A multicenter study found that IVUS guidance over angiography guidance during DES implantation reduces target vessel failure by lowering the rate of TVF at one year. The ULTIMATE trial showed improved clinical outcomes, particularly for patients who had an IVUS-defined optimal procedure.
A study published in PNAS reveals that an ancient retrovirus, HK2, is more frequently found in drug addicts and associated with addiction. The virus integrates near a gene involved in dopaminergic activity, manipulating nearby genes and predisposing individuals to addictive behavior.
A large-scale international study published in PLOS Medicine found that a new medication called Nilvadipine showed promise in slowing the progression of mild and moderate Alzheimer's disease. However, the overall group of patients did not benefit from the treatment. Further research is needed to explore its potential.
Researchers in Brazil develop an effective method to minimize lost coffee berries during mechanical harvesting, reducing soil compaction and improving profit margins. The study suggests using a subsoiler followed by a crusher as the most cost-effective solution.
A collection of JAMA articles explores the intersection of race, ancestry, and medical research, highlighting historical context and current challenges. The studies reveal the importance of accurately representing diverse populations in medical journals.
Researchers discover Jinguofortis perplexus, a Pygostylia species with both bird-like and dinosaur-like features, providing insight into the evolution of modern birds. The study highlights the role of developmental plasticity in shaping the avian shoulder girdle.
The Gemini Observatory will receive a $4 million NSF award to enhance its capabilities in multi-messenger astronomy, including the development of an advanced multi-conjugate adaptive optics system. This will enable the detection of transient phenomena and improve our understanding of the universe.
Researchers discover cancer cells hide a key gene marker from immune system, allowing tumors to recur. By reactivating this marker, the team hopes to develop more effective immunotherapies to combat relapse.
A new study from Harvard T.H. Chan School of Public Health found that children whose mothers use marijuana are more likely to start using the drug themselves an average of two years earlier. This can lead to negative consequences such as impairments in concentration and decision-making, increased impulsivity, and reductions in IQ.
Current guidelines on anticoagulation therapy for atrial fibrillation may be insufficient due to varying stroke rates among studies, suggesting a need for individualized risk assessments. A case report also highlights the successful treatment of multiple cancers with pembrolizumab in a patient with Lynch syndrome
Researchers developed a method to estimate seismic risk by modeling various earthquake scenarios and identifying common impacts. The study suggests that most scenarios produce lower impacts than the worst-case scenario, with urban areas posing less risk than rural western Nepal.
A new study published in The Gerontologist found that older adults with a 'fall plan of care' are less likely to suffer fall-related hospitalizations. This initiative, which includes screening for fall risk, assessing modifiable risk factors, and prescribing evidence-based interventions, was shown to reduce hospitalizations by 0.6 times.
A new study from the Monell Chemical Senses Center reveals that healthy animals' bodily odors change when they are near sick animals, potentially impacting social contacts and disease spread. The findings suggest that exposure to sickness-related odors can trigger protective responses in others.
A new study finds that DNA islands can be engineered to disable Staphylococcus aureus bacteria, which are often resistant to antibiotics. The 'drone-like' vehicles deliver genetic payloads to bacterial populations, killing the bacteria and rescuing treated animals.
A newly discovered extinct bird species, Jinguofortis perplexus, sheds light on early flight development and evolutionary variation. The fossil's unique traits, including a fused shoulder girdle, suggest different flying styles during the Cretaceous period.
Researchers developed a genome editing tool to target and eliminate damaged mitochondrial DNA, resulting in improved mitochondrial function in mice. The treatment, known as mtZFN, could provide a practical route to treating patients with mitochondrial diseases.
Researchers used machine learning to detect small DNA changes in single brain cells, revealing thousands of previously unknown variations. The study found that these changes peaked during a key stage of brain development, implying a regulated process.
Researchers analyzed silicon and oxygen isotopes in zircon crystals to infer the presence of sedimentary rocks, such as cherts or banded iron formations, on early Earth. The findings suggest that these rocks may have existed over 4 billion years ago, providing a window into the planet's primordial chemistry.
A study of teenage twins reveals that both genetic and environmental factors shape brain activity during sleep. The findings suggest that frontal regions are under stronger environmental control, while regions towards the back of the brain are more influenced by genetics.
Researchers found a correlation between neurobehavioral symptoms and unemployment among individuals with moderate-to-severe TBI. Frontal system neurobehavioral syndromes can predict employment outcomes, highlighting the need for rehabilitative strategies to address these behaviors.
A research team led by University of Nevada, Reno is investigating how changes in mountain snowpack affect available water and agricultural production in the arid West. The project aims to improve decision-making for water allocation and understand its impact on the economic well-being of various groups.
