabilities of CKD development over five years.
A new oral drug, ZS-9, has been shown to normalize high potassium levels in 98% of patients with chronic kidney disease treated with Renin Angiotensin Aldosterone System inhibitors (RAASI's). This effective treatment reduces the risk of fatal cardiac arrhythmias associated with hyperkalemia.
HIV+ kidney transplant recipients who are not infected with HCV have similar 5-year and 10-year kidney survival rates as uninfected recipients. Patient survival among mono-infected HIV+ recipients is also comparable to uninfected recipients, while co-infected patients experience inferior outcomes.
A recent study published in the Journal of the American Society of Nephrology found that even mild stages of chronic kidney disease during pregnancy can increase risks of preterm delivery, neonatal intensive care, and hypertension. In contrast, risks of intrauterine death or fetal malformations were not significantly higher in women wi...
A new study found that high phosphate levels cause a stress signal inside blood vessel cells, leading to the release of microparticles that promote blood clot formation. This process is a common cause of injury and death, particularly in patients with kidney disease who lose the ability to excrete excess phosphate.
Researchers found that dialysis patients have altered enzyme activities and compromised HDL function, which may lead to advances in protecting kidney disease patients' heart health. Heart disease is a leading cause of death in these patients.
Researchers found that many low-yield tests are frequently conducted without significant impact on diagnosis and management of CKD. The study suggests that an evidence-based approach could reduce costs and improve efficiency in CKD evaluation.
Chronic pain in patients with chronic kidney disease is common and associated with improper use of pain medications. An estimated 26 million people in the US have CKD, making it a significant concern for patient safety.
A recent study found that patients with advanced kidney disease have been initiating dialysis progressively earlier over time. Despite no measurable differences in patient sickness or reasons for dialysis, the trend suggests a shift towards embracing higher levels of kidney function as acceptable for dialysis initiation.
As of January 1, 2016, Elsevier will publish the flagship journals Kidney International and Kidney International Supplements from the International Society of Nephrology. These journals are highly regarded for their original research in nephrology and kidney disease.
A new study found that lowering systolic blood pressure to below 140 mm Hg significantly reduces the risk of stroke in people over 60, with especially high risks for Hispanics and blacks. The study also highlights the importance of targeting this group with specific treatment guidelines.
A new BU study finds a decline in kidney function among Nicaraguan sugarcane workers, suggesting heat stress and dehydration may play a role in the high rates of chronic kidney disease. The research team recruited 284 workers performing different tasks and found that those with longer employment duration had worse kidney function.
Researchers at Cleveland Clinic have linked trimethylamine N-oxide (TMAO) to chronic kidney disease, finding higher levels in patients with the condition associated with greater mortality risk. Elevated TMAO levels are also linked to cardiovascular disease and kidney disease progression.
A new algorithm is a useful tool for measuring chronic kidney disease patients' readiness to make decisions about initiating dialysis. Patients with knowledge and fewer lifestyle barriers to home dialysis are more likely to be ready to make decisions, while clinicians who explain treatment options can increase readiness.
A new clinical study found that tetrahydrobiopterin (BH4) supplementation can dial back excessive sympathetic nervous system activation, leading to positive effects on arterial stiffness. BH4 is a cofactor for nitric oxide synthesis and has been shown to have beneficial effects on blood pressure and cardiovascular risk factors.
Researchers have discovered that small changes in blood acidity can lead to inaccurate calcium level monitoring, resulting in higher PTH levels and increased risk of artery damage. This affects patients with chronic kidney disease, who already face a high risk of fatal calcification.
A systematic review of the literature suggests that metformin is safe for patients with mild to moderate kidney disease, contrary to FDA guidelines. The risk of lactic acidosis is extremely low and comparable to those who do not take metformin.
A five-year national trial will investigate interventions for patients with multiple chronic conditions, including chronic kidney disease, diabetes, and hypertension. The study aims to identify effective treatments for patients with coexistent diseases and implement integrated healthcare delivery models.
A study found that decreased blood levels of Klotho increase the risk of heart disease in mice with chronic kidney disease, suggesting potential treatment strategy to protect kidney disease patients' heart health. If confirmed in humans, increasing Klotho levels may help protect the hearts of patients with chronic kidney disease.
The investigational drug patiromer decreased high potassium levels and maintained normal levels in patients with chronic kidney disease. Elevated potassium increases the risk of death in high-risk patients and limits the use of certain drugs used to control hypertension and cardiovascular disease.
