University of Tokyo researchers have developed a trans-omics approach that maps the interactions between molecules inside cells in response to insulin. This comprehensive understanding may lead to better therapies for type 2 diabetes by identifying potential drug targets and optimizing insulin regimens.
Researchers discovered that GTPases like EF-Tu can exist in a mixture of structures, rather than being fixed as 'on' or 'off'. This flexibility may help develop targeted drugs for bacterial infections and cancer treatment.
A Stanford University study found that lack of transparency in US home buyout programs leads to lower participation rates and perpetuates social inequality. The research suggests increasing clarity on decision criteria, community involvement, and emphasis on equitable relocation can improve the program's effectiveness.
Fifty ERC grant holders have been awarded Proof of Concept Grants to explore the commercial potential of their frontier research results. The grants aim to transform top science into practical innovations that can benefit society.
Researchers from Singapore University of Technology and Design have resolved a major mystery in 2D material Schottky diodes by employing a rigorous theoretical analysis. A new theory describes different variants under a unifying framework, laying down a foundation to unite prior contrasting models.
In a mouse model, researchers found that dysfunctional regulatory T-lymphocytes contribute to sustained inflammation and cardiac enlargement. Removing these cells restored normal function and reversed disease progression. This therapeutic approach suggests a new target for treating human heart failure.
A team of researchers from Clemson University and two other institutions is working to understand the genetics and structural mechanics behind stalk lodging in corn and sorghum. The study aims to break down complex traits into smaller, intermediate characteristics that can be easily grasped at both genetic and structural levels.
New York University has received nearly $66 million in funding from the National Institutes of Health to investigate how environmental factors impact children's health. The ECHO initiative will explore how early life exposures affect brain development, obesity risk, and overall well-being.
Coronary angiography is essential for detecting acutely occluded epicardial coronary arteries in resuscitated individuals with out-of-hospital cardiac arrest. Numerous cohort studies have shown an association between survival and early coronary angiography and/or percutaneous coronary intervention.
A new study from Duke University reveals racial wealth inequality is a key contributor to urban unrest. The racial wealth gap has worsened over the past 50 years, with black and Latino households holding significantly less wealth than white households.
Researchers discovered a link between BSEP inhibition and FXR activation, explaining the weak concordance between BSEP inhibition potency and cholestatic DILI incidence. The C-DILI assay has been shown to have high in vitro-in vivo correlation among compounds known to have a risk of DILI.
New research found that for every one-degree-Celsius increase in temperature, mountaintop species shift upslope by 100 metres, resulting in shrinking inhabited areas and dramatic population declines. This supports predictions of extinctions among top species due to global warming.
A study found that brain teaser questions give interviewers power and speak to their dark personality traits, such as narcissism and sadistic tendencies. Participants who support the use of these questions were less socially competent and relied heavily on intuition in the hiring process.
Researchers identified BAP1-regulated target genes and mechanisms linking ferroptosis to tumor suppression in various cancers. Treatment with ROS inducer resulted in increased ferroptosis-related cell death in BAP1 cancer cells, suggesting a potential new area of therapy research.
Researchers developed a predictive model to identify the most beneficial 3D distortions for controlling edge localized modes (ELMs) in tokamaks. The KSTAR facility validated these predictions with remarkable accuracy, paving the way for ITER's successful operation.
Scientists at Kyoto University have discovered a protein, AIP1, that plays a crucial role in regulating cell arrangement during wing development in fruitflies. The study reveals how cells sense and respond to tissue tension, which is essential for shaping tissues like wings.
A new study from St. Michael's Hospital examines health-care interventions to support patients seeking work and identifies key features of successful interventions. These include multidisciplinary teams, packages of services, one-on-one tailored services, comprehensive views of social needs, and communication with employers.
The project, called Playing & Learning Across a Year (PLAY), will create a digital library of videos of mothers going about their daily activities with their children. Researchers will gather video data from over 900 infants and their mothers, which will be transcribed, annotated, and uploaded to an open-source video library.
A novel nano material with electrical and magnetic properties has been synthesized by researchers at DTU Chemistry. The material, Chromium-Chloride-Pyrazine, is an organic/inorganic hybrid with promising prospects for quantum computing, superconductors, catalysts, batteries, fuel cells, and electronics.