A project at St. Pölten University of Applied Sciences combines traditional woodworking techniques with innovative cinematic forms of communication to create documentary-style tutorials. The project, funded by the Federal Ministry of Education, Science and Research, aims to preserve traditional crafts for future generations.
Research led by the University of Bristol found that children aged 11-19 can effectively use collective intelligence to make group decisions, revealing a geometric mean rule-of-thumb approach. The study revealed that pupils used their original guesses to come to a final consensus, even in cases of disagreement.
A research team led by the University of Nevada, Reno will investigate how changes in mountain snowpack affect available water and agricultural production in the West. The project aims to inform decision-makers on adapting to long-term changes in runoff timing and develop more effective water management practices.
A new study found that a high-carbohydrate diet led to significant weight loss and improvements in insulin function in overweight individuals. The plant-based diet group consumed whole, complex carbohydrates from fruits, vegetables, and legumes, leading to reduced body mass index, body weight, and fat mass.
Scientists at the Medical University of South Carolina discovered that over-expression of VRK1 actually slows down cancer cell migration and invasion, but enables cells to form colonies under 3D conditions. High levels of VRK1 are associated with aggressive breast cancers and poor prognoses in patients with metastatic breast cancer.
New studies from UC Davis Health reveal that fractures lead to bone density losses throughout the body, particularly around the time of fracture and in bones far from the site of injury. The research also identifies age-related recovery differences, with younger mice regaining pre-fracture bone mineral density levels.
UCSB researchers propose a new method for estimating the number of people in a room based on WiFi signal strength measurements. The technique, which uses received signal power to estimate occupant numbers, has shown high accuracy in experiments with up to 20 people and various wall properties.
A survey of over 2,500 respondents found low awareness of urological conditions, particularly among men. Men are less knowledgeable about urological symptoms than women, and many do not take early signs seriously, leading to delayed diagnosis and potentially life-threatening consequences.
Researchers identified SynuClean-D as a potential therapeutic for neurodegeneration, which disrupts amyloid fibrils and inhibits alpha-synuclein aggregation. The compound reversed degeneration of dopaminergic neurons in animal models, offering hope for halting Parkinson's disease-related neurodegeneration.
Scientists discovered that a North Korean nuclear bomb test in 2017 set off aftershocks over eight months, providing insight into the physics of nuclear explosions and how natural earthquakes can be triggered. The analysis used new methods to pinpoint the locations of the quakes with greater precision, revealing a hidden fracture.
The study evaluated [18F]SRF101, a PET radiotracer for astrocytosis detection. The results showed no systemic signs of toxicity in mice and estimated the human radiation dosimetry to be comparable to other 18F radiopharmaceuticals.
Researchers at Brookhaven National Laboratory identified a key molecular signal that helps plant cells decide when to produce oil. The study found that trehalose 6-phosphate interacts with the sugar-sensing complex, inhibiting the shutdown of oil production and leading to increased oil synthesis.
A team from Imperial College London used gene drive to completely block the reproductive capacity of malaria-carrying mosquitoes, Anopheles gambiae. The technology successfully transmitted genetic modifications that caused female infertility and population collapse.
A team of researchers discovered that flowering plants exhibit a morning peak of gene activity, contrary to the previously established evening peak theory. The study, conducted in natural environments, suggests that artificial growing conditions used in labs may have influenced earlier findings.
Researchers found that desert ants can learn multiple food odors in a short time and retain them throughout their lives. In contrast, they require repeated exposure to learn a single nest odor and may forget it quickly after removal from the nest. These findings suggest different memory processes for food and nest-related cues.
A systematic review of 25 studies found physical activity significantly reduces heart disease risk by 40%, with moderate-intensity exercise lowering systolic blood pressure by up to 15mmHg. Replacing sedentary behaviors with daily activities can also lower all-cause mortality.
Researchers developed a new seismic risk modeling approach to assess earthquake impacts and identify common hazards across multiple scenarios. The 'ensemble modeling' method provides critical information on likelihood and probable scale of future earthquakes' impacts, enabling targeted disaster mitigation resources distribution.
The COAPT trial found that the MitraClip device significantly reduced hospitalization rates and mortality, while improving quality-of-life measures and functional capacity in heart failure patients with secondary mitral regurgitation. The study also showed a substantial reduction in the need for heart transplants or left ventricular as...
A multicenter clinical trial found that the transcatheter mitral valve repair significantly reduced hospitalizations and mortality for heart failure patients with moderate-to-severe or severe functional mitral regurgitation. The procedure improved symptoms, quality of life, and survival rates.
