Articles tagged with Nephropathies
Researchers aim to evaluate a low dose blood-thinning medication for people with advanced kidney disease, a condition affecting over 30.5 million globally. The five-year trial will also investigate the safety of this medication in reducing heart attacks, strokes and deaths.
Chronic kidney disease (CKD) is characterized by progressive loss of kidney function, which can be attributed to faulty cellular energy sensing. Researchers have identified a link between decreased AMPK activity and CKD progression, highlighting a potential therapeutic target for treatment.
A new study by American Society of Nephrology examined 281,233 patients with diabetes and CKD in 130 VA facilities. The findings point to areas where care might be improved and standardized among facilities.
Researchers discovered a new pathway to enhance kidney self-repair by reprogramming the body's metabolism. The 'lift and push' process involves shifting glucose from energy production to repair damaged cells, resulting in improved lifespan for injured animals.
A pilot program in rural New Mexico promoted patients' active involvement in their daily care, leading to modest improvements in clinical measures. The intervention also showed significant benefits in mental health quality of life and reduced CKD risk factors.
Researchers at NYIT are investigating the process of molecular calcification to develop a new therapy for vascular calcification. The study will validate theories on phosphatase enzyme activity and test a compound known as SBI-425 as a potential treatment.
Researchers analyzed data from 28 papers involving over 1,300 participants and found no evidence linking high protein diets to kidney disease in healthy individuals or those at risk of kidney disease. A high-protein diet can actually increase kidney function, making it a safe and important tool for muscle health across the lifespan.
Researchers have successfully developed kidney tissue that exhibits the early stages of congenital kidney disease using iPS cells from a patient with a nephrin mutation. The study found that repairing the nephrin mutation can normalize abnormalities and may lead to the development of effective drugs for kidney disease.
Adults with chronic kidney disease have a higher likelihood of receiving opioid prescriptions and using them, suggesting a link to the national opioid epidemic. Multiple comorbid conditions, including pain-causing and non-pain-related conditions, are associated with increased prescription opioid use in patients with CKD.
A phase II clinical trial found that sparsentan significantly reduces proteinuria by 45% in patients with focal segmental glomerulosclerosis (FSGS), a rare kidney disorder. The study also suggests potential implications for other kidney diseases characterized by proteinuria.
A new study found that Medicaid expansion led to a significant decrease in mortality rates among patients with end-stage kidney disease. In states that expanded Medicaid, the number of deaths within a year of starting dialysis decreased by 0.8 percentage points compared to non-expansion states.
Researchers have found that intensive blood pressure lowering does not necessarily lead to true kidney disease, but rather benign reductions in kidney blood flow. This major advancement challenges current clinical standards for diagnosing and monitoring chronic kidney disease.
A comprehensive national registry for pediatric chronic kidney disease (CKD) is essential to improve lifespan and quality of life. The study emphasizes the importance of identifying children at risk, with high mortality rates among those requiring renal replacement therapy.
The Dartmouth Institute has received a $3.5 million grant to test preventative interventions for acute kidney injury (AKI) in patients undergoing cardiac catheterization. The study aims to evaluate the effectiveness of virtual learning collaboratives with and without automated surveillance reporting.
Researchers found that patients taking full-dose allopurinol for gout flares had a lower risk of developing Stage 3 Chronic Kidney Disease (CKD) compared to non-users. The use of allopurinol may be beneficial in reducing kidney disease risk, contrary to previous concerns.
A large multi-ethnic study found that high circulating levels of an inflammatory marker are linked to long-term decline in kidney function. The study suggests a novel marker, soluble TNFR-1, is strongly related to kidney function decline over time.
Researchers found that extending specialized care to patients with advanced kidney disease before their kidneys fail could save the US healthcare system more than $1 billion annually. Improving care coordination among these patients is crucial for reducing costs and improving health outcomes.
Researchers identified specific genes and cells associated with CKD, including the adaptor protein DAB2 in the TGF-β pathway. Further experiments confirmed that reducing DAB2 expression protected mice from CKD. The findings could inform treatment options for this complex disease.
Researchers found that vitamin B complex supplementation improved blood glucose regulation and kidney function in children with type-1 diabetes. The study suggests that simple supplementation may be a safe and cost-effective strategy for early protection of kidney function.
Researchers found a relationship between high FGF23 levels and structural compromise in the brain, particularly in the frontal lobes, which control learning and complex cognitive functions. Elevated FGF23 levels were also associated with increased disconnection in the brain, indicating problems with brain health in those areas.