Researchers analyzed climate change's effects on marine aquaculture production, finding it's already impacting producers today and will worsen unless proactive measures are taken. The study highlights the need for countries to prepare for climate change and develop adaptive measures to ensure sustainable seafood production worldwide.
A randomized clinical trial found that a Tai Ji Qan balance training program was more effective than other exercise programs in reducing falls among older adults at high risk. The study included 670 participants and lasted six months, with results suggesting improved fall prevention through the specific focus on balance training.
A new antimalarial drug called DM1157 is being tested in a Phase 1 clinical trial for its safety and efficacy. The trial aims to enroll up to 104 healthy volunteers and assess the drug's impact on the human body.
Hurricane Helene has strengthened and become highly organized, with maximum sustained winds reaching 105 mph. It is forecast to become a major hurricane by tonight and then undergo steady weakening by late Tuesday.
The automatic tool improves both inter-operator and intra-operator reliability, with a peak force sharper than the sliding hammer. Both tools have high learnability, but the automatic tool is 75% more efficient.
A team of researchers from the Moscow Institute of Physics and Technology has developed a model for predicting hand movement trajectories based on electrocorticogram data. This technology could enable exoskeletons that allow patients with impaired mobility to regain movement.
Hurricane Olivia is expected to affect Hawaii with strong winds and heavy rainfall, according to NASA. The Central Pacific Hurricane Center has issued Tropical Storm Warnings for Maui County and a Tropical Storm Watch for Oahu.
A team of scientists from Newcastle University has discovered three new species of snailfish in the Atacama Trench, a record-breaking 8000-metre-deep location. The fish, which are part of the Liparidae family, are highly adapted to living in extreme pressure and cold conditions.
A review paper published in the Journal of the American College of Cardiology found that high levels of optimism can lead to a reduced risk of heart disease. Optimistic patients were more likely to engage in healthy behaviors such as regular physical activity, healthy eating and not smoking.
The Global Leadership Initiative on Malnutrition has published a consensus report outlining five criteria for malnutrition diagnosis. The criteria include phenotypic and etiologic measures to assess malnutrition in adults. A two-step approach is recommended for diagnosis, involving screening and assessment.
Bilingual individuals exhibit unique brain activity when switching between languages, with increased cognitive control activity during disengagement. In contrast, engaging in a new language comes relatively cost-free from a neurobiological standpoint, suggesting that the burden of language-switching lies in disengagement.
A recent pilot study reveals that e-cigarette users are exposed to hazardous aldehydes like formaldehyde, which can cause cancer. The study found that concentrations of these chemicals increased tenfold after vaping sessions, suggesting a significant amount remains in the lungs.
A recent study published in the British Journal of General Practice found that prescribing antibiotics to children with cough does not significantly reduce the risk of hospitalization. However, a strategy of delayed antibiotic prescribing may help reduce unnecessary return visits to the GP.
Researchers found that mental imagery techniques can effectively regulate pain perception independently of the opioid system. The study used heat pain and visual cues to manipulate participants' expectations, showing that mental imagery is an opioid-independent approach to pain management.
A commentary suggests using smart technology and artificial intelligence to improve the detection of sepsis in children in Canada. The authors propose automating data combinations of sepsis symptoms and other relevant information to create more accurate and low-cost trigger tools.
A large Taiwanese study found that patients with sepsis are at increased risk of cardiovascular events, including stroke and heart attack, within the first 4 weeks after hospital discharge. Younger patients with sepsis aged 20 to 45 years were particularly at higher risk.
Researchers have developed a method to separate infected and uninfected cells, revealing how Zika virus manipulates the human immune system by suppressing gene production in macrophage cells. This approach provides a more accurate account of Zika's effect on macrophages and shows that the virus uses two methods to stop their function.
Researchers at the University of Edinburgh discovered that tiny vibrations can be used to heat small amounts of liquid, potentially improving systems that prevent ice build-up on aeroplanes and wind turbines. The findings could also lead to more efficient drying of clothes in appliances.