Playing golf regularly is associated with increased longevity and reduced risk of heart disease, as well as improved mental health for those with disabilities. To maximize these benefits, golfers should aim to play for 150 minutes a week and prioritize sun protection and injury prevention.
A recent study evaluated the effects of combined individual- and community-level interventions to reduce underage drinking by American Indian/Alaska Native youths. Reports of drinking frequency declined among students in the intervention group relative to comparison groups, with significant reductions in heavy drinking frequency.
The SOLVE-TAVI trial found that local anesthesia is both safe and effective for patients undergoing transcatheter aortic valve replacement (TAVR), especially those with intermediate to high surgical risk. The study also showed similar outcomes between current-generation balloon-expandable and self-expanding valves.
The SCAI-WIN program aims to increase female participation in interventional cardiology. Megha Prasad has been selected for a $100,000 fellowship to develop complex and high-risk intervention skills.
A large study found that severe cases of prosthesis-patient mismatch after transcatheter aortic valve replacement increase the risk of death and heart failure readmissions by 19% and 12%, respectively. The study identified predictors of PPM, including smaller valve prostheses, larger body surface areas, and female or younger patients.
Researchers at the University of Surrey have successfully identified biomarkers in blood that can detect sleep deprivation. A machine learning algorithm detected changes in gene expression levels with 92% accuracy, paving the way for a future test to assess driver fitness.
Scientists at Tokyo Metropolitan University have developed a method to pin the edge of drying droplets, creating various geometric patterns. By adding microscopic latex particles to salt solution droplets, they can achieve controlled re-crystallization and form beautiful snowflake-like patterns.
Researchers analyzed data from the National Social Life, Health, and Aging Project to study the relationship between sexual behavior, function, and cognition. The study found that nearly half of men with dementia were sexually active, as well as 18% of women.
A new MIT study finds that 10 major European auto manufacturers produced diesel cars emitting up to 16 times more NOx on the road than in lab tests, resulting in approximately 2,700 premature deaths per year across Europe. Improving emissions control technologies could prevent up to 1,900 premature deaths annually.
ASTN2 helps move proteins away from the membrane, supporting neuronal connections; defects lead to neurodevelopmental disorders like autism and intellectual disabilities. The cerebellum's complex roles in cognition and language may be linked to ASTN2 dysfunction.
A new information tool helps parents make informed decisions about their children's care after minor head trauma, leading to increased parent knowledge and reduced healthcare utilization. However, the tool did not reduce the rate of CT imaging in emergency departments.
Colorado State University chemists are developing biologically friendly coatings to mitigate blood-device interactions in extracorporeal life support systems. These advancements aim to eliminate the need for blood thinners, reducing side effects and improving patient outcomes.
Researchers identified a rare genetic disorder in a human patient caused by mutations in the ornithine decarboxylase 1 (ODC1) gene. The disorder is characterized by large birth weight, hair loss, and developmental delays, and may be treatable with the FDA-approved drug DFMO.
A new study from Imperial College London found that removing tobacco displays from shops reduced the proportion of children buying cigarettes by 17 percent. However, more than two-thirds of child smokers reported being refused cigarettes when trying to buy them, suggesting that enforcement is still crucial.
Researchers at the University of Oxford have demonstrated pre-clinical success for a universal flu vaccine by identifying regions of limited variability in the influenza virus. The vaccine targets these regions, which are targeted by the immune system and can induce cross-reactivity to historical strains.
A new study finds that injecting insulin into the rectum can effectively treat chronic bowel inflammation in humans like Colitis Ulcerosa. The treatment strengthens bowel cells' own defence, reducing inflammation and improving symptoms such as weight loss and bloody diarrhoea.
A new model predicts that ocean acidification could reduce the US sea scallop population by more than 50% in 30 to 80 years, but proactive climate policy may mitigate this impact. The study combines four major factors, including future climate change scenarios, ocean acidification impacts, fisheries management policies, and fuel costs.
UAB researchers develop potential therapy for TTP, a rare and deadly blood-clotting disorder, by delivering ADAMTS13 enzyme via platelets. The treatment inhibits thrombus formation in human and mouse blood, showing therapeutic benefit.
The TESS mission captured a detailed picture of the southern sky with its four wide-field cameras, while Parker Solar Probe and GOLD returned initial data on their instruments and science potential. The three missions offer new perspectives on exoplanets, solar activity, and space weather.
A new type of battery developed by MIT researchers can convert carbon dioxide into a solid mineral carbonate as it discharges. This approach could potentially reduce the cost of carbon capture systems and make them more economically viable. The battery is made from lithium metal, carbon, and an electrolyte that incorporates captured CO2.