A 12-week exercise program improved physical function and quality of life for patients with advanced chronic kidney disease, decreasing their pain. The study suggests that incorporating exercise into kidney disease care can significantly improve patients' lives.
A study found that perceived racial discrimination may contribute to disparities in kidney disease by increasing stress-related pathways. Among African Americans and whites, those who experienced 'a lot' of discrimination had higher systolic blood pressure but a lower prevalence of diabetes.
The Ferric Citrate OLE study demonstrated the iron-based phosphate binder's long-term safety and efficacy in managing elevated serum phosphorus levels. Patients treated with Ferric Citrate showed improvements in laboratory parameters, including reduced serum phosphorus levels and increased hemoglobin
Studies found that a higher-quality diet reduces the risk of needing dialysis or dying from kidney problems by 16-23%. High potassium intake also shows promise in reducing future risk. Dietary modifications are considered a low-cost and simple intervention to reduce chronic kidney disease burden.
A recent study has found a strong association between air pollution and the development of chronic kidney disease. The research, which analyzed data from over 1.1 million people in the US, revealed that even low levels of particulate matter can increase the risk of CKD.
A study found that sodium-reduced meat and poultry products contain significantly higher levels of potassium due to additives. This can pose a risk for patients with kidney disease who require low phosphorus and potassium diets.
A study of 699 African American adults found that those with severe periodontal disease developed chronic kidney disease at a rate 4 times higher than those without. Targeting periodontal disease may be an important path towards reducing disparities in chronic and end-stage kidney disease.
A study found that sleep apnea is associated with more rapid loss of renal function in patients with diabetic nephropathy. Researchers identified high-risk scores for obstructive sleep apnea, which were common in non-dialysis CKD patients and linked to decreased kidney function.
Exercise training slows kidney function decline and improves cardio-respiratory fitness in patients with progressive stages 3–4 CKD. A personalized, low-intensity home exercise program also improves physical performance in dialysis patients.
Two cholesterol management guidelines agree that nearly all patients with chronic kidney disease should receive statins, but 50% of those recommended are not taking them. The study found the Pooled Cohort risk equations to be accurate among people with CKD, indicating a valid tool for estimating heart disease risk.
A recent study by researchers at the University of Edinburgh estimates that more than 20 million Nigerians have hypertension, affecting one-third of men and one-fourth of women. The number of cases is projected to rise to 39 million by 2030, straining Nigeria's already-overburdened health system.
A comprehensive analysis of sex-specific differences in end-stage kidney disease treatment found that more men than women are on hemodialysis. Women's survival after hemodialysis is virtually equal to men's survival, but they were not receiving treatment as early, leading to higher mortality rates.
Researchers have developed a device that can detect markers of kidney disease and prostate cancer in urine samples, offering instant results and potentially higher accuracy. The device uses DNA sequences to latch onto disease markers, allowing for early detection at ultra-low concentrations.
A new study finds that calcium buildup in coronary arteries is a strong indicator of heart disease risk in individuals with chronic kidney disease. This measure outperforms other commonly used tests in predicting cardiovascular disease among CKD patients, who are at high risk for heart disease.
Researchers found that calcium build-up in coronary artery walls is a more useful indicator of heart disease risk in patients with CKD than traditional measures of atherosclerosis. The study suggests that this finding could help safeguard the heart health of millions of people globally who have chronic kidney disease.
A commentary published in Annals of Internal Medicine reveals the history of 'miraculous' Ebola virus serotherapy, inspired by 19th century discoveries. Additionally, two systematic reviews address challenges of interpreting troponin levels in patients with chronic kidney disease.
A study published in PLOS ONE found that ancestral exposure to the pesticide methoxychlor can lead to adult-onset diseases like kidney disease and obesity in future generations. The researchers discovered epigenetic changes caused by methoxychlor exposure, which were transmitted through the female line and affected gene expression.
A study published in the Journal of the American Society of Nephrology found that risk factors for chronic kidney disease are present and identifiable 30 years before diagnosis. The researchers identified significant associations between obesity, high blood pressure, and diabetes with future CKD development.
The UC Irvine Health Division of Nephrology & Hypertension will examine the nature and outcomes of transition to dialysis or kidney transplantation in advanced chronic kidney disease patients. The study will analyze data from veterans and Kaiser Permanente Southern California members.