Researchers have demonstrated graphene's ability to convert electronic signals at gigahertz frequencies into signals at several times higher frequencies, paving the way for ultrafast graphene-based nanoelectronics. The breakthrough achieved using a novel terahertz radiation source enables efficient frequency multiplication in graphene.
Researchers discovered that highly robust regulatory proteins can acquire binding to new promoters in response to mutations, challenging the long-held assumption that robustness and evolvability are mutually exclusive. This finding has significant implications for understanding gene regulation and evolution.
Researchers found that people generally rate themselves more positively than others, but struggle to accurately estimate how much others like them. This 'liking gap' can hinder the formation of new relationships and has significant implications for personal and professional lives.
Researchers used a computer model to study the effect of increased cholesterol on a specific ion channel involved in regulating potassium levels in the heart. They found that increasing cholesterol levels made interactions with the channel more numerous, overwhelming it and interfering with its ability to open and close normally.
Researchers developed a new method for detecting hazardous nitrogen-containing substances using nuclear magnetic resonance (NMR) relaxometry. The technique analyzes 14N NMR relaxation signals to identify explosives and toxic substances, offering improved efficiency and accuracy compared to traditional methods.
Researchers have developed a new approach to conserving tree species, focusing on increasing genetic diversity and efficiency in protection. The method can be tailored for successful conservation of any species, including custom-tailored seed collection protocols.
A new study published in JAMA Internal Medicine found that one in four older adults prescribed benzodiazepines continue to use them long-term. The research highlights the need for better education and critical thinking among healthcare providers to reduce the risk of long-term use, particularly among low-income older adults.
A study published by the American Psychological Association suggests that focusing on feelings instead of logic in decision-making leads to increased attitude certainty and stronger advocacy for chosen options. This approach can also change behavior, as seen in experiments where participants who made intuitive decisions shared their ch...
Two DNA testing programs in Spain and UK successfully matched patient tumor profiles with targeted therapies, enabling new opportunities for personalized medicine. The programs use whole genome sequencing to identify specific genetic features of tumors and match them with early clinical trials.
A widely used drug has been identified as a contributor to skin cancer development, with researchers calling for enhanced sun protection advice. The study, published in Nature Communications, found a strong association between azathioprine use and a specific mutational signature in cutaneous squamous cell carcinoma.
A high-throughput screening study has identified six potent small-molecule inhibitors of α-synuclein aggregation, which could potentially halt Parkinson's disease development. The compounds target the monomeric state of αSN and share a common core structure.
The new California Climate Tracker tool provides more than 120 years of historical climate data, allowing users to analyze trends and patterns in temperature and precipitation. The updated version incorporates a user-friendly web interface, improved accuracy using PRISM data, and access to archived maps and data dating back to 1895.
Hurricane Florence's maximum sustained winds have increased to near 115 mph, making it a category 3 hurricane. Satellite data reveal powerful thunderstorms with cloud tops as cold as minus 63 degrees Fahrenheit, capable of generating heavy rainfall.
A new AI-powered workflow enables scientists to systematically and sustainably evaluate large amounts of high-resolution deep-sea images. The workflow, developed by GEOMAR researchers, uses machine learning algorithms to automatically detect features such as manganese nodules in the seafloor.
A new framework combines three existing methods to find large DNA mutations in cancer cells, providing a comprehensive view of the genome. The approach may help researchers understand how cancers begin and identify potential treatment targets.
Researchers at EMBL have developed an interactive map of proteins involved in human cell division, allowing users to track protein dynamics and identify critical vulnerabilities. The tool has the potential to advance our understanding of cellular processes and disease mechanisms.
Researchers found that nearly 9% of people who died by suicide in 18 states between 2003 and 2014 had chronic pain documented in their incident records. Chronic pain was associated with risk factors for suicide, but previous studies primarily examined nonfatal suicidal behaviors.
Researchers found that medical cannabis provides immediate symptom relief across various health conditions, including chronic pain and insomnia. Patients reported an average symptom reduction of nearly 4 points on a 1-10 scale following cannabis consumption.
A recent study by Alfred Wegener Institute researchers found that the loss of Arctic permafrost through coastal erosion led to significant increases in carbon dioxide concentrations in the atmosphere during the last glacial period. This phenomenon is now being studied to understand its potential impact on future climate warming.