Exposure to PFAS has been linked to worse kidney function and other signs of kidney damage in studies analyzing all relevant research. The analysis points to the need for further research on the effects of PFAS on kidney health.
A new study suggests that moderate caffeine consumption may help reduce the risk of death for individuals with chronic kidney disease. Participants who consumed more caffeine had a nearly 25% lower risk of mortality over a median follow-up period of 60 months.
A study published in Canadian Medical Association Journal found that patients with acute critical illness without pre-existing kidney disease are at increased risk of developing chronic kidney disease and end-stage renal disease. The study also shows that these patients have a higher risk of death.
A new study published in PLOS ONE suggests that polluted air may be a threat to your kidneys, increasing the risk of chronic kidney disease. Air pollution contains fine particulate matter (PM2.5), which can cause serious health effects when inhaled regularly.
A study published in the Journal of the American Society of Nephrology found that black and Hispanic veterans with chronic kidney disease are more likely to progress to advanced kidney disease despite equal access to nephrologist care. Genetic or environmental factors, such as APOL1 mutations, may be central to these disparities.
A study found that 12 weeks of aerobic and strength-based exercise reduces symptoms and levels of fatigue in patients with chronic kidney disease. Exercise also improves blood pressure, cholesterol, and diabetic control, making it a beneficial treatment option for patients with CKD.
A study of over 350,000 patients found elderly kidney disease patients on dialysis have a substantially higher risk of dementia than healthy community-dwelling older adults. The study calls for more monitoring and prevention measures to address this pressing issue.
A new study by the University of Leicester found that larger muscles can compensate for poor muscle quality in Chronic Kidney Disease (CKD) patients, improving physical function and strength. The research suggests that muscle size is a more important factor than muscle quality in maintaining good physical performance.
A study found that direct oral anticoagulants increase the risk of bleeding in patients with chronic kidney disease, highlighting the need for caution in their prescription. The findings suggest a higher risk of bleeding events compared to conventional anticoagulant warfarin use.
Researchers have successfully used viral vectors to deliver genetic material to kidney cells, paving the way for new treatments for chronic kidney disease. The discovery could lead to gene therapies that slow or reverse the growth of cells contributing to CKD.
A study of 27 patients with late-stage CKD found that interactions with clinicians and the health system can take a large emotional toll. Patients struggle to make sense of their illness, blame themselves, and feel abandoned or isolated.
A study found that the blood pressure-lowering medication ramipril reduced protein excretion in children with chronic kidney disease, which was linked to a lower risk of disease progression. The findings suggest that proteinuria lowering is an important target in managing pediatric CKD.
A study published in Radiology found that children with chronic kidney disease exhibit increased cerebral blood flow compared to healthy controls. This may indicate compensatory hyperactivity or disturbances in blood flow regulation, potentially leading to white matter injury and cognitive problems.
A recent study suggests that metformin is safe for most adults with diabetes and chronic kidney disease (CKD). The research, conducted by Johns Hopkins Medicine, found no association between metformin use and acidosis in patients with mild to moderate CKD. However, the risk of acidosis increased significantly among patients with severe...
Research suggests that women who have had gestational diabetes may benefit from periodic checkups to detect early-stage kidney damage. The study found a link between high glomerular filtration rates and pre-diabetes, indicating a potential risk for chronic kidney disease.
A new study published in PNAS reveals that a protein called hamartin plays a central role in shutting down the nephron formation process in preterm infants. By reducing hamartin levels, researchers found that preterm babies could develop 25% more nephrons than control groups.
A new study finds that individuals with chronic kidney disease who slept 7 hours/day had higher health-related quality of life compared to those who slept 5 or 9 hours/day. Sleep disorders are common among CKD patients, leading to fatigue, lack of energy, and drowsiness.
Medical College of Georgia scientists found that drinking baking soda encourages the spleen to promote an anti-inflammatory environment, reducing destructive inflammation in autoimmune diseases. This shift was observed in rats and healthy people, with a reduction in pro-inflammatory cells and an increase in anti-inflammatory macrophages.
Researchers have developed a technique to analyze old proteins on historical artifacts, providing insight into past lifestyles and medical conditions. This method, using chromatography resins, can identify biomarkers like morphine and kidney disease indicators, shedding light on the lives of those who created or used these items.
A new staging system for children with chronic kidney disease (CKD) predicts the length of time until a child will need a transplant or dialysis. The system takes into account three factors: glomerular filtration rate, proteinuria, and disease etiology.
