Articles tagged with Nephropathies
UTA professor Paul Fadel receives a four-year NIH grant to study high sympathetic nerve activity in patients with chronic kidney disease and its link to ADMA, a natural occurring chemical in the body. The goal is to develop a treatment to lower sympathetic nerve activity and prevent dialysis, improving patient outcomes.
A new thematic issue of The Open Urology & Nephrology Journal reports on the association between hyperuricemia and kidney disease. Chronic inflammation is a common link between the two conditions, with research exploring its role in uric acid excretion and progression of renal disease.
Chronic kidney disease affects over a third of cats over 10 years old, causing significant quality of life compromise. The ISFM Consensus Guidelines provide practical diagnostic and treatment options, including dietary management and antihypertensive medication use.
Patients with chronic kidney disease and periodontitis have a significantly higher all-cause mortality rate compared to those with chronic kidney disease alone. The study analyzed data from 13,734 participants and found an increased risk of death at 10 years for individuals with both conditions.
A recent study found two genetic mutations in the SLC19A3 gene to be strongly associated with reduced risk of diabetic retinopathy and nephropathy. These mutations, which prevent high blood sugar damage to tiny blood vessels, have significant implications for diabetes prevention and treatment.
The American College of Physicians recommends using either cognitive behavioral therapy or second-generation antidepressants to treat adults with major depressive disorder. Both treatments are found to be similarly effective for treating depression, and physicians should consider a discussion with the patient about treatment effects, a...
New research published in Respirology suggests a significant link between sleep apnea and an increased risk of developing chronic kidney disease. Adults with sleep apnea were found to have a 58% higher risk of developing the condition over a 3.9-year follow-up period.
A ketoanalogue-supplemented vegetarian very low-protein diet was found to slow disease progression in patients with advanced CKD. The study suggests that this type of nutritional intervention could be used to postpone dialysis initiation in compliant patients.
A study in JCI Insight identifies Dickkopf-3 as a driver of renal fibrosis in chronic kidney disease. DKK3 expression is elevated in stressed tubular epithelia and associates with profibrotic T cell responses, leading to interstitial fibrosis and impaired kidney function.
A study found that high levels of mitochondrial DNA in the blood are associated with a lower risk of developing chronic kidney disease (CKD). The researchers analyzed data from over 9,500 participants and discovered that individuals with higher mitochondrial DNA copy numbers had a 25% lower risk of CKD compared to those with lower levels.
The USRDS annual data report reveals a decline in deaths among dialysis and transplant patients, while prevalence of end-stage kidney disease continues to rise. Home dialysis use has increased, offering improved quality of life, but awareness of kidney disease remains low.
The NHS Health Check programme effectively identifies people at risk of cardiovascular incidents and helps diagnose conditions like type 2 diabetes, high blood pressure, and chronic kidney disease. The study found that the programme prevented 2,500 cases from treatment following the check over its first five years.
A large cohort study found proton pump inhibitors associated with a higher risk of developing chronic kidney disease. The study suggests that up to 70% of PPI prescriptions may be without an appropriate indication, and discontinuing therapy without symptoms could prevent CKD in long-term users.
The study found substantial variation in CKD prevalence across European countries, ranging from 3% to 17%, which may be due to factors other than diabetes, hypertension, and obesity. The findings could guide future projections of the CKD burden in Europe and inform prevention and disease management strategies.
Researchers found a 15-20% reduction in hospitalization risk for heart failure or death among patients with cardiac resynchronization therapy compared to those with implantable cardioverter defibrillators. The treatment is associated with improved outcomes, but further studies are needed.
Researchers have identified a simple, non-invasive test to identify patients at risk of chronic kidney disease progression by measuring epidermal growth factor levels in urine. Decreased epidermal growth factor protein is an early sign of diminishing kidney function and pinpoints the at-risk patient population.
Studies found that many African Americans with uncontrolled hypertension lack access to essential food categories, such as fruits, whole grains, and plant proteins. The Dietary Approaches to Stop Hypertension (DASH) diet is particularly beneficial for this population, but discussions about diet with doctors are often inadequate.
A study finds that advanced stages of chronic kidney disease significantly increase the risk of falling into poverty. Black ethnicity, low educational attainment, single adult households, and low income are also linked to a higher likelihood of financial hardship.
Research links combat injuries to increased risk of high blood pressure, diabetes, and kidney disease in US veterans. The more severe the injury, the higher the risk of developing these conditions due to inflammation and other factors.
Two new studies show that increased use of proton pump inhibitors (PPIs) may contribute to the CKD epidemic. PPI users were between 20% and 50% more likely to develop CKD than non-PPI users, even after accounting for baseline differences.