A new study finds that rice farms emit 45 times more nitrous oxide than continuously flooded farms, which also predominantly emit methane. The authors call for scientists to map flooding regimes and measure emissions, as well as optimize water use to reduce climate impacts.
Researchers reconstruct relative sea level record from Mallorca island using phreatic overgrowths on speleothems, finding stability instead of fluctuations. This accurate record provides insight into future sea level rise due to global warming and challenges current estimates.
Two lunar transits were observed by NASA's Solar Dynamics Observatory in September 2018, with the first lasting one hour and obscuring 92% of the Sun. The second transit was shorter, lasting 49 minutes and showing a distinct view of the Moon's surface due to the lack of atmospheric distortion.
Researchers at Northwestern University developed a simple blood test called TimeSignature that can identify the body's precise internal time clock. The test measures gene expression markers and can be taken any time of day, allowing for more accurate diagnosis and treatment of diseases such as heart disease, diabetes, and Alzheimer's.
Researchers surveyed 1400 Kenyans affected by drought, finding that those who relocated are more likely to experience violence. However, migrants themselves do not express increased support for violence, suggesting a complex relationship between migration and conflict.
The authors explore clopidogrel's use in stable ischemic heart disease, acute coronary syndrome, stroke, and peripheral vascular disease. They evaluate the data behind its use in patients on oral anticoagulation, aiming to better understand its role in cardiovascular disease.
The Francis Crick Institute will run a new accelerator programme called KQ Labs to support data-driven biomedical start-ups, providing £40,000 each to ten companies to validate their proposals. The programme is part of a growing ecosystem around King's Cross, Euston and Bloomsbury.
A subpopulation of PD-1-expressing NK cells within tumors responds to checkpoint blockade, activating anti-cancer effects. These cells contribute significantly to the efficacy of checkpoint-targeting immunotherapies, suggesting new strategies for improving treatment outcomes.
Researchers found that papaverine reduces tumor oxygen consumption and hypoxia in mouse models, making tumors more sensitive to radiation. This suggests repurposing papaverine to enhance radiation therapy effectiveness.
Research finds cardiorespiratory fitness, high-intensity physical activity and low sedentary time all lower type 2 diabetes risk. The study, published in Diabetologia, suggests that a combination of these traits may be more beneficial than individual components.
Kessler Foundation will analyze the impact of its spatial neglect assessment and treatment protocols on stroke survivor recovery and independence. The two-year grant aims to confirm functional benefits and improve clinical benchmarks for stroke rehabilitation.
Pharmaceutical companies are adopting improved safety screening strategies to enhance the drug discovery process, including integrated screening paradigms and computational methods. These approaches aim to identify higher-quality drug candidates and mitigate off-target toxicity.
A recent study published in Biotropica investigates collaboration among scientists in tropical ecology, revealing an increase in international collaboration and representation of tropically-based scientists. The study analyzed years' worth of articles to look for changes in author affiliations and found that more scientists from tropic...
Researchers analyzed Twitter conversations around OpenAPS, a DIY system combining off-the-shelf CGMs and insulin pumps, to understand its benefits and limitations. The study found that OpenAPS improved self-reported A1C and glucose variability while reducing daily distress and burden, but also raised concerns about safety and regulation.
Studies have found that roadside dust contains traffic-related abrasion particles, including tire wear and brake pad debris, which can pose health risks to humans and wildlife. Researchers are warning that climate change may exacerbate this problem, leading to increased pollution and potential harm to ecosystems.
Researchers develop 3-D tissue culture models to study host-microbe interactions and combat infectious diseases. The models mimic native tissues and offer valuable insights into mechanisms of infection, aiding in the design of effective vaccines and therapeutic agents.
A new study identifies missed opportunities for catching depression in non-White and medically ill patients, as well as men, who are less likely to be screened. The research suggests that combining hazardous alcohol use screening with a simple questionnaire could improve treatment outcomes for these at-risk populations.
A randomized controlled trial shows that a behavioral treatment, Behavioral Activation, can reduce the risk of future memory loss by increasing social, cognitive, and/or physical activity. The study found an 88% reduction in cognitive decline compared to the control group.