Researchers from the University of Pennsylvania identified three novel cell populations and understood how kidney disease develops at a single-cell level. They found that specific cell types convert to each other, leading to conditions like chronic kidney disease, which affects about 14 percent of Americans.
A new study suggests that multidisciplinary care programs for patients with mild to moderate chronic kidney disease (CKD) are likely to be cost-effective. The study estimates that such programs add 0.23 quality-adjusted life years over usual care, with a cost of $51,285 per QALY gained.
A recent VA study found that over 30% of diabetic veterans had prior signs of chronic kidney disease. The results highlight the importance of early detection and screening for CKD in at-risk populations. Researchers propose broadening screening among patients with increased risk of CKD to prevent organ damage.
Patients with non-dialysis chronic kidney disease (CKD) who performed combined exercise showed greater increases in muscle mass and strength compared to those doing aerobic exercise alone. The study found that combining both modes of exercise led to significant health benefits, including increased cardiorespiratory fitness.
Researchers found that high glucose levels are associated with a higher risk of heart attack and kidney dysfunction in people with prediabetes. The study suggests that identifying and treating this group can lead to significant reductions in cardio-metabolic risks.
An analysis of published studies found that children with CKD had lower intellectual functioning compared to children in the general population, particularly those on dialysis. Deficits were evident for attention, memory, and executive function domains.
Children with chronic kidney disease (CKD) experience deficits in academic skills, visual and verbal memory, and executive function, according to a new study. The analysis of 34 studies found that CKD patients have an average IQ 10 points lower than healthy children, with those on dialysis showing an even greater decline.
A US researcher has received a grant to investigate the role of ALCALM in lupus, a complex autoimmune disease. The study aims to understand how ALCALM drives the immune system to attack healthy tissues, and potentially find new treatments or even a cure for lupus.
Researchers explore mechanisms protecting animals from chronic kidney disease, such as naked mole rats' longevity and hibernation adaptations. Biomimetics collaboration could lead to novel therapeutic approaches and improved human health.
A recent study has found that people over 65 with chronic kidney disease and atrial fibrillation are at increased risk of stroke when taking blood thinners. The researchers estimate that half a million UK adults fall into this category, highlighting the need for cautious prescribing practices.
A study by Kaiser Permanente and University of Washington found that patients with chronic kidney disease who receive implantable cardioverter defibrillators experience a significantly increased risk of subsequent hospitalization. The use of ICDs was associated with a 49% increased risk of hospitalization for heart failure and a 25% in...
Researchers from ColoradoSPH identified new risk factors for a mysterious kidney illness affecting farm workers worldwide. The study found that access to water, rest, and shade reduces the rates of kidney disease onset and injury severity.
Scientists at Joslin Diabetes Center found a connection between eye damage and cardiovascular disease in people with type 1 diabetes, suggesting shared biological mechanisms. The study also showed that kidney disease was not necessarily linked to cardiovascular disease, challenging previous assumptions.
A new study by Boston University researchers confirms the link between chronic kidney disease and increased risk of blood clots, identifying specific tryptophan metabolites as key players. The findings provide a promising approach for risk stratification and potential treatment strategies for CKD patients.
A group of articles highlights the factors threatening job satisfaction and high-quality care delivery among nephrology specialists. Experts propose measures to improve professional lives, including fellowship training reform, practice transformation, and creating a stronger community of nephrologists.
A study found that undocumented immigrants with emergency-only dialysis were more likely to die after three and five years, as well as spend more days in the hospital. The study highlights the need for states to consider the human and economic toll of providing access to less-than-standard dialysis for these patients.
A new therapeutic paradox targets thrombo-vascular complications in kidney disease by boosting a regulatory protein called STUB1, which interacts with tissue factor to trigger clotting. This approach may offer an alternative to standard heparin treatment while maintaining a balance between pro-clotting and anticoagulant factors.
A recent study published in PLOS Medicine reveals that HIV patients are at a higher risk of both chronic kidney disease and cardiovascular disease. The research found that nearly 11% of patients experienced both conditions within one year of each other.
Research highlights the need for better nutritional management in chronic kidney disease, where high protein diets may have deleterious impacts on kidney health. A low protein, low salt diet may slow progression and help patients defer dialysis initiation.
A study of 3725 participants with chronic kidney disease found that depressive symptoms were associated with a higher risk of early death in white individuals, but not in black individuals. Treatment of depressive symptoms may help lower this risk.