A study found disparities in kidney disease patients' access to electronic health record portals, which may reinforce existing health-related inequities. Patients with black race, lower neighborhood household income, older age, and Medicaid/Medicare insurance status were less likely to adopt the portal.
A recent study found that each 80 minutes/day increase in sedentary duration was linked with a 20% increased likelihood of having chronic kidney disease. The association was independent of moderate/vigorous physical activity and other factors.
Scientists at Brigham and Women's Hospital have developed a method to create kidney structures from adult stem cells, which could be used to study diseases such as chronic kidney disease and test new therapies. These kidney structures can model the development of kidney abnormalities and susceptibility to drug toxicity.
A new study suggests that chronic dehydration caused by global climate change may be responsible for the Mesoamerican Nephropathy epidemic, which has killed over 20,000 people. The disease is most prevalent among manual laborers on sugar cane plantations in Central America.
A new study by the Veterans Affairs Research Communications found that individuals with restless legs syndrome (RLS) are at a higher risk for stroke, coronary heart disease, chronic kidney disease, and earlier death. The study of over 3 million veterans revealed a fourfold higher incidence of stroke and heart disease in the RLS group.
A multi-site landmark study found that targeting a blood pressure of 120 millimeters of mercury reduces cardiovascular disease morbidity and event rates. Adults 50 years and older also experienced reduced rates of heart attack, heart failure, stroke, and death compared to the target systolic pressure of 140 mm Hg.
A study published in JAMA found that finerenone significantly reduces albuminuria in patients with diabetes and kidney disease. The medication also shows a lower risk of hyperkalemia compared to other treatments.
Janos Peti-Peterdi, a USC kidney researcher, has made significant advances in visualizing the function of the living kidney's filter and studying kidney stem cells. He aims to find new treatments and therapies for patients with chronic kidney disease.
Researchers found that TMAO levels increase with advancing severity of kidney disease and are linked to atherosclerosis and premature death. Targeting TMAO generation by intestinal bacteria may be a novel strategy for safeguarding heart health in patients with CKD.
A study found that tailored mobile health technologies can help patients with chronic kidney disease take their medications appropriately, with a 5% error rate. The technologies were designed to provide safe and easy-to-use medication guidance for patients.
A new study by University of California, San Diego researchers has identified a pivotal player in diabetic kidney disease and a potential biomarker for diagnosing and monitoring chronic kidney disease. The study uses metabolomics analysis to clarify a central mechanism of action involving the NADPH oxidase proteins NOX1 and NOX4.
A new drug, patiromer, significantly reduced serum potassium levels in patients with diabetic kidney disease and hyperkalemia. The study found that patiromer maintained normal potassium levels over 52 weeks, with minimal discontinuations due to adverse events.
A yearlong study found that patiromer can reduce elevated blood-potassium levels and prevent life-threatening adverse events in patients with chronic diabetic kidney disease. The drug consistently maintained normal serum potassium levels over 52 weeks, with minimal discontinuation due to adverse events.
Certain ECG measures can identify individuals with chronic kidney disease at high risk of dying from heart disease. A panel of 5 common ECG parameters was found to enhance prediction of cardiovascular death in this population, suggesting potential novel interventions to prevent cardiovascular complications.
Experts identified strategies for optimizing EHRs to better manage CKD patients, including standardizing data storage and accessibility. Well-designed EHRs can monitor patient conditions, facilitate collaboration among providers, and support patient self-management.
The European Society of Cardiology has published first-ever recommendations for managing cardiac arrhythmias in patients with chronic kidney disease. The guidelines emphasize the importance of considering renal impairment when choosing antiarrhythmic strategies, drugs, and anticoagulants.
A recent study published in Hemodialysis International found that the association between poverty and kidney disease changes over time. Adults beginning dialysis are more likely to be living in a poor zip code, with rates increasing from 27.4% in 1995-2004 to 34% in 2005-2010.
Researchers have discovered a new treatment approach targeting tiny blood and lymphatic vessels inside the kidneys, which improves renal function and slows disease progression in mice. This innovative therapy may offer hope for patients with polycystic kidney disease, particularly those with rare forms of the condition.
A study found that over 90% of educational materials for kidney disease patients have literacy levels above an average patient's grade level, making it hard for them to comprehend. This can lead to poor management and higher mortality rates among those with low health literacy.
A collaborative meta-analysis found that creatinine-based eGFR and albuminuria improve cardiovascular prediction, particularly for mortality and heart failure. The assessment of albumin-to-creatinine ratio (ACR) outperformed traditional risk factors, suggesting its potential broad implications for cardiovascular risk classification.