Transradial access has emerged as a preferred option for patients presenting with acute coronary syndromes, offering lower vascular and bleeding complications and reduced mortality rates. The study reviews the current evidence supporting transradial access across various patient populations.
Peatlands, which store up to 530 billion tons of global carbon, are vulnerable to climate change due to changing temperature and precipitation patterns. The study found that temperate regions in warmer periods can accumulate more carbon than tropical regions, but ultimately release it as warming intensifies.
Archaeologists have discovered the oldest known abstract drawing made with a piece of ocher used as a pencil, dated to 73,000 years ago. The drawing, found on a silcrete fragment in Blombos Cave in South Africa, confirms that early humans intentionally created and used symbols.
Researchers used laboratory economic games to demonstrate that societal stereotypes about group warmth and competence can predict treatment disparities. The study found patterns of disparity similar to those documented in educational and labor markets.
Researchers found that geographically isolated populations of parasitic blister beetles use distinct adaptations to target different host bee species. The larvae emit chemical cues tailored to the pheromones of local hosts, attracting male bees and exploiting their nests.
Researchers developed a new predictive model for multilateral war, finding that without a dominant player, the likely outcome is mutual annihilation. The Lanchester multiduel model considers three or more players and their objective to maximize surviving numbers.
Researchers discuss bivalirudin's role in reducing bleeding complications and its potential for increased acute stent thrombosis risk. The study aims to clarify the optimal anticoagulation strategy for interventional cardiovascular procedures.
A two-year study in Vancouver and Toronto reveals large trucks are the greatest contributors to black carbon emissions close to major roadways. The study suggests retrofitting older diesel trucks with better emission treatment systems can improve air quality in cities.
Researchers found that nucleosomes inhibit Cas9 binding and target DNA cleavage in yeast cells, but not zinc finger nucleases. Nucleosome position maps may improve genome-editing efficiency for certain applications.
Research found that the intensity of shame people feel when imagining various actions accurately predicts the degree to which those actions would lead others to devalue them. This universal human quality helps individuals balance personal costs and benefits with social costs and benefits.
A Swiss research team has identified a factor influencing immune response in HIV-1 infected individuals: the virus genome. Broadly neutralizing antibodies were found to target envelope proteins with varying levels of efficiency.
Research reveals obesity activates microglia, consuming healthy synapses and leading to dendritic spine loss. Microglial activity is causally linked to obesity-induced cognitive decline, suggesting a potential therapeutic target for this condition.
Repeated binge drinking alters gene expression in the brain, affecting hormone signaling and immune function in females, while nerve signaling is impacted in males. This study highlights the importance of tailoring treatments for male and female patients with alcohol use disorder.
Tropical Storm 27W is forecast to intensify over the next three days before making landfall on Sept. 13 over China's Luichow Peninsula. The storm will then emerge into the Gulf of Tonkin, making a final landfall north of Hanoi, Vietnam.
Researchers created a system with just seven photons and found that phase transitions occur in these small systems, allowing for the study of quantum properties. This discovery has potential applications in measurement or sensing, as well as exploring properties at the smallest scale when phase transitions occur.
The University of Oklahoma team has received a National Science Foundation Major Research Instrumentation grant to develop the OU and Regional Research Store, a massive tape archive serving as a national model. The project will provide affordable storage for over 85 research teams across 27 institutions in 17 states.
Researchers at Southwest Research Institute studied the Patroclus-Menoetius binary asteroid pair and found that its existence indicates an earlier dynamical instability. This instability pushed Uranus and Neptune outwards, scattering small bodies into the Kuiper Belt, where they formed the Trojan asteroids.
A study published in Canadian Medical Association Journal found that patients with acute critical illness without pre-existing kidney disease are at increased risk of developing chronic kidney disease and end-stage renal disease. The study also shows that these patients have a higher risk of death.
A new study published in CANCER journal reveals that social support is the most decisive factor associated with life satisfaction among young patients with cancer. The research found that young adults with cancer who have strong social connections experience higher life satisfaction, regardless of other factors.
The Ben and Catherine Ivy Foundation has partnered with Barrow Neurological Institute to fund a $50 million effort to accelerate drug discovery and clinical testing for glioblastoma. The new Ivy Brain Tumor Center aims to provide individualized experimental therapies to malignant brain tumor patients worldwide.
Biologists have discovered that amphipods carry pteropods piggyback to avoid predators, but these pteropods starve due to limited access to food. The association may provide protection for both animals, but its benefits are still unclear.
NASA's Aqua satellite detected a thick ring of powerful storms around Hurricane Isaac's central dense overcast, with coldest cloud tops reaching minus 70 degrees Fahrenheit. The storm is expected to strengthen over the next day or two before weakening by the middle of the week.
New research suggests global warming will cause peatlands to absorb more carbon initially, but the effect will weaken as warming increases. The study highlights the importance of protecting intact peatlands and restoring drained peatlands to prevent rapid rates of peat decomposition.
In a study led by the Max Planck Institute for Evolutionary Anthropology, researchers found that active participation in group-hunts increased successful hunts and encouraged sharing of meat among chimpanzees. Oxytocin activation during hunting behavior also supported cooperative interactions.
Mice deficient in tPA exhibited greater white matter damage and cognitive function loss after TBI, while tPA treatment improved neurological function. The study suggests a potential therapeutic target for recovering from TBI.
New research reveals that low-severity burns weaken soil structure, increasing risk of erosion, while also releasing organic carbon into the atmosphere, contributing to climate change. Soils in burned areas show deteriorating physical properties over weeks and months.
A team of engineers and physicians at USC and UC San Francisco developed a novel decoding technology that can predict mood variations from neural signals in the human brain. The study may lead to new closed-loop, tailored therapies for depression and anxiety disorders.
Scientists at the University of Cambridge have developed a new technique to determine the structure and interactions of the Zika virus genome inside human cells. This technique, called COMRADES, can screen for host-virus RNA base-pairing and reveal interacting sequences, offering potential targets for anti-viral therapies.
Research by UPNA finds that muscle strength training can reverse age-related muscle loss and improve cardiovascular health. The study emphasizes the importance of considering physical exercise as a treatment for cardiovascular diseases.
UTSA researchers have developed numerical models to replicate toxic gas dispersal, allowing for accurate projections of deadly gas trajectory. The tools can help direct evacuations in as little as 10 minutes.
A new study by the JRC found that adopting a healthy diet could reduce the water footprint by 11-35% for meat-based diets, 33-55% for pescetarian diets, and 35-55% for vegetarian diets. This shift towards a more resource-efficient vegetable-rich diet is crucial due to the high water footprint of animal products.
Researchers at McMaster University have identified a previously unknown cell population that triggers the return of acute myeloid leukemia after remission. This discovery provides a potential new target for therapies and offers hope for improving treatment outcomes for patients with leukemia.
The RAND Opioid Policy Tools and Information Center (OPTIC) will analyze policies aimed at curbing the nation's opioid epidemic, developing more powerful tools for tackling the crisis. Researchers will create a simulation tool to inform methods for identifying effective policies in specific communities.
Researchers analyzed precipitation and temperature records with NDVI data from 1982-2011 to find a shift in the climate factors controlling vegetation dynamics on the central and southeastern Tibetan Plateau. The study suggests that global warming may be contributing to this change, potentially impacting regional ecosystems.
A new Clemson University program, THINKER, aims to close the skills gap in advanced manufacturing by matching graduate students with technical college students. The program will equip students with both technical and soft skills, including communication and collaboration.
Two research letters examine the impact of Medicaid work requirements on recipients, estimating the number at risk of losing coverage and calculating associated spending. State-level estimates also provide insight into those meeting proposed work requirements.
A recent Arizona State University study reveals that intergranular stress-corrosion cracking can occur independently of simultaneous stress and corrosion, highlighting the need for new corrosion-resistant alloys.
A recent study by Boston Medical Center found that only 24% of youths receive FDA-approved medications for opioid use disorder within three months of diagnosis. Patients who receive medication are more likely to remain in treatment compared to those who only receive behavioral health services.
UCLA engineers have developed a new computational tool that accurately models how magnetic materials interact with incoming radio signals at the nanoscale. This allows for the design of next-generation communications devices with improved data transport capabilities and reduced noise interference.