A new study published in The Lancet reveals that ACE inhibitors and angiotensin-receptor blockers (ARBs) are the most effective treatments for preventing end-stage kidney disease in adults with diabetes. These medications, used alone or in combination, have been shown to protect kidney function in the long term.
A retrospective study found that Caucasian and Hispanic children who undergo lung transplantation are at greater risk for developing chronic kidney disease. The study also identified high tacrolimus levels and acute kidney injury as risk factors for CKD in pediatric lung transplant patients.
Researchers analyzed over 1.3 million patient records to find that mildly abnormal results on kidney function tests are the strongest risk factor for acute kidney injury. Physicians can identify high-risk patients by paying close attention to common blood and urine tests for kidney function, potentially preventing the devastating injury.
The RUBY-1 study evaluates ombitasvir/paritaprevir/ritonavir and dasabuvir in patients with stage 4 or 5 CKD and HCV GT1 infection, revealing a well-tolerated combination with rapid viral load suppression.
A study at Columbia University Medical Center found significant DNA anomalies in 31% of children with CKD, linked to neurocognitive disorders. Routine genetic screening could lead to personalized care and earlier detection of complications like diabetes and seizures.
A new assay developed by researchers can identify novel drug candidates that protect kidney cells from damage, which could lead to the development of new treatments for chronic kidney disease. The system has already identified a small molecule called pyrintegrin that effectively protected rodent kidney cells.
A study developed a risk score model to predict the likelihood of developing chronic kidney disease (CKD) in patients with HIV. The model uses nine clinical and demographic factors to assess CKD risk, with participants having low, medium, or high risk scores experiencing respective probabilities of CKD development over five years.
A new oral drug, ZS-9, has been shown to normalize high potassium levels in 98% of patients with chronic kidney disease treated with Renin Angiotensin Aldosterone System inhibitors (RAASI's). This effective treatment reduces the risk of fatal cardiac arrhythmias associated with hyperkalemia.
HIV+ kidney transplant recipients who are not infected with HCV have similar 5-year and 10-year kidney survival rates as uninfected recipients. Patient survival among mono-infected HIV+ recipients is also comparable to uninfected recipients, while co-infected patients experience inferior outcomes.
A recent study published in the Journal of the American Society of Nephrology found that even mild stages of chronic kidney disease during pregnancy can increase risks of preterm delivery, neonatal intensive care, and hypertension. In contrast, risks of intrauterine death or fetal malformations were not significantly higher in women wi...
A new study found that high phosphate levels cause a stress signal inside blood vessel cells, leading to the release of microparticles that promote blood clot formation. This process is a common cause of injury and death, particularly in patients with kidney disease who lose the ability to excrete excess phosphate.
Researchers found that dialysis patients have altered enzyme activities and compromised HDL function, which may lead to advances in protecting kidney disease patients' heart health. Heart disease is a leading cause of death in these patients.
Researchers found that many low-yield tests are frequently conducted without significant impact on diagnosis and management of CKD. The study suggests that an evidence-based approach could reduce costs and improve efficiency in CKD evaluation.
Chronic pain in patients with chronic kidney disease is common and associated with improper use of pain medications. An estimated 26 million people in the US have CKD, making it a significant concern for patient safety.
A recent study found that patients with advanced kidney disease have been initiating dialysis progressively earlier over time. Despite no measurable differences in patient sickness or reasons for dialysis, the trend suggests a shift towards embracing higher levels of kidney function as acceptable for dialysis initiation.
As of January 1, 2016, Elsevier will publish the flagship journals Kidney International and Kidney International Supplements from the International Society of Nephrology. These journals are highly regarded for their original research in nephrology and kidney disease.
A new study found that lowering systolic blood pressure to below 140 mm Hg significantly reduces the risk of stroke in people over 60, with especially high risks for Hispanics and blacks. The study also highlights the importance of targeting this group with specific treatment guidelines.
A new BU study finds a decline in kidney function among Nicaraguan sugarcane workers, suggesting heat stress and dehydration may play a role in the high rates of chronic kidney disease. The research team recruited 284 workers performing different tasks and found that those with longer employment duration had worse kidney function.
Researchers at Cleveland Clinic have linked trimethylamine N-oxide (TMAO) to chronic kidney disease, finding higher levels in patients with the condition associated with greater mortality risk. Elevated TMAO levels are also linked to cardiovascular disease and kidney disease progression.
A new algorithm is a useful tool for measuring chronic kidney disease patients' readiness to make decisions about initiating dialysis. Patients with knowledge and fewer lifestyle barriers to home dialysis are more likely to be ready to make decisions, while clinicians who explain treatment options can increase readiness.