Tropical Storm Paul is experiencing wind shear, displacing its strongest storms from the center. This displacement has led to a lack of well-organized convection and minimal banding features, according to the National Hurricane Center. As a result, weakening is forecast, and Paul is expected to become a remnant low in a few days.
A new study simulates the effects of wildfire smoke on human health, predicting that deaths from chronic inhalation of wildfire smoke could increase to over 40,000 per year by the end of the 21st century. The number of fire-related particulate matter deaths is expected to more than double in the worst-case-scenario prediction model.
A study reveals that intermittent flooding in rice cultivation leads to higher nitrous oxide emissions, potentially up to 30-45 times higher than continuous flooding. Co-management of water, nitrogen, and carbon can reduce climate impacts by 10-90%.
The use of intravascular ultrasound guidance during percutaneous coronary intervention has been shown to improve clinical outcomes, particularly in reducing ischemia-driven target lesion revascularization. IVUS guidance has also been associated with a decrease in intraobserver variability in angiographic borderline lesions.
Researchers at Cincinnati Children's Hospital Medical Center genetically deleted Ago2 from the livers of mice, stabilizing energy metabolism and preventing obesity and diabetes. The study provides a solid basis for further research into novel therapeutic approaches to treat chronic metabolic disorders.
Researchers create device that reduces energy needed for magnetic field detectors, enabling applications in navigation, medical imaging, and natural resource exploration. The technology uses nitrogen-infused diamonds to detect magnetic fields with lower power consumption.
Researchers at MIT CSAIL have developed a robot system that can inspect and understand objects, allowing it to perform specific tasks such as picking up objects from a cluttered space. The system, called Dense Object Nets, uses a self-supervised approach and doesn't require human annotations.
Researchers identify β-Hydroxybutyrate as a molecule with anti-aging effects on the vascular system. The compound can delay cellular aging and promote cell division, potentially reducing the incidence and severity of human diseases such as cardiovascular disease and Alzheimer's disease.
A team of researchers from the University of Minnesota and University of Massachusetts Amherst has developed a method to predict molecular motion with high accuracy when confining molecules in small nanocages. This breakthrough discovery could improve the production of fuels and chemicals, as well as capture CO2 from the air.
A study at UCSF discovered how a mutation in the TERT promoter gene confers immortality on tumor cells, enabling their aggressive growth. Eliminating a specific protein subunit using CRISPR-based gene editing slowed cancer cell growth.
Typhoon Mangkhut brought damaging winds to Guam and the Northern Marianas Islands, with sustained winds reaching up to 115mph. The storm is expected to intensify through Wednesday, September 12, before moving away from the region.
A study found that chronic stress alters blood flow regulation in specific brain regions, including the temporal and prefrontal cortex. The researchers suggest understanding these changes may aid in assessing individuals' risk for stress-related illnesses.
A national analysis of physician visit records found that nearly 30 percent of outpatient opioid prescriptions lack clear documentation of the reason for use. This raises concerns about inappropriate prescribing and lax documentation practices. The study highlights the need for stricter requirements on documenting the need for opioids.
Researchers found gene cassettes transfer across generations in strawberry plants, leading to sex chromosome changes and homomorphic female heterogametic inheritance. The discovery sheds light on the mechanisms behind sex chromosome evolution and has implications for creating new crop varieties.
PolyU has received a generous HK$100 million donation from Ir Dr Otto Poon for strategic research in smart city, smart mobility, and sustainable energy. The fund will support the establishment of two research institutes and two endowed professorships.
Natural Killer cells have been found to play a key role in responding to checkpoint inhibitors, which are transforming the treatment of cancer. Researchers discovered that these cells can produce the same checkpoint receptor molecules as T cells, enabling them to respond directly to the therapy.
A microfluidic device created by Cornell University scientists can corral viable sperm in minutes, improving IVF chances. The device uses rheotaxis to separate highly motile sperm from weaker ones, reducing the time-consuming and tedious process of conventional methods.
Human clinical trials for DesignMedix and Portland State's anti-malarial drug DM1157 have begun, assessing the drug's safety and absorption in healthy volunteers. The Phase I study aims to overcome growing resistance among malaria medicines, with potential approval for treatment